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Cruises from Italy to USA

Are you looking for a cruise from Italy to USA? November is the most popular month to cruise between Italy and USA and there are 34 departures available from nine of the world's leading cruise lines.
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34 Cruises (34 Cruise Departures)
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

17 Days (16 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 07 April 2026
Visit: Italy, France, Spain, Portugal, Saint Martin, Bahamas, USA
Grand Voyages Sale
Inside
-
Oceanview
-
Balcony
$1,430
Suite
-
From
US$1,430
Per Person
View Trip
22 Day Jewels Of Andalusia & Atlantic Crossing with Seabourn
Cruise
 (1)

22 Days (21 Nights) Rome to Miami
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 01 November 2026
Visit: Italy, Corsica, Sardinia, Spain, Portugal, USA
Explore More
Exclusive Savings
Inside
-
Oceanview
$9,699
Balcony
$11,948
Suite
$18,945
From
US$9,699
Save 160
Per Person
View Trip
26 Day Allura Autumn Crossing with Oceania Cruises
Cruise

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 07 November 2026
Visit: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Spain, Morocco, Puerto Rico, USA
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,731
Suite
$14,660
From
US$10,731
Save 11,267
Per Person
View Trip
26 Day Europe To The Caribbean with Oceania Cruises
Cruise
 (3)

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 November 2026
Visit: Italy, Sicily, Malta, Tunisia (+6 more), Sardinia, Spain, Portugal, Puerto Rico, Dominican Republic, USA
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$6,800
Oceanview
-
Balcony
$9,225
Suite
$12,329
From
US$6,800
Save 7,098
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

18 Days (17 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Visit: Italy, France, Spain, Portugal, Saint Martin, Bahamas, USA
Inside
-
Oceanview
-
Balcony
$1,454
Suite
-
From
US$1,454
Per Person
View Trip
16 Day Spain & Portugal Transatlantic with Royal Caribbean
Cruise
 (2)

16 Days (15 Nights) Rome to Tampa
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 06 November 2027
Visit: Italy, Spain, Portugal, Bermuda, USA
Bonus Onboard Credit
Exclusive Savings
Inside
$1,034
Oceanview
$1,154
Balcony
$1,504
Suite
$2,627
From
US$1,034
Save 495
Per Person
View Trip
16 Day Canary Islands & Moroccan Passage with Princess
Cruise
 (1)

16 Days (15 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 20 November 2027
Visit: Italy, Spain, Gibraltar, Morocco, Bermuda, USA
Princess Standard
Inside
$1,479
Oceanview
$2,378
Balcony
$2,166
Suite
$2,979
From
US$1,479
Per Person
View Trip
33 Day Something Old, Something New with Oceania Cruises
Cruise

33 Days (32 Nights) Trieste to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 31 October 2027
Visit: Italy, Croatia, Montenegro, Albania (+8 more), Sicily, Sardinia, Corsica, France, Spain, Portugal, Bermuda, USA
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,084
Suite
$18,322
From
US$13,084
Save 13,714
Per Person
View Trip
44 Day Land Of Love To Lady Liberty with Oceania Cruises
Cruise
 (1)

44 Days (43 Nights) Venice to New York
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 07 August 2027
Visit: Italy, Croatia, Montenegro, Greece (+13 more), Sicily, France, Spain, Morocco, Gibraltar, Portugal, Guernsey, England, Ireland, Northern Ireland, Iceland, Canada, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$12,150
Oceanview
$12,829
Balcony
$18,746
Suite
$25,924
From
US$12,150
Save 12,648
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Genoa to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 05 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
$16,622
Oceanview
$19,493
Balcony
$28,272
Suite
-
From
US$16,622
Save 427
Per Person
View Trip
25 Day Msc Grand Voyages with MSC Cruises
Cruise

25 Days (24 Nights) Florence to Miami
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 18 October 2026
Visit: Italy, France, Spain, Gibraltar, Morocco, Portugal, USA
Bonus Onboard Credit
Inside
$1,939
Oceanview
$2,289
Balcony
$2,561
Suite
$6,528
From
US$1,939
Per Person
View Trip
24 Day Old & New Worlds with Oceania Cruises
Cruise
 (3)

24 Days (23 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 27 November 2027
Visit: Italy, Corsica, France, Spain, Gibraltar, Portugal, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$5,194
Oceanview
$6,503
Balcony
$7,813
Suite
$11,208
From
US$5,194
Save 5,404
Per Person
View Trip
24 Day Mediterranean, Aegean & Moroccan Passage with Princess
Cruise
 (1)

24 Days (23 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 10 November 2026
Visit: Italy, Greece, Turkey, Spain, Gibraltar, Morocco, USA
Princess Standard
Inside
$2,194
Oceanview
-
Balcony
$3,264
Suite
$3,563
From
US$2,194
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 26 October 2026
Visit: Italy, Spain, Portugal, Puerto Rico, USA
Bonus Onboard Credit
Inside
$1,211
Oceanview
$1,470
Balcony
$1,747
Suite
$6,804
From
US$1,211
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 04 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
$16,622
Oceanview
$20,065
Balcony
$28,272
Suite
-
From
US$16,622
Save 427
Per Person
View Trip
23 Day Mediterranean, Canary Islands & Moroccan Grand Adventure with Princess
Cruise
 (1)

