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347 Cruises (2,121 Cruise Departures)
23 Day South American Passage with Princess
Cruise
 (7)

23 Days (22 Nights) London to Buenos Aires
Cruise Line: Princess
Ship: Majestic Princess
Departure: 30 October 2027
Visit: England, Spain, Portugal, Brazil, Uruguay, Argentina
Princess Standard
Inside
$2,214
Oceanview
-
Balcony
$3,403
Suite
$3,928
From
US$2,214
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Santos to London
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil, Portugal, Spain, England
Drinks, WiFi & Onboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$6,070
From
US$6,070
Save 174
Per Person
View Trip
35 Day MSC World Cruise with MSC Cruises
Cruise

35 Days (34 Nights) Barcelona to Valparaiso
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 07 January 2027
Visit: Spain, Gibraltar, Morocco, Cape Verde (+4 more), Brazil, Argentina, Falkland Islands, Chile
Exclusive Savings
Inside
$4,342
Oceanview
$5,157
Balcony
-
Suite
-
From
US$4,342
Save 107
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Barcelona to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 15 November 2026
Visit: Spain, Gibraltar, Morocco, Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$1,627
Oceanview
$1,987
Balcony
$2,147
Suite
$3,194
From
US$1,627
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Rio de Janeiro to London
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 03 April 2026
Visit: Brazil, Portugal, Spain, England
Bonus Onboard Credit
Inside
-
Oceanview
-
Balcony
$1,890
Suite
$3,215
From
US$1,890
Per Person
View Trip
35 Day Hamburg To Rio De Janeiro with Cunard
Cruise

35 Days (34 Nights) Hamburg to Rio de Janeiro
Cruise Line: Cunard
Ship: Queen Anne
Departure: 05 January 2027
Visit: Germany, Holland, Belgium, England (+5 more), Bermuda, USA, Turks and Caicos Islands, Barbados, Brazil
Inside
$5,369
Oceanview
$7,686
Balcony
$8,696
Suite
$18,576
From
US$5,369
Per Person
View Trip
83 Day South America Discovery with Cunard
Cruise

83 Days (82 Nights) London to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 10 January 2027
Visit: England, Bermuda, USA, Turks and Caicos Islands (+10 more), Barbados, Brazil, Uruguay, Argentina, Chile, Peru, Ecuador, Panama, Aruba, Portugal
Exclusive Savings
Inside
$13,068
Oceanview
$18,117
Balcony
$20,058
Suite
$40,016
From
US$13,068
Per Person
View Trip
54 Day Chilean Fjords, Antarctica & South Atlantic Explorer with Seabourn
Cruise
 (1)

54 Days (53 Nights) Valparaiso to Cape Town
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 05 February 2028
Visit: Chile, Argentina, Antarctica, Falkland Islands (+4 more), Uruguay, Saint Helena, South Africa, Mozambique
Exclusive Savings
Inside
-
Oceanview
$31,858
Balcony
$35,386
Suite
-
From
US$31,858
Save 541
Per Person
View Trip
83 Day South America, Antarctica, South Atlantic & Africa with Seabourn
Cruise
 (1)

83 Days (82 Nights) Miami to Cape Town
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 07 January 2028
Visit: USA, Panama, Ecuador, Peru (+8 more), Chile, Argentina, Antarctica, Falkland Islands, Uruguay, Saint Helena, South Africa, Mozambique
Exclusive Savings
Inside
-
Oceanview
$48,689
Balcony
$54,863
Suite
$100,727
From
US$48,689
Save 810
Per Person
View Trip
64 Day World Cruise: Panama Canal, Polynesia & New Zealand with Seabourn
Cruise
 (1)

64 Days (63 Nights) Miami to Sydney
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 05 January 2027
Visit: USA, Panama, Ecuador, Peru (+6 more), Chile, French Polynesia, Cook Islands, Tonga, New Zealand, Australia
Explore More
Exclusive Savings
Inside
-
Oceanview
$29,548
Balcony
$34,796
Suite
$150,500
From
US$29,548
Save 456
Per Person
View Trip
29 Day Caribbean, Central America & Peru Cruise: Aruba, Miami & Panama Canal with Azamara Cruises
Cruise
 (4)

29 Days (28 Nights) Bridgetown to Valparaiso
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 27 December 2027
Visit: Barbados, Bonaire, Curacao, Aruba (+11 more), Dominican Republic, Bahamas, USA, Mexico, Belize, Honduras, Costa Rica, Panama, Ecuador, Peru, Chile
Azamara Always Included
Exclusive Savings
Inside
$8,979
Oceanview
$10,570
Balcony
$12,878
Suite
$18,824
From
US$8,979
Save 210
Per Person
View Trip
57 Day South America Discovery From Fort Lauderdale with Cunard
Cruise

