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Cruises from Italy to USA

Are you looking for a cruise from Italy to USA? November is the most popular month to cruise between Italy and USA and there are 31 departures available from eight of the world's leading cruise lines.
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14 Days
122 Days
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31 Cruises (31 Cruise Departures)
26 Day Allura Autumn Crossing with Oceania Cruises
Cruise

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 07 November 2026
Visit: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Spain, Morocco, Puerto Rico, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,489
Suite
$15,096
From
US$10,489
Save 11,009
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 04 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
$16,622
Oceanview
$19,493
Balcony
$28,272
Suite
-
From
US$16,622
Save 427
Per Person
View Trip
14 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise
 (1)

14 Days (13 Nights) Bologna to Philadelphia
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Pearl
Departure: 01 November 2026
Visit: Italy, Malta, Spain, USA
Inside
$1,069
Oceanview
$1,129
Balcony
$1,519
Suite
$2,037
From
US$1,069
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Rome to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 October 2026
Visit: Italy, Spain, Portugal, Puerto Rico, USA
Inside
$996
Oceanview
$1,267
Balcony
$1,505
Suite
$6,545
From
US$996
Per Person
View Trip
15 Day Italy & Portugal Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 29 October 2027
Visit: Italy, Sardinia, Gibraltar, Portugal, Bermuda, USA
Exclusive Savings
Inside
$1,457
Oceanview
$1,575
Balcony
$2,082
Suite
$6,364
From
US$1,457
Save 896
Per Person
View Trip
15 Day New World Passage with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 November 2026
Visit: Italy, Spain, Gibraltar, Portugal, Bermuda, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,195
Suite
$12,273
From
US$11,195
Save 11,603
Per Person
View Trip
24 Day Mediterranean, Aegean & Moroccan Passage with Princess
Cruise
 (1)

24 Days (23 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 10 November 2026
Visit: Italy, Greece, Turkey, Spain, Gibraltar, Morocco, USA
Princess Standard
Inside
$2,629
Oceanview
$3,474
Balcony
$3,587
Suite
$3,778
From
US$2,629
Per Person
View Trip
16 Day Spain & Portugal Transatlantic with Royal Caribbean
Cruise
 (2)

16 Days (15 Nights) Rome to Tampa
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 06 November 2027
Visit: Italy, Spain, Portugal, Bermuda, USA
Bonus Onboard Credit
Exclusive Savings
Inside
$1,051
Oceanview
$1,121
Balcony
$1,544
Suite
$2,983
From
US$1,051
Save 503
Per Person
View Trip
33 Day Something Old, Something New with Oceania Cruises
Cruise

33 Days (32 Nights) Trieste to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 31 October 2027
Visit: Italy, Croatia, Montenegro, Albania (+8 more), Sicily, Sardinia, Corsica, France, Spain, Portugal, Bermuda, USA
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,278
Suite
$19,001
From
US$13,278
Save 13,920
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

19 Days (18 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 26 October 2026
Visit: Italy, Spain, Portugal, Puerto Rico, USA
Inside
$1,099
Oceanview
$1,359
Balcony
$1,582
Suite
$3,343
From
US$1,099
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Genoa to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 05 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
$16,622
Oceanview
$19,493
Balcony
$28,272
Suite
$73,949
From
US$16,622
Save 427
Per Person
View Trip
22 Day Jewels Of Andalusia & Atlantic Crossing with Seabourn
Cruise
 (1)

22 Days (21 Nights) Rome to Miami
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 01 November 2026
Visit: Italy, Corsica, Sardinia, Spain, Portugal, USA
Yours to Explore
Exclusive Savings
Inside
-
Oceanview
$11,502
Balcony
$14,540
Suite
$23,752
From
US$11,502
Save 197
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

17 Days (16 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 07 April 2026
Visit: Italy, France, Spain, Portugal, Saint Martin, Bahamas, USA
Inside
-
Oceanview
-
Balcony
$1,541
Suite
-
From
US$1,541
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 October 2026
Visit: Italy, Spain, Portugal, Puerto Rico, USA
Inside
$929
Oceanview
$1,183
Balcony
$1,408
Suite
$7,648
From
US$929
Per Person
View Trip
58 Day Old & New World Discovery with Oceania Cruises
Cruise
 (1)

58 Days (57 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Visit: Italy, Croatia, Montenegro, Greece (+14 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
$16,309
Balcony
$24,700
Suite
$33,090
From
US$16,309
Save 16,989
Per Person
View Trip
44 Day Land Of Love To Lady Liberty with Oceania Cruises
Cruise
 (1)

44 Days (43 Nights) Venice to New York
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 07 August 2027
Visit: Italy, Croatia, Montenegro, Greece (+13 more), Sicily, France, Spain, Morocco, Gibraltar, Portugal, Guernsey, England, Ireland, Northern Ireland, Iceland, Canada, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$12,247
Oceanview
$12,829
Balcony
$18,746
Suite
$25,924
From
US$12,247
Save 12,751
Per Person
View Trip
17 Day Spain & Morocco Transatlantic with Celebrity Cruises
Cruise

