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South America Luxury Cruises

Explore the best luxury cruises around South America. Choose from 134 unique cruise itineraries with 160 past traveler reviews from 10 leading cruise lines. January is the most popular month to join a luxury cruise around South America with 253 departures starting between April 2026 and February 2029.
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134 Cruises (253 Cruise Departures)
36 Day Buenos Aires To Miami Grand Voyage with Azamara Cruises
Cruise
 (5)

36 Days (35 Nights) Buenos Aires to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 16 February 2028
Visit: Argentina, Uruguay, Brazil, French Guiana (+9 more), Trinidad and Tobago, Barbados, Grenada, Saint Lucia, Martinique, Dominica, Saint Martin, Virgin Islands, USA
Azamara Always Included
Inside
$12,429
Oceanview
$13,829
Balcony
$16,729
Suite
$24,219
From
US$12,429
Per Person
View Trip
25 Day Southern Caribbean Yacht Harbors & Coast Of Brazil with Seabourn
Cruise

25 Days (24 Nights) Halifax to Rio de Janeiro
Cruise Line: Seabourn
Ship: Seabourn Venture
Departures: Oct 2026 to Oct 2027
Visit: Canada, Saint Kitts and Nevis, Spain, Saint Lucia (+4 more), Barbados, Trinidad and Tobago, French Guiana, Brazil
Yours to Explore
Inside
-
Oceanview
-
Balcony
-
Suite
$14,399
From
US$14,399
Per Person
View Trip
20 Day An Extended Journey of Rainforest Wonders & Ocean Serenity with Explora Journeys
Cruise

20 Days (19 Nights) Manaus to Miami
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 17 February 2027
Visit: Brazil, French Guiana, Saint Vincent, Barbados (+9 more), Saint Lucia, Saint Barthelemy, Saint Kitts and Nevis, Puerto Rico, Antigua and Barbuda, Anguilla, Virgin Islands, Turks and Caicos Islands, USA
Sky & Sea
Inside
-
Oceanview
-
Balcony
-
Suite
$11,625
From
US$11,625
Per Person
View Trip
22 Day Amazonian Spirit with Oceania Cruises
Cruise
 (1)

22 Days (21 Nights) Rio de Janeiro to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 19 March 2027
Visit: Brazil, Barbados, Antigua and Barbuda, Virgin Islands, USA
Your World Inclusions
Exclusive Savings
Inside
$5,535
Oceanview
$5,850
Balcony
$8,100
Suite
$10,890
From
US$5,535
Save 6,763
Per Person
View Trip
15 Day Empires Of The Sun with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Lima
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 13 January 2028
Visit: USA, Cayman Islands, Jamaica, Colombia (+4 more), Costa Rica, Panama, Ecuador, Peru
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,799
Suite
$17,349
From
US$16,799
Save 16,799
Per Person
View Trip
22 Day Amazonian Exploration with Oceania Cruises
Cruise
 (1)

22 Days (21 Nights) Rio de Janeiro to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 February 2028
Visit: Brazil, Barbados, Guadeloupe, Virgin Islands, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$6,699
Oceanview
$7,299
Balcony
$9,599
Suite
$13,499
From
US$6,699
Save 6,699
Per Person
View Trip
19 Day White Sands & Brazilian Sun with Regent Seven Seas
Cruise

19 Days (18 Nights) Miami to Rio de Janeiro
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 04 January 2027
Visit: USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Barbados, French Guiana, Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,999
Suite
$16,999
From
US$15,999
Save 15,999
Per Person
View Trip
15 Day Panama Canal To Machu Picchu with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Miami to Lima
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 January 2028
Visit: USA, Cayman Islands, Jamaica, Colombia, Panama, Ecuador, Peru
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$4,399
Oceanview
$4,799
Balcony
$6,199
Suite
$8,799
From
US$4,399
Save 4,399
Per Person
View Trip
26 Day Amazon & Caribbean Isles with Oceania Cruises
Cruise
 (1)

26 Days (25 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 November 2026
Visit: USA, Virgin Islands, Antigua and Barbuda, Saint Lucia (+7 more), Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin, Puerto Rico, Bahamas
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$5,670
Balcony
$8,330
Suite
$28,649
From
US$5,670
Save 10,528
Per Person
View Trip
35 Day South America Cruise: Miami, Rio De Janeiro & Buenos Aires with Azamara Cruises
Cruise
 (3)