57 Days (56 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Anne
Departure: 22 January 2027
Visit: USA, Turks and Caicos Islands, Barbados, Brazil (+7 more), Uruguay, Argentina, Chile, Peru, Ecuador, Panama, Aruba
Exclusive Savings
Inside
$11,019
Oceanview
$15,811
Balcony
$17,157
Suite
$35,175
From
US$11,019
Per Person
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise
 (1)

20 Days (19 Nights) Santiago to New York
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2026 to Apr 2028
Visit: Chile, Peru, Panama, Jamaica, Bahamas
Flights Included
Viking $999 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,995
Suite
$15,995
From
US$9,995
Save 2,500
Per Person
View Trip
37 Day Caribbean To Cape Horn with Oceania Cruises
Cruise
 (1)

37 Days (36 Nights) Miami to Buenos Aires
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 19 December 2026
Visit: USA, Curacao, Aruba, Colombia (+7 more), Panama, Ecuador, Peru, Chile, Argentina, Falkland Islands, Uruguay
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$10,002
Oceanview
$10,633
Balcony
$14,076
Suite
$20,430
From
US$10,002
Save 10,396
Per Person
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise
 (1)

20 Days (19 Nights) New York to Santiago
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 25 October 2026
Visit: USA, Bahamas, Jamaica, Panama, Peru, Chile
Flights Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,495
Suite
$15,995
From
US$9,495
Save 1,500
Per Person
View Trip
42 Day Antarctic Explorer & the Americas with Viking Cruises
Cruise
 (1)

42 Days (41 Nights) Buenos Aires to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 26 February 2027
Visit: Argentina, Antarctica, Chile, Peru (+4 more), Ecuador, Panama, Mexico, USA
Viking $1,499 Air Deal
Inside
-
Oceanview
-
Balcony
$39,585
Suite
-
From
US$39,585
Per Person
View Trip
41 Day Buenos Aires To Miami Grand Voyage with Azamara Cruises
Cruise
 (3)

41 Days (40 Nights) Buenos Aires to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 17 February 2027
Visit: Argentina, Uruguay, Falkland Islands, Antarctica (+7 more), Chile, Peru, Panama, Costa Rica, Colombia, Mexico, USA
Azamara Always Included
Exclusive Savings
Inside
$15,631
Oceanview
$16,581
Balcony
$18,725
Suite
$30,443
From
US$15,631
Save 368
Per Person
View Trip
29 Day The Mediterranean & South Atlantic with Viking Cruises
Cruise
 (6)

29 Days (28 Nights) Buenos Aires to Rome
Cruise Line: Viking Cruises
Ship: Viking Jupiter
Departure: 11 March 2026
Visit: Argentina, Uruguay, Brazil, Cape Verde (+4 more), Morocco, Spain, France, Italy
Viking $1,299 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$16,998
From
US$16,998
Save 1,050
Per Person
View Trip
69 Day Miami To Bridgetown Grand Voyage with Azamara Cruises
Cruise
 (4)

69 Days (68 Nights) Miami to Bridgetown
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 05 January 2028
Visit: USA, Mexico, Belize, Honduras (+13 more), Costa Rica, Panama, Ecuador, Peru, Chile, Argentina, Antarctica, Falkland Islands, Uruguay, Brazil, French Guiana, Trinidad and Tobago, Barbados
Azamara Always Included
Exclusive Savings
Inside
$22,787
Oceanview
$26,511
Balcony
$31,943
Suite
$46,028
From
US$22,787
Save 522
Per Person
View Trip
43 Day Miami To Buenos Aires Grand Voyage with Azamara Cruises
Cruise
 (4)

43 Days (42 Nights) Miami to Buenos Aires
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 05 January 2028
Visit: USA, Mexico, Belize, Honduras (+9 more), Costa Rica, Panama, Ecuador, Peru, Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Azamara Always Included
Exclusive Savings
Inside
$14,374
Oceanview
$16,217
Balcony
$20,194
Suite
$28,351
From
US$14,374
Save 335
Per Person
View Trip
22 Day Brazil Coast, Cape Verde & Canary Islands Crossing with Seabourn
Cruise

22 Days (21 Nights) Rio de Janeiro to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Venture
Departure: 04 April 2026
Visit: Brazil, Cape Verde, Spain, Morocco
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,205
Suite
$9,205
From
US$9,205
Save 144
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Rio de Janeiro to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 15 March 2027
Visit: Brazil, Spain, Morocco, Gibraltar, Italy
Bonus Onboard Credit
Inside
$1,247
Oceanview
$1,527
Balcony
$1,847
Suite
$3,088
From
US$1,247
Per Person
View Trip
58 Day Old & New World Discovery with Oceania Cruises
Cruise
 (1)

