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333 Cruises (1,577 Cruise Departures)
20 Day Spirit of Peru with Belmond Andean Explorer Train and Galápagos Cruise with APT
New ReleaseTour + Cruise

20 Days Lima to Guayaquil
Operated By: APT
Departures: May 2027 to Oct 2028
Visit: Peru, Ecuador, Galapagos
From
US$21,995
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Santos to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco
Inside
$1,484
Oceanview
$1,664
Balcony
$1,954
Suite
$5,414
From
US$1,484
Per Person
View Trip
14 Day Chilean Fjords & The Glaciers of The Beagle Channel with Scenic
Cruise

14 Days (13 Nights) Buenos Aires to Santiago
Cruise Line: Scenic
Ships: Scenic Eclipse II
Departures: Mar 2027 to Mar 2028
Visit: Chile, Argentina
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,529
Suite
$23,332
From
US$15,529
Save 3,901
Per Person
View Trip
12 Day Nights Of Samba & Tango with Regent Seven Seas
Cruise

12 Days (11 Nights) Rio de Janeiro to Buenos Aires
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 22 January 2027
Visit: Brazil, Uruguay, Argentina
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,699
Suite
$14,499
From
US$13,699
Save 13,699
Per Person
View Trip
10 Day Galápagos – Central and East Islands aboard the Reina Silvia Voyager with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jun 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$6,112
Save 2,037
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise

10 Days (9 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 08 January 2027
Visit: Brazil, Uruguay, Argentina
Inside
-
Oceanview
-
Balcony
$2,075
Suite
$2,957
From
US$2,075
Per Person
View Trip
8 Day San Cristóbal to San Cristóbal with Silversea
Cruise

8 Days (7 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departures: May 2026 to Mar 2028
Visit: Ecuador, Galapagos
Last Minute Fare
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,600
Suite
$17,400
From
US$11,600
Save 2,500
Per Person
View Trip
6 Day Galapagos Escape - Solaris (Itinerary C) with Exodus Tours
Cruise

6 Days (5 Nights) Quito to Guayaquil
Operated By: Exodus Tours
Departures: Jun 2026 to Dec 2027
Visit: Ecuador, Galapagos
Sign Up Savings
Exclusive Savings
From
US$5,670
Save 660
Per Person
View Trip
17 Day Complete Galápagos - Yolita with G Adventures
Cruise

17 Days (16 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jun 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$9,759
Save 2,440
Per Person
View Trip
116 Day MSC World Cruise with MSC Cruises
Cruise

116 Days (115 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 04 January 2028
Visit: Italy, France, Spain, Turks and Caicos Islands (+24 more), Bahamas, Mexico, Costa Rica, Panama, Ecuador, Peru, Chile, French Polynesia, Tonga, New Caledonia, New Zealand, Australia, Indonesia, Vietnam, Thailand, Cambodia, Singapore, Malaysia, Sri Lanka, India, United Arab Emirates, Oman, Jordan, Egypt
Inside
$18,749
Oceanview
$21,609
Balcony
$30,399
Suite
-
From
US$18,749
Per Person
View Trip
17 Day Trinidad To Rio: South American Expedition with Seabourn
Cruise

17 Days (16 Nights) Bridgetown to Rio de Janeiro
Cruise Line: Seabourn
Ship: Seabourn Venture
Departures: Oct 2026 to Oct 2028
Visit: Barbados, Trinidad and Tobago, French Guiana, Brazil
Inside
-
Oceanview
-
Balcony
-
Suite
$9,598
From
US$9,598
Per Person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Chile to Panama with Scenic
New ReleaseCruise

14 Days (13 Nights) Santiago to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 21 March 2027
Visit: Chile, Peru, Ecuador, Colombia, Panama
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,536
Suite
$11,962
From
US$8,536
Save 3,009
Per Person
View Trip
19 Day White Sands & Brazilian Sun with Regent Seven Seas
Cruise

19 Days (18 Nights) Miami to Rio de Janeiro
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 04 January 2027
Visit: USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Barbados, French Guiana, Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,399
Suite
$18,099
From
US$17,399
Save 17,399
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Salvador to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 30 March 2027
Visit: Brazil
Inside
$546
Oceanview
$627
Balcony
$742
Suite
$1,236
From
US$546
Per Person
View Trip
26 Day Best of South America with Galápagos Cruise with APT
New ReleaseTour + Cruise

26 Days Rio de Janeiro to Guayaquil
Operated By: APT
Departures: Apr 2027 to Nov 2028
Visit: Brazil, Argentina, Chile, Peru, Ecuador, Galapagos
From
US$24,795
Per Person
View Trip
18 Day Land of the Incas with Galápagos Legend North and Central Cruise with Trafalgar
Tour + Cruise

