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South America Luxury Cruises

Explore the best luxury cruises around South America. Choose from 143 unique cruise itineraries with 127 past traveler reviews from 10 leading cruise lines. January is the most popular month to join a luxury cruise around South America with 273 departures starting between February 2026 and February 2029.
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143 Cruises (273 Cruise Departures)
34 Day Captain Drake's Crossroads with Oceania Cruises
Cruise
 (1)

34 Days (33 Nights) Valparaiso to Rio de Janeiro
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 February 2027
Visit: Chile, Argentina, Antarctica, Falkland Islands, Uruguay, Brazil
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$9,791
Oceanview
$10,082
Balcony
$14,447
Suite
$20,170
From
US$9,791
Save 10,207
Per Person
View Trip
20 Day Journey to Austral Lands and Valdes Peninsula with Ponant
Cruise
 (2)

20 Days (19 Nights) Buenos Aires to Buenos Aires
Cruise Line: Ponant
Ship: Le Boreal
Departure: 04 March 2026
Visit: Argentina, Antarctica, South Georgia Island, Falkland Islands
Inside
-
Oceanview
$18,610
Balcony
$19,900
Suite
$30,940
From
US$18,610
Per Person
View Trip
66 Day South American Adventure with Oceania Cruises
Cruise
 (1)

66 Days (65 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 January 2028
Visit: USA, Cayman Islands, Jamaica, Colombia (+12 more), Panama, Ecuador, Peru, Chile, Argentina, Antarctica, Falkland Islands, Uruguay, Brazil, Barbados, Guadeloupe, Virgin Islands
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$20,133
Oceanview
$20,958
Balcony
$27,408
Suite
$38,466
From
US$20,133
Save 20,965
Per Person
View Trip
50 Day Valparaiso To Bridgetown Grand Voyage with Azamara Cruises
Cruise
 (4)

50 Days (49 Nights) Valparaiso to Bridgetown
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 24 January 2028
Visit: Chile, Argentina, Antarctica, Falkland Islands (+5 more), Uruguay, Brazil, French Guiana, Trinidad and Tobago, Barbados
Azamara Always Included
Exclusive Savings
Inside
$17,404
Oceanview
$18,665
Balcony
$22,545
Suite
$34,214
From
US$17,404
Save 415
Per Person
View Trip
21 Day Spectacular Antarctica with Oceania Cruises
Cruise
 (3)

21 Days (20 Nights) San Antonio to Buenos Aires
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 February 2026
Visit: Chile, Argentina, Antarctica, Falkland Islands
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,489
Suite
-
From
US$8,489
Save 8,909
Per Person
View Trip
14 Day Argentina, Antarctica & Uruguay Cruise: Ushuaia, Punta Del Este & Montevideo with Azamara Cruises
Cruise
 (4)

14 Days (13 Nights) Ushuaia to Buenos Aires
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 03 February 2028
Visit: Argentina, Antarctica, Falkland Islands, Uruguay
Azamara Always Included
Exclusive Savings
Inside
$4,012
Oceanview
$4,750
Balcony
$5,778
Suite
$8,959
From
US$4,012
Save 97
Per Person
View Trip
22 Day Antarctica & Chilean Fjords Cruise: Buenos Aires, Ushuaia & Santiago with Azamara Cruises
Cruise
 (3)

22 Days (21 Nights) Buenos Aires to Santiago
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 17 February 2027
Visit: Argentina, Uruguay, Falkland Islands, Antarctica, Chile
Azamara Always Included
Exclusive Savings
Inside
$9,976
Oceanview
$11,102
Balcony
$12,392
Suite
$19,764
From
US$9,976
Save 253
Per Person
View Trip
58 Day Panama Canal, Chilean Fjords, Antarctica & Falklands with Seabourn
Cruise
 (1)

58 Days (57 Nights) Miami to Buenos Aires
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 07 January 2028
Visit: USA, Panama, Ecuador, Peru (+5 more), Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Exclusive Savings
Inside
-
Oceanview
$37,371
Balcony
$42,271
Suite
-
From
US$37,371
Save 628
Per Person
View Trip
24 Day Chile, Antarctica & Falkland Islands Cruise: Chilean Fjords, Ushuaia & Montevideo with Azamara Cruises
Cruise
 (4)

24 Days (23 Nights) Valparaiso to Buenos Aires
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 24 January 2028
Visit: Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Azamara Always Included
Exclusive Savings
Inside
$7,187
Oceanview
$8,438
Balcony
$10,340
Suite
$17,993
From
US$7,187
Save 172
Per Person
View Trip
22 Day Southern Fjords & Glaciers with Oceania Cruises
Cruise
 (1)