58 Days (57 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Visit: Italy, Croatia, Montenegro, Greece (+14 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$14,951
Oceanview
$16,212
Balcony
$24,360
Suite
$32,508
From
US$14,951
Save 15,547
Per Person
View Trip
37 Day Northern Lights Grand Adventure with Princess
Cruise
 (7)

37 Days (36 Nights) London to Buenos Aires
Cruise Line: Princess
Ship: Majestic Princess
Departure: 16 October 2027
Visit: England, Norway, Spain, Portugal, Brazil, Uruguay, Argentina
Princess Standard
Exclusive Savings
Inside
$4,343
Oceanview
-
Balcony
$6,467
Suite
$7,627
From
US$4,343
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Rio de Janeiro to Oslo
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 03 April 2026
Visit: Brazil, Portugal, Spain, England (+4 more), France, Belgium, Denmark, Norway
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$4,859
From
US$4,859
Save 132
Per Person
View Trip
48 Day Footsteps Of Columbus with Oceania Cruises
Cruise
 (1)

48 Days (47 Nights) Barcelona to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 02 November 2026
Visit: Spain, Portugal, Puerto Rico, Bahamas (+9 more), USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$11,961
Oceanview
$13,028
Balcony
$19,285
Suite
$25,832
From
US$11,961
Save 12,437
Per Person
View Trip
78 Day Circle South America Grand Voyage with Azamara Cruises
Cruise
 (4)

78 Days (77 Nights) Miami to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 05 January 2028
Visit: USA, Mexico, Belize, Honduras (+19 more), Costa Rica, Panama, Ecuador, Peru, Chile, Argentina, Antarctica, Falkland Islands, Uruguay, Brazil, French Guiana, Trinidad and Tobago, Barbados, Grenada, Saint Lucia, Martinique, Dominica, Saint Martin, Virgin Islands
Azamara Always Included
Exclusive Savings
Inside
$25,403
Oceanview
$29,613
Balcony
$35,821
Suite
$51,826
From
US$25,403
Save 586
Per Person
View Trip
75 Day Circle South America Grand Voyage with Azamara Cruises
Cruise
 (3)

75 Days (74 Nights) Miami to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 14 January 2027
Visit: USA, Virgin Islands, Saint Martin, Saint Kitts and Nevis (+18 more), Antigua and Barbuda, Martinique, Saint Vincent, Grenada, Barbados, Trinidad and Tobago, French Guiana, Brazil, Uruguay, Argentina, Falkland Islands, Antarctica, Chile, Peru, Panama, Costa Rica, Colombia, Mexico
Azamara Always Included
Exclusive Savings
Inside
$28,068
Oceanview
$29,261
Balcony
$32,763
Suite
$54,908
From
US$28,068
Save 661
Per Person
View Trip
66 Day Grand South America Mosaic with Regent Seven Seas
Cruise

66 Days (65 Nights) Miami to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 13 January 2028
Visit: USA, Cayman Islands, Jamaica, Colombia (+12 more), Costa Rica, Panama, Ecuador, Peru, Chile, Antarctica, Falkland Islands, Argentina, Uruguay, Brazil, Saint Lucia, Saint Kitts and Nevis
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$65,072
Suite
$66,983
From
US$65,072
Save 67,426
Per Person
View Trip
62 Day Longitudinal World Cruise IV with Viking Cruises
Cruise

62 Days (61 Nights) Milwaukee to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Octantis
Departure: 22 September 2028
Visit: USA, Canada, Mexico, Panama (+5 more), Ecuador, Peru, Chile, Argentina, Antarctica
Flights Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$52,995
Suite
$75,995
From
US$52,995
Save 2,100
Per Person
View Trip
Results: 301-330 of 347

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South & Central America Cruises

Amazon Cruises Antarctica Cruises Argentina Cruises Bahamas Cruises Barbados Cruises Bermunda Cruises Brazil Cruises Cape Horn Cruises Caribbean Cruises Central America Cruises Chile Cruises Ecuador Cruises Falkland Island Cruises Falkland Islands Cruises France Cruises French Polynesia Cruises Galapagos Cruises Mexico Cruises Morocco Cruises Panama Cruises Patagonia Cruises Peru Cruises Portugal Cruises South America Cruises Spain Cruises Uruguay Cruises

Travel Styles

Active Adventures Coach Cruises Luxury Cruises Short Cruise Breaks Wellness Cruises Wildlife Cruises

Cities

Cruises from Baltra Island Cruises from Barcelona Cruises from Bridgetown Cruises from Buenos Aires Cruises from Colon Cruises from Lima Cruises from Lisbon Cruises from Maceio Cruises from Manaus Cruises from Marseille Cruises from Montevideo Cruises from Panama City Cruises from Puerto Williams Cruises from Quito Cruises from Rio de Janeiro Cruises from Salvador Cruises from San Antonio Cruises from San Cristobal Island Cruises from Santiago Cruises from Santiago Cruises from Santos Cruises from Sao Paulo Cruises from Tahiti Cruises from Valencia Cruises from Valparaiso