18 Days Lima to Quito
Operated By: Trafalgar
Departures: Oct 2026 to Nov 2026
Visit: Peru, Ecuador
Today's Deal
Exclusive Savings
From
US$9,361
Save 470
Per Person
View Trip
34 Day San Antonio To Southampton with Cunard
Cruise

34 Days (33 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Visit: Chile, Peru, Ecuador, Panama (+4 more), Aruba, USA, Portugal, England
Bonus Onboard Credit
Value Fare
Inside
$5,209
Oceanview
$7,269
Balcony
$8,109
Suite
$18,109
From
US$5,209
Per Person
View Trip
13 Day Miami, Fl to Lima (Callao) with Silversea
Cruise

13 Days (12 Nights) Miami to Lima
Cruise Line: Silversea
Ship: Silver Ray
Departure: 15 January 2028
Visit: USA, Mexico, Costa Rica, Panama, Ecuador, Peru
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,400
Suite
$14,200
From
US$8,400
Save 3,000
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise

20 Days (19 Nights) Rome to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 16 November 2027
Visit: Italy, Spain, Brazil, Uruguay, Argentina
Inside
$1,869
Oceanview
$2,319
Balcony
$2,529
Suite
$3,949
From
US$1,869
Per Person
View Trip
13 Day A Journey From Amazon Adventures To Caribbean Charms with Explora Journeys
Cruise

13 Days (12 Nights) Manaus to San Juan
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 17 February 2027
Visit: Brazil, French Guiana, Saint Vincent, Barbados (+4 more), Saint Lucia, Saint Barthelemy, Saint Kitts and Nevis, Puerto Rico
Inside
-
Oceanview
-
Balcony
-
Suite
$9,595
From
US$9,595
Per Person
View Trip
10 Day Galápagos - East, Central, & West Islands aboard the Eden with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jun 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$4,623
Save 1,156
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 29 November 2026
Visit: Brazil, Uruguay, Argentina
Inside
-
Oceanview
-
Balcony
$1,281
Suite
-
From
US$1,281
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Seaview, MSC Virtuosa
Departures: Nov 2026 to Mar 2027
Visit: Brazil
Inside
$393
Oceanview
$453
Balcony
$543
Suite
$733
From
US$393
Per Person
View Trip
13 Day Highlights of Peru with Galápagos Legend North and Central Cruise with Trafalgar
Tour + Cruise

13 Days Lima to Quito
Operated By: Trafalgar
Departures: Sep 2026 to Nov 2026
Visit: Peru, Ecuador, Galapagos
Sign Up Savings
Today's Deal
Exclusive Savings
From
US$7,217
Save 258
Per Person
View Trip
13 Day Chilean Fjords & The Glaciers of The Beagle Channel with Scenic
Cruise

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ships: Scenic Eclipse I
Departures: Nov 2026 to Nov 2028
Visit: Chile, Argentina
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,530
Suite
$25,734
From
US$16,530
Save 3,385
Per Person
View Trip
21 Day Rio De Janeiro to Bridgetown with Silversea
Cruise

21 Days (20 Nights) Rio de Janeiro to Bridgetown
Cruise Line: Silversea
Ship: Silver Ray
Departure: 29 February 2028
Visit: Brazil, French Guiana, Barbados
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,900
Suite
$26,800
From
US$16,900
Save 3,500
Per Person
View Trip
8 Day Galápagos - West & Central Islands aboard the Reina Silvia Voyager (Cruise Only) with G Adventures
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Operated By: G Adventures
Departures: Jul 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$5,759
Save 1,490
Per Person
View Trip
21 Day South America Revealed with Galápagos Legend North and Central Cruise with Trafalgar
Tour + Cruise

21 Days Rio de Janeiro to Quito
Operated By: Trafalgar
Departure: 02 October 2026
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
Today's Deal
Exclusive Savings
From
US$11,220
Save 630
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Genoa to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 15 November 2027
Visit: Italy, Spain, Brazil, Uruguay, Argentina
Inside
$1,969
Oceanview
$2,439
Balcony
$2,659
Suite
$4,169
From
US$1,969
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise

10 Days (9 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 22 December 2026
Visit: Brazil, Uruguay, Argentina
Inside
-
Oceanview
-
Balcony
$2,033
Suite
$2,816
From
US$2,033
Per Person
View Trip
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South & Central America Cruises

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Travel Styles

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Cities

Cruises from Barcelona Cruises from Bridgetown Cruises from Buenos Aires Cruises from Colon Cruises from Lima Cruises from Lisbon Cruises from Maceio Cruises from Manaus Cruises from Marseille Cruises from Panama City Cruises from Puerto Williams Cruises from Quito Cruises from Rio de Janeiro Cruises from Salvador Cruises from San Antonio Cruises from Santiago Cruises from Santiago Cruises from Santos Cruises from Sao Paulo Cruises from Ushuaia Cruises from Valencia Cruises from Valparaiso

