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Cruises from Italy to USA

Are you looking for a cruise from Italy to USA? November is the most popular month to cruise between Italy and USA and there are 33 departures available from nine of the world's leading cruise lines.
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32 Cruises (33 Departures)
32 Cruises (33 Departures)
Departures
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Duration
14 Days
46 Days
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Price
$600pp
$40,398pp
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37 Day Mediterranean, Aegean & Moroccan Grand Adventure with Princess
Cruise
 (2)

37 Days (36 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 28 October 2028
Visits: Italy, Croatia, Montenegro, Greece +7 more, Turkey, Sicily, Spain, Gibraltar, Morocco, Bermuda, USA
Inside
$5,101
Oceanview
-
Balcony
$6,482
Suite
$8,011
From (Per Person)
US$5,101
Per Person
View Trip
26 Day Europe To The Caribbean with Oceania Cruises
Cruise
 (3)

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania
Ship: Oceania Marina
Departure: 15 November 2026
Visits: Italy, Sicily, Malta, Tunisia +6 more, Sardinia, Spain, Portugal, Puerto Rico, Dominican Republic, USA
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,849
Suite
$19,949
From (Per Person)
US$9,849
Save 9,849
Per Person
View Trip
36 Day World Cruise Liner - Mediterranean & Panama Canal with Princess
Cruise
 (4)

36 Days (35 Nights) Rome to Los Angeles
Cruise Line: Princess
Ship: Coral Princess
Departure: 08 April 2028
Visits: Italy, Corsica, France, Spain +7 more, Morocco, Portugal, USA, Colombia, Panama, El Salvador, Mexico
Inside
$5,760
Oceanview
$6,118
Balcony
$7,119
Suite
$12,260
From (Per Person)
US$5,760
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 October 2026
Visits: Italy, Spain, Portugal, Puerto Rico, USA
Inside
$620
Oceanview
$830
Balcony
$1,060
Suite
-
From (Per Person)
US$620
Per Person
View Trip
21 Day Transatlantic Combination Cruise: Rome To Miami with Azamara Cruises
Cruise
 (8)

21 Days (20 Nights) Rome to Miami
Cruise Line: Azamara
Ship: Azamara Onward
Departure: 02 December 2027
Visits: Italy, Sicily, Tunisia, Algeria +4 more, Spain, Morocco, Virgin Islands, USA
Azamara Always Included
Inside
$3,669
Oceanview
$4,289
Balcony
$6,149
Suite
$9,339
From (Per Person)
US$3,669
Per Person
View Trip
24 Day Mediterranean, Aegean & Moroccan Passage with Princess
Cruise
 (2)

24 Days (23 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 10 November 2026
Visits: Italy, Greece, Turkey, Spain, Gibraltar, Morocco, USA
Inside
-
Oceanview
$3,569
Balcony
$3,007
Suite
-
From (Per Person)
US$3,007
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

19 Days (18 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 26 October 2026
Visits: Italy, Spain, Portugal, Puerto Rico, USA
Inside
-
Oceanview
$987
Balcony
$1,167
Suite
$7,057
From (Per Person)
US$987
Per Person
View Trip
22 Day Jewels Of Andalusia & Atlantic Crossing with Seabourn
Cruise
 (1)

22 Days (21 Nights) Rome to Miami
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 01 November 2026
Visits: Italy, Corsica, Sardinia, Spain, Portugal, USA
Bonus Onboard Credit
Oceanview
-
Balcony
$14,398
Suite
$24,198
From (Per Person)
US$14,398
Per Person
View Trip
14 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise
 (1)

14 Days (13 Nights) Bologna to Philadelphia
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Pearl
Departure: 01 November 2026
Visits: Italy, Malta, Spain, USA
Inside
$939
Oceanview
$1,039
Balcony
$1,169
Suite
$1,339
From (Per Person)
US$939
Per Person
View Trip
15 Day Italy & Portugal Transatlantic with Celebrity Cruises
Cruise
 (1)

