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Cruises from Italy to USA

Are you looking for a cruise from Italy to USA? October is the most popular month to cruise between Italy and USA and there are 40 departures available from twelve of the world's leading cruise lines.
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40 Cruises (40 Cruise Departures)
27 Day Mediterranean Grand Adventure with Princess
Cruise
 (3)

27 Days (26 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Sun Princess
Departure: 21 October 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+3 more), Spain, Gibraltar, USA
Exclusive DealBonus Instant Savings
INSIDE
$3,001
OCEANVIEW
$3,601
BALCONY
$4,081
SUITE
$5,081
From (per person) 3,001
View Trip
22 Day Transatlantic with MSC Cruises
Cruise

22 Days (21 Nights) Naples to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 16 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Grand Voyages Sale
INSIDE
$1,331
OCEANVIEW
$1,621
BALCONY
$1,981
SUITE
-
From (per person) 1,331
View Trip
17 Day Moroccan Passage with Princess
Cruise
 (1)

17 Days (16 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 17 November 2026
Countries Visited: Italy, Spain, Gibraltar, Morocco (+1 more), USA
Exclusive DealBonus Instant Savings
INSIDE
$989
OCEANVIEW
-
BALCONY
$1,483
SUITE
$2,019
From (per person) 989
View Trip
15 Day Splendid Atlantic Sojourn with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to New York
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 18 May 2027
Countries Visited: Italy, Spain, Morocco, Bermuda (+1 more), USA
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$9,099
SUITE
$9,999
Save (per person) 15,699
From (per person) 9,099
View Trip
22 Day Atlantic Ocean Isles with Regent Seven Seas
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 November 2026
Countries Visited: Italy, Spain, Gibraltar, Portugal (+5 more), Bermuda, USA, Honduras, Belize, Mexico
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$11,499
SUITE
$12,499
Save (per person) 19,499
From (per person) 11,499
View Trip
16 Day Canary Islands & Moroccan Passage with Princess
Cruise
 (1)

16 Days (15 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 20 November 2027
Countries Visited: Italy, Spain, Gibraltar, Morocco (+1 more), USA
Bonus Instant Savings
INSIDE
$1,480
OCEANVIEW
$2,479
BALCONY
$2,309
SUITE
$2,980
From (per person) 1,480
View Trip
17 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

17 Days (16 Nights) Rome to Tampa
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 31 October 2025
Countries Visited: Italy, Spain, Portugal, Bermuda (+2 more), Bahamas, USA
Bonus Onboard Credit
INSIDE
$1,076
OCEANVIEW
-
BALCONY
$2,006
SUITE
$22,253
Save (per person) 491
From (per person) 1,076
View Trip
24 Day Mediterranean, Aegean & Moroccan Passage with Princess
Cruise
 (1)

24 Days (23 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 10 November 2026
Countries Visited: Italy, Greece, Turkey, Spain (+3 more), Gibraltar, Morocco, USA
Exclusive DealBonus Instant Savings
INSIDE
$2,265
OCEANVIEW
$3,565
BALCONY
$3,362
SUITE
$4,045
From (per person) 2,265
View Trip
26 Day Allura Autumn Crossing with Oceania Cruises
Cruise

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 07 November 2026
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Spain, Morocco, Puerto Rico, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,099
SUITE
$12,999
Save (per person) 8,099
From (per person) 8,099
View Trip
22 Day Atlantic Crossing & Mediterranean with Viking Cruises
Cruise
 (5)

22 Days (21 Nights) Rome to Fort Lauderdale
Operated By: Viking Cruises
Ship: Viking Sky
Departure: 28 November 2025
Countries Visited: Italy, Monaco, France, Spain (+3 more), Portugal, Sint Maarten, USA
Viking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$6,348
SUITE
$9,498
Save (per person) 950
From (per person) 6,348
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 18 October 2025
Countries Visited: Italy, France, Spain, Portugal (+5 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA, Bahamas
Grand Voyages Sale
INSIDE
$1,579
OCEANVIEW
$1,939
BALCONY
$2,069
SUITE
-
From (per person) 1,579
View Trip
22 Day Mediterranean with MSC Cruises
Cruise

22 Days (21 Nights) Livorno to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 26 October 2025
Countries Visited: Italy, France, Spain, Morocco (+5 more), Barbados, Grenada, Sint Maarten, Puerto Rico, USA
Grand Voyages Sale
INSIDE
-
OCEANVIEW
$1,301
BALCONY
$1,711
SUITE
$3,321
From (per person) 1,301
View Trip
14 Day Italy & Bermuda Transatlantic with Celebrity Cruises
Cruise

14 Days (13 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 31 October 2025
Countries Visited: Italy, Sardinia, Gibraltar, Bermuda (+1 more), USA
Bonus Onboard Credit
INSIDE
-
OCEANVIEW
-
BALCONY
$2,680
SUITE
-
Save (per person) 1,546
From (per person) 2,680
View Trip
33 Day Adriatic To Caribbean Isles with Oceania Cruises
Cruise

