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South America Luxury Cruises

Explore the best luxury cruises around South America. Choose from 143 unique cruise itineraries with 127 past traveler reviews from 10 leading cruise lines. January is the most popular month to join a luxury cruise around South America with 273 departures starting between February 2026 and February 2029.
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121 Days
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143 Cruises (273 Cruise Departures)
30 Day Southampton To Rio De Janeiro with Cunard
Cruise

30 Days (29 Nights) London to Rio de Janeiro
Cruise Line: Cunard
Ship: Queen Anne
Departure: 10 January 2027
Visit: England, Bermuda, USA, Turks and Caicos Islands, Barbados, Brazil
Inside
$4,289
Oceanview
$5,909
Balcony
$6,347
Suite
$14,891
From
US$4,289
Per Person
View Trip
41 Day Amazon & Tropical Isles with Oceania Cruises
Cruise
 (1)

41 Days (40 Nights) Lisbon to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 09 November 2026
Visit: Portugal, Spain, Puerto Rico, Bahamas (+9 more), USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$9,706
Oceanview
$10,822
Balcony
$15,720
Suite
$21,152
From
US$9,706
Save 10,092
Per Person
View Trip
55 Day Epic Antarctic & Amazon with Oceania Cruises
Cruise
 (1)

55 Days (54 Nights) Valparaiso to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 February 2027
Visit: Chile, Argentina, Antarctica, Falkland Islands (+6 more), Uruguay, Brazil, Barbados, Antigua and Barbuda, Virgin Islands, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$15,577
Oceanview
$16,110
Balcony
$22,900
Suite
$31,824
From
US$15,577
Save 16,221
Per Person
View Trip
32 Day South America, Canary Islands, Spain & France with Seabourn
Cruise

32 Days (31 Nights) Rio de Janeiro to Amsterdam
Cruise Line: Seabourn
Ship: Seabourn Venture
Departure: 06 April 2027
Visit: Brazil, Cape Verde, Spain, Morocco, Portugal, France, Holland
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$14,816
From
US$14,816
Save 228
Per Person
View Trip
35 Day Hamburg To Rio De Janeiro with Cunard
Cruise

35 Days (34 Nights) Hamburg to Rio de Janeiro
Cruise Line: Cunard
Ship: Queen Anne
Departure: 05 January 2027
Visit: Germany, Holland, Belgium, England (+5 more), Bermuda, USA, Turks and Caicos Islands, Barbados, Brazil
Inside
$5,369
Oceanview
$7,686
Balcony
$8,696
Suite
$18,576
From
US$5,369
Per Person
View Trip
83 Day South America Discovery with Cunard
Cruise

83 Days (82 Nights) London to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 10 January 2027
Visit: England, Bermuda, USA, Turks and Caicos Islands (+10 more), Barbados, Brazil, Uruguay, Argentina, Chile, Peru, Ecuador, Panama, Aruba, Portugal
Exclusive Savings
Inside
$13,068
Oceanview
$18,117
Balcony
$20,058
Suite
$40,016
From
US$13,068
Per Person
View Trip
64 Day World Cruise: Panama Canal, Polynesia & New Zealand with Seabourn
Cruise
 (1)

64 Days (63 Nights) Miami to Sydney
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 05 January 2027
Visit: USA, Panama, Ecuador, Peru (+6 more), Chile, French Polynesia, Cook Islands, Tonga, New Zealand, Australia
Explore More
Exclusive Savings
Inside
-
Oceanview
$29,548
Balcony
$34,796
Suite
$150,500
From
US$29,548
Save 456
Per Person
View Trip
29 Day Caribbean, Central America & Peru Cruise: Aruba, Miami & Panama Canal with Azamara Cruises
Cruise
 (4)

29 Days (28 Nights) Bridgetown to Valparaiso
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 27 December 2027
Visit: Barbados, Bonaire, Curacao, Aruba (+11 more), Dominican Republic, Bahamas, USA, Mexico, Belize, Honduras, Costa Rica, Panama, Ecuador, Peru, Chile
Azamara Always Included
Exclusive Savings
Inside
$8,979
Oceanview
$10,570
Balcony
$12,878
Suite
$18,824
From
US$8,979
Save 210
Per Person
View Trip
54 Day Chilean Fjords, Antarctica & South Atlantic Explorer with Seabourn
Cruise
 (1)

