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Cruises from USA to Italy

Are you looking for a cruise from USA to Italy? April is the most popular month to cruise between USA and Italy and there are 29 departures available from nine of the world's leading cruise lines.
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122 Days
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29 Cruises (29 Cruise Departures)
24 Day Grand Atlantic To Adriatic with Oceania Cruises
Cruise
 (2)

24 Days (23 Nights) Miami to Trieste
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 25 March 2027
Visit: USA, Portugal, Spain, France (+5 more), Italy, Sicily, Greece, Montenegro, Croatia
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$6,363
Oceanview
$7,430
Balcony
$8,594
Suite
$11,213
From
US$6,363
Save 6,635
Per Person
View Trip
21 Day Atlantic & Mediterranean Horizons with Viking Cruises
New ReleaseCruise
 (8)

21 Days (20 Nights) Fort Lauderdale to Rome
Cruise Line: Viking Cruises
Ship: Viking Mars
Departure: 23 February 2028
Visit: USA, Sint Maarten, Portugal, Spain, France, Monaco, Italy
Viking $1,299 Air Deal
Inside
-
Oceanview
-
Balcony
$7,298
Suite
$12,098
From
US$7,298
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Miami to Genoa
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 April 2026
Visit: USA, Saint Martin, Portugal, Spain, France, Italy
Grand Voyages Sale
Inside
$749
Oceanview
$949
Balcony
$1,139
Suite
$2,873
From
US$749
Per Person
View Trip
15 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 20 April 2026
Visit: USA, Bermuda, Portugal, Spain, Italy
Exclusive Savings
Inside
$1,809
Oceanview
$2,142
Balcony
$2,560
Suite
-
From
US$1,809
Save 992
Per Person
View Trip
25 Day Miami to Rome with Silversea
Cruise
 (1)

25 Days (24 Nights) Miami to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 31 May 2026
Visit: USA, Portugal, Spain, France, Monaco, Italy
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$11,900
Suite
$18,800
From
US$11,900
Per Person
View Trip
22 Day Atlantic & Italian Stars with Oceania Cruises
Cruise
 (2)

22 Days (21 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 07 April 2026
Visit: USA, Bermuda, Portugal, Gibraltar (+5 more), Spain, France, Italy, Corsica, Sardinia
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,622
Suite
-
From
US$7,622
Save 7,976
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Miami to Rome
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 April 2026
Visit: USA, Saint Martin, Portugal, Spain, France, Italy
Grand Voyages Sale
Inside
$1,015
Oceanview
$1,155
Balcony
$1,395
Suite
-
From
US$1,015
Per Person
View Trip
24 Day New World To Ancient Shores with Oceania Cruises
Cruise

24 Days (23 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 31 March 2027
Visit: USA, Bermuda, Portugal, Spain, Gibraltar, France, Italy
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,331
Suite
$12,047
From
US$9,331
Save 9,767
Per Person
View Trip
15 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 19 April 2027
Visit: USA, Bermuda, Portugal, Spain, Italy
Exclusive Savings
Inside
$1,413
Oceanview
$1,650
Balcony
$1,892
Suite
$5,061
From
US$1,413
Save 771
Per Person
View Trip
20 Day Western Mediterranean & Adriatic Grand Adventure with Princess
Cruise
 (1)

20 Days (19 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Visit: USA, Portugal, Gibraltar, Corsica, Italy, Montenegro, Greece
Princess Standard
Inside
$1,298
Oceanview
-
Balcony
$1,970
Suite
-
From
US$1,298
Per Person
View Trip
16 Day Western Mediterranean Passage with Princess
Cruise
 (1)

16 Days (15 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 16 April 2027
Visit: USA, Bermuda, Portugal, Gibraltar, Spain, Corsica, Italy
Princess Standard
Inside
$1,200
Oceanview
$1,728
Balcony
$1,547
Suite
$2,539
From
US$1,200
Per Person
View Trip
38 Day Miami To Venice Transatlantic Grand Voyage with Azamara Cruises
Cruise
 (3)

