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Cruises from Italy to USA

Are you looking for a cruise from Italy to USA? October is the most popular month to cruise between Italy and USA and there are 42 departures available from twelve of the world's leading cruise lines.
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58 Days
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42 Cruises (42 Cruise Departures)
20 Day MSC Grand Voyages with MSC Cruises
Cruise

20 Days (19 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 18 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Grand Voyages Sale
INSIDE
$1,239
OCEANVIEW
$1,419
BALCONY
$1,669
SUITE
$3,249
From (per person) 1,239
View Trip
22 Day Atlantic Ocean Isles with Regent Seven Seas
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 November 2026
Countries Visited: Italy, Spain, Gibraltar, Portugal (+5 more), Bermuda, USA, Honduras, Belize, Mexico
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$11,499
SUITE
$12,499
Save (per person) 19,499
From (per person) 11,499
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 October 2026
Countries Visited: Italy, Spain, Portugal, Puerto Rico (+1 more), USA
Escape To Sea
INSIDE
$1,153
OCEANVIEW
$1,313
BALCONY
$1,583
SUITE
$5,493
From (per person) 1,153
View Trip
15 Day Splendid Atlantic Sojourn with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to New York
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 18 May 2027
Countries Visited: Italy, Spain, Morocco, Bermuda (+1 more), USA
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$9,099
SUITE
$9,999
Save (per person) 15,699
From (per person) 9,099
View Trip
23 Day Mediterranean, Canary Islands & Moroccan Grand Adventure with Princess
Cruise
 (1)

23 Days (22 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 13 November 2027
Countries Visited: Italy, Greece, Montenegro, Croatia (+4 more), Spain, Gibraltar, Morocco, USA
Summer Swing Sale
INSIDE
$2,600
OCEANVIEW
$4,049
BALCONY
$3,799
SUITE
$5,000
From (per person) 2,600
View Trip
15 Day Cultural Crossing With Andalusia And Azores with Holland America
Cruise
 (2)

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Statendam
Departure: 15 November 2025
Countries Visited: Italy, Spain, Gibraltar, Portugal (+1 more), USA
Exclusive Deal
INSIDE
-
OCEANVIEW
$1,134
BALCONY
$1,444
SUITE
$2,344
From (per person) 1,134
View Trip
22 Day Atlantic Crossing & Mediterranean with Viking Cruises
Cruise
 (5)

22 Days (21 Nights) Rome to Fort Lauderdale
Operated By: Viking Cruises
Ship: Viking Sky
Departure: 28 November 2025
Countries Visited: Italy, Monaco, France, Spain (+3 more), Portugal, Sint Maarten, USA
Viking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$6,348
SUITE
$9,498
Save (per person) 950
From (per person) 6,348
View Trip
22 Day Riviera Gems & Atlantic Crossing with Seabourn
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 11 November 2025
Countries Visited: Italy, Corsica, Sardinia, Spain (+3 more), Portugal, Bermuda, USA
A Sail To Remember
INSIDE
-
OCEANVIEW
-
BALCONY
$7,394
SUITE
$12,494
From (per person) 7,394
View Trip
26 Day A Grand Journey Of European Gems And Tropical Idylls with Explora Journeys
Cruise

26 Days (25 Nights) Venice to Miami
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 18 October 2025
Countries Visited: Italy, Croatia, Montenegro, Monaco (+6 more), Spain, Portugal, Antigua and Barbuda, Virgin Islands, Puerto Rico, USA
Best Available FareGrand Journey Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$12,245
SUITE
$16,210
From (per person) 12,245
View Trip
24 Day Mediterranean, Aegean & Moroccan Passage with Princess
Cruise
 (1)

24 Days (23 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 10 November 2026
Countries Visited: Italy, Greece, Turkey, Spain (+3 more), Gibraltar, Morocco, USA
Summer Swing Sale
INSIDE
$2,465
OCEANVIEW
$3,765
BALCONY
$3,715
SUITE
$4,145
From (per person) 2,465
View Trip
22 Day Mediterranean with MSC Cruises
Cruise

22 Days (21 Nights) Livorno to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 26 October 2025
Countries Visited: Italy, France, Spain, Morocco (+5 more), Barbados, Grenada, Sint Maarten, Puerto Rico, USA
Grand Voyages Sale
INSIDE
$1,061
OCEANVIEW
$1,301
BALCONY
$1,741
SUITE
$3,321
From (per person) 1,061
View Trip
14 Day Italy & Bermuda Transatlantic with Celebrity Cruises
Cruise

14 Days (13 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 31 October 2025
Countries Visited: Italy, Sardinia, Gibraltar, Bermuda (+1 more), USA
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$1,706
BALCONY
$2,582
SUITE
-
From (per person) 2,746
View Trip
31 Day A Journey Of Sun And Sea with Regent Seven Seas
Cruise

31 Days (30 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 25 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+7 more), Corsica, Monaco, Spain, Portugal, Bermuda, Bahamas, USA
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$20,299
SUITE
$23,199
Save (per person) 35,699
From (per person) 20,299
View Trip
26 Day Rome to Fort Lauderdale with Silversea
Cruise

26 Days (25 Nights) Rome to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Ray
Departure: 07 November 2025
Countries Visited: Italy, France, Spain, Portugal (+2 more), Bermuda, USA
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$12,000
From (per person) 12,000
View Trip
58 Day Old & New World Discovery with Oceania Cruises
Cruise

