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Cruises from Santos

Choose from 26 unique expeditions and cruises starting in Santos, and traveling to Amalfi, Barcelona, Funchal, Genoa, Maceio and more. April is the most popular month to join a cruise from Santos and you can select from 43 departures available from one leading cruise lines.
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2 Days
24 Days
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26 Cruises (43 Cruise Departures)
2 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

2 Days (1 Nights) Santos to Rio de Janeiro
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Musica (+2 more), MSC Preziosa, MSC Virtuosa
Departures: Apr 2026 to Apr 2027
Visit: Brazil
Drinks & WiFi Package
Inside
$79
Oceanview
$119
Balcony
$179
Suite
$379
From
US$79
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Santos to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco
Inside
$1,394
Oceanview
$1,664
Balcony
$1,894
Suite
$5,265
From
US$1,394
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Jan 2027
Visit: Brazil, Uruguay, Argentina
Inside
$1,320
Oceanview
$1,368
Balcony
$1,464
Suite
-
From
US$1,320
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Santos to Genoa
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 11 April 2026
Visit: Brazil, Spain, Gibraltar, France, Italy
Grand Voyages Sale
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$4,261
From
US$4,261
Save 118
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Preziosa
Departures: Mar 2026 to Mar 2027
Visit: Brazil
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$1,637
From
US$475
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Santos to Amalfi
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily, Italy
Inside
$1,681
Oceanview
$2,031
Balcony
$2,541
Suite
-
From
US$1,681
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 28 December 2026
Visit: Brazil, Uruguay, Argentina
Exclusive Savings
Inside
$2,303
Oceanview
$2,359
Balcony
$2,470
Suite
-
From
US$2,303
Save 62
Per Person
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Maceio
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visit: Brazil
Inside
$279
Oceanview
$349
Balcony
$509
Suite
-
From
US$279
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Sinfonia
Departures: Mar 2026 to Mar 2027
Visit: Brazil
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$1,655
From
US$475
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Santos to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visit: Brazil, Spain, France, Italy
Inside
$1,077
Oceanview
$1,231
Balcony
$1,674
Suite
-
From
US$1,077
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

20 Days (19 Nights) Santos to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 14 March 2027
Visit: Brazil, Spain, Morocco, Gibraltar, Italy
Inside
$1,379
Oceanview
$1,609
Balcony
$1,939
Suite
$3,274
From
US$1,379
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Nov 2026 to Dec 2026
Visit: Brazil
Inside
$475
Oceanview
$505
Balcony
$575
Suite
-
From
US$475
Per Person
View Trip
13 Day MSC Grand Voyages with MSC Cruises
Cruise

13 Days (12 Nights) Santos to Funchal
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil, Portugal
Inside
-
Oceanview
$1,468
Balcony
-
Suite
-
From
US$1,468
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise

15 Days (14 Nights) Santos to Santiago De Compostela
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil, Portugal, Spain
Inside
-
Oceanview
$1,509
Balcony
-
Suite
-
From
US$1,509
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

22 Days (21 Nights) Santos to Valencia
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visit: Brazil, Spain, France, Italy, Sicily
Inside
$1,501
Oceanview
$1,711
Balcony
$2,230
Suite
-
From
US$1,501
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

16 Days (15 Nights) Santos to Marseille
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visit: Brazil, Spain, France
Inside
$927
Oceanview
$1,071
Balcony
$1,475
Suite
-
From
US$927
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Preziosa
Departures: Mar 2026 to Mar 2027
Visit: Brazil, Uruguay, Argentina
Drinks & WiFi Package
Exclusive Savings
Inside
$1,018
Oceanview
$1,098
Balcony
$1,248
Suite
$1,547
From
US$1,018
Save 81
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

15 Days (14 Nights) Santos to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visit: Brazil, Spain
Inside
$888
Oceanview
$1,028
Balcony
$1,428
Suite
-
From
US$888
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Santos to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 14 March 2027
Visit: Brazil, Spain, Morocco, Gibraltar
Inside
$1,259
Oceanview
$1,439
Balcony
$1,889
Suite
$3,815
From
US$1,259
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Santos to Genoa
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visit: Brazil, Spain, France, Italy
Inside
$1,004
Oceanview
$1,168
Balcony
$1,561
Suite
-
From
US$1,004
Per Person
View Trip
6 Day MSC Grand Voyages with MSC Cruises
Cruise

6 Days (5 Nights) Santos to Maceio
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil
Inside
-
Oceanview
$566
Balcony
-
Suite
$1,804
From
US$566
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise

24 Days (23 Nights) Santos to Marseille
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily, Italy, France
Inside
$1,949
Oceanview
$2,209
Balcony
$2,550
Suite
$10,660
From
US$1,949
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Santos to Maceio
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departures: Dec 2026 to Jan 2027
Visit: Brazil
Inside
$869
Oceanview
$773
Balcony
$893
Suite
$1,409
From
US$773
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visit: Brazil
Inside
$475
Oceanview
$505
Balcony
$575
Suite
-
From
US$475
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Santos to Palermo
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily
Inside
$1,709
Oceanview
$2,049
Balcony
$2,188
Suite
$7,397
From
US$1,709
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 26 December 2026
Visit: Brazil
Inside
$1,834
Oceanview
$1,864
Balcony
$1,975
Suite
$13,207
From
US$1,834
Per Person
View Trip
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Departure Months

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