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332 Cruises (1,776 Cruise Departures)
23 Day Journey To The Amazon with Regent Seven Seas
Cruise

23 Days (22 Nights) Panama City to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 March 2027
Visit: Panama, Aruba, Trinidad and Tobago, Brazil, Grenada, Curacao
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$20,049
Suite
$20,735
From
US$20,049
Save 20,749
Per Person
View Trip
23 Day South America & Antarctica Holiday with Holland America
Cruise
 (3)

23 Days (22 Nights) Buenos Aires to San Antonio
Cruise Line: Holland America
Ship: Oosterdam
Departure: 19 December 2026
Visit: Argentina, Uruguay, Falkland Islands, Antarctica, Chile
Fare Saver
Exclusive Savings
Inside
$5,022
Oceanview
$5,120
Balcony
$6,786
Suite
$8,648
From
US$5,022
Save 77
Per Person
View Trip
23 Day South America & Antarctica with Holland America
Cruise
 (3)

23 Days (22 Nights) Buenos Aires to Santiago
Cruise Line: Holland America
Ships: Nieuw Amsterdam, Oosterdam
Departures: Feb 2027 to Jan 2028
Visit: Argentina, Uruguay, Falkland Islands, Antarctica, Chile
Fare Saver
Book Early & Have It All Fare Option
Exclusive Savings
Inside
$4,443
Oceanview
$4,933
Balcony
$6,403
Suite
$8,608
From
US$4,443
Save 71
Per Person
View Trip
42 Day Grand South America & Antarctica Voyage with Holland America
Cruise
 (3)

42 Days (41 Nights) Fort Lauderdale to Buenos Aires
Cruise Line: Holland America
Ship: Zaandam
Departure: 03 January 2027
Visit: USA, Cayman Islands, Panama, Ecuador (+6 more), Peru, Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Advantage Fare
Exclusive Savings
Inside
$10,137
Oceanview
$11,264
Balcony
$19,839
Suite
-
From
US$10,137
Per Person
View Trip
23 Day South America & Antarctica with Holland America
Cruise
 (3)

23 Days (22 Nights) San Antonio to Buenos Aires
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 08 January 2028
Visit: Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Book Early & Have It All Fare Option
Exclusive Savings
Inside
$4,590
Oceanview
$5,080
Balcony
$6,991
Suite
$9,588
From
US$4,590
Save 69
Per Person
View Trip
19 Day Journey to Austral Lands and Valdes Peninsula with Ponant
Cruise

19 Days (18 Nights) Buenos Aires to Buenos Aires
Cruise Line: Ponant
Ships: L'Austral, Le Boreal
Departures: Feb 2027 to Mar 2027
Visit: Argentina, Antarctica, South Georgia Island, Falkland Islands
Inside
-
Oceanview
$21,040
Balcony
$22,550
Suite
$35,310
From
US$21,040
Per Person
View Trip
27 Day Puerto Williams to Valparaiso with Silversea
Cruise

27 Days (26 Nights) Puerto Williams to Valparaiso
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 12 February 2027
Visit: Chile, South Georgia Island, Antarctica, Argentina
All-Inclusive Plus Fare
Inside
-
Oceanview
$23,300
Balcony
$32,300
Suite
$41,100
From
US$23,300
Per Person
View Trip
14 Day Argentina, Antarctica & Uruguay Cruise: Ushuaia, Punta Del Este & Montevideo with Azamara Cruises
Cruise
 (5)

14 Days (13 Nights) Ushuaia to Buenos Aires
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 03 February 2028
Visit: Argentina, Antarctica, Falkland Islands, Uruguay
Azamara Always Included
Exclusive Savings
Inside
$4,012
Oceanview
$4,750
Balcony
$5,778
Suite
$8,959
From
US$4,012
Save 97
Per Person
View Trip
50 Day Valparaiso To Bridgetown Grand Voyage with Azamara Cruises
Cruise
 (5)

50 Days (49 Nights) Valparaiso to Bridgetown
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 24 January 2028
Visit: Chile, Argentina, Antarctica, Falkland Islands (+5 more), Uruguay, Brazil, French Guiana, Trinidad and Tobago, Barbados
Azamara Always Included
Exclusive Savings
Inside
$17,404
Oceanview
$18,665
Balcony
$22,545
Suite
$34,214
From
US$17,404
Save 415
Per Person
View Trip
24 Day Chile, Antarctica & Falkland Islands Cruise: Chilean Fjords, Ushuaia & Montevideo with Azamara Cruises
Cruise
 (5)

