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South America Luxury Cruises

Explore the best luxury cruises around South America. Choose from 141 unique cruise itineraries from 10 leading cruise lines. January and February are the most popular months to join a luxury cruise around South America with 276 departures starting between December 2025 and March 2028.
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177 Days
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$125,598pp
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141 Cruises (276 Cruise Departures)
59 Day Valparaiso To Miami Grand Voyage with Azamara Cruises
Cruise
 (4)

59 Days (58 Nights) Valparaiso to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 24 January 2028
Visit: Chile, Argentina, Antarctica, Falkland Islands (+12 more), Uruguay, Brazil, French Guiana, Trinidad and Tobago, Barbados, Grenada, Saint Lucia, Martinique, Dominica, Saint Martin, Virgin Islands, USA
Azamara Always Included
Exclusive Savings
Inside
$18,523
Oceanview
$20,657
Balcony
$25,216
Suite
$35,595
From
US$18,523
Save 446
Per Person
View Trip
66 Day South American Adventure with Oceania Cruises
Cruise
 (3)

66 Days (65 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 January 2028
Visit: USA, Cayman Islands, Jamaica, Colombia (+12 more), Panama, Ecuador, Peru, Chile, Argentina, Antarctica, Falkland Islands, Uruguay, Brazil, Barbados, Guadeloupe, Virgin Islands
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$20,133
Oceanview
$20,958
Balcony
$27,408
Suite
$38,369
From
US$20,133
Save 20,965
Per Person
View Trip
55 Day Epic Antarctic & Amazon with Oceania Cruises
Cruise
 (1)

55 Days (54 Nights) Valparaiso to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 February 2027
Visit: Chile, Argentina, Antarctica, Falkland Islands (+6 more), Uruguay, Brazil, Barbados, Antigua and Barbuda, Virgin Islands, USA
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$14,946
Oceanview
$16,110
Balcony
$21,203
Suite
$29,545
From
US$14,946
Save 15,552
Per Person
View Trip
83 Day South America Discovery with Cunard
Cruise

83 Days (82 Nights) London to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 10 January 2027
Visit: England, Bermuda, USA, Turks and Caicos Islands (+10 more), Barbados, Brazil, Uruguay, Argentina, Chile, Peru, Ecuador, Panama, Aruba, Portugal
Exclusive Savings
Inside
$13,071
Oceanview
$18,120
Balcony
$20,060
Suite
$40,018
From
US$13,071
Per Person
View Trip
35 Day Hamburg To Rio De Janeiro with Cunard
Cruise

35 Days (34 Nights) Hamburg to Rio de Janeiro
Cruise Line: Cunard
Ship: Queen Anne
Departure: 05 January 2027
Visit: Germany, Holland, Belgium, England (+5 more), Bermuda, USA, Turks and Caicos Islands, Barbados, Brazil
Inside
$5,369
Oceanview
$7,687
Balcony
$8,697
Suite
$18,577
From
US$5,369
Per Person
View Trip
29 Day Caribbean, Central America & Peru Cruise: Aruba, Miami & Panama Canal with Azamara Cruises
Cruise
 (4)

29 Days (28 Nights) Bridgetown to Valparaiso
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 27 December 2027
Visit: Barbados, Bonaire, Curacao, Aruba (+11 more), Dominican Republic, Bahamas, USA, Mexico, Belize, Honduras, Costa Rica, Panama, Ecuador, Peru, Chile
Azamara Always Included
Exclusive Savings
Inside
$8,331
Oceanview
$9,912
Balcony
$12,221
Suite
$17,313
From
US$8,331
Save 198
Per Person
View Trip
64 Day World Cruise: Panama Canal, Polynesia & New Zealand with Seabourn
Cruise
 (1)

64 Days (63 Nights) Miami to Sydney
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 05 January 2027
Visit: USA, Panama, Ecuador, Peru (+6 more), Chile, French Polynesia, Cook Islands, Tonga, New Zealand, Australia
Explore More
Exclusive Savings
Inside
-
Oceanview
$29,548
Balcony
$34,796
Suite
$150,500
From
US$29,548
Save 456
Per Person
View Trip
57 Day South America Discovery From Fort Lauderdale with Cunard
Cruise

