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Cruises from Italy to USA

Are you looking for a cruise from Italy to USA? October and November are the most popular months to cruise between Italy and USA and there are 34 departures available from nine of the world's leading cruise lines.
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58 Days
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33 Cruises (34 Cruise Departures)
37 Day Mediterranean, Aegean & Moroccan Grand Adventure with Princess
Cruise
 (2)

37 Days (36 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 28 October 2028
Visit: Italy, Croatia, Montenegro, Greece (+7 more), Turkey, Sicily, Spain, Gibraltar, Morocco, Bermuda, USA
Princess Standard
Exclusive Savings
Inside
$5,840
Oceanview
-
Balcony
$7,042
Suite
$9,032
From
A$5,840
Per Person
View Trip
14 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise
 (1)

14 Days (13 Nights) Bologna to Philadelphia
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Pearl
Departure: 01 November 2026
Visit: Italy, Malta, Spain, USA
Just Cruise Fare
Exclusive Savings
Inside
$2,044
Oceanview
$2,118
Balcony
$2,312
Suite
$2,818
From
A$2,044
Per Person
View Trip
33 Day Adriatic To Caribbean Isles with Oceania Cruises
Cruise
 (1)

33 Days (32 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Visit: Italy, Croatia, Montenegro, Greece (+6 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$14,750
Balcony
$20,134
Suite
$44,073
From
A$14,750
Save 2,320
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

20 Days (19 Nights) Genoa to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 26 October 2026
Visit: Italy, Spain, Portugal, Puerto Rico, USA
Exclusive Savings
Inside
$2,139
Oceanview
$2,733
Balcony
$3,138
Suite
-
From
A$2,139
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Rome to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 October 2026
Visit: Italy, Spain, Portugal, Puerto Rico, USA
Exclusive Savings
Inside
$1,647
Oceanview
$2,013
Balcony
$2,340
Suite
-
From
A$1,647
Per Person
View Trip
44 Day Land Of Love To Lady Liberty with Oceania Cruises
Cruise
 (1)

44 Days (43 Nights) Venice to New York
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 07 August 2027
Visit: Italy, Croatia, Montenegro, Greece (+13 more), Sicily, France, Spain, Morocco, Gibraltar, Portugal, Guernsey, England, Ireland, Northern Ireland, Iceland, Canada, USA
Your World Inclusions
Exclusive Savings
Inside
$17,443
Oceanview
$18,268
Balcony
$26,697
Suite
$36,911
From
A$17,443
Save 2,347
Per Person
View Trip
21 Day Transatlantic Combination Cruise: Rome To Miami with Azamara Cruises
Cruise
 (8)

21 Days (20 Nights) Rome to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 02 December 2027
Visit: Italy, Sicily, Tunisia, Algeria (+4 more), Spain, Morocco, Virgin Islands, USA
Azamara Always Included
Exclusive Savings
Inside
$5,440
Oceanview
$5,891
Balcony
$8,429
Suite
$12,780
From
A$5,440
Per Person
View Trip
23 Day Mediterranean, Canary Islands & Moroccan Grand Adventure with Princess
Cruise
 (2)

23 Days (22 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 13 November 2027
Visit: Italy, Greece, Montenegro, Croatia (+5 more), Spain, Gibraltar, Morocco, Bermuda, USA
Princess Standard
Exclusive Savings
Inside
$4,068
Oceanview
-
Balcony
$5,444
Suite
$6,939
From
A$4,068
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

19 Days (18 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 26 October 2026
Visit: Italy, Spain, Portugal, Puerto Rico, USA
Exclusive Savings
Inside
$1,715
Oceanview
$2,051
Balcony
$2,299
Suite
$5,239
From
A$1,715
Per Person
View Trip
24 Day Old & New Worlds with Oceania Cruises
Cruise
 (3)

24 Days (23 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 27 November 2027
Visit: Italy, Corsica, France, Spain, Gibraltar, Portugal, USA
Your World Inclusions
Exclusive Savings
Inside
$7,679
Oceanview
$9,503
Balcony
$11,200
Suite
$15,749
From
A$7,679
Save 2,151
Per Person
View Trip
16 Day Canary Islands & Moroccan Passage with Princess
Cruise
 (2)

16 Days (15 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departures: Nov 2027 to Nov 2028
Visit: Italy, Spain, Gibraltar, Morocco, Bermuda, USA
Princess Standard
Exclusive Savings
Inside
$1,724
Oceanview
$2,807
Balcony
$2,673
Suite
$3,189
From
A$1,724
Per Person
View Trip
26 Day Europe To The Caribbean with Oceania Cruises
Cruise
 (3)

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 November 2026
Visit: Italy, Sicily, Malta, Tunisia (+6 more), Sardinia, Spain, Portugal, Puerto Rico, Dominican Republic, USA
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,668
Suite
$18,547
From
A$13,668
Save 2,332
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 October 2026
Visit: Italy, Spain, Portugal, Puerto Rico, USA
Exclusive Savings
Inside
$1,539
Oceanview
$1,896
Balcony
$2,203
Suite
-
From
A$1,539
Per Person
View Trip
58 Day Old & New World Discovery with Oceania Cruises
Cruise
 (1)

58 Days (57 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Visit: Italy, Croatia, Montenegro, Greece (+14 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$26,310
Balcony
$36,311
Suite
$81,707
From
A$26,310
Save 2,570
Per Person
View Trip
22 Day Jewels Of Andalusia & Atlantic Crossing with Seabourn
Cruise
 (1)

