Cruises from Italy to USA

Are you looking for a cruise from Italy to USA? October is the most popular month to cruise between Italy and USA and there are 42 departures available from twelve of the world's leading cruise lines.
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14 Days
58 Days
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$55,998pp
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42 Cruises (42 Cruise Departures)
Cruise

20 Days (19 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 18 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Grand Voyages Sale
INSIDE
$1,239
OCEANVIEW
$1,419
BALCONY
$1,669
SUITE
$3,249
From (per person) 1,239
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Departure: 08 November 2026
Countries Visited: Italy, Spain, Gibraltar, Portugal (+5 more), Bermuda, USA, Honduras, Belize, Mexico
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$11,499
SUITE
$12,499
Save (per person) 19,499
From (per person) 11,499
Cruise

17 Days (16 Nights) Rome to Miami
Cruise Line: MSC Cruises
Departure: 28 October 2026
Countries Visited: Italy, Spain, Portugal, Puerto Rico (+1 more), USA
Escape To Sea
INSIDE
$1,153
OCEANVIEW
$1,313
BALCONY
$1,583
SUITE
$5,493
From (per person) 1,153
Cruise

15 Days (14 Nights) Rome to New York
Cruise Line: Regent Seven Seas
Departure: 18 May 2027
Countries Visited: Italy, Spain, Morocco, Bermuda (+1 more), USA
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$9,099
SUITE
$9,999
Save (per person) 15,699
From (per person) 9,099
Cruise
 (1)

23 Days (22 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Departure: 13 November 2027
Countries Visited: Italy, Greece, Montenegro, Croatia (+4 more), Spain, Gibraltar, Morocco, USA
Summer Swing Sale
INSIDE
$2,600
OCEANVIEW
$4,049
BALCONY
$3,799
SUITE
$5,000
From (per person) 2,600
Cruise
 (2)

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Holland America
Departure: 15 November 2025
Countries Visited: Italy, Spain, Gibraltar, Portugal (+1 more), USA
Exclusive Deal
INSIDE
-
OCEANVIEW
$1,134
BALCONY
$1,444
SUITE
$2,344
From (per person) 1,134
Cruise
 (5)

22 Days (21 Nights) Rome to Fort Lauderdale
Operated By: Viking Cruises
Ship: Viking Sky
Departure: 28 November 2025
Countries Visited: Italy, Monaco, France, Spain (+3 more), Portugal, Sint Maarten, USA
Viking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$6,348
SUITE
$9,498
Save (per person) 950
From (per person) 6,348
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Seabourn
Departure: 11 November 2025
Countries Visited: Italy, Corsica, Sardinia, Spain (+3 more), Portugal, Bermuda, USA
A Sail To Remember
INSIDE
-
OCEANVIEW
-
BALCONY
$7,394
SUITE
$12,494
From (per person) 7,394
Cruise

26 Days (25 Nights) Venice to Miami
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 18 October 2025
Countries Visited: Italy, Croatia, Montenegro, Monaco (+6 more), Spain, Portugal, Antigua and Barbuda, Virgin Islands, Puerto Rico, USA
Best Available FareGrand Journey Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$12,245
SUITE
$16,210
From (per person) 12,245
Cruise
 (1)

24 Days (23 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Departure: 10 November 2026
Countries Visited: Italy, Greece, Turkey, Spain (+3 more), Gibraltar, Morocco, USA
Summer Swing Sale
INSIDE
$2,465
OCEANVIEW
$3,765
BALCONY
$3,715
SUITE
$4,145
From (per person) 2,465
Cruise

22 Days (21 Nights) Livorno to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 26 October 2025
Countries Visited: Italy, France, Spain, Morocco (+5 more), Barbados, Grenada, Sint Maarten, Puerto Rico, USA
Grand Voyages Sale
INSIDE
$1,061
OCEANVIEW
$1,301
BALCONY
$1,741
SUITE
$3,321
From (per person) 1,061
Cruise

14 Days (13 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Departure: 31 October 2025
Countries Visited: Italy, Sardinia, Gibraltar, Bermuda (+1 more), USA
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$1,706
BALCONY
$2,582
SUITE
-
From (per person) 2,746
Cruise

31 Days (30 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Departure: 25 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+7 more), Corsica, Monaco, Spain, Portugal, Bermuda, Bahamas, USA
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$20,299
SUITE
$23,199
Save (per person) 35,699
From (per person) 20,299
Cruise

26 Days (25 Nights) Rome to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Ray
Departure: 07 November 2025
Countries Visited: Italy, France, Spain, Portugal (+2 more), Bermuda, USA
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$12,000
From (per person) 12,000
Cruise

58 Days (57 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Departure: 23 October 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+14 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin
Exclusive Deal
INSIDE
$14,799
OCEANVIEW
$16,299
BALCONY
$22,999
SUITE
$31,899
Save (per person) 14,799
From (per person) 14,799
Cruise