24 Days (23 Nights) Valparaiso to Buenos Aires
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 24 January 2028
Visit: Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Azamara Always Included
Exclusive Savings
Inside
$7,187
Oceanview
$8,438
Balcony
$10,340
Suite
$17,993
From
US$7,187
Save 172
Per Person
View Trip
23 Day South America & Antarctica with Holland America
Cruise
 (3)

23 Days (22 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 10 January 2027
Visit: Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Fare Saver
Exclusive Savings
Inside
$4,825
Oceanview
-
Balcony
$7,618
Suite
$12,567
From
US$4,825
Save 74
Per Person
View Trip
19 Day Journey to Austral Lands and Valdes Peninsula with Ponant
Cruise
 (2)

19 Days (18 Nights) Buenos Aires to Buenos Aires
Cruise Line: Ponant
Ship: Le Boreal
Departure: 12 November 2026
Visit: Argentina, Falkland Islands, South Georgia Island, Antarctica
Inside
-
Oceanview
$22,390
Balcony
$25,260
Suite
$38,400
From
US$22,390
Per Person
View Trip
66 Day South American Adventure with Oceania Cruises
Cruise
 (1)

66 Days (65 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 January 2028
Visit: USA, Cayman Islands, Jamaica, Colombia (+12 more), Panama, Ecuador, Peru, Chile, Argentina, Antarctica, Falkland Islands, Uruguay, Brazil, Barbados, Guadeloupe, Virgin Islands
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$20,182
Oceanview
$20,958
Balcony
$27,408
Suite
-
From
US$20,182
Save 21,016
Per Person
View Trip
16 Day South America & Antarctica with Norwegian Cruise Line
Cruise
 (1)

16 Days (15 Nights) Buenos Aires to Santiago
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Star
Departures: Jan 2028 to Feb 2028
Visit: Argentina, Uruguay, Falkland Islands, Antarctica, Chile
Exclusive Savings
Inside
$2,826
Oceanview
$3,224
Balcony
$4,504
Suite
$4,892
From
US$2,826
Save 75
Per Person
View Trip
59 Day Valparaiso To Miami Grand Voyage with Azamara Cruises
Cruise
 (5)

59 Days (58 Nights) Valparaiso to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 24 January 2028
Visit: Chile, Argentina, Antarctica, Falkland Islands (+12 more), Uruguay, Brazil, French Guiana, Trinidad and Tobago, Barbados, Grenada, Saint Lucia, Martinique, Dominica, Saint Martin, Virgin Islands, USA
Azamara Always Included
Exclusive Savings
Inside
$19,740
Oceanview
$21,874
Balcony
$26,433
Suite
$40,294
From
US$19,740
Save 469
Per Person
View Trip
22 Day Southern Fjords & Glaciers with Oceania Cruises
Cruise
 (1)

22 Days (21 Nights) Valparaiso to Buenos Aires
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 February 2027
Visit: Chile, Argentina, Antarctica, Falkland Islands
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$6,451
Oceanview
$6,839
Balcony
$9,216
Suite
$12,756
From
US$6,451
Save 6,747
Per Person
View Trip
34 Day Captain Drake's Crossroads with Oceania Cruises
Cruise
 (1)

34 Days (33 Nights) Valparaiso to Rio de Janeiro
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 February 2027
Visit: Chile, Argentina, Antarctica, Falkland Islands, Uruguay, Brazil
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$9,742
Oceanview
$10,227
Balcony
-
Suite
$36,175
From
US$9,742
Save 10,156
Per Person
View Trip
29 Day Ultimate Antarctica & the Fjords of Southern Chile with Scenic
New ReleaseCruise

29 Days (28 Nights) Buenos Aires to Buenos Aires
Cruise Line: Scenic
Ships: Scenic Eclipse I, Scenic Ikon
Departures: Feb 2027 to Feb 2029
Visit: Argentina, Antarctica, Chile, Uruguay
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$38,563
Suite
$84,357
From
US$38,563
Save 2,715
Per Person
View Trip
58 Day Panama Canal, Chilean Fjords, Antarctica & Falklands with Seabourn
Cruise
 (1)

58 Days (57 Nights) Miami to Buenos Aires
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 07 January 2028
Visit: USA, Panama, Ecuador, Peru (+5 more), Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Weekend Sail
Yours to Explore
Exclusive Savings
Inside
-
Oceanview
$37,371
Balcony
$42,271
Suite
-
From
US$37,371
Save 628
Per Person
View Trip
18 Day Antarctica & South America with Princess
Cruise
 (8)

18 Days (17 Nights) Buenos Aires to Buenos Aires
Cruise Line: Princess
Ship: Majestic Princess
Departures: Jan 2027 to Jan 2027
Visit: Argentina, Chile, Antarctica, Falkland Islands, Uruguay
Princess Standard
Exclusive Savings
Inside
$3,387
Oceanview
-
Balcony
$3,742
Suite
$4,465
From
US$3,387
Save 53
Per Person
View Trip
22 Day Southern Fjords & Glaciers with Oceania Cruises
Cruise
 (1)