17 Days (16 Nights) Rome to Tampa
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 29 October 2027
Visit: Italy, Spain, Gibraltar, Morocco, USA
Exclusive Savings
Inside
$978
Oceanview
$1,063
Balcony
$1,877
Suite
-
From
US$978
Save 607
Per Person
View Trip
26 Day Europe To The Caribbean with Oceania Cruises
Cruise
 (3)

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 November 2026
Visit: Italy, Sicily, Malta, Tunisia (+6 more), Sardinia, Spain, Portugal, Puerto Rico, Dominican Republic, USA
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$7,576
Oceanview
-
Balcony
$9,516
Suite
$12,863
From
US$7,576
Save 7,922
Per Person
View Trip
17 Day Moroccan Passage with Princess
Cruise
 (1)

17 Days (16 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 17 November 2026
Visit: Italy, Spain, Gibraltar, Morocco, USA
Princess Standard
Inside
$1,399
Oceanview
-
Balcony
$1,888
Suite
$2,525
From
US$1,399
Per Person
View Trip
33 Day Adriatic To Caribbean Isles with Oceania Cruises
Cruise
 (1)

33 Days (32 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Visit: Italy, Croatia, Montenegro, Greece (+6 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$8,574
Oceanview
$9,253
Balcony
$13,473
Suite
$17,644
From
US$8,574
Save 8,924
Per Person
View Trip
16 Day Canary Islands & Moroccan Passage with Princess
Cruise
 (1)

16 Days (15 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 20 November 2027
Visit: Italy, Spain, Gibraltar, Morocco, Bermuda, USA
Princess Standard
Inside
$1,429
Oceanview
-
Balcony
$2,116
Suite
$2,979
From
US$1,429
Per Person
View Trip
23 Day Mediterranean, Canary Islands & Moroccan Grand Adventure with Princess
Cruise
 (1)

23 Days (22 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 13 November 2027
Visit: Italy, Greece, Montenegro, Croatia (+5 more), Spain, Gibraltar, Morocco, Bermuda, USA
Princess Standard
Inside
$2,758
Oceanview
-
Balcony
$3,905
Suite
$5,037
From
US$2,758
Per Person
View Trip
15 Day Spain & Portugal Transatlantic with Royal Caribbean
Cruise

15 Days (14 Nights) Rome to New York
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 31 October 2027
Visit: Italy, Spain, Portugal, USA
Bonus Onboard Credit
Exclusive Savings
Inside
$1,312
Oceanview
$1,613
Balcony
$1,785
Suite
$3,407
From
US$1,312
Save 635
Per Person
View Trip
26 Day MSC Grand Voyages with MSC Cruises
Cruise

26 Days (25 Nights) Amalfi to Miami
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 17 October 2026
Visit: Italy, France, Spain, Gibraltar, Morocco, Portugal, USA
Inside
$1,727
Oceanview
$2,182
Balcony
$2,449
Suite
-
From
US$1,727
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

18 Days (17 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Visit: Italy, France, Spain, Portugal, Saint Martin, Bahamas, USA
Inside
-
Oceanview
-
Balcony
$1,510
Suite
-
From
US$1,510
Per Person
View Trip
24 Day Old & New Worlds with Oceania Cruises
Cruise
 (3)

24 Days (23 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 27 November 2027
Visit: Italy, Corsica, France, Spain, Gibraltar, Portugal, USA
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$5,242
Oceanview
$6,503
Balcony
$7,813
Suite
$11,208
From
US$5,242
Save 5,456
Per Person
View Trip
15 Day Italy & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 30 October 2026
Visit: Italy, Sardinia, Spain, Portugal, Bermuda, USA
Exclusive Savings
Inside
-
Oceanview
$2,311
Balcony
$2,510
Suite
$35,410
From
US$2,311
Save 1,382
Per Person
View Trip
25 Day Msc Grand Voyages with MSC Cruises
Cruise

25 Days (24 Nights) Florence to Miami
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 18 October 2026
Visit: Italy, France, Spain, Gibraltar, Morocco, Portugal, USA
Inside
$1,693
Oceanview
$2,104
Balcony
$2,357
Suite
$6,339
From
US$1,693
Per Person
View Trip
22 Day Atlantic Ocean Isles with Regent Seven Seas
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 November 2026
Visit: Italy, Spain, Gibraltar, Portugal (+6 more), Bermuda, USA, Honduras, Guatemala, Belize, Mexico
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,828
Suite
$18,955
From
US$17,828
Save 18,470
Per Person
View Trip
16 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Rome to Tampa
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Gem
Departure: 01 November 2026
Visit: Italy, France, Spain, Bahamas, USA
Inside
$1,109
Oceanview
$1,149
Balcony
$1,559
Suite
$1,689
From
US$1,109
Per Person
View Trip
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