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 29 October 2027
Visits: Italy, Sardinia, Gibraltar, Portugal, Bermuda, USA
Exclusive Savings
Inside
$1,367
Oceanview
$1,572
Balcony
$1,972
Suite
$9,680
From (Per Person)
US$1,623
Save 586
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Rome to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 October 2026
Visits: Italy, Spain, Portugal, Puerto Rico, USA
Inside
$834
Oceanview
$944
Balcony
$1,164
Suite
$6,854
From (Per Person)
US$834
Per Person
View Trip
15 Day Italy & Bermuda Transatlantic with Celebrity Cruises
Cruise
 (1)

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 30 October 2026
Visits: Italy, Sardinia, Spain, Portugal, Bermuda, USA
Exclusive Savings
Inside
$1,415
Oceanview
$2,030
Balcony
$2,510
Suite
-
From (Per Person)
US$1,672
Save 588
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

20 Days (19 Nights) Genoa to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 26 October 2026
Visits: Italy, Spain, Portugal, Puerto Rico, USA
Inside
-
Oceanview
$1,459
Balcony
-
Suite
-
From (Per Person)
US$1,459
Per Person
View Trip
24 Day Old & New Worlds with Oceania Cruises
Cruise
 (3)

24 Days (23 Nights) Rome to Miami
Cruise Line: Oceania
Ship: Oceania Marina
Departure: 27 November 2027
Visits: Italy, Corsica, France, Spain, Gibraltar, Portugal, USA
Your World Inclusions
Exclusive Savings
Inside
$5,449
Oceanview
-
Balcony
$8,099
Suite
$11,549
From (Per Person)
US$5,449
Save 5,449
Per Person
View Trip
16 Day Canary Islands & Moroccan Passage with Princess
Cruise
 (2)

16 Days (15 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departures: Nov 2027 to Nov 2028
Visits: Italy, Spain, Gibraltar, Morocco, Bermuda, USA
Inside
$1,429
Oceanview
$2,129
Balcony
$1,924
Suite
$2,779
From (Per Person)
US$1,429
Per Person
View Trip
17 Day Moroccan Passage with Princess
Cruise
 (2)

17 Days (16 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 17 November 2026
Visits: Italy, Spain, Gibraltar, Morocco, USA
Inside
-
Oceanview
-
Balcony
$1,913
Suite
-
From (Per Person)
US$1,913
Per Person
View Trip
23 Day Mediterranean, Canary Islands & Moroccan Grand Adventure with Princess
Cruise
 (2)

23 Days (22 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 13 November 2027
Visits: Italy, Greece, Montenegro, Croatia +5 more, Spain, Gibraltar, Morocco, Bermuda, USA
Inside
$2,928
Oceanview
-
Balcony
$3,801
Suite
-
From (Per Person)
US$2,928
Per Person
View Trip
44 Day Land Of Love To Lady Liberty with Oceania Cruises
Cruise
 (1)

44 Days (43 Nights) Venice to New York
Cruise Line: Oceania
Ship: Oceania Sirena
Departure: 07 August 2027
Visits: Italy, Croatia, Montenegro, Greece +13 more, Sicily, France, Spain, Morocco, Gibraltar, Portugal, Guernsey, England, Ireland, Northern Ireland, Iceland, Canada, USA
Your World Inclusions
Exclusive Savings
Inside
$12,499
Oceanview
$13,099
Balcony
$19,199
Suite
$26,599
From (Per Person)
US$12,499
Save 12,499
Per Person
View Trip
15 Day Splendid Atlantic Sojourn with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to New York
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 18 May 2027
Visits: Italy, Spain, Morocco, Canada, USA
Exclusive Savings
Balcony
$11,220
Suite
$11,700
From (Per Person)
US$11,220
Save 15,178
Per Person
View Trip
29 Day Iberian & Tropical Discovery with Oceania Cruises
Cruise

29 Days (28 Nights) Rome to Miami
Cruise Line: Oceania
Ship: Oceania Sonata
Departure: 19 October 2028
Visits: Italy, Sicily, Malta, Tunisia +5 more, Sardinia, Spain, Portugal, Puerto Rico, USA
Your World Inclusions
Exclusive Savings
Balcony
$11,699
Suite
$16,099
From (Per Person)
US$11,699
Save 11,699
Per Person
View Trip
24 Day Romance, Rivieras & Reggae with Oceania Cruises
Cruise