23 Days (22 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 13 November 2027
Visit: Italy, Greece, Montenegro, Croatia (+5 more), Spain, Gibraltar, Morocco, Bermuda, USA
Princess Standard
Inside
$2,983
Oceanview
$4,389
Balcony
$4,147
Suite
$5,376
From
US$2,983
Per Person
View Trip
58 Day Old & New World Discovery with Oceania Cruises
Cruise
 (1)

58 Days (57 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Visit: Italy, Croatia, Montenegro, Greece (+14 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
$16,309
Balcony
$24,554
Suite
$32,557
From
US$16,309
Save 16,989
Per Person
View Trip
17 Day Spain & Morocco Transatlantic with Celebrity Cruises
Cruise

17 Days (16 Nights) Rome to Tampa
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 29 October 2027
Visit: Italy, Spain, Gibraltar, Morocco, USA
Exclusive Savings
Inside
$893
Oceanview
$1,019
Balcony
$1,370
Suite
$7,476
From
US$893
Save 516
Per Person
View Trip
17 Day Moroccan Passage with Princess
Cruise
 (1)

17 Days (16 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 17 November 2026
Visit: Italy, Spain, Gibraltar, Morocco, USA
Princess Standard
Inside
$1,169
Oceanview
-
Balcony
$1,719
Suite
$1,879
From
US$1,169
Per Person
View Trip
14 Day Transatlantic Repositioning Cruise From Bologna to Philadelphia with Norwegian Cruise Line
Cruise
 (1)

14 Days (13 Nights) Bologna to Philadelphia
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Pearl
Departure: 01 November 2026
Visit: Italy, Malta, Sardinia, Spain, USA
Inside
$1,169
Oceanview
$1,219
Balcony
$1,839
Suite
$2,250
From
US$1,169
Per Person
View Trip
36 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

36 Days (35 Nights) Rome to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Visit: Italy, France, Spain, Portugal (+7 more), Saint Martin, Bahamas, USA, Colombia, Panama, Costa Rica, Mexico
Bonus Onboard Credit
Exclusive Savings
Inside
$2,646
Oceanview
$3,040
Balcony
$3,717
Suite
-
From
US$2,646
Save 53
Per Person
View Trip
22 Day Atlantic Ocean Isles with Regent Seven Seas
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 November 2026
Visit: Italy, Spain, Gibraltar, Portugal (+6 more), Bermuda, USA, Honduras, Guatemala, Belize, Mexico
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,516
Suite
$14,790
From
US$13,516
Save 21,982
Per Person
View Trip
33 Day Adriatic To Caribbean Isles with Oceania Cruises
Cruise
 (1)

33 Days (32 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Visit: Italy, Croatia, Montenegro, Greece (+6 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$8,235
Oceanview
$9,253
Balcony
$13,473
Suite
$18,177
From
US$8,235
Save 8,563
Per Person
View Trip
32 Day Transatlantic Cruise: Rome To Miami with Azamara Cruises
Cruise
 (8)

32 Days (31 Nights) Rome to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 30 October 2027
Visit: Italy, Monaco, France, Spain (+4 more), Gibraltar, Portugal, Morocco, USA
Azamara Always Included
Exclusive Savings
Inside
$8,349
Oceanview
$9,639
Balcony
$12,627
Suite
$19,213
From
US$8,349
Save 190
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 October 2026
Visit: Italy, Spain, Portugal, Puerto Rico, USA
Bonus Onboard Credit
Inside
$1,109
Oceanview
$1,339
Balcony
$1,568
Suite
-
From
US$1,109
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Rome to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 October 2026
Visit: Italy, Spain, Portugal, Puerto Rico, USA
Bonus Onboard Credit
Inside
$1,214
Oceanview
$1,444
Balcony
$1,704
Suite
-
From
US$1,214
Per Person
View Trip
16 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Rome to Tampa
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Gem
Departure: 01 November 2026
Visit: Italy, France, Spain, Bahamas, USA
Inside
$1,049
Oceanview
$1,159
Balcony
$1,749
Suite
$1,989
From
US$1,049
Per Person
View Trip
15 Day Italy & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 30 October 2026
Visit: Italy, Sardinia, Spain, Portugal, Bermuda, USA
Exclusive Savings
Inside
-
Oceanview
$2,535
Balcony
$2,535
Suite
-
From
US$2,535
Save 1,477
Per Person
View Trip
26 Day MSC Grand Voyages with MSC Cruises
Cruise

26 Days (25 Nights) Amalfi to Miami
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 17 October 2026
Visit: Italy, France, Spain, Gibraltar, Morocco, Portugal, USA
Bonus Onboard Credit
Inside
$1,964
Oceanview
$2,330
Balcony
$2,627
Suite
$6,816
From
US$1,964
Per Person
View Trip
15 Day Italy & Portugal Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 29 October 2027
Visit: Italy, Sardinia, Gibraltar, Portugal, Bermuda, USA
Exclusive Savings
Inside
$1,646
Oceanview
$1,884
Balcony
$2,125
Suite
$6,270
From
US$1,646
Save 969
Per Person
View Trip
Results: 1-30 of 34

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