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South America Luxury Cruises

Explore the best luxury cruises around South America. Choose from 134 unique cruise itineraries with 160 past traveler reviews from 10 leading cruise lines. January is the most popular month to join a luxury cruise around South America with 253 departures starting between April 2026 and February 2029.
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134 Cruises (253 Cruise Departures)
17 Day Buenos Aires to Valparaiso with Silversea
Cruise
 (1)

17 Days (16 Nights) Buenos Aires to Valparaiso
Cruise Line: Silversea
Ship: Silver Nova
Departure: 17 February 2027
Visit: Argentina, Falkland Islands, Chile
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$13,800
Suite
-
From
US$13,800
Per Person
View Trip
18 Day Valparaiso to Buenos Aires with Silversea
Cruise

18 Days (17 Nights) Valparaiso to Buenos Aires
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 29 January 2028
Visit: Chile, Argentina, Falkland Islands
All-Inclusive Fare
Inside
-
Oceanview
$13,800
Balcony
$15,500
Suite
$42,500
From
US$13,800
Per Person
View Trip
9 Day Cruising the Galapagos Islands with Tauck
Tour + Cruise

9 Days Guayaquil to Guayaquil
Operated By: Tauck
Departures: Nov 2026 to Dec 2027
Visit: Ecuador, Galapagos
From
US$9,490
Per Person
View Trip
21 Day Rio De Janeiro to Bridgetown with Silversea
Cruise

21 Days (20 Nights) Rio de Janeiro to Bridgetown
Cruise Line: Silversea
Ship: Silver Ray
Departure: 29 February 2028
Visit: Brazil, French Guiana, Barbados
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,000
Suite
$26,500
From
US$16,000
Save 3,500
Per Person
View Trip
12 Day Rhythms of the Brazilian Coastline with Scenic
New ReleaseCruise

12 Days (11 Nights) Buenos Aires to Rio de Janeiro
Cruise Line: Scenic
Ships: Scenic Eclipse I
Departures: Mar 2027 to Mar 2028
Visit: Argentina, Uruguay, Brazil
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,707
Suite
$11,624
From
US$9,707
Save 3,193
Per Person
View Trip
12 Day Puerto Williams to Valparaiso with Silversea
Cruise

12 Days (11 Nights) Puerto Williams to Valparaiso
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 27 February 2027
Visit: Chile, Argentina
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$9,400
Balcony
$12,600
Suite
$18,800
From
US$9,400
Save 1,500
Per Person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Chile to Panama with Scenic
New ReleaseCruise

14 Days (13 Nights) Santiago to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 21 March 2027
Visit: Chile, Peru, Ecuador, Colombia, Panama
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,476
Suite
$11,962
From
US$9,476
Save 3,174
Per Person
View Trip
17 Day Trinidad To Rio: South American Expedition with Seabourn
Cruise

17 Days (16 Nights) Bridgetown to Rio de Janeiro
Cruise Line: Seabourn
Ship: Seabourn Venture
Departures: Oct 2026 to Oct 2027
Visit: Barbados, Trinidad and Tobago, French Guiana, Brazil
Yours to Explore
Inside
-
Oceanview
-
Balcony
-
Suite
$10,299
From
US$10,299
Per Person
View Trip
8 Day San Cristóbal to San Cristóbal with Silversea
Cruise

8 Days (7 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departures: May 2026 to Mar 2028
Visit: Ecuador, Galapagos
Last Minute Fare
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,400
Suite
$17,400
From
US$10,400
Save 2,500
Per Person
View Trip
16 Day Hidden Galapagos & Peru with Tauck
Tour + Cruise

16 Days Lima to Guayaquil or Lima to Quito
Operated By: Tauck
Ships: Silver Origin
Departures: Sep 2026 to Oct 2027
Visit: Peru, Ecuador, Galapagos
Inside
-
Oceanview
-
Balcony
$16,990
Suite
$29,235
From
US$16,990
Per Person
View Trip
17 Day Patagonia & the Chilean Fjords with Scenic
New ReleaseCruise

17 Days (16 Nights) Buenos Aires to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 14 November 2027
Visit: Argentina, Uruguay, Chile
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$19,958
Suite
$24,422
From
US$19,958
Save 3,587
Per Person
View Trip
8 Day San Cristóbal to San Cristóbal with Silversea
Cruise

8 Days (7 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departures: Apr 2026 to Mar 2028
Visit: Ecuador, Galapagos
Last Minute Fare
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,400
Suite
$17,400
From
US$10,400
Save 2,500
Per Person
View Trip
20 Day Falklands, South Georgia & Valdes Peninsula: In the Heart of the Wilderness with Ponant
Cruise

20 Days (19 Nights) Buenos Aires to Buenos Aires
Cruise Line: Ponant
Ship: Le Lyrial
Departure: 02 March 2028
Visit: Argentina, South Georgia Island, Falkland Islands
Inside
-
Oceanview
$19,070
Balcony
$20,400
Suite
$31,910
From
US$19,070
Per Person
View Trip
13 Day Chilean Fjords & The Glaciers of The Beagle Channel with Scenic
Cruise

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Visit: Chile, Argentina
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,645
Suite
-
From
US$15,645
Save 4,270
Per Person
View Trip
15 Day Cartagena to Valparaiso with Silversea
Cruise

15 Days (14 Nights) Cartagena to Valparaiso
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 15 January 2028
Visit: Colombia, Panama, Ecuador, Peru, Chile
All-Inclusive Fare
Inside
-
Oceanview
$8,000
Balcony
$10,000
Suite
$26,400
From
US$8,000
Per Person
View Trip
6 Day Ocean Voyage: Callao - Valparaiso with Ponant
Cruise