35 Days (34 Nights) Miami to Buenos Aires
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 14 January 2027
Visit: USA, Virgin Islands, Saint Martin, Saint Kitts and Nevis (+10 more), Antigua and Barbuda, Martinique, Saint Vincent, Grenada, Barbados, Trinidad and Tobago, French Guiana, Brazil, Uruguay, Argentina
Azamara Always Included
Inside
$12,329
Oceanview
$12,429
Balcony
$14,739
Suite
$23,149
From
US$12,329
Per Person
View Trip
11 Day A Journey Through Amazonian Mesmerising Wonders to the Caribbean Sunlit Landscapes with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Manaus to San Juan
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 17 February 2028
Visit: Brazil, Trinidad and Tobago, Saint Lucia, Dominica, Saint Martin, Puerto Rico
Inside
-
Oceanview
-
Balcony
-
Suite
$7,195
From
US$7,195
Per Person
View Trip
22 Day Secrets Of The Selva with Regent Seven Seas
Cruise

22 Days (21 Nights) Rio de Janeiro to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 26 February 2028
Visit: Brazil, Saint Lucia, Saint Kitts and Nevis, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$22,499
Suite
$23,399
From
US$22,499
Save 22,499
Per Person
View Trip
25 Day An Extended Journey into Island Elegance & Mysteries of the Amazon with Explora Journeys
Cruise

25 Days (24 Nights) San Juan to San Juan
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 05 February 2027
Visit: Puerto Rico, Saint Barthelemy, Martinique, Barbados (+6 more), Trinidad and Tobago, Brazil, French Guiana, Saint Vincent, Saint Lucia, Saint Kitts and Nevis
Inside
-
Oceanview
-
Balcony
-
Suite
$18,180
From
US$18,180
Per Person
View Trip
13 Day A Journey From Amazon Adventures To Caribbean Charms with Explora Journeys
Cruise

13 Days (12 Nights) Manaus to San Juan
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 17 February 2027
Visit: Brazil, French Guiana, Saint Vincent, Barbados (+4 more), Saint Lucia, Saint Barthelemy, Saint Kitts and Nevis, Puerto Rico
Inside
-
Oceanview
-
Balcony
-
Suite
$9,830
From
US$9,830
Per Person
View Trip
13 Day A Journey Of Amazon Exploration & Cultural Discovery with Explora Journeys
Cruise

13 Days (12 Nights) San Juan to Manaus
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 05 February 2027
Visit: Puerto Rico, Saint Barthelemy, Martinique, Barbados, Trinidad and Tobago, Brazil
Inside
-
Oceanview
-
Balcony
-
Suite
$9,585
From
US$9,585
Per Person
View Trip
20 Day An Extended Journey of Caribbean Charms & Amazonian Wonders with Explora Journeys
Cruise

20 Days (19 Nights) Miami to Manaus
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 29 January 2027
Visit: USA, Dominican Republic, Saint Martin, Guadeloupe (+7 more), Saint Kitts and Nevis, Puerto Rico, Saint Barthelemy, Martinique, Barbados, Trinidad and Tobago, Brazil
Inside
-
Oceanview
-
Balcony
-
Suite
$10,535
From
US$10,535
Per Person
View Trip
38 Day Fort Lauderdale To San Antonio with Cunard
Cruise

38 Days (37 Nights) Fort Lauderdale to Santiago
Cruise Line: Cunard
Ship: Queen Anne
Departure: 22 January 2027
Visit: USA, Turks and Caicos Islands, Barbados, Brazil, Uruguay, Argentina, Chile
Bonus Onboard Credit
Inside
$7,398
Oceanview
$10,233
Balcony
$11,230
Suite
$24,780
From
US$7,398
Per Person
View Trip
22 Day Antarctica & Chilean Fjords Cruise: Buenos Aires, Ushuaia & Santiago with Azamara Cruises
Cruise
 (3)

22 Days (21 Nights) Buenos Aires to Santiago
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 17 February 2027
Visit: Argentina, Uruguay, Falkland Islands, Antarctica, Chile
Azamara Always Included
Inside
$10,579
Oceanview
$11,779
Balcony
$13,159
Suite
$21,069
From
US$10,579
Per Person
View Trip
59 Day Valparaiso To Miami Grand Voyage with Azamara Cruises
Cruise
 (5)

59 Days (58 Nights) Valparaiso to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 24 January 2028
Visit: Chile, Argentina, Antarctica, Falkland Islands (+12 more), Uruguay, Brazil, French Guiana, Trinidad and Tobago, Barbados, Grenada, Saint Lucia, Martinique, Dominica, Saint Martin, Virgin Islands, USA
Azamara Always Included
Inside
$20,209
Oceanview
$22,409
Balcony
$27,109
Suite
$41,399
From
US$20,209
Per Person
View Trip
19 Day Colossal Coastlines with Regent Seven Seas
Cruise