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Departure: 07 November 2026
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Spain, Morocco, Puerto Rico, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,599
SUITE
$12,699
Save (per person) 9,599
From (per person) 9,599
Cruise

22 Days (21 Nights) Naples to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 16 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Grand Voyages Sale
INSIDE
$1,331
OCEANVIEW
$1,621
BALCONY
$1,911
SUITE
-
From (per person) 1,331
Cruise
 (1)

16 Days (15 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Departure: 20 November 2027
Countries Visited: Italy, Spain, Gibraltar, Morocco (+1 more), USA
Summer Swing Sale
INSIDE
$1,480
OCEANVIEW
$2,479
BALCONY
$2,309
SUITE
$2,980
From (per person) 1,480
Cruise

15 Days (14 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Departure: 08 November 2026
Countries Visited: Italy, Spain, Gibraltar, Portugal (+2 more), Bermuda, USA
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$7,099
SUITE
$8,199
Save (per person) 13,699
From (per person) 7,099
Cruise
 (1)

17 Days (16 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Departure: 17 November 2026
Countries Visited: Italy, Spain, Gibraltar, Morocco (+1 more), USA
Summer Swing Sale
INSIDE
$1,089
OCEANVIEW
-
BALCONY
$1,533
SUITE
$2,019
From (per person) 1,089
Cruise

18 Days (17 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Countries Visited: Italy, France, Spain, Portugal (+3 more), Saint Martin, Bahamas, USA
Grand Voyages Sale
INSIDE
$814
OCEANVIEW
$1,014
BALCONY
$1,484
SUITE
$3,864
From (per person) 814
Cruise
 (3)

27 Days (26 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Sun Princess
Departure: 21 October 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+3 more), Spain, Gibraltar, USA
Exclusive DealSummer Swing Sale
INSIDE
$3,001
OCEANVIEW
$3,601
BALCONY
$4,230
SUITE
$5,081
From (per person) 3,001
Cruise

14 Days (13 Nights) Bologna to Philadelphia
Cruise Line: Norwegian Cruise Line
Departure: 01 November 2026
Countries Visited: Italy, Malta, Sardinia, Spain (+1 more), USA
INSIDE
$1,139
OCEANVIEW
$1,289
BALCONY
$2,189
SUITE
$2,339
From (per person) 1,139
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Seabourn
Departure: 01 November 2026
Countries Visited: Italy, Corsica, Sardinia, Spain (+2 more), Portugal, USA
A Sail To Remember
INSIDE
-
OCEANVIEW
$8,754
BALCONY
$10,964
SUITE
$18,784
From (per person) 8,754
Cruise

22 Days (21 Nights) Florence to New York
Cruise Line: MSC Cruises
Departure: 18 October 2026
Countries Visited: Italy, France, Spain, Gibraltar (+2 more), Portugal, USA
Escape To Sea
INSIDE
$1,703
OCEANVIEW
$1,903
BALCONY
$2,213
SUITE
-
From (per person) 1,703
Cruise

17 Days (16 Nights) Rome to Tampa
Cruise Line: Celebrity Cruises
Departure: 31 October 2025
Countries Visited: Italy, Spain, Portugal, Bermuda (+2 more), Bahamas, USA
Bonus Onboard Credit + SaveExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$1,876
SUITE
$22,050
From (per person) 3,009
Cruise

23 Days (22 Nights) Amalfi to New York
Cruise Line: MSC Cruises
Departure: 17 October 2026
Countries Visited: Italy, France, Spain, Gibraltar (+2 more), Portugal, USA
Escape To Sea
INSIDE
$1,785
OCEANVIEW
$1,995
BALCONY
$2,305
SUITE
-
From (per person) 1,785
Cruise

15 Days (14 Nights) Rome to Jacksonville
Cruise Line: Norwegian Cruise Line
Departure: 01 November 2026
Countries Visited: Italy, France, Spain, Portugal (+1 more), USA
INSIDE
$1,219
OCEANVIEW
$1,519
BALCONY
$2,469
SUITE
$2,569
From (per person) 1,219
Cruise

23 Days (22 Nights) Naples to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 25 October 2025
Countries Visited: Italy, France, Spain, Morocco (+5 more), Barbados, Grenada, Sint Maarten, Puerto Rico, USA
Grand Voyages Sale
INSIDE
$1,211
OCEANVIEW
$1,501
BALCONY
$2,011
SUITE
$4,021
From (per person) 1,211
Cruise

23 Days (22 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 18 October 2025
Countries Visited: Italy, France, Spain, Portugal (+5 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA, Bahamas
Grand Voyages Sale
INSIDE
$1,579
OCEANVIEW
$1,869
BALCONY
$2,069
SUITE
-
From (per person) 1,579
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