Routes

Cruises from Barcelona to Fort Lauderdale Cruises from Barcelona to Trieste Cruises from Barcelona to Athens Cruises from Barcelona to Lisbon Cruises from Barcelona to London Cruises from Barcelona to Rome Cruises from Barcelona to Barcelona Cruises from Barcelona to Miami Cruises from Bridgetown to Miami Cruises from Bridgetown to Bridgetown Cruises from Buenos Aires to San Antonio Cruises from Buenos Aires to Rio de Janeiro Cruises from Buenos Aires to Buenos Aires Cruises from Buenos Aires to Santiago Cruises from Fort Lauderdale to London Cruises from Fort Lauderdale to Fort Lauderdale Cruises from Genoa to Genoa Cruises from Hamburg to London Cruises from Hamburg to Hamburg Cruises from Lima to Buenos Aires Cruises from Lima to Quito Cruises from Lisbon to Lisbon Cruises from Lisbon to London Cruises from Lisbon to Barcelona Cruises from Lisbon to Rome Cruises from London to Hamburg Cruises from London to Barcelona Cruises from London to Fort Lauderdale Cruises from London to Rome Cruises from London to London Cruises from London to Lisbon Cruises from London to New York Cruises from Los Angeles to Miami Cruises from Los Angeles to Los Angeles Cruises from Marseille to Marseille Cruises from Miami to San Juan Cruises from Miami to Lisbon Cruises from Miami to Los Angeles Cruises from Miami to Rome Cruises from Miami to Bridgetown Cruises from Miami to Panama City Cruises from Miami to Barcelona Cruises from Miami to Miami Cruises from Miami to London Cruises from New York to New York Cruises from New York to London Cruises from Panama City to Miami Cruises from Quito to Quito Cruises from Reykjavik to London Cruises from Rio de Janeiro to Buenos Aires Cruises from Rio de Janeiro to Rio de Janeiro Cruises from Rio de Janeiro to Barcelona Cruises from Rome to Trieste Cruises from Rome to London Cruises from Rome to Lisbon Cruises from Rome to Miami Cruises from Rome to Athens Cruises from Rome to Barcelona Cruises from Rome to Fort Lauderdale Cruises from Rome to Rome Cruises from San Antonio to Buenos Aires Cruises from San Diego to Fort Lauderdale Cruises from San Juan to Miami Cruises from San Juan to San Juan Cruises from Santiago to Buenos Aires Cruises from Santiago to Santiago Cruises from Santos to Santos Cruises from Sao Paulo to Sao Paulo Cruises from Tahiti to Tahiti Cruises from Ushuaia to Ushuaia Cruises from Vancouver to Los Angeles Cruises from Venice to Athens Cruises from Venice to Barcelona Cruises from Venice to Rome

Country Routes

Cruises from Peru to Argentina Cruises from USA to Portugal Cruises from USA to Germany Cruises from Italy to England Cruises from England to Holland Cruises from Germany to England Cruises from France to Spain Cruises from Portugal to England Cruises from Iceland to USA Cruises from Puerto Rico to USA Cruises from Iceland to Holland Cruises from Portugal to France Cruises from Chile to USA Cruises from France to Brazil Cruises from Brazil to France Cruises from Iceland to Canada Cruises from England to Canada Cruises from England to Germany Cruises from Brazil to Portugal Cruises from Dominican Republic to USA Cruises from Brazil to Spain Cruises from USA to Puerto Rico Cruises from Canada to England Cruises from French Polynesia to New Zealand Cruises from Argentina to Brazil Cruises from USA to Brazil Cruises from Argentina to Chile Cruises from Brazil to Italy Cruises from Argentina to USA Cruises from Peru to USA Cruises from Barbados to USA Cruises from Brazil to Argentina Cruises from Canada to USA Cruises from Chile to Argentina Cruises from England to Italy Cruises from England to Spain Cruises from England to USA Cruises from France to Italy Cruises from French Polynesia to USA Cruises from USA to Dominican Republic Cruises from Iceland to England Cruises from Italy to Brazil Cruises from Italy to France Cruises from Italy to Greece Cruises from Italy to Portugal Cruises from Italy to Spain Cruises from Italy to USA Cruises from Panama to USA Cruises from Spain to Brazil Cruises from Peru to Ecuador Cruises from Portugal to Italy Cruises from Portugal to Spain Cruises from Portugal to USA Cruises from Spain to France Cruises from Spain to Greece Cruises from Spain to Italy Cruises from Spain to Portugal Cruises from Spain to USA Cruises from USA to Argentina Cruises from USA to Australia Cruises from USA to Barbados Cruises from USA to Canada Cruises from England to Portugal Cruises from USA to Chile Cruises from USA to England Cruises from USA to French Polynesia Cruises from USA to Holland Cruises from USA to Italy Cruises from Spain to England Cruises from USA to Panama Cruises from USA to Peru Cruises from USA to Spain

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

South America Tours

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