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Cruises from Italy to USA

Are you looking for a cruise from Italy to USA? October is the most popular month to cruise between Italy and USA and there are 32 departures available from twelve of the world's leading cruise lines.
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57 Days
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32 Cruises (32 Cruise Departures)
24 Day Mediterranean, Aegean & Moroccan Passage with Princess
Cruise
 (1)

24 Days (23 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 10 November 2026
Countries Visited: Italy, Greece, Turkey, Spain (+3 more), Gibraltar, Morocco, USA
Exclusive Deal
INSIDE
$3,507
OCEANVIEW
$5,598
BALCONY
$5,071
SUITE
$6,528
From (per person) 3,507
View Trip
22 Day Atlantic Crossing & Mediterranean with Viking Cruises
Cruise
 (5)

22 Days (21 Nights) Rome to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Sky
Departure: 28 November 2025
Countries Visited: Italy, Monaco, France, Spain (+3 more), Portugal, Sint Maarten, USA
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$11,182
SUITE
$17,320
Save (per person) 913
From (per person) 11,182
View Trip
57 Day Venice To Miami Grand Voyage with Azamara Cruises
Cruise
 (2)

57 Days (56 Nights) Venice to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 06 October 2026
Countries Visited: Italy, Greece, Turkey, Egypt (+9 more), Malta, Sicily, Monaco, France, Spain, Gibraltar, Portugal, Puerto Rico, USA
INSIDE
$13,956
OCEANVIEW
$16,936
BALCONY
$23,054
SUITE
$33,647
From (per person) 13,956
View Trip
27 Day Mediterranean Grand Adventure with Princess
Cruise
 (2)

27 Days (26 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Sun Princess
Departure: 21 October 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+3 more), Spain, Gibraltar, USA
Exclusive Deal
INSIDE
$5,346
OCEANVIEW
$6,297
BALCONY
$8,158
SUITE
$10,079
From (per person) 5,346
View Trip
17 Day Moroccan Passage with Princess
Cruise
 (1)

17 Days (16 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 17 November 2026
Countries Visited: Italy, Spain, Gibraltar, Morocco (+1 more), USA
Exclusive Deal
INSIDE
$1,789
OCEANVIEW
$2,725
BALCONY
$2,365
SUITE
$3,339
From (per person) 1,789
View Trip
19 Day Western Mediterranean Passage with Princess
Cruise
 (2)

19 Days (18 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Island Princess
Departure: 04 December 2024
Countries Visited: Italy, Sardinia, Spain, Morocco (+3 more), Portugal, Cape Verde, USA
Exclusive Deal
INSIDE
$1,702
OCEANVIEW
$1,771
BALCONY
$2,229
SUITE
$6,988
From (per person) 1,702
View Trip
22 Day Western Mediterranean & Trans-Atlantic Crossing with Princess
Cruise
 (2)

22 Days (21 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Island Princess
Departure: 11 April 2025
Countries Visited: Italy, Corsica, France, Spain (+2 more), Morocco, USA
Exclusive Deal
INSIDE
$4,006
OCEANVIEW
$4,253
BALCONY
$4,580
SUITE
$6,530
From (per person) 4,006
View Trip
15 Day Cultural Crossing With Andalusia And Azores with Holland America
Cruise
 (2)

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Statendam
Departure: 15 November 2025
Countries Visited: Italy, Spain, Gibraltar, Portugal (+1 more), USA
Exclusive Deal
INSIDE
$1,747
OCEANVIEW
$2,044
BALCONY
$2,435
SUITE
$4,068
From (per person) 1,747
View Trip
34 Day Mediterranean, Iceland & British Isles Grand Adventure with Princess
Cruise
 (3)

34 Days (33 Nights) Rome to Boston
Cruise Line: Princess
Ship: Majestic Princess
Departure: 30 June 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+7 more), Spain, Gibraltar, England, Scotland, Iceland, Canada, USA
Exclusive Deal
INSIDE
$9,193
OCEANVIEW
-
BALCONY
$8,979
SUITE
$13,394
From (per person) 8,979
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 26 October 2024
Countries Visited: Italy, Sicily, Spain, Barbados (+3 more), Grenada, Puerto Rico, USA
Save And Sail Offer
INSIDE
$2,934
OCEANVIEW
$3,409
BALCONY
$4,011
SUITE
$5,999
From (per person) 2,934
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 27 October 2024
Countries Visited: Italy, Sicily, Spain, Barbados (+3 more), Grenada, Puerto Rico, USA
Save And Sail Offer
INSIDE
$2,790
OCEANVIEW
$3,265
BALCONY
$3,925
SUITE
$5,758
From (per person) 2,790
View Trip
22 Day Mediterranean with MSC Cruises
Cruise

22 Days (21 Nights) Livorno to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 26 October 2025
Countries Visited: Italy, France, Spain, Morocco (+5 more), Barbados, Grenada, Sint Maarten, Puerto Rico, USA
Early Booking Offer
INSIDE
$3,100
OCEANVIEW
$3,527
BALCONY
$4,099
SUITE
$6,204
From (per person) 3,100
View Trip
15 Day Spanish Transatlantic Cruise with Royal Caribbean
Cruise

15 Days (14 Nights) Rome to New York
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 03 November 2024
Countries Visited: Italy, Spain, Portugal, USA
Exclusive Deal
INSIDE
$2,117
OCEANVIEW
$3,620
BALCONY
$3,441
SUITE
$12,147
Save (per person) 1,022
From (per person) 2,117
View Trip
17 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise

