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Cruises From Manaus

Choose from 3 unique expeditions and cruises starting in Manaus, and traveling to Guayaquil and San Juan. September, November and October are the most popular months to join a cruise from Manaus and you can select from 23 departures available from three leading cruise lines.
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3 Cruises (23 Cruise Departures)
30 Day Ultimate South America with Brazil's Amazon & Galapagos Cruise with Cosmos
Tour + Cruise
 (3)

30 Days Manaus to Guayaquil
Operated By: Cosmos
Departures: Jun 2025 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador (+1 more), Galapagos
Exclusive Savings
Save (per person) 176
From (per person) 11,321
View Trip
13 Day A Journey From Amazon Adventures To Caribbean Charms with Explora Journeys
Cruise

13 Days (12 Nights) Manaus to San Juan
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 17 February 2027
Countries Visited: Brazil, French Guiana, Saint Vincent, Barbados (+4 more), Saint Lucia, Saint Barthelemy, Saint Kitts and Nevis, Puerto Rico
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$7,030
SUITE
$8,090
From (per person) 7,030
View Trip
27 Day South American Discovery with Brazil's Amazon & Galápagos Cruise with Globus
Tour + Cruise

27 Days Manaus to Guayaquil
Operated By: Globus
Departures: Jul 2025 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador (+1 more), Galapagos
Exclusive Savings
Save (per person) 238
From (per person) 13,746
View Trip
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