57 Days (56 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Anne
Departure: 22 January 2027
Visit: USA, Turks and Caicos Islands, Barbados, Brazil (+7 more), Uruguay, Argentina, Chile, Peru, Ecuador, Panama, Aruba
Exclusive Savings
Inside
$11,071
Oceanview
$15,961
Balcony
$18,347
Suite
$35,177
From
US$11,071
Per Person
View Trip
69 Day Miami To Bridgetown Grand Voyage with Azamara Cruises
Cruise
 (4)

69 Days (68 Nights) Miami to Bridgetown
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 05 January 2028
Visit: USA, Mexico, Belize, Honduras (+13 more), Costa Rica, Panama, Ecuador, Peru, Chile, Argentina, Antarctica, Falkland Islands, Uruguay, Brazil, French Guiana, Trinidad and Tobago, Barbados
Azamara Always Included
Exclusive Savings
Inside
$20,906
Oceanview
$24,611
Balcony
$30,043
Suite
$42,071
From
US$20,906
Save 483
Per Person
View Trip
43 Day Miami To Buenos Aires Grand Voyage with Azamara Cruises
Cruise
 (4)

43 Days (42 Nights) Miami to Buenos Aires
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 05 January 2028
Visit: USA, Mexico, Belize, Honduras (+9 more), Costa Rica, Panama, Ecuador, Peru, Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Azamara Always Included
Exclusive Savings
Inside
$13,189
Oceanview
$15,032
Balcony
$19,009
Suite
$25,896
From
US$13,189
Save 310
Per Person
View Trip
41 Day Buenos Aires To Miami Grand Voyage with Azamara Cruises
Cruise
 (3)

41 Days (40 Nights) Buenos Aires to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 17 February 2027
Visit: Argentina, Uruguay, Falkland Islands, Antarctica (+7 more), Chile, Peru, Panama, Costa Rica, Colombia, Mexico, USA
Azamara Always Included
Exclusive Savings
Inside
$15,631
Oceanview
$16,581
Balcony
$18,725
Suite
$30,443
From
US$15,631
Save 368
Per Person
View Trip
22 Day Brazil Coast, Cape Verde & Canary Islands Crossing with Seabourn
Cruise

22 Days (21 Nights) Rio de Janeiro to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Venture
Departure: 04 April 2026
Visit: Brazil, Cape Verde, Spain, Morocco
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,205
Suite
$9,205
From
US$9,205
Save 144
Per Person
View Trip
32 Day Brazil, Cape Verde, Canary Islands & Riviera Harbors with Seabourn
Cruise

32 Days (31 Nights) Rio de Janeiro to Rome
Cruise Line: Seabourn
Ship: Seabourn Venture
Departure: 04 April 2026
Visit: Brazil, Cape Verde, Spain, Morocco, France, Monaco, Italy
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$18,057
From
US$18,057
Save 302
Per Person
View Trip
58 Day Old & New World Discovery with Oceania Cruises
Cruise
 (1)

58 Days (57 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Visit: Italy, Croatia, Montenegro, Greece (+14 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$14,854
Oceanview
$16,115
Balcony
$24,166
Suite
$32,314
From
US$14,854
Save 15,444
Per Person
View Trip
48 Day Footsteps Of Columbus with Oceania Cruises
Cruise
 (1)

48 Days (47 Nights) Barcelona to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 02 November 2026
Visit: Spain, Portugal, Puerto Rico, Bahamas (+9 more), USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$11,816
Oceanview
$12,980
Balcony
$19,139
Suite
$25,541
From
US$11,816
Save 12,282
Per Person
View Trip
78 Day Circle South America Grand Voyage with Azamara Cruises
Cruise
 (4)

