Cruises from Italy to USA

Are you looking for a cruise from Italy to USA? October is the most popular month to cruise between Italy and USA and there are 34 departures available from twelve of the world's leading cruise lines.
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14 Days
57 Days
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$1,300pp
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33 Cruises (34 Cruise Departures)
19 Day Moroccan Passage with Princess
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Cruise
 (2)

19 Days (18 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Departure: 04 December 2024
Countries Visited: Italy, Sardinia, Spain, Morocco (+3 more), Portugal, Cape Verde, USA
Exclusive Deal
INSIDE
$1,620
OCEANVIEW
$1,660
BALCONY
$1,967
SUITE
$2,511
From 1,620
39 Day Mediterranean Grand Adventure with Princess
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Cruise
 (2)

39 Days (38 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Departure: 14 November 2024
Countries Visited: Italy, Greece, Turkey, Cyprus (+6 more), Sardinia, Spain, Morocco, Portugal, Cape Verde, USA
Exclusive Deal
INSIDE
$5,118
OCEANVIEW
$5,432
BALCONY
$6,316
SUITE
$7,870
From 5,118
34 Day Mediterranean, Iceland & British Isles Grand Adventure with Princess
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Cruise
 (3)

34 Days (33 Nights) Rome to Boston
Cruise Line: Princess
Departure: 30 June 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+7 more), Spain, Gibraltar, England, Scotland, Iceland, Canada, USA
Exclusive Deal
INSIDE
$9,847
OCEANVIEW
-
BALCONY
$11,619
SUITE
$14,420
From 9,847
15 Day Passage To America with Holland America
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Cruise
 (2)

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Holland America
Departure: 16 November 2024
Countries Visited: Italy, Spain, Portugal, USA
Have It All Offer
INSIDE
$2,343
OCEANVIEW
$2,462
BALCONY
$2,828
SUITE
$4,046
From 2,343
17 Day Moroccan Passage with Princess
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Cruise
 (1)

17 Days (16 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Departure: 17 November 2026
Countries Visited: Italy, Spain, Gibraltar, Morocco (+1 more), USA
Exclusive Deal
INSIDE
$1,608
OCEANVIEW
$2,370
BALCONY
$2,063
SUITE
$3,063
From 1,608
27 Day Mediterranean Grand Adventure with Princess
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Cruise
 (1)

27 Days (26 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Sun Princess
Departure: 21 October 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+3 more), Spain, Gibraltar, USA
Exclusive Deal
INSIDE
$5,267
OCEANVIEW
$6,510
BALCONY
$7,758
SUITE
$9,629
From 5,267
15 Day Cultural Crossing With Andalusia And Azores with Holland America
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Cruise
 (2)

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Holland America
Departure: 15 November 2025
Countries Visited: Italy, Spain, Gibraltar, Portugal (+1 more), USA
Have It All Offer
INSIDE
$2,927
OCEANVIEW
$3,224
BALCONY
$3,570
SUITE
$5,204
From 2,927
16 Day Transatlantic Crossing And Mediterranean Highlights with Cunard
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Cruise
 (3)

16 Days (15 Nights) Rome to New York
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 20 April 2025
Countries Visited: Italy, Sardinia, Spain, England (+2 more), France, USA
Exclusive Deal
INSIDE
$4,048
OCEANVIEW
-
BALCONY
-
SUITE
$10,349
From 4,048
22 Day World Cruise Segment - Western Mediterranean Transatlantic with Princess
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Cruise
 (2)

22 Days (21 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Departure: 11 April 2025
Countries Visited: Italy, Corsica, France, Spain (+2 more), Morocco, USA
Exclusive Deal
INSIDE
$4,002
OCEANVIEW
$4,249
BALCONY
$4,535
SUITE
-
From 4,002
24 Day Mediterranean, Aegean & Moroccan Passage with Princess
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Cruise
 (1)

24 Days (23 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Departure: 10 November 2026
Countries Visited: Italy, Greece, Turkey, Spain (+3 more), Gibraltar, Morocco, USA
Exclusive Deal
INSIDE
$3,199
OCEANVIEW
$5,090
BALCONY
$4,555
SUITE
$6,238
From 3,199
14 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
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Cruise
 (1)

14 Days (13 Nights) Rome to Orlando
Departure: 17 October 2024
Countries Visited: Italy, France, Spain, Portugal (+1 more), USA
Free At Sea Offer
INSIDE
$1,537
OCEANVIEW
-
BALCONY
$1,996
SUITE
$2,378
From 1,537
22 Day Atlantic Crossing & Mediterranean with Viking Cruises
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Cruise
 (5)

22 Days (21 Nights) Rome to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Sky
Departures: Nov 2024 to Nov 2025
Countries Visited: Italy, Monaco, France, Spain (+3 more), Portugal, Sint Maarten, USA
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$10,192
SUITE
$16,330
Save 1,932
From 10,192
17 Day Moroccan Passage with Princess
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Cruise

17 Days (16 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Departure: 10 November 2024
Countries Visited: Italy, Spain, Morocco, Portugal (+1 more), USA
Exclusive Deal
INSIDE
$1,322
OCEANVIEW
$1,374
BALCONY
$2,689
SUITE
$8,473
From 1,322
17 Day From Rome to Miami with Virgin Voyages
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Cruise