22 Days (21 Nights) Buenos Aires to Valparaiso
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 January 2027
Visit: Argentina, Falkland Islands, Antarctica, Chile
Your World Inclusions
Upgrade Your Experience
Exclusive Savings
Inside
$6,259
Oceanview
$6,647
Balcony
$9,024
Suite
$13,146
From
US$6,259
Save 6,539
Per Person
View Trip
24 Day Ultimate Chilean Fjords & Antarctica’s Weddell Sea with Scenic
New ReleaseCruise

24 Days (23 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 13 November 2027
Visit: Chile, Argentina, Antarctica
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$84,842
Suite
$173,888
From
US$84,842
Save 2,438
Per Person
View Trip
19 Day Antarctic Encounter with Regent Seven Seas
Cruise

19 Days (18 Nights) Buenos Aires to Lima
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 20 February 2027
Visit: Argentina, Falkland Islands, Antarctica, Chile, Peru
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,752
Suite
$15,614
From
US$13,752
Save 21,646
Per Person
View Trip
59 Day Valparaiso To Miami Grand Voyage with Azamara Cruises
Cruise
 (4)

59 Days (58 Nights) Valparaiso to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 24 January 2028
Visit: Chile, Argentina, Antarctica, Falkland Islands (+12 more), Uruguay, Brazil, French Guiana, Trinidad and Tobago, Barbados, Grenada, Saint Lucia, Martinique, Dominica, Saint Martin, Virgin Islands, USA
Azamara Always Included
Exclusive Savings
Inside
$19,740
Oceanview
$21,874
Balcony
$26,433
Suite
$40,294
From
US$19,740
Save 469
Per Person
View Trip
22 Day Southern Fjords & Glaciers with Oceania Cruises
Cruise
 (1)

22 Days (21 Nights) Valparaiso to Buenos Aires
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 February 2027
Visit: Chile, Argentina, Antarctica, Falkland Islands
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$6,500
Oceanview
$6,839
Balcony
$9,216
Suite
$12,368
From
US$6,500
Save 6,798
Per Person
View Trip
20 Day Journey to Austral Lands and Valdes Peninsula with Ponant
Cruise

20 Days (19 Nights) Buenos Aires to Buenos Aires
Cruise Line: Ponant
Ship: L'Austral
Departure: 27 February 2026
Visit: Argentina, Antarctica, South Georgia Island, Falkland Islands
Inside
-
Oceanview
$19,630
Balcony
$21,020
Suite
$32,790
From
US$19,630
Per Person
View Trip
19 Day Colossal Coastlines with Regent Seven Seas
Cruise

19 Days (18 Nights) Buenos Aires to Buenos Aires
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 02 February 2027
Visit: Argentina, Chile, Antarctica, Falkland Islands, Uruguay
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,017
Suite
$14,046
From
US$13,017
Save 20,881
Per Person
View Trip
20 Day Journey to Austral Lands and Valdes Peninsula with Ponant
Cruise

20 Days (19 Nights) Buenos Aires to Buenos Aires
Cruise Line: Ponant
Ship: Le Lyrial
Departure: 09 March 2027
Visit: Argentina, Antarctica, South Georgia Island, Falkland Islands
Inside
-
Oceanview
$17,900
Balcony
$20,280
Suite
$31,540
From
US$17,900
Per Person
View Trip
31 Day Chilean Fjords, Glaciers & Antarctic Wildlife Explorer with Scenic
Cruise

31 Days (30 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Visit: Chile, Argentina, Falkland Islands, South Georgia Island, Antarctica
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$99,972
Suite
-
From
US$99,972
Save 2,983
Per Person
View Trip
19 Day Journey to Austral Lands and Valdes Peninsula with Ponant
Cruise

19 Days (18 Nights) Buenos Aires to Buenos Aires
Cruise Line: Ponant
Ships: L'Austral, Le Boreal
Departures: Feb 2027 to Mar 2027
Visit: Argentina, Antarctica, South Georgia Island, Falkland Islands
Inside
-
Oceanview
$21,040
Balcony
$22,550
Suite
$35,310
From
US$21,040
Per Person
View Trip
31 Day Verdant Empire with Regent Seven Seas
Cruise