24 Days (23 Nights) Rome to Miami
Cruise Line: Oceania
Ship: Oceania Sonata
Departure: 09 November 2027
Visits: Italy, Sardinia, Corsica, France +4 more, Spain, Portugal, Bermuda, USA
Your World Inclusions
Exclusive Savings
Balcony
$9,749
Suite
$14,749
From (Per Person)
US$9,749
Save 9,749
Per Person
View Trip
17 Day Spain & Morocco Transatlantic with Celebrity Cruises
Cruise

17 Days (16 Nights) Rome to Tampa
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 29 October 2027
Visits: Italy, Spain, Gibraltar, Morocco, USA
Exclusive Savings
Inside
$1,606
Oceanview
$1,664
Balcony
$3,933
Suite
-
From (Per Person)
US$1,909
Save 681
Per Person
View Trip
15 Day Spain & Portugal Transatlantic with Royal Caribbean
Cruise

15 Days (14 Nights) Rome to New York
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 31 October 2027
Visits: Italy, Spain, Portugal, USA
Exclusive Savings
Inside
$1,075
Oceanview
$1,345
Balcony
$1,635
Suite
$4,575
From (Per Person)
US$1,075
Save 372
Per Person
View Trip
33 Day Something Old, Something New with Oceania Cruises
Cruise

33 Days (32 Nights) Trieste to Miami
Cruise Line: Oceania
Ship: Oceania Sonata
Departure: 31 October 2027
Visits: Italy, Croatia, Montenegro, Albania +8 more, Sicily, Sardinia, Corsica, France, Spain, Portugal, Bermuda, USA
Your World Inclusions
Exclusive Savings
Balcony
$14,099
Suite
$21,499
From (Per Person)
US$14,099
Save 14,099
Per Person
View Trip
15 Day New World Passage with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 November 2026
Visits: Italy, Spain, Gibraltar, Portugal, Bermuda, USA
Exclusive Savings
Balcony
$12,499
Suite
$13,249
From (Per Person)
US$12,499
Save 12,499
Per Person
View Trip
46 Day Grand Latin & Iberian Quest with Oceania Cruises
Cruise

46 Days (45 Nights) Rome to Los Angeles
Cruise Line: Oceania
Ship: Oceania Sonata
Departure: 19 October 2028
Visits: Italy, Sicily, Malta, Tunisia +12 more, Sardinia, Spain, Portugal, Puerto Rico, USA, Cayman Islands, Colombia, Panama, Costa Rica, Nicaragua, Guatemala, Mexico
Your World Inclusions
Exclusive Savings
Balcony
$20,199
Suite
$27,999
From (Per Person)
US$20,199
Save 20,199
Per Person
View Trip
21 Day Sailing Toward History with Regent Seven Seas
Cruise

21 Days (20 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 13 November 2028
Visits: Italy, Spain, Portugal, Puerto Rico, USA
Exclusive Savings
Balcony
$18,499
Suite
$20,099
From (Per Person)
US$18,499
Save 18,499
Per Person
View Trip
26 Day MSC Grand Voyages with MSC Cruises
Cruise

26 Days (25 Nights) Amalfi to Miami
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 17 October 2026
Visits: Italy, France, Spain, Gibraltar, Morocco, Portugal, USA
Inside
-
Oceanview
-
Balcony
$2,764
Suite
-
From (Per Person)
US$2,764
Per Person
View Trip
16 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Rome to Tampa
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Gem
Departure: 01 November 2026
Visits: Italy, France, Spain, Bahamas, USA
Inside
$1,059
Oceanview
$1,159
Balcony
$1,349
Suite
$1,439
From (Per Person)
US$1,059
Per Person
View Trip
25 Day Msc Grand Voyages with MSC Cruises
Cruise

25 Days (24 Nights) Florence to Miami
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 18 October 2026
Visits: Italy, France, Spain, Gibraltar, Morocco, Portugal, USA
Inside
-
Oceanview
-
Balcony
$2,309
Suite
-
From (Per Person)
US$2,309
Per Person
View Trip
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