17 Days (16 Nights) Rome to New York
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Prima
Departure: 07 November 2024
Countries Visited: Italy, France, Spain, Portugal (+1 more), USA
More At Sea Offer
INSIDE
$2,730
OCEANVIEW
-
BALCONY
-
SUITE
$7,201
From (per person) 2,730
View Trip
22 Day Atlantic Ocean Isles with Regent Seven Seas
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 November 2026
Countries Visited: Italy, Spain, Gibraltar, Portugal (+5 more), Bermuda, USA, Honduras, Belize, Mexico
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$14,959
SUITE
$17,474
Save (per person) 8,871
From (per person) 14,959
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise

20 Days (19 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 18 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Early Booking Offer
INSIDE
$2,628
OCEANVIEW
$3,025
BALCONY
$3,345
SUITE
$5,208
From (per person) 2,628
View Trip
23 Day Mediterranean with MSC Cruises
Cruise

23 Days (22 Nights) Naples to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 25 October 2025
Countries Visited: Italy, France, Spain, Morocco (+5 more), Barbados, Grenada, Sint Maarten, Puerto Rico, USA
Early Booking Offer
INSIDE
$3,254
OCEANVIEW
$3,681
BALCONY
$4,292
SUITE
$6,465
From (per person) 3,254
View Trip
15 Day New World Passage with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 November 2026
Countries Visited: Italy, Spain, Gibraltar, Portugal (+2 more), Bermuda, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,066
SUITE
$11,621
Save (per person) 7,334
From (per person) 10,066
View Trip
57 Day Antiquity To America with Oceania Cruises
Cruise

57 Days (56 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 04 October 2025
Countries Visited: Italy, Sicily, Malta, Greece (+12 more), Turkey, Cyprus, Croatia, Montenegro, Tunisia, Spain, Morocco, Portugal, Barbados, Antigua and Barbuda, Puerto Rico, USA
Bonus SavingsExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$29,485
SUITE
$41,655
Save (per person) 3,795
From (per person) 29,485
View Trip
26 Day Rome to Fort Lauderdale with Silversea
Cruise

26 Days (25 Nights) Rome to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Ray
Departure: 07 November 2025
Countries Visited: Italy, France, Spain, Portugal (+2 more), Bermuda, USA
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$16,830
From (per person) 16,830
View Trip
28 Day Atlantic Sands & Sunsets with Oceania Cruises
Cruise

28 Days (27 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 20 November 2024
Countries Visited: Italy, Spain, Antigua and Barbuda, Puerto Rico (+8 more), USA, Mexico, Guatemala, Belize, Honduras, Cayman Islands, Jamaica, Bahamas
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,375
SUITE
-
Save (per person) 2,095
From (per person) 12,375
View Trip
17 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

17 Days (16 Nights) Rome to Tampa
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 31 October 2025
Countries Visited: Italy, Spain, Portugal, Bermuda (+2 more), Bahamas, USA
Exclusive Deal
INSIDE
$2,024
OCEANVIEW
$2,594
BALCONY
$3,835
SUITE
-
Save (per person) 3,638
From (per person) 2,024
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Genoa to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 November 2025
Countries Visited: Italy, France, Spain, Puerto Rico (+2 more), Virgin Islands, USA
Early Booking Offer
INSIDE
$2,398
OCEANVIEW
$2,698
BALCONY
$3,048
SUITE
$5,443
From (per person) 2,398
View Trip
16 Day New World Horizons with Oceania Cruises
Cruise

16 Days (15 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 20 November 2024
Countries Visited: Italy, Spain, Antigua and Barbuda, Puerto Rico (+1 more), USA
Exclusive DealSingles Special Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$6,163
SUITE
-
Save (per person) 2,047
From (per person) 6,163
View Trip
17 Day From Rome to Miami with Virgin Voyages
Cruise

17 Days (16 Nights) Rome to Miami
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 28 November 2024
Countries Visited: Italy, Spain, Portugal, USA
70% Off Second Sailor + Save
INSIDE
$2,462
OCEANVIEW
$2,666
BALCONY
$2,696
SUITE
$10,461
From (per person) 2,462
View Trip
14 Day Italy & Bermuda Transatlantic with Celebrity Cruises
Cruise

14 Days (13 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 31 October 2025
Countries Visited: Italy, Sardinia, Gibraltar, Bermuda (+1 more), USA
Exclusive Deal
INSIDE
$1,711
OCEANVIEW
$2,427
BALCONY
$2,885
SUITE
-
Save (per person) 3,224
From (per person) 1,711
View Trip
31 Day A Journey Of Sun And Sea with Regent Seven Seas
Cruise

31 Days (30 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 25 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+7 more), Corsica, Monaco, Spain, Portugal, Bermuda, Bahamas, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$29,363
SUITE
$31,798
Save (per person) 14,617
From (per person) 29,363
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 18 October 2025
Countries Visited: Italy, France, Spain, Portugal (+5 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA, Bahamas
Early Booking Offer
INSIDE
$2,963
OCEANVIEW
$3,390
BALCONY
$3,778
SUITE
-
From (per person) 2,963
View Trip
22 Day Transatlantic with MSC Cruises
Cruise

22 Days (21 Nights) Naples to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 16 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Early Booking Offer
INSIDE
$2,809
OCEANVIEW
$3,333
BALCONY
$4,099
SUITE
-
From (per person) 2,809
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 November 2025
Countries Visited: Italy, France, Spain, Puerto Rico (+2 more), Virgin Islands, USA
Early Booking Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$3,096
SUITE
-
From (per person) 3,096
View Trip
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