19 Days (18 Nights) Buenos Aires to Buenos Aires
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 02 February 2027
Visit: Argentina, Chile, Antarctica, Falkland Islands, Uruguay
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,099
Suite
$17,099
From
US$16,099
Save 16,099
Per Person
View Trip
34 Day Captain Drake's Crossroads with Oceania Cruises
Cruise
 (1)

34 Days (33 Nights) Valparaiso to Rio de Janeiro
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 February 2027
Visit: Chile, Argentina, Antarctica, Falkland Islands, Uruguay, Brazil
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$9,999
Oceanview
$10,649
Balcony
$15,599
Suite
$20,399
From
US$9,999
Save 9,999
Per Person
View Trip
50 Day Valparaiso To Bridgetown Grand Voyage with Azamara Cruises
Cruise
 (5)

50 Days (49 Nights) Valparaiso to Bridgetown
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 24 January 2028
Visit: Chile, Argentina, Antarctica, Falkland Islands (+5 more), Uruguay, Brazil, French Guiana, Trinidad and Tobago, Barbados
Azamara Always Included
Inside
$17,819
Oceanview
$19,119
Balcony
$23,119
Suite
$35,149
From
US$17,819
Per Person
View Trip
24 Day Ultimate Chilean Fjords & Antarctica’s Weddell Sea with Scenic
New ReleaseCruise

24 Days (23 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 13 November 2027
Visit: Chile, Argentina, Antarctica
Inside
-
Oceanview
-
Balcony
$50,420
Suite
$93,545
From
US$50,420
Per Person
View Trip
22 Day Southern Fjords & Glaciers with Oceania Cruises
Cruise
 (1)

22 Days (21 Nights) Buenos Aires to Valparaiso
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 January 2027
Visit: Argentina, Falkland Islands, Antarctica, Chile
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$6,699
Oceanview
$6,849
Balcony
$9,999
Suite
-
From
US$6,699
Save 6,699
Per Person
View Trip
14 Day Argentina, Antarctica & Uruguay Cruise: Ushuaia, Punta Del Este & Montevideo with Azamara Cruises
Cruise
 (5)

14 Days (13 Nights) Ushuaia to Buenos Aires
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 03 February 2028
Visit: Argentina, Antarctica, Falkland Islands, Uruguay
Azamara Always Included
Inside
$4,109
Oceanview
$4,869
Balcony
$5,929
Suite
$9,209
From
US$4,109
Per Person
View Trip
66 Day South American Adventure with Oceania Cruises
Cruise
 (1)

66 Days (65 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 January 2028
Visit: USA, Cayman Islands, Jamaica, Colombia (+12 more), Panama, Ecuador, Peru, Chile, Argentina, Antarctica, Falkland Islands, Uruguay, Brazil, Barbados, Guadeloupe, Virgin Islands
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$20,849
Oceanview
$21,499
Balcony
$28,649
Suite
-
From
US$20,849
Save 20,849
Per Person
View Trip
58 Day Panama Canal, Chilean Fjords, Antarctica & Falklands with Seabourn
Cruise
 (1)

58 Days (57 Nights) Miami to Buenos Aires
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 07 January 2028
Visit: USA, Panama, Ecuador, Peru (+5 more), Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Yours to Explore
Inside
-
Oceanview
$37,999
Balcony
$42,999
Suite
-
From
US$37,999
Per Person
View Trip
19 Day Journey to Austral Lands and Valdes Peninsula with Ponant
Cruise
 (2)

19 Days (18 Nights) Buenos Aires to Buenos Aires
Cruise Line: Ponant
Ship: Le Boreal
Departure: 12 November 2026
Visit: Argentina, Falkland Islands, South Georgia Island, Antarctica
Inside
-
Oceanview
$22,390
Balcony
$25,260
Suite
$38,400
From
US$22,390
Per Person
View Trip
20 Day Journey to Austral Lands and Valdes Peninsula with Ponant
Cruise

20 Days (19 Nights) Buenos Aires to Buenos Aires
Cruise Line: Ponant
Ship: Le Lyrial
Departure: 09 March 2027
Visit: Argentina, Antarctica, South Georgia Island, Falkland Islands
Inside
-
Oceanview
$20,000
Balcony
$21,410
Suite
$33,430
From
US$20,000
Per Person
View Trip
24 Day Chile, Antarctica & Falkland Islands Cruise: Chilean Fjords, Ushuaia & Montevideo with Azamara Cruises
Cruise
 (5)

24 Days (23 Nights) Valparaiso to Buenos Aires
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 24 January 2028
Visit: Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Azamara Always Included
Inside
$7,359
Oceanview
$8,649
Balcony
$10,609
Suite
$18,499
From
US$7,359
Per Person
View Trip
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