58 Days (57 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+14 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin
Exclusive Deal
INSIDE
$14,799
OCEANVIEW
$16,299
BALCONY
$22,999
SUITE
$31,899
Save (per person) 14,799
From (per person) 14,799
View Trip
26 Day Allura Autumn Crossing with Oceania Cruises
Cruise

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 07 November 2026
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Spain, Morocco, Puerto Rico, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,599
SUITE
$12,699
Save (per person) 9,599
From (per person) 9,599
View Trip
22 Day Transatlantic with MSC Cruises
Cruise

22 Days (21 Nights) Naples to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 16 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Grand Voyages Sale
INSIDE
$1,331
OCEANVIEW
$1,621
BALCONY
$1,911
SUITE
-
From (per person) 1,331
View Trip
16 Day Canary Islands & Moroccan Passage with Princess
Cruise
 (1)

16 Days (15 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 20 November 2027
Countries Visited: Italy, Spain, Gibraltar, Morocco (+1 more), USA
Summer Swing Sale
INSIDE
$1,480
OCEANVIEW
$2,479
BALCONY
$2,309
SUITE
$2,980
From (per person) 1,480
View Trip
15 Day New World Passage with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 November 2026
Countries Visited: Italy, Spain, Gibraltar, Portugal (+2 more), Bermuda, USA
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$7,099
SUITE
$8,199
Save (per person) 13,699
From (per person) 7,099
View Trip
17 Day Moroccan Passage with Princess
Cruise
 (1)

17 Days (16 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 17 November 2026
Countries Visited: Italy, Spain, Gibraltar, Morocco (+1 more), USA
Summer Swing Sale
INSIDE
$1,089
OCEANVIEW
-
BALCONY
$1,533
SUITE
$2,019
From (per person) 1,089
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Countries Visited: Italy, France, Spain, Portugal (+3 more), Saint Martin, Bahamas, USA
Grand Voyages Sale
INSIDE
$814
OCEANVIEW
$1,014
BALCONY
$1,484
SUITE
$3,864
From (per person) 814
View Trip
27 Day Mediterranean Grand Adventure with Princess
Cruise
 (3)

27 Days (26 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Sun Princess
Departure: 21 October 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+3 more), Spain, Gibraltar, USA
Exclusive DealSummer Swing Sale
INSIDE
$3,001
OCEANVIEW
$3,601
BALCONY
$4,230
SUITE
$5,081
From (per person) 3,001
View Trip
14 Day Transatlantic Repositioning Cruise From Bologna to Philadelphia with Norwegian Cruise Line
Cruise

14 Days (13 Nights) Bologna to Philadelphia
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Pearl
Departure: 01 November 2026
Countries Visited: Italy, Malta, Sardinia, Spain (+1 more), USA
INSIDE
$1,139
OCEANVIEW
$1,289
BALCONY
$2,189
SUITE
$2,339
From (per person) 1,139
View Trip
22 Day Jewels Of Andalusia & Atlantic Crossing with Seabourn
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 01 November 2026
Countries Visited: Italy, Corsica, Sardinia, Spain (+2 more), Portugal, USA
A Sail To Remember
INSIDE
-
OCEANVIEW
$8,754
BALCONY
$10,964
SUITE
$18,784
From (per person) 8,754
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Florence to New York
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 18 October 2026
Countries Visited: Italy, France, Spain, Gibraltar (+2 more), Portugal, USA
Escape To Sea
INSIDE
$1,703
OCEANVIEW
$1,903
BALCONY
$2,213
SUITE
-
From (per person) 1,703
View Trip
17 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

17 Days (16 Nights) Rome to Tampa
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 31 October 2025
Countries Visited: Italy, Spain, Portugal, Bermuda (+2 more), Bahamas, USA
Bonus Onboard Credit + SaveExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$1,876
SUITE
$22,050
From (per person) 3,009
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Amalfi to New York
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 17 October 2026
Countries Visited: Italy, France, Spain, Gibraltar (+2 more), Portugal, USA
Escape To Sea
INSIDE
$1,785
OCEANVIEW
$1,995
BALCONY
$2,305
SUITE
-
From (per person) 1,785
View Trip
15 Day Transatlantic Repositioning Cruise From Rome To Jacksonville with Norwegian Cruise Line
Cruise

15 Days (14 Nights) Rome to Jacksonville
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Gem
Departure: 01 November 2026
Countries Visited: Italy, France, Spain, Portugal (+1 more), USA
INSIDE
$1,219
OCEANVIEW
$1,519
BALCONY
$2,469
SUITE
$2,569
From (per person) 1,219
View Trip
23 Day Mediterranean with MSC Cruises
Cruise

23 Days (22 Nights) Naples to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 25 October 2025
Countries Visited: Italy, France, Spain, Morocco (+5 more), Barbados, Grenada, Sint Maarten, Puerto Rico, USA
Grand Voyages Sale
INSIDE
$1,211
OCEANVIEW
$1,501
BALCONY
$2,011
SUITE
$4,021
From (per person) 1,211
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 18 October 2025
Countries Visited: Italy, France, Spain, Portugal (+5 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA, Bahamas
Grand Voyages Sale
INSIDE
$1,579
OCEANVIEW
$1,869
BALCONY
$2,069
SUITE
-
From (per person) 1,579
View Trip
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