31 Days (30 Nights) Lima to Rio de Janeiro
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 27 January 2028
Visit: Peru, Chile, Antarctica, Falkland Islands, Argentina, Uruguay, Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$22,066
Suite
$25,300
From
US$22,066
Save 36,832
Per Person
View Trip
29 Day Ultimate Antarctica & the Fjords of Southern Chile with Scenic
New ReleaseCruise

29 Days (28 Nights) Buenos Aires to Buenos Aires
Cruise Line: Scenic
Ships: Scenic Eclipse I, Scenic Ikon
Departures: Feb 2027 to Feb 2029
Visit: Argentina, Antarctica, Chile, Uruguay
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$70,995
Suite
$108,184
From
US$70,995
Save 2,715
Per Person
View Trip
63 Day Atolls To Eastern Empires with Oceania Cruises
Cruise

63 Days (62 Nights) Tahiti to Tokyo
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 08 February 2027
Visit: French Polynesia, Cook Islands, Niue, Tonga (+11 more), Fiji, Vanuatu, New Caledonia, Australia, Indonesia, Singapore, Thailand, Vietnam, China, South Korea, Japan
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$31,025
Suite
$40,967
From
US$31,025
Save 32,673
Per Person
View Trip
20 Day Easter & Pitcairn Islands: Marooned, Moai & Mutineers with Seabourn
Cruise

20 Days (19 Nights) Tahiti to Santiago
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 16 October 2026
Visit: French Polynesia, Pitcairn Islands, Chile
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,447
Suite
$19,195
From
US$14,447
Save 257
Per Person
View Trip
36 Day World Cruise: Panama Canal Crossing & Polynesia with Seabourn
Cruise
 (1)

36 Days (35 Nights) Miami to Tahiti
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 05 January 2027
Visit: USA, Panama, Ecuador, Peru, Chile, Easter Island, French Polynesia
Explore More
Exclusive Savings
Inside
-
Oceanview
$16,821
Balcony
$18,903
Suite
$37,646
From
US$16,821
Save 263
Per Person
View Trip
37 Day San Antonio To Hamburg with Cunard
Cruise

37 Days (36 Nights) Santiago to Hamburg
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Visit: Chile, Peru, Ecuador, Panama (+6 more), Aruba, USA, Portugal, England, Belgium, Germany
Inside
$5,929
Oceanview
$8,128
Balcony
$9,247
Suite
$20,038
From
US$5,929
Per Person
View Trip
19 Day Valparaiso to Miami with Silversea
Cruise
 (1)

19 Days (18 Nights) Valparaiso to Miami
Cruise Line: Silversea
Ship: Silver Nova
Departure: 05 March 2027
Visit: Chile, Peru, Ecuador, Panama, Mexico, USA
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,670
Suite
$18,220
From
US$12,670
Save 5,430
Per Person
View Trip
20 Day Panama, Peru & Chile Cruise: Panama Canal, Lima & Coquimbo with Azamara Cruises
Cruise
 (4)

20 Days (19 Nights) Miami to Valparaiso
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 05 January 2028
Visit: USA, Mexico, Belize, Honduras (+5 more), Costa Rica, Panama, Ecuador, Peru, Chile
Azamara Always Included
Exclusive Savings
Inside
$6,711
Oceanview
$7,594
Balcony
$9,223
Suite
$13,210
From
US$6,711
Save 148
Per Person
View Trip
20 Day Southern America & Panama Canal Cruise: Lima, Panama City & Cozumel with Azamara Cruises
Cruise
 (3)

20 Days (19 Nights) Santiago to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 March 2027
Visit: Chile, Peru, Panama, Costa Rica, Colombia, Mexico, USA
Azamara Always Included
Exclusive Savings
Inside
$6,446
Oceanview
$7,231
Balcony
$8,075
Suite
$13,410
From
US$6,446
Save 143
Per Person
View Trip
13 Day Miami, Fl to Lima (Callao) with Silversea
Cruise

13 Days (12 Nights) Miami to Lima
Cruise Line: Silversea
Ship: Silver Ray
Departure: 15 January 2028
Visit: USA, Mexico, Costa Rica, Panama, Ecuador, Peru
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,640
Suite
$14,440
From
US$8,640
Save 2,160
Per Person
View Trip
17 Day Machu Picchu & Mayan Ruins with Regent Seven Seas
Cruise

17 Days (16 Nights) Lima to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 10 March 2027
Visit: Peru, Ecuador, Costa Rica, Panama (+4 more), Honduras, Belize, Mexico, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,677
Suite
$13,755
From
US$12,677
Save 19,121
Per Person
View Trip
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