Routes

Cruises from Baltra Island to Baltra Island Cruises from Barcelona to Fort Lauderdale Cruises from Barcelona to Trieste Cruises from Barcelona to Athens Cruises from Barcelona to Lisbon Cruises from Barcelona to Rome Cruises from Barcelona to Barcelona Cruises from Barcelona to Miami Cruises from Bridgetown to Miami Cruises from Bridgetown to Bridgetown Cruises from Buenos Aires to Rio de Janeiro Cruises from Buenos Aires to Buenos Aires Cruises from Fort Lauderdale to Los Angeles Cruises from Fort Lauderdale to Barcelona Cruises from Fort Lauderdale to Fort Lauderdale Cruises from Genoa to Genoa Cruises from Hamburg to London Cruises from Hamburg to Hamburg Cruises from Lima to Buenos Aires Cruises from Lima to Quito Cruises from Lisbon to Lisbon Cruises from Lisbon to London Cruises from Lisbon to Barcelona Cruises from Lisbon to Rome Cruises from London to Hamburg Cruises from London to Barcelona Cruises from London to Fort Lauderdale Cruises from London to London Cruises from London to Lisbon Cruises from London to New York Cruises from Marseille to Marseille Cruises from Miami to San Juan Cruises from Miami to Lisbon Cruises from Miami to Los Angeles Cruises from Miami to Rome Cruises from Miami to Bridgetown Cruises from Miami to Panama City Cruises from Miami to Barcelona Cruises from Miami to Miami Cruises from Miami to London Cruises from New York to New York Cruises from New York to London Cruises from Panama City to Miami Cruises from Quito to Guayaquil Cruises from Quito to Quito Cruises from Rio de Janeiro to Rio de Janeiro Cruises from Rio de Janeiro to Barcelona Cruises from Rome to Trieste Cruises from Rome to Lisbon Cruises from Rome to Miami Cruises from Rome to Athens Cruises from Rome to Barcelona Cruises from Rome to Fort Lauderdale Cruises from Rome to Rome Cruises from San Antonio to Buenos Aires Cruises from San Cristobal Island to San Cristobal Island Cruises from San Juan to Miami Cruises from San Juan to San Juan Cruises from Santiago to Buenos Aires Cruises from Santiago to Santiago Cruises from Santos to Santos Cruises from Sao Paulo to Sao Paulo Cruises from Tahiti to Tahiti Cruises from Ushuaia to Ushuaia Cruises from Venice to Athens Cruises from Venice to Barcelona Cruises from Venice to Rome

Country Routes

Cruises from Peru to Argentina Cruises from USA to Portugal Cruises from Germany to England Cruises from Canada to Japan Cruises from France to Spain Cruises from Portugal to England Cruises from Puerto Rico to USA Cruises from Chile to USA Cruises from France to Brazil Cruises from Brazil to France Cruises from England to Germany Cruises from Dominican Republic to USA Cruises from Brazil to Spain Cruises from USA to Puerto Rico Cruises from Argentina to Brazil Cruises from USA to Brazil Cruises from Argentina to Chile Cruises from Brazil to Italy Cruises from Argentina to USA Cruises from Peru to USA Cruises from Barbados to USA Cruises from Canada to USA Cruises from Chile to Argentina Cruises from England to Spain Cruises from England to USA Cruises from France to Italy Cruises from French Polynesia to USA Cruises from USA to Dominican Republic Cruises from England to Norway Cruises from Italy to Brazil Cruises from Italy to France Cruises from Italy to Greece Cruises from Italy to Portugal Cruises from Italy to Spain Cruises from Italy to USA Cruises from Panama to USA Cruises from Spain to Brazil Cruises from Peru to Ecuador Cruises from Portugal to Italy Cruises from Portugal to Spain Cruises from Portugal to USA Cruises from Spain to France Cruises from Spain to Greece Cruises from Spain to Italy Cruises from Spain to Portugal Cruises from Spain to USA Cruises from USA to Australia Cruises from USA to Barbados Cruises from USA to Canada Cruises from England to Portugal Cruises from USA to Chile Cruises from USA to England Cruises from USA to French Polynesia Cruises from USA to Italy Cruises from USA to Japan Cruises from Spain to England Cruises from USA to Panama Cruises from USA to Peru Cruises from USA to Spain

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

South America Tours

All South America Tours Amazon Tours Argentina Tours Brazil Tours Chile Tours Colombia Tours Ecuador Tours Galapagos Tours Patagonia Tours Peru Tours

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