78 Days (77 Nights) Miami to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 05 January 2028
Visit: USA, Mexico, Belize, Honduras (+19 more), Costa Rica, Panama, Ecuador, Peru, Chile, Argentina, Antarctica, Falkland Islands, Uruguay, Brazil, French Guiana, Trinidad and Tobago, Barbados, Grenada, Saint Lucia, Martinique, Dominica, Saint Martin, Virgin Islands
Azamara Always Included
Exclusive Savings
Inside
$23,453
Oceanview
$27,644
Balcony
$33,852
Suite
$47,529
From
US$23,453
Save 546
Per Person
View Trip
75 Day Circle South America Grand Voyage with Azamara Cruises
Cruise
 (3)

75 Days (74 Nights) Miami to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 14 January 2027
Visit: USA, Virgin Islands, Saint Martin, Saint Kitts and Nevis (+18 more), Antigua and Barbuda, Martinique, Saint Vincent, Grenada, Barbados, Trinidad and Tobago, French Guiana, Brazil, Uruguay, Argentina, Falkland Islands, Antarctica, Chile, Peru, Panama, Costa Rica, Colombia, Mexico
Azamara Always Included
Exclusive Savings
Inside
$26,176
Oceanview
$29,261
Balcony
$32,763
Suite
$54,908
From
US$26,176
Save 603
Per Person
View Trip
66 Day Grand South America Mosaic with Regent Seven Seas
Cruise

66 Days (65 Nights) Miami to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 13 January 2028
Visit: USA, Cayman Islands, Jamaica, Colombia (+12 more), Costa Rica, Panama, Ecuador, Peru, Chile, Antarctica, Falkland Islands, Argentina, Uruguay, Brazil, Saint Lucia, Saint Kitts and Nevis
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$46,991
Suite
$50,225
From
US$46,991
Save 78,607
Per Person
View Trip
127 Day World Cruise: Australia & South Pacific Panorama with Seabourn
Cruise
 (1)

127 Days (126 Nights) Miami to Los Angeles
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 05 January 2027
Visit: USA, Panama, Ecuador, Peru (+11 more), Chile, French Polynesia, Cook Islands, Tonga, New Zealand, Australia, Papua New Guinea, New Caledonia, Vanuatu, Fiji, Samoa
Explore More
Exclusive Savings
Inside
-
Oceanview
$74,867
Balcony
$103,257
Suite
-
From
US$74,867
Save 1,227
Per Person
View Trip
146 Day World Cruise: Australia & South Pacific Panorama with Seabourn
Cruise
 (1)

146 Days (145 Nights) Miami to Miami
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 05 January 2027
Visit: USA, Panama, Ecuador, Peru (+15 more), Chile, French Polynesia, Cook Islands, Tonga, New Zealand, Australia, Papua New Guinea, New Caledonia, Vanuatu, Fiji, Samoa, Mexico, Guatemala, Costa Rica, Colombia
Explore More
Exclusive Savings
Inside
-
Oceanview
$84,227
Balcony
$95,399
Suite
$179,189
From
US$84,227
Save 1,367
Per Person
View Trip
177 Day Azamara World Cruise with Azamara Cruises
Cruise
 (8)

177 Days (176 Nights) Miami to Athens
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 05 January 2028
Visit: USA, Aruba, Curacao, Colombia (+37 more), Panama, Ecuador, Peru, Chile, Pitcairn Islands, French Polynesia, Cook Islands, New Zealand, Australia, Indonesia, Malaysia, Philippines, China, Vietnam, Thailand, Singapore, Sri Lanka, India, Maldives, Mauritius, Reunion, Madagascar, South Africa, Namibia, Cape Verde, Spain, Morocco, Gibraltar, France, Italy, Sicily, Malta, Montenegro, Croatia, Slovenia, Greece, Turkey
Azamara Always Included
Exclusive Savings
Inside
$52,087
Oceanview
$57,907
Balcony
$67,607
Suite
$104,467
From
US$52,087
Save 1,252
Per Person
View Trip
Results: 121-141 of 141

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