22 Days (21 Nights) Buenos Aires to Valparaiso
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 January 2027
Visit: Argentina, Falkland Islands, Antarctica, Chile
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$6,308
Oceanview
$6,647
Balcony
$9,557
Suite
$13,340
From
US$6,308
Save 6,590
Per Person
View Trip
16 Day South America & Antarctica with Norwegian Cruise Line
Cruise
 (1)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Star
Departures: Jan 2028 to Mar 2028
Visit: Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Exclusive Savings
Inside
$2,817
Oceanview
$3,205
Balcony
$4,602
Suite
$4,854
From
US$2,817
Save 82
Per Person
View Trip
31 Day Verdant Empire with Regent Seven Seas
Cruise

31 Days (30 Nights) Lima to Rio de Janeiro
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 27 January 2028
Visit: Peru, Chile, Antarctica, Falkland Islands, Argentina, Uruguay, Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$28,534
Suite
$31,621
From
US$28,534
Save 29,564
Per Person
View Trip
17 Day South America & Antarctica From Buenos Aires To Santiago with Norwegian Cruise Line
Cruise
 (1)

17 Days (16 Nights) Buenos Aires to Santiago
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Star
Departure: 17 December 2027
Visit: Argentina, Uruguay, Falkland Islands, Antarctica, Chile
Exclusive Savings
Inside
$3,527
Oceanview
$4,177
Balcony
$5,709
Suite
$6,252
From
US$3,527
Save 92
Per Person
View Trip
22 Day Antarctica & Chilean Fjords Cruise: Buenos Aires, Ushuaia & Santiago with Azamara Cruises
Cruise
 (3)

22 Days (21 Nights) Buenos Aires to Santiago
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 17 February 2027
Visit: Argentina, Uruguay, Falkland Islands, Antarctica, Chile
Azamara Always Included
Exclusive Savings
Inside
$10,316
Oceanview
$11,480
Balcony
$14,594
Suite
$20,491
From
US$10,316
Save 263
Per Person
View Trip
21 Day Valparaiso to Puerto Williams with Silversea
Cruise

21 Days (20 Nights) Valparaiso to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 15 November 2027
Visit: Chile, Argentina, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$31,500
Suite
$43,100
From
US$31,500
Save 3,500
Per Person
View Trip
37 Day Antarctic Voyage with South America and Galápagos Islands with APT
New ReleaseTour + Cruise

37 Days Guayaquil to Rio de Janeiro
Operated By: APT
Ship: Seabourn Venture
Departure: 23 January 2027
Trip Styles: Cruise, Wildlife, Scenic
Visit: Ecuador, Galapagos, Peru, Argentina, Antarctica, Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$42,039
Suite
$44,587
From
US$42,039
Save 756
Per Person
View Trip
20 Day Journey to Austral Lands and Valdes Peninsula with Ponant
Cruise

20 Days (19 Nights) Buenos Aires to Buenos Aires
Cruise Line: Ponant
Ship: Le Lyrial
Departure: 09 March 2027
Visit: Argentina, Antarctica, South Georgia Island, Falkland Islands
Inside
-
Oceanview
$20,000
Balcony
$21,410
Suite
$33,430
From
US$20,000
Per Person
View Trip
19 Day Colossal Coastlines with Regent Seven Seas
Cruise

19 Days (18 Nights) Buenos Aires to Buenos Aires
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 02 February 2027
Visit: Argentina, Chile, Antarctica, Falkland Islands, Uruguay
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,104
Suite
$17,182
From
US$16,104
Save 16,694
Per Person
View Trip
19 Day Antarctic Encounter with Regent Seven Seas
Cruise

19 Days (18 Nights) Buenos Aires to Lima
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 20 February 2027
Visit: Argentina, Falkland Islands, Antarctica, Chile, Peru
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,182
Suite
$19,240
From
US$17,182
Save 17,816
Per Person
View Trip
Results: 211-240 of 332

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South & Central America Cruises

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Travel Styles

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Cities

Cruises from Barcelona Cruises from Bridgetown Cruises from Buenos Aires Cruises from Colon Cruises from Lima Cruises from Lisbon Cruises from Maceio Cruises from Manaus Cruises from Marseille Cruises from Panama City Cruises from Puerto Williams Cruises from Quito Cruises from Rio de Janeiro Cruises from Salvador Cruises from San Antonio Cruises from Santiago Cruises from Santiago Cruises from Santos Cruises from Sao Paulo Cruises from Ushuaia Cruises from Valencia Cruises from Valparaiso