6 Days (5 Nights) Lima to Valparaiso
Cruise Line: Ponant
Ship: L'Austral
Departure: 30 October 2026
Visit: Peru, Chile
Inside
-
Oceanview
$1,590
Balcony
$1,700
Suite
$2,490
From
US$1,590
Per Person
View Trip
13 Day Buenos Aires to Rio De Janeiro with Silversea
Cruise

13 Days (12 Nights) Buenos Aires to Rio de Janeiro
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 15 February 2028
Visit: Argentina, Uruguay, Brazil
All-Inclusive Fare
Inside
-
Oceanview
$12,900
Balcony
$14,600
Suite
$29,500
From
US$12,900
Per Person
View Trip
8 Day San Cristóbal to San Cristóbal with Silversea
Cruise

8 Days (7 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departure: 19 September 2026
Visit: Galapagos, Ecuador
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,300
Suite
$18,100
From
US$11,300
Save 2,500
Per Person
View Trip
15 Day The Best of Chilean Fjords with Ponant
Cruise

15 Days (14 Nights) Valparaiso to Buenos Aires
Cruise Line: Ponant
Ships: L'Austral, Le Lyrial
Departures: Oct 2027 to Nov 2027
Visit: Chile, Argentina
Inside
-
Oceanview
$11,080
Balcony
$11,890
Suite
$19,500
From
US$11,080
Per Person
View Trip
15 Day Peru & the Galapagos Islands with Tauck
Tour + Cruise

15 Days Lima to Guayaquil
Operated By: Tauck
Departures: Apr 2026 to Oct 2027
Visit: Peru, Ecuador, Galapagos
From
US$14,690
Per Person
View Trip
20 Day San Antonio To Fort Lauderdale with Cunard
Cruise

20 Days (19 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Visit: Chile, Peru, Ecuador, Panama, Aruba, USA
Bonus Onboard Credit
Inside
$3,399
Oceanview
-
Balcony
$5,549
Suite
$12,529
From
US$3,399
Per Person
View Trip
22 Day South America, Canary Islands & Spain with Seabourn
Cruise

22 Days (21 Nights) Rio de Janeiro to Seville
Cruise Line: Seabourn
Ship: Seabourn Venture
Departure: 06 April 2027
Visit: Brazil, Cape Verde, Spain, Morocco
Yours to Explore
Inside
-
Oceanview
-
Balcony
-
Suite
$12,399
From
US$12,399
Per Person
View Trip
34 Day San Antonio To Southampton with Cunard
Cruise

34 Days (33 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Visit: Chile, Peru, Ecuador, Panama (+4 more), Aruba, USA, Portugal, England
Bonus Onboard Credit
Inside
$5,209
Oceanview
$7,349
Balcony
$8,109
Suite
$18,109
From
US$5,209
Per Person
View Trip
24 Day Buenos Aires to Dakar with Silversea
Cruise

24 Days (23 Nights) Buenos Aires to Dakar
Cruise Line: Silversea
Ship: Silver Endeavour
Departure: 25 March 2027
Visit: Argentina, Uruguay, Brazil, Australia (+4 more), Scotland, Sierra Leone, Guinea-Bissau, Senegal
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,800
Suite
$25,800
From
US$14,800
Save 3,500
Per Person
View Trip
12 Day A Journey Through Coastal History & the Heart of the Amazon with Explora Journeys
Cruise
 (1)

12 Days (11 Nights) San Juan to Manaus
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 06 February 2028
Visit: Puerto Rico, Montserrat, Barbados, French Guiana, Brazil
Inside
-
Oceanview
-
Balcony
-
Suite
$7,905
From
US$7,905
Per Person
View Trip
23 Day Journey To The Amazon with Regent Seven Seas
Cruise

23 Days (22 Nights) Panama City to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 March 2027
Visit: Panama, Aruba, Trinidad and Tobago, Brazil, Grenada, Curacao
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$21,299
Suite
$22,249
From
US$21,299
Save 21,299
Per Person
View Trip
34 Day Brazil Unbound with Oceania Cruises
Cruise
 (1)

34 Days (33 Nights) Buenos Aires to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 07 March 2027
Visit: Argentina, Uruguay, Brazil, Barbados, Antigua and Barbuda, Virgin Islands, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$9,649
Oceanview
$10,199
Balcony
$14,949
Suite
$19,449
From
US$9,649
Save 9,649
Per Person
View Trip
23 Day Secrets Of The Amazon with Regent Seven Seas
Cruise

23 Days (22 Nights) Miami to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 09 November 2026
Visit: USA, Barbados, Trinidad and Tobago, Brazil, Grenada, Puerto Rico
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$18,399
Suite
$18,899
From
US$18,399
Save 18,399
Per Person
View Trip
25 Day Ultimate South America to the Caribbean Through the Panama Canal with Scenic
New ReleaseCruise

25 Days (24 Nights) Santiago to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 21 March 2027
Visit: Chile, Peru, Ecuador, Colombia (+5 more), Panama, Curacao, Saint Vincent, Saint Lucia, Barbados
Inside
-
Oceanview
-
Balcony
$24,800
Suite
$30,200
From
US$24,800
Per Person
View Trip
18 Day Fort Lauderdale To Rio De Janeiro with Cunard
Cruise

18 Days (17 Nights) Fort Lauderdale to Rio de Janeiro
Cruise Line: Cunard
Ship: Queen Anne
Departure: 22 January 2027
Visit: USA, Turks and Caicos Islands, Barbados, Brazil
Bonus Onboard Credit
Inside
$3,149
Oceanview
$3,849
Balcony
$3,899
Suite
$9,999
From
US$3,149
Per Person
View Trip
Results: 31-60 of 134

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