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Cruises from Italy to USA

Are you looking for a cruise from Italy to USA? November is the most popular month to cruise between Italy and USA and there are 30 departures available from eight of the world's leading cruise lines.
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122 Days
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30 Cruises (30 Cruise Departures)
17 Day Moroccan Passage with Princess
Cruise
 (1)

17 Days (16 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 17 November 2026
Visit: Italy, Spain, Gibraltar, Morocco, USA
Princess Standard
Inside
$1,489
Oceanview
-
Balcony
$1,937
Suite
$2,763
From
US$1,489
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Rome to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 October 2026
Visit: Italy, Spain, Portugal, Puerto Rico, USA
Inside
$952
Oceanview
$1,267
Balcony
$1,505
Suite
$6,734
From
US$952
Per Person
View Trip
15 Day Italy & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 30 October 2026
Visit: Italy, Sardinia, Spain, Portugal, Bermuda, USA
Exclusive Savings
Inside
$1,544
Oceanview
$2,183
Balcony
$2,510
Suite
$15,396
From
US$1,827
Save 639
Per Person
View Trip
16 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Rome to Tampa
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Gem
Departure: 01 November 2026
Visit: Italy, France, Spain, Bahamas, USA
Inside
$1,109
Oceanview
$1,149
Balcony
$1,439
Suite
$1,639
From
US$1,109
Per Person
View Trip
24 Day Mediterranean, Aegean & Moroccan Passage with Princess
Cruise
 (1)

24 Days (23 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 10 November 2026
Visit: Italy, Greece, Turkey, Spain, Gibraltar, Morocco, USA
Princess Standard
Inside
$2,719
Oceanview
$3,529
Balcony
$3,644
Suite
$3,989
From
US$2,719
Per Person
View Trip
22 Day Jewels Of Andalusia & Atlantic Crossing with Seabourn
Cruise
 (1)

22 Days (21 Nights) Rome to Miami
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 01 November 2026
Visit: Italy, Corsica, Sardinia, Spain, Portugal, USA
Yours to Explore
Inside
-
Oceanview
-
Balcony
$14,799
Suite
$24,199
From
US$14,799
Per Person
View Trip
26 Day Allura Autumn Crossing with Oceania Cruises
Cruise

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 07 November 2026
Visit: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Spain, Morocco, Puerto Rico, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,699
Suite
$15,199
From
US$10,699
Save 10,699
Per Person
View Trip
26 Day Europe To The Caribbean with Oceania Cruises
Cruise
 (3)

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 November 2026
Visit: Italy, Sicily, Malta, Tunisia (+6 more), Sardinia, Spain, Portugal, Puerto Rico, Dominican Republic, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$7,899
Oceanview
-
Balcony
$10,099
Suite
$13,299
From
US$7,899
Save 7,899
Per Person
View Trip
33 Day Something Old, Something New with Oceania Cruises
Cruise

33 Days (32 Nights) Trieste to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 31 October 2027
Visit: Italy, Croatia, Montenegro, Albania (+8 more), Sicily, Sardinia, Corsica, France, Spain, Portugal, Bermuda, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,549
Suite
$20,449
From
US$13,549
Save 13,549
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

19 Days (18 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 26 October 2026
Visit: Italy, Spain, Portugal, Puerto Rico, USA
Inside
$1,051
Oceanview
$1,271
Balcony
$1,513
Suite
$3,249
From
US$1,051
Per Person
View Trip
33 Day Adriatic To Caribbean Isles with Oceania Cruises
Cruise
 (1)

33 Days (32 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Visit: Italy, Croatia, Montenegro, Greece (+6 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$8,899
Oceanview
$10,199
Balcony
$13,899
Suite
$18,599
From
US$8,899
Save 8,899
Per Person
View Trip
23 Day Mediterranean, Canary Islands & Moroccan Grand Adventure with Princess
Cruise
 (1)

23 Days (22 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 13 November 2027
Visit: Italy, Greece, Montenegro, Croatia (+5 more), Spain, Gibraltar, Morocco, Bermuda, USA
Princess Standard
Inside
$2,908
Oceanview
-
Balcony
$4,014
Suite
$5,218
From
US$2,908
Per Person
View Trip
24 Day Old & New Worlds with Oceania Cruises
Cruise
 (3)

24 Days (23 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 27 November 2027
Visit: Italy, Corsica, France, Spain, Gibraltar, Portugal, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$5,449
Oceanview
$6,849
Balcony
$8,199
Suite
$11,499
From
US$5,449
Save 5,449
Per Person
View Trip
16 Day Canary Islands & Moroccan Passage with Princess
Cruise
 (1)

16 Days (15 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 20 November 2027
Visit: Italy, Spain, Gibraltar, Morocco, Bermuda, USA
Princess Standard
Inside
$1,429
Oceanview
-
Balcony
$2,116
Suite
$2,979
From
US$1,429
Per Person
View Trip
44 Day Land Of Love To Lady Liberty with Oceania Cruises
Cruise
 (1)