Routes

Cruises from Barcelona to Fort Lauderdale Cruises from Barcelona to Trieste Cruises from Barcelona to Athens Cruises from Barcelona to Lisbon Cruises from Barcelona to Rome Cruises from Barcelona to Barcelona Cruises from Barcelona to Miami Cruises from Bridgetown to Miami Cruises from Bridgetown to Bridgetown Cruises from Buenos Aires to San Antonio Cruises from Buenos Aires to Rio de Janeiro Cruises from Buenos Aires to Buenos Aires Cruises from Buenos Aires to Santiago Cruises from Fort Lauderdale to Los Angeles Cruises from Fort Lauderdale to London Cruises from Fort Lauderdale to Barcelona Cruises from Fort Lauderdale to Fort Lauderdale Cruises from Genoa to Genoa Cruises from Hamburg to London Cruises from Hamburg to Hamburg Cruises from Lima to Quito Cruises from Lisbon to Lisbon Cruises from Lisbon to London Cruises from Lisbon to Barcelona Cruises from Lisbon to Rome Cruises from London to Hamburg Cruises from London to Fort Lauderdale Cruises from London to Copenhagen Cruises from London to London Cruises from London to Lisbon Cruises from London to New York Cruises from Los Angeles to Miami Cruises from Los Angeles to Los Angeles Cruises from Marseille to Marseille Cruises from Miami to San Juan Cruises from Miami to Lisbon Cruises from Miami to Los Angeles Cruises from Miami to Rome Cruises from Miami to Bridgetown Cruises from Miami to Panama City Cruises from Miami to Barcelona Cruises from Miami to Miami Cruises from Miami to London Cruises from New York to New York Cruises from New York to London Cruises from Panama City to Miami Cruises from Quito to Quito Cruises from Rio de Janeiro to Buenos Aires Cruises from Rio de Janeiro to Rio de Janeiro Cruises from Rio de Janeiro to Barcelona Cruises from Rome to Trieste Cruises from Rome to Lisbon Cruises from Rome to Athens Cruises from Rome to Barcelona Cruises from Rome to Fort Lauderdale Cruises from Rome to Rome Cruises from San Antonio to Buenos Aires Cruises from San Diego to Fort Lauderdale Cruises from San Juan to Miami Cruises from San Juan to San Juan Cruises from Santiago to Buenos Aires Cruises from Santiago to Santiago Cruises from Santos to Santos Cruises from Sao Paulo to Sao Paulo Cruises from Tahiti to Tahiti Cruises from Ushuaia to Ushuaia Cruises from Vancouver to Los Angeles Cruises from Venice to Athens Cruises from Venice to Barcelona Cruises from Venice to Rome

Country Routes

Cruises from USA to Portugal Cruises from USA to Germany Cruises from England to Holland Cruises from Germany to England Cruises from France to Spain Cruises from Portugal to England Cruises from Puerto Rico to USA Cruises from Portugal to France Cruises from Chile to USA Cruises from France to Brazil Cruises from Brazil to France Cruises from England to Canada Cruises from England to Germany Cruises from Dominican Republic to USA Cruises from Brazil to Spain Cruises from USA to Puerto Rico Cruises from Argentina to Brazil Cruises from USA to Brazil Cruises from Argentina to Chile Cruises from Brazil to Italy Cruises from Argentina to USA Cruises from Peru to USA Cruises from Barbados to USA Cruises from Brazil to Argentina Cruises from Canada to USA Cruises from Chile to Argentina Cruises from England to Denmark Cruises from England to USA Cruises from France to Italy Cruises from French Polynesia to USA Cruises from USA to Dominican Republic Cruises from Italy to Brazil Cruises from Italy to France Cruises from Italy to Greece Cruises from Italy to Portugal Cruises from Italy to Spain Cruises from Italy to USA Cruises from Panama to USA Cruises from Spain to Brazil Cruises from Peru to Ecuador Cruises from Portugal to Italy Cruises from Portugal to Spain Cruises from Portugal to USA Cruises from Spain to France Cruises from Spain to Greece Cruises from Spain to Italy Cruises from Spain to Portugal Cruises from Spain to USA Cruises from USA to Argentina Cruises from USA to Australia Cruises from USA to Barbados Cruises from USA to Canada Cruises from England to Portugal Cruises from USA to Chile Cruises from USA to England Cruises from USA to French Polynesia Cruises from USA to Holland Cruises from USA to Italy Cruises from Spain to England Cruises from USA to Panama Cruises from USA to Peru Cruises from USA to Spain

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

South America Tours

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