17 Days (16 Nights) Rome to Miami
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 28 November 2024
Countries Visited: Italy, Spain, Portugal, USA
INSIDE
$2,549
OCEANVIEW
$2,791
BALCONY
$2,791
SUITE
$10,829
From 2,549
22 Day Mediterranean with MSC Cruises
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Cruise

22 Days (21 Nights) Livorno to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 26 October 2025
Countries Visited: Italy, France, Spain, Morocco (+5 more), Barbados, Grenada, Sint Maarten, Puerto Rico, USA
Early Booking Offer
INSIDE
$3,100
OCEANVIEW
$3,527
BALCONY
$4,099
SUITE
$6,204
From 3,100
21 Day Transatlantic with MSC Cruises
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Cruise

21 Days (20 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 17 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Early Booking Offer
INSIDE
$2,646
OCEANVIEW
$3,072
BALCONY
$3,460
SUITE
$5,856
From 2,646
23 Day MSC Grand Voyages with MSC Cruises
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Cruise

23 Days (22 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 18 October 2025
Countries Visited: Italy, France, Spain, Portugal (+5 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA, Bahamas
Early Booking Offer
INSIDE
$2,963
OCEANVIEW
$3,390
BALCONY
$3,778
SUITE
$10,642
From 2,963
57 Day Antiquity To America with Oceania Cruises
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Cruise

57 Days (56 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Departure: 04 October 2025
Countries Visited: Italy, Sicily, Malta, Greece (+12 more), Turkey, Cyprus, Croatia, Montenegro, Tunisia, Spain, Morocco, Portugal, Barbados, Antigua and Barbuda, Puerto Rico, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$32,451
SUITE
$45,546
Save 2,799
From 32,451
14 Day Italy & Bermuda Transatlantic with Celebrity Cruises
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Cruise

14 Days (13 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Departure: 31 October 2025
Countries Visited: Italy, Sardinia, Gibraltar, Bermuda (+1 more), USA
Exclusive Deal
INSIDE
$1,831
OCEANVIEW
$2,019
BALCONY
$2,168
SUITE
$9,589
Save 3,294
From 1,831
28 Day Atlantic Sands & Sunsets with Oceania Cruises
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Cruise

28 Days (27 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Departure: 20 November 2024
Countries Visited: Italy, Spain, Antigua and Barbuda, Puerto Rico (+8 more), USA, Mexico, Guatemala, Belize, Honduras, Cayman Islands, Jamaica, Bahamas
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,089
SUITE
$16,871
Save 2,281
From 12,089
17 Day Spain & Bermuda Transatlantic with Celebrity Cruises
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Cruise

17 Days (16 Nights) Rome to Tampa
Cruise Line: Celebrity Cruises
Departure: 31 October 2025
Countries Visited: Italy, Spain, Portugal, Bermuda (+2 more), Bahamas, USA
Exclusive Deal
INSIDE
$1,762
OCEANVIEW
$1,790
BALCONY
$2,772
SUITE
-
Save 3,481
From 1,762
20 Day MSC Grand Voyages with MSC Cruises
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Cruise

20 Days (19 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 18 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Early Booking Offer
INSIDE
$2,540
OCEANVIEW
$2,938
BALCONY
$3,248
SUITE
$5,130
From 2,540
22 Day MSC Grand Voyages with MSC Cruises
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Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 27 October 2024
Countries Visited: Italy, Sicily, Spain, Barbados (+3 more), Grenada, Puerto Rico, USA
Save And Sail Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$7,649
From 7,649
22 Day Transatlantic with MSC Cruises
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Cruise

22 Days (21 Nights) Naples to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 16 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Early Booking Offer
INSIDE
$2,809
OCEANVIEW
$3,333
BALCONY
$3,857
SUITE
$6,156
From 2,809
26 Day Rome to Fort Lauderdale with Silversea
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Cruise

26 Days (25 Nights) Rome to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Ray
Departure: 07 November 2025
Countries Visited: Italy, France, Spain, Portugal (+2 more), Bermuda, USA
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$20,097
From 20,097
16 Day New World Horizons with Oceania Cruises
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Cruise

16 Days (15 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Departure: 20 November 2024
Countries Visited: Italy, Spain, Antigua and Barbuda, Puerto Rico (+1 more), USA
Exclusive DealSingles Special Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$6,902
SUITE
$9,443
Save 2,168
From 6,902
23 Day MSC Grand Voyages with MSC Cruises
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Cruise

23 Days (22 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 26 October 2024
Countries Visited: Italy, Sicily, Spain, Barbados (+3 more), Grenada, Puerto Rico, USA
Save And Sail Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$3,506
SUITE
$5,495
From 3,506
17 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
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Cruise

17 Days (16 Nights) Rome to New York
Departure: 07 November 2024
Countries Visited: Italy, France, Spain, Portugal (+1 more), USA
Free At Sea Offer
INSIDE
$2,772
OCEANVIEW
$2,894
BALCONY
$3,306
SUITE
$3,842
From 2,772
15 Day Spanish Transatlantic Cruise with Royal Caribbean
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Cruise

15 Days (14 Nights) Rome to New York
Cruise Line: Royal Caribbean
Departure: 03 November 2024
Countries Visited: Italy, Spain, Portugal, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$4,000
SUITE
-
Save 2,709
From 4,000
31 Day A Journey Of Sun And Sea with Regent Seven Seas
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Cruise

31 Days (30 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Departure: 25 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+7 more), Corsica, Monaco, Spain, Portugal, Bermuda, Bahamas, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$31,214
SUITE
$33,570
Save 12,736
From 31,214
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