54 Days (53 Nights) Valparaiso to Cape Town
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 05 February 2028
Visit: Chile, Argentina, Antarctica, Falkland Islands (+4 more), Uruguay, Saint Helena, South Africa, Mozambique
Exclusive Savings
Inside
-
Oceanview
$35,386
Balcony
$39,306
Suite
-
From
US$35,386
Save 613
Per Person
View Trip
37 Day Caribbean To Cape Horn with Oceania Cruises
Cruise
 (1)

37 Days (36 Nights) Miami to Buenos Aires
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 19 December 2026
Visit: USA, Curacao, Aruba, Colombia (+7 more), Panama, Ecuador, Peru, Chile, Argentina, Falkland Islands, Uruguay
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$10,245
Oceanview
$10,778
Balcony
$14,513
Suite
$20,527
From
US$10,245
Save 10,653
Per Person
View Trip
83 Day South America, Antarctica, South Atlantic & Africa with Seabourn
Cruise
 (1)

83 Days (82 Nights) Miami to Cape Town
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 07 January 2028
Visit: USA, Panama, Ecuador, Peru (+8 more), Chile, Argentina, Antarctica, Falkland Islands, Uruguay, Saint Helena, South Africa, Mozambique
Exclusive Savings
Inside
-
Oceanview
$54,079
Balcony
$60,939
Suite
-
From
US$54,079
Save 920
Per Person
View Trip
57 Day South America Discovery From Fort Lauderdale with Cunard
Cruise

57 Days (56 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Anne
Departure: 22 January 2027
Visit: USA, Turks and Caicos Islands, Barbados, Brazil (+7 more), Uruguay, Argentina, Chile, Peru, Ecuador, Panama, Aruba
Exclusive Savings
Inside
$11,019
Oceanview
$14,682
Balcony
$15,375
Suite
$35,175
From
US$11,019
Per Person
View Trip
69 Day Miami To Bridgetown Grand Voyage with Azamara Cruises
Cruise
 (4)

69 Days (68 Nights) Miami to Bridgetown
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 05 January 2028
Visit: USA, Mexico, Belize, Honduras (+13 more), Costa Rica, Panama, Ecuador, Peru, Chile, Argentina, Antarctica, Falkland Islands, Uruguay, Brazil, French Guiana, Trinidad and Tobago, Barbados
Azamara Always Included
Exclusive Savings
Inside
$22,787
Oceanview
$26,511
Balcony
$31,943
Suite
$46,028
From
US$22,787
Save 522
Per Person
View Trip
43 Day Miami To Buenos Aires Grand Voyage with Azamara Cruises
Cruise
 (4)

43 Days (42 Nights) Miami to Buenos Aires
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 05 January 2028
Visit: USA, Mexico, Belize, Honduras (+9 more), Costa Rica, Panama, Ecuador, Peru, Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Azamara Always Included
Exclusive Savings
Inside
$14,374
Oceanview
$16,217
Balcony
$20,194
Suite
$28,351
From
US$14,374
Save 335
Per Person
View Trip
22 Day Brazil Coast, Cape Verde & Canary Islands Crossing with Seabourn
Cruise

22 Days (21 Nights) Rio de Janeiro to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Venture
Departure: 04 April 2026
Visit: Brazil, Cape Verde, Spain, Morocco
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$9,205
From
US$9,205
Save 144
Per Person
View Trip
41 Day Buenos Aires To Miami Grand Voyage with Azamara Cruises
Cruise
 (3)

41 Days (40 Nights) Buenos Aires to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 17 February 2027
Visit: Argentina, Uruguay, Falkland Islands, Antarctica (+7 more), Chile, Peru, Panama, Costa Rica, Colombia, Mexico, USA
Azamara Always Included
Exclusive Savings
Inside
$16,174
Oceanview
$16,581
Balcony
$19,317
Suite
$30,443
From
US$16,174
Save 385
Per Person
View Trip
58 Day Old & New World Discovery with Oceania Cruises
Cruise
 (1)