22 Days (21 Nights) Rome to Miami
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 01 November 2026
Visit: Italy, Corsica, Sardinia, Spain, Portugal, USA
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$31,432
From
A$31,432
Save 612
Per Person
View Trip
17 Day Moroccan Passage with Princess
Cruise
 (2)

17 Days (16 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 17 November 2026
Visit: Italy, Spain, Gibraltar, Morocco, USA
Princess Standard
Exclusive Savings
Inside
$2,560
Oceanview
-
Balcony
$3,405
Suite
$4,085
From
A$2,560
Per Person
View Trip
24 Day Mediterranean, Aegean & Moroccan Passage with Princess
Cruise
 (2)

24 Days (23 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 10 November 2026
Visit: Italy, Greece, Turkey, Spain, Gibraltar, Morocco, USA
Princess Standard
Exclusive Savings
Inside
-
Oceanview
$4,563
Balcony
$4,563
Suite
$5,434
From
A$4,563
Per Person
View Trip
26 Day Allura Autumn Crossing with Oceania Cruises
Cruise

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 07 November 2026
Visit: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Spain, Morocco, Puerto Rico, USA
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,321
Suite
-
From
A$15,321
Save 2,379
Per Person
View Trip
33 Day Something Old, Something New with Oceania Cruises
Cruise

33 Days (32 Nights) Trieste to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 31 October 2027
Visit: Italy, Croatia, Montenegro, Albania (+8 more), Sicily, Sardinia, Corsica, France, Spain, Portugal, Bermuda, USA
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$19,016
Suite
$29,240
From
A$19,016
Save 2,454
Per Person
View Trip
22 Day Atlantic Ocean Isles with Regent Seven Seas
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 November 2026
Visit: Italy, Spain, Gibraltar, Portugal (+6 more), Bermuda, USA, Honduras, Guatemala, Belize, Mexico
Exquisite Escapes
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,262
Suite
$16,746
From
A$15,262
Save 13,668
Per Person
View Trip
46 Day Grand Latin & Iberian Quest with Oceania Cruises
Cruise

46 Days (45 Nights) Rome to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 19 October 2028
Visit: Italy, Sicily, Malta, Tunisia (+12 more), Sardinia, Spain, Portugal, Puerto Rico, USA, Cayman Islands, Colombia, Panama, Costa Rica, Nicaragua, Guatemala, Mexico
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$27,393
Suite
$37,947
From
A$27,393
Save 2,787
Per Person
View Trip
25 Day Msc Grand Voyages with MSC Cruises
Cruise

25 Days (24 Nights) Florence to Miami
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 18 October 2026
Visit: Italy, France, Spain, Gibraltar, Morocco, Portugal, USA
Exclusive Savings
Inside
$3,100
Oceanview
$3,783
Balcony
$3,961
Suite
-
From
A$3,100
Per Person
View Trip
15 Day Spain & Portugal Transatlantic with Royal Caribbean
Cruise

15 Days (14 Nights) Rome to New York
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 31 October 2027
Visit: Italy, Spain, Portugal, USA
Exclusive Savings
Inside
$1,869
Oceanview
$2,031
Balcony
$2,607
Suite
$6,187
From
A$1,869
Save 963
Per Person
View Trip
24 Day Romance, Rivieras & Reggae with Oceania Cruises
Cruise

24 Days (23 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 09 November 2027
Visit: Italy, Sardinia, Corsica, France (+4 more), Spain, Portugal, Bermuda, USA
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,091
Suite
$20,066
From
A$13,091
Save 2,309
Per Person
View Trip
15 Day Italy & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 30 October 2026
Visit: Italy, Sardinia, Spain, Portugal, Bermuda, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,524
Suite
-
From
A$5,963
Per Person
View Trip
15 Day Italy & Portugal Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 29 October 2027
Visit: Italy, Sardinia, Gibraltar, Portugal, Bermuda, USA
Exclusive Savings
Inside
$2,038
Oceanview
$2,314
Balcony
$3,197
Suite
$11,615
From
A$2,038
Save 1,162
Per Person
View Trip
26 Day MSC Grand Voyages with MSC Cruises
Cruise

26 Days (25 Nights) Amalfi to Miami
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 17 October 2026
Visit: Italy, France, Spain, Gibraltar, Morocco, Portugal, USA
Exclusive Savings
Inside
$3,217
Oceanview
$3,672
Balcony
$4,177
Suite
$11,920
From
A$3,217
Per Person
View Trip
16 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Rome to Tampa
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Gem
Departure: 01 November 2026
Visit: Italy, France, Spain, Bahamas, USA
Just Cruise Fare
Exclusive Savings
Inside
$2,310
Oceanview
$2,384
Balcony
$2,667
Suite
$2,949
From
A$2,310
Per Person
View Trip
21 Day Sailing Toward History with Regent Seven Seas
Cruise

21 Days (20 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 13 November 2028
Visit: Italy, Spain, Portugal, Puerto Rico, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$26,008
Suite
$28,243
From
A$26,008
Save 2,472
Per Person
View Trip
17 Day Spain & Morocco Transatlantic with Celebrity Cruises
Cruise

17 Days (16 Nights) Rome to Tampa
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 29 October 2027
Visit: Italy, Spain, Gibraltar, Morocco, USA
Exclusive Savings
Inside
$2,644
Oceanview
$2,494
Balcony
$5,237
Suite
-
From
A$2,494
Save 1,456
Per Person
View Trip
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