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South America Luxury Cruises

Explore the best luxury cruises around South America. Choose from 143 unique cruise itineraries with 127 past traveler reviews from 10 leading cruise lines. January is the most popular month to join a luxury cruise around South America with 273 departures starting between February 2026 and February 2029.
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143 Cruises (273 Cruise Departures)
8 Day San Cristóbal to San Cristóbal with Silversea
Cruise

8 Days (7 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departure: 19 September 2026
Visit: Galapagos, Ecuador
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,280
Suite
$18,840
From
US$11,280
Save 2,820
Per Person
View Trip
13 Day Chilean Fjords & The Glaciers of The Beagle Channel with Scenic
Cruise

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Visit: Chile, Argentina
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,171
Suite
-
From
US$16,171
Save 22,219
Per Person
View Trip
17 Day Trinidad To Rio: South American Expedition with Seabourn
Cruise

17 Days (16 Nights) Bridgetown to Rio de Janeiro
Cruise Line: Seabourn
Ship: Seabourn Venture
Departures: Oct 2026 to Oct 2027
Visit: Barbados, Trinidad and Tobago, French Guiana, Brazil
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$8,281
From
US$8,281
Save 158
Per Person
View Trip
15 Day San Cristóbal to San Cristóbal with Silversea
Cruise

15 Days (14 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departures: Jun 2026 to Mar 2027
Visit: Ecuador, Galapagos
All-Inclusive Plus Fare
Inside
-
Oceanview
-
Balcony
$21,400
Suite
$45,000
From
US$21,400
Per Person
View Trip
7 Day Ocean Voyage: Ushuaia - Buenos Aires with Ponant
Cruise
 (2)

7 Days (6 Nights) Ushuaia to Buenos Aires
Cruise Line: Ponant
Ship: Le Boreal
Departure: 12 March 2028
Visit: Argentina
Inside
-
Oceanview
$1,950
Balcony
$2,080
Suite
$3,040
From
US$1,950
Per Person
View Trip
11 Day Panama, Ecuadaor & Peru Cruise: Panama City, Manta & Lima (Callao) with Azamara Cruises
Cruise
 (4)

11 Days (10 Nights) Panama City to Valparaiso
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 14 January 2028
Visit: Panama, Ecuador, Peru, Chile
Azamara Always Included
Exclusive Savings
Inside
$3,165
Oceanview
$3,708
Balcony
$4,552
Suite
$6,657
From
US$3,165
Save 74
Per Person
View Trip
11 Day Chile Intensive Cruise: Puerto Montt, Castro & Punta Arenas with Azamara Cruises
Cruise
 (4)

11 Days (10 Nights) Valparaiso to Ushuaia
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 24 January 2028
Visit: Chile, Argentina
Azamara Always Included
Exclusive Savings
Inside
$3,174
Oceanview
$3,717
Balcony
$4,551
Suite
$6,976
From
US$3,174
Save 75
Per Person
View Trip
8 Day San Cristóbal to San Cristóbal with Silversea
Cruise

8 Days (7 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departures: Mar 2026 to Mar 2028
Visit: Ecuador, Galapagos
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,160
Suite
$17,280
From
US$11,160
Save 1,600
Per Person
View Trip
9 Day Cruising the Galapagos Islands with Tauck
Tour + Cruise

9 Days Guayaquil to Guayaquil
Operated By: Tauck
Departures: Feb 2026 to Dec 2027
Visit: Ecuador, Galapagos
From
US$9,490
Per Person
View Trip
26 Day Ultimate Ancient Treasures, Fjords & Wonders of South America with Scenic
New ReleaseCruise

26 Days (25 Nights) Panama City to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 31 October 2027
Visit: Panama, Colombia, Ecuador, Peru, Chile, Argentina
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$71,899
Suite
$97,604
From
US$71,899
Save 2,081
Per Person
View Trip
27 Day Brazil Intensive Cruise: Sao Paulo, Rio De Janiero & Salvador with Azamara Cruises
Cruise
 (4)

27 Days (26 Nights) Buenos Aires to Bridgetown
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 16 February 2028
Visit: Argentina, Uruguay, Brazil, French Guiana, Trinidad and Tobago, Barbados
Azamara Always Included
Exclusive Savings
Inside
$8,636
Oceanview
$10,159
Balcony
$12,264
Suite
$17,812
From
US$8,636
Save 193
Per Person
View Trip
15 Day Brazil Intensive Cruise: Salvador, Natal & Belem with Azamara Cruises
Cruise
 (4)

15 Days (14 Nights) Rio de Janeiro to Bridgetown
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 28 February 2028
Visit: Brazil, French Guiana, Trinidad and Tobago, Barbados
Azamara Always Included
Exclusive Savings
Inside
$4,576
Oceanview
$5,381
Balcony
$6,478
Suite
$9,485
From
US$4,576
Save 103
Per Person
View Trip
13 Day Chairman’s Voyage: Chilean Fjords & The Glaciers of The Beagle Channel with Scenic
Cruise

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 13 November 2027
Visit: Chile, Argentina
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$18,529
Suite
$25,998
From
US$18,529
Save 22,461
Per Person
View Trip
18 Day Fjords & Glaciers of Southern Chile & Patagonia with Scenic
New ReleaseCruise

18 Days (17 Nights) Buenos Aires to Buenos Aires
Cruise Line: Scenic
Ships: Scenic Eclipse I, Scenic Ikon
Departures: Feb 2027 to Feb 2029
Visit: Argentina, Chile, Uruguay
Early Booking Savings
Fly Free Business Class
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,851
Suite
$25,684
From
US$12,851
Save 26,113
Per Person
View Trip
11 Day From Panama’s Wild Beauty to Peruvian Shores with Ponant
Cruise