44 Days (43 Nights) Venice to New York
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 07 August 2027
Visit: Italy, Croatia, Montenegro, Greece (+13 more), Sicily, France, Spain, Morocco, Gibraltar, Portugal, Guernsey, England, Ireland, Northern Ireland, Iceland, Canada, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$12,499
Oceanview
$13,099
Balcony
$19,199
Suite
$26,599
From
US$12,499
Save 12,499
Per Person
View Trip
22 Day Atlantic Ocean Isles with Regent Seven Seas
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 November 2026
Visit: Italy, Spain, Gibraltar, Portugal (+6 more), Bermuda, USA, Honduras, Guatemala, Belize, Mexico
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$18,649
Suite
$19,599
From
US$18,649
Save 18,649
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Genoa to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 05 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Inside
$17,049
Oceanview
$20,009
Balcony
$29,059
Suite
-
From
US$17,049
Per Person
View Trip
16 Day Spain & Portugal Transatlantic with Royal Caribbean
Cruise
 (2)

16 Days (15 Nights) Rome to Tampa
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 06 November 2027
Visit: Italy, Spain, Portugal, Bermuda, USA
Bonus Onboard Credit
Exclusive Savings
Inside
$1,015
Oceanview
$1,081
Balcony
$1,481
Suite
$2,974
From
US$1,015
Save 487
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 October 2026
Visit: Italy, Spain, Portugal, Puerto Rico, USA
Inside
$888
Oceanview
$1,131
Balcony
$1,346
Suite
-
From
US$888
Per Person
View Trip
58 Day Old & New World Discovery with Oceania Cruises
Cruise
 (1)

58 Days (57 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Visit: Italy, Croatia, Montenegro, Greece (+14 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$18,199
Balcony
$25,249
Suite
$59,049
From
US$18,199
Save 18,199
Per Person
View Trip
17 Day Spain & Morocco Transatlantic with Celebrity Cruises
Cruise

17 Days (16 Nights) Rome to Tampa
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 29 October 2027
Visit: Italy, Spain, Gibraltar, Morocco, USA
Exclusive Savings
Inside
$1,275
Oceanview
$1,349
Balcony
$2,417
Suite
-
From
US$1,275
Save 785
Per Person
View Trip
26 Day MSC Grand Voyages with MSC Cruises
Cruise

26 Days (25 Nights) Amalfi to Miami
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 17 October 2026
Visit: Italy, France, Spain, Gibraltar, Morocco, Portugal, USA
Inside
$1,727
Oceanview
$2,182
Balcony
$2,502
Suite
-
From
US$1,727
Per Person
View Trip
14 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise
 (1)

14 Days (13 Nights) Bologna to Philadelphia
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Pearl
Departure: 01 November 2026
Visit: Italy, Malta, Spain, USA
Inside
$989
Oceanview
$1,039
Balcony
$1,359
Suite
$1,789
From
US$989
Per Person
View Trip
25 Day Msc Grand Voyages with MSC Cruises
Cruise

25 Days (24 Nights) Florence to Miami
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 18 October 2026
Visit: Italy, France, Spain, Gibraltar, Morocco, Portugal, USA
Inside
$1,813
Oceanview
$2,284
Balcony
$2,409
Suite
-
From
US$1,813
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 04 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Inside
$18,229
Oceanview
$20,009
Balcony
$29,059
Suite
-
From
US$18,229
Per Person
View Trip
15 Day Splendid Atlantic Sojourn with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to New York
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 18 May 2027
Visit: Italy, Spain, Morocco, Canada, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,999
Suite
$13,899
From
US$12,999
Save 12,999
Per Person
View Trip
15 Day New World Passage with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 November 2026
Visit: Italy, Spain, Gibraltar, Portugal, Bermuda, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,649
Suite
$12,499
From
US$11,649
Save 11,649
Per Person
View Trip
24 Day Romance, Rivieras & Reggae with Oceania Cruises
Cruise

24 Days (23 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 09 November 2027
Visit: Italy, Sardinia, Corsica, France (+4 more), Spain, Portugal, Bermuda, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,349
Suite
$13,849
From
US$9,349
Save 9,349
Per Person
View Trip
15 Day Italy & Portugal Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 29 October 2027
Visit: Italy, Sardinia, Gibraltar, Portugal, Bermuda, USA
Exclusive Savings
Inside
$1,341
Oceanview
$1,516
Balcony
$2,082
Suite
$5,914
From
US$1,341
Save 826
Per Person
View Trip
15 Day Spain & Portugal Transatlantic with Royal Caribbean
Cruise

15 Days (14 Nights) Rome to New York
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 31 October 2027
Visit: Italy, Spain, Portugal, USA
Bonus Onboard Credit
Exclusive Savings
Inside
$1,245
Oceanview
$1,511
Balcony
$1,845
Suite
$3,816
From
US$1,245
Save 606
Per Person
View Trip
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