33 Days (32 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+6 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA
Exclusive Deal
INSIDE
$8,199
OCEANVIEW
$9,199
BALCONY
$12,899
SUITE
$17,499
Save (per person) 8,199
From (per person) 8,199
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 26 October 2026
Countries Visited: Italy, Spain, Portugal, Puerto Rico (+1 more), USA
Escape To Sea
INSIDE
$1,278
OCEANVIEW
$1,488
BALCONY
$1,768
SUITE
$6,188
From (per person) 1,278
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 November 2025
Countries Visited: Italy, France, Spain, Puerto Rico (+2 more), Virgin Islands, USA
Grand Voyages Sale
INSIDE
$850
OCEANVIEW
$1,040
BALCONY
$1,240
SUITE
$3,430
From (per person) 850
View Trip
15 Day Italy & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 30 October 2026
Countries Visited: Italy, Sardinia, Spain, Portugal (+2 more), Bermuda, USA
Bonus Onboard Credit
INSIDE
$1,519
OCEANVIEW
$1,705
BALCONY
$2,680
SUITE
$13,474
Save (per person) 803
From (per person) 1,519
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Rome to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 October 2026
Countries Visited: Italy, Spain, Portugal, Puerto Rico (+1 more), USA
Escape To Sea
INSIDE
$1,215
OCEANVIEW
$1,485
BALCONY
$1,655
SUITE
$5,855
From (per person) 1,215
View Trip
15 Day New World Passage with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 November 2026
Countries Visited: Italy, Spain, Gibraltar, Portugal (+2 more), Bermuda, USA
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$7,099
SUITE
$8,199
Save (per person) 13,699
From (per person) 7,099
View Trip
15 Day Cultural Crossing With Andalusia And Azores with Holland America
Cruise
 (2)

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Statendam
Departure: 15 November 2025
Countries Visited: Italy, Spain, Gibraltar, Portugal (+1 more), USA
Exclusive Deal
INSIDE
$884
OCEANVIEW
$1,134
BALCONY
$1,444
SUITE
$2,344
From (per person) 884
View Trip
23 Day Mediterranean, Canary Islands & Moroccan Grand Adventure with Princess
Cruise
 (1)

23 Days (22 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 13 November 2027
Countries Visited: Italy, Greece, Montenegro, Croatia (+4 more), Spain, Gibraltar, Morocco, USA
Bonus Instant Savings
INSIDE
$2,600
OCEANVIEW
$4,049
BALCONY
$3,799
SUITE
$5,000
From (per person) 2,600
View Trip
23 Day Mediterranean with MSC Cruises
Cruise

23 Days (22 Nights) Naples to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 25 October 2025
Countries Visited: Italy, France, Spain, Morocco (+5 more), Barbados, Grenada, Sint Maarten, Puerto Rico, USA
Grand Voyages Sale
INSIDE
$1,211
OCEANVIEW
$1,501
BALCONY
$2,011
SUITE
$4,021
From (per person) 1,211
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 07 April 2026
Countries Visited: Italy, France, Spain, Portugal (+3 more), Saint Martin, Bahamas, USA
Grand Voyages Sale
INSIDE
$740
OCEANVIEW
$930
BALCONY
$1,220
SUITE
$3,620
From (per person) 740
View Trip
26 Day Europe To The Caribbean with Oceania Cruises
Cruise

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 November 2026
Countries Visited: Italy, Sicily, Malta, Tunisia (+6 more), Sardinia, Spain, Portugal, Puerto Rico, Bahamas, USA
Exclusive Deal
INSIDE
$6,599
OCEANVIEW
$8,099
BALCONY
$9,399
SUITE
$12,699
Save (per person) 6,599
From (per person) 6,599
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise

20 Days (19 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 18 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Grand Voyages Sale
INSIDE
$1,239
OCEANVIEW
$1,419
BALCONY
$1,669
SUITE
$3,249
From (per person) 1,239
View Trip
58 Day Old & New World Discovery with Oceania Cruises
Cruise

58 Days (57 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+14 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin
Exclusive Deal
INSIDE
$14,799
OCEANVIEW
$16,299
BALCONY
$22,999
SUITE
$31,899
Save (per person) 14,799
From (per person) 14,799
View Trip
22 Day Jewels Of Andalusia & Atlantic Crossing with Seabourn
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 01 November 2026
Countries Visited: Italy, Corsica, Sardinia, Spain (+2 more), Portugal, USA
A Sail To Remember
INSIDE
-
OCEANVIEW
$8,754
BALCONY
$10,964
SUITE
$18,784
From (per person) 8,754
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Genoa to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 November 2025
Countries Visited: Italy, France, Spain, Puerto Rico (+2 more), Virgin Islands, USA
Grand Voyages Sale
INSIDE
$749
OCEANVIEW
$939
BALCONY
$1,149
SUITE
$2,879
From (per person) 749
View Trip
14 Day Transatlantic Repositioning Cruise From Bologna to Philadelphia with Norwegian Cruise Line
Cruise

14 Days (13 Nights) Bologna to Philadelphia
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Pearl
Departure: 01 November 2026
Countries Visited: Italy, Malta, Sardinia, Spain (+1 more), USA
INSIDE
$1,139
OCEANVIEW
$1,289
BALCONY
$2,189
SUITE
$2,339
From (per person) 1,139
View Trip
57 Day Antiquity To America with Oceania Cruises
Cruise

57 Days (56 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 04 October 2025
Countries Visited: Italy, Sicily, Malta, Greece (+12 more), Turkey, Cyprus, Croatia, Montenegro, Tunisia, Spain, Morocco, Portugal, Barbados, Antigua and Barbuda, Puerto Rico, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$21,499
SUITE
-
Save (per person) 21,499
From (per person) 21,499
View Trip
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