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Round-trip Cruises from Santos

Are you looking for a cruise starting and ending in Santos? December is the most popular month to join a roundtrip cruise from Santos and we have 43 departures available from one of the world's leading cruise lines.
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10 Cruises (43 Cruise Departures)
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 19 January 2026
Visit: Brazil
Bonus Onboard Credit
Inside
-
Oceanview
$1,260
Balcony
-
Suite
$2,010
From
US$1,260
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Preziosa
Departures: Jan 2026 to Mar 2027
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$889
Oceanview
$959
Balcony
$1,089
Suite
$1,349
From
US$889
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Preziosa, MSC Sinfonia
Departures: Jan 2026 to Mar 2027
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$1,375
From
US$475
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$575
Suite
-
From
US$475
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Sinfonia
Departures: Mar 2026 to Mar 2027
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$1,465
From
US$475
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 28 December 2026
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Exclusive Savings
Inside
$2,014
Oceanview
$2,062
Balcony
$2,159
Suite
-
From
US$2,014
Save 53
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Sinfonia
Departures: Jan 2026 to Dec 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$565
Suite
-
From
US$475
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Jan 2027
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$1,104
Oceanview
$1,144
Balcony
$1,224
Suite
-
From
US$1,104
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 22 February 2026
Visit: Brazil, Argentina, Uruguay
Bonus Onboard Credit
Inside
$1,113
Oceanview
$1,259
Balcony
$1,470
Suite
$2,061
From
US$1,113
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 26 December 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$1,619
Oceanview
$1,669
Balcony
$1,789
Suite
$2,091
From
US$1,619
Per Person
View Trip
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