11 Days (10 Nights) Colon to Lima
Cruise Line: Ponant
Ship: L'Austral
Departure: 20 October 2026
Visit: Panama, Peru
Inside
-
Oceanview
$6,250
Balcony
$6,760
Suite
$10,670
From
US$6,250
Per Person
View Trip
14 Day Chile, Peru & Panama Voyage with Azamara Cruises
Cruise
 (4)

14 Days (13 Nights) San Antonio to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 March 2026
Visit: Chile, Peru, Panama
Azamara Always Included
Inside
-
Oceanview
-
Balcony
$2,359
Suite
-
From
US$2,359
Per Person
View Trip
8 Day San Cristóbal to San Cristóbal with Silversea
Cruise

8 Days (7 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departures: Apr 2026 to Mar 2028
Visit: Ecuador, Galapagos
Last Minute Fare
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,200
Suite
$17,930
From
US$11,200
Save 2,800
Per Person
View Trip
19 Day Buenos Aires to Valparaiso with Silversea
Cruise

19 Days (18 Nights) Buenos Aires to Valparaiso
Cruise Line: Silversea
Ship: Silver Whisper
Departure: 26 February 2026
Visit: Argentina, Uruguay, Falkland Islands, Chile
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$12,720
Balcony
-
Suite
-
From
US$12,720
Save 3,180
Per Person
View Trip
6 Day Ocean Voyage: Callao - Valparaiso with Ponant
Cruise

6 Days (5 Nights) Lima to Valparaiso
Cruise Line: Ponant
Ship: L'Austral
Departure: 30 October 2026
Visit: Peru, Chile
Inside
-
Oceanview
$1,590
Balcony
$1,700
Suite
$2,490
From
US$1,590
Per Person
View Trip
12 Day Puerto Williams to Valparaiso with Silversea
Cruise

12 Days (11 Nights) Puerto Williams to Valparaiso
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 27 February 2027
Visit: Chile, Argentina
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$8,080
Balcony
$9,520
Suite
$15,110
From
US$8,080
Save 2,020
Per Person
View Trip
20 Day Falklands, South Georgia & Valdes Peninsula: In the Heart of the Wilderness with Ponant
Cruise

20 Days (19 Nights) Buenos Aires to Buenos Aires
Cruise Line: Ponant
Ship: Le Lyrial
Departure: 02 March 2028
Visit: Argentina, South Georgia Island, Falkland Islands
Inside
-
Oceanview
$18,000
Balcony
$19,240
Suite
$29,980
From
US$18,000
Per Person
View Trip
11 Day Chile Intensive Cruise: Punta Arenas, Chilean Fjords & San Antonio with Azamara Cruises
Cruise
 (4)

11 Days (10 Nights) Ushuaia to Santiago
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 20 February 2026
Visit: Argentina, Chile
Azamara Always Included
Inside
-
Oceanview
$2,289
Balcony
-
Suite
-
From
US$2,289
Per Person
View Trip
15 Day San Cristobal to San Cristobal with Silversea
Cruise

15 Days (14 Nights) Quito to Quito
Cruise Line: Silversea
Ship: Silver Origin
Departures: Aug 2026 to Dec 2026
Visit: Galapagos, Ecuador
All-Inclusive Plus Fare
Inside
-
Oceanview
-
Balcony
$21,400
Suite
$34,200
From
US$21,400
Per Person
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Visit: Panama, Chile
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,806
Suite
$8,970
From
US$7,806
Save 11,184
Per Person
View Trip
11 Day Rio De Janeiro to Buenos Aires with Silversea
Cruise
 (1)

11 Days (10 Nights) Rio de Janeiro to Buenos Aires
Cruise Line: Silversea
Ship: Silver Nova
Departure: 07 February 2027
Visit: Brazil, Uruguay, Argentina
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$12,100
Suite
$16,700
From
US$12,100
Per Person
View Trip
7 Day Ecuador and Galápagos Islands Cruise with APT
New ReleaseTour + Cruise

7 Days Guayaquil to Guayaquil
Operated By: APT
Departure: 26 August 2026
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$14,697
Save 298
Per Person
View Trip
15 Day Chilean Heritage & Fjords with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Lima to Punta Arenas
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 19 January 2028
Visit: Peru, Chile
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$4,305
Oceanview
$4,693
Balcony
$6,148
Suite
$8,670
From
US$4,305
Save 4,493
Per Person
View Trip
17 Day Buenos Aires to Valparaiso with Silversea
Cruise
 (1)

17 Days (16 Nights) Buenos Aires to Valparaiso
Cruise Line: Silversea
Ship: Silver Nova
Departure: 17 February 2027
Visit: Argentina, Falkland Islands, Chile
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$14,200
Suite
-
From
US$14,200
Per Person
View Trip
24 Day Brazil & Argentina Cruise: Rio De Janeiro, Salvador & Buenos Aires with Azamara Cruises
Cruise
 (3)

24 Days (23 Nights) Bridgetown to Buenos Aires
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 25 January 2027
Visit: Barbados, Trinidad and Tobago, French Guiana, Brazil, Uruguay, Argentina
Azamara Always Included
Exclusive Savings
Inside
$7,880
Oceanview
$8,802
Balcony
$11,023
Suite
$15,737
From
US$7,880
Save 179
Per Person
View Trip
12 Day Rhythms of the Brazilian Coastline with Scenic
New ReleaseCruise

12 Days (11 Nights) Buenos Aires to Rio de Janeiro
Cruise Line: Scenic
Ships: Scenic Eclipse I
Departures: Mar 2027 to Mar 2028
Visit: Argentina, Uruguay, Brazil
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,739
Suite
$11,582
From
US$9,739
Save 14,230
Per Person
View Trip
Results: 1-30 of 143

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