58 Days (57 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Visit: Italy, Croatia, Montenegro, Greece (+14 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
$16,309
Balcony
$24,554
Suite
$32,557
From
US$16,309
Save 16,989
Per Person
View Trip
48 Day Footsteps Of Columbus with Oceania Cruises
Cruise
 (1)

48 Days (47 Nights) Barcelona to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 02 November 2026
Visit: Spain, Portugal, Puerto Rico, Bahamas (+9 more), USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
$13,028
Balcony
$19,479
Suite
$25,832
From
US$13,028
Save 13,570
Per Person
View Trip
75 Day Circle South America Grand Voyage with Azamara Cruises
Cruise
 (3)

75 Days (74 Nights) Miami to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 14 January 2027
Visit: USA, Virgin Islands, Saint Martin, Saint Kitts and Nevis (+18 more), Antigua and Barbuda, Martinique, Saint Vincent, Grenada, Barbados, Trinidad and Tobago, French Guiana, Brazil, Uruguay, Argentina, Falkland Islands, Antarctica, Chile, Peru, Panama, Costa Rica, Colombia, Mexico
Azamara Always Included
Exclusive Savings
Inside
$28,068
Oceanview
$29,261
Balcony
$33,810
Suite
$53,443
From
US$28,068
Save 661
Per Person
View Trip
78 Day Circle South America Grand Voyage with Azamara Cruises
Cruise
 (4)

78 Days (77 Nights) Miami to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 05 January 2028
Visit: USA, Mexico, Belize, Honduras (+19 more), Costa Rica, Panama, Ecuador, Peru, Chile, Argentina, Antarctica, Falkland Islands, Uruguay, Brazil, French Guiana, Trinidad and Tobago, Barbados, Grenada, Saint Lucia, Martinique, Dominica, Saint Martin, Virgin Islands
Azamara Always Included
Exclusive Savings
Inside
$25,403
Oceanview
$29,613
Balcony
$35,821
Suite
$51,826
From
US$25,403
Save 586
Per Person
View Trip
66 Day Grand South America Mosaic with Regent Seven Seas
Cruise

66 Days (65 Nights) Miami to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 13 January 2028
Visit: USA, Cayman Islands, Jamaica, Colombia (+12 more), Costa Rica, Panama, Ecuador, Peru, Chile, Antarctica, Falkland Islands, Argentina, Uruguay, Brazil, Saint Lucia, Saint Kitts and Nevis
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$51,107
Suite
$53,214
From
US$51,107
Save 82,891
Per Person
View Trip
121 Day Cape To Cape World Cruise: Miami To Dover with Seabourn
Cruise
 (1)

121 Days (120 Nights) Miami to London
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 07 January 2028
Visit: USA, Panama, Ecuador, Peru (+20 more), Chile, Argentina, Antarctica, Falkland Islands, Uruguay, Saint Helena, South Africa, Mozambique, Namibia, Angola, Sao Tome and Principe, Benin, Ghana, Senegal, Cape Verde, Spain, Morocco, Portugal, France, England
Exclusive Savings
Inside
-
Oceanview
$76,702
Balcony
$87,482
Suite
$163,922
From
US$76,702
Save 1,297
Per Person
View Trip
113 Day Cape To Cape World Cruise: Miami To Lisbon with Seabourn
Cruise
 (1)

113 Days (112 Nights) Miami to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 07 January 2028
Visit: USA, Panama, Ecuador, Peru (+18 more), Chile, Argentina, Antarctica, Falkland Islands, Uruguay, Saint Helena, South Africa, Mozambique, Namibia, Angola, Sao Tome and Principe, Benin, Ghana, Senegal, Cape Verde, Spain, Morocco, Portugal
Exclusive Savings
Inside
-
Oceanview
$71,586
Balcony
$80,406
Suite
-
From
US$71,586
Save 1,213
Per Person
View Trip
Results: 121-143 of 143

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