38 Days (37 Nights) Miami to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 29 March 2027
Visit: USA, Bermuda, Portugal, Spain (+8 more), Morocco, Gibraltar, France, Monaco, Italy, Montenegro, Croatia, Slovenia
Azamara Always Included
Exclusive Savings
Inside
$9,784
Oceanview
$10,570
Balcony
$13,276
Suite
$22,006
From
US$9,784
Save 215
Per Person
View Trip
26 Day Western Mediterranean & Adriatic Grand Adventure with Princess
Cruise
 (1)

26 Days (25 Nights) Fort Lauderdale to Trieste
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 16 April 2027
Visit: USA, Bermuda, Portugal, Gibraltar (+7 more), Spain, Corsica, Italy, Sardinia, Malta, Montenegro, Croatia
Princess Standard
Exclusive Savings
Inside
$3,508
Oceanview
$4,402
Balcony
$4,784
Suite
$5,664
From
US$3,508
Per Person
View Trip
15 Day Spain, Italy, Azores Transatlantic with Royal Caribbean
Cruise

15 Days (14 Nights) New York to Rome
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 25 April 2027
Visit: USA, Portugal, Spain, Italy
Bonus Onboard Credit
Exclusive Savings
Inside
$1,553
Oceanview
$1,816
Balcony
$1,896
Suite
$3,098
From
US$1,553
Save 691
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 04 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
-
Oceanview
$19,493
Balcony
$28,272
Suite
-
From
US$19,493
Save 516
Per Person
View Trip
22 Day Mediterranean Grand Adventure with Princess
Cruise
 (6)

22 Days (21 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 28 March 2027
Visit: USA, Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Inside
$2,145
Oceanview
$2,743
Balcony
$3,425
Suite
$4,288
From
US$2,145
Per Person
View Trip
21 Day Atlantic & Mediterranean Horizons with Viking Cruises
Cruise
 (8)

21 Days (20 Nights) Fort Lauderdale to Rome
Cruise Line: Viking Cruises
Ship: Viking Mars
Departure: 24 February 2026
Visit: USA, Sint Maarten, Portugal, Spain, France, Monaco, Italy
Viking $799 Air Deal
Inside
-
Oceanview
-
Balcony
$8,448
Suite
$19,598
From
US$8,448
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Genoa to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 05 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
$16,622
Oceanview
$19,493
Balcony
$28,272
Suite
-
From
US$16,622
Save 427
Per Person
View Trip
17 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise
 (1)

17 Days (16 Nights) Miami to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sun
Departure: 16 April 2027
Visit: USA, Bahamas, Portugal, Spain, France, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$8,580
From
US$8,580
Save 249
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Miami to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 09 April 2026
Visit: USA, Virgin Islands, Spain, France, Italy
Inside
$729
Oceanview
-
Balcony
$1,029
Suite
$2,591
From
US$729
Per Person
View Trip
36 Day Crossing To Antiquity with Oceania Cruises
Cruise
 (1)

36 Days (35 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 March 2026
Visit: USA, Bermuda, Portugal, Spain (+6 more), Morocco, Gibraltar, France, Corsica, Sardinia, Italy
Your World Inclusions
Exclusive Savings
Inside
$9,312
Oceanview
-
Balcony
$14,841
Suite
$35,502
From
US$9,312
Save 9,686
Per Person
View Trip
17 Day Cosmopolitan Crossing with Oceania Cruises
Cruise
 (2)

17 Days (16 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 25 March 2027
Visit: USA, Portugal, Spain, France, Italy
Your World Inclusions
Upgrade Your Experience
Exclusive Savings
Inside
$3,819
Oceanview
$4,789
Balcony
$5,614
Suite
$7,020
From
US$3,819
Save 3,979
Per Person
View Trip
15 Day Western Mediterranean Passage with Princess
Cruise
 (1)

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Visit: USA, Portugal, Gibraltar, Corsica, Italy
Princess Standard
Inside
$792
Oceanview
-
Balcony
$1,173
Suite
$1,669
From
US$792
Per Person
View Trip
17 Day Passage To The Past with Oceania Cruises
Cruise
 (2)

17 Days (16 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 25 March 2028
Visit: USA, Bermuda, Portugal, Spain, France, Italy
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$3,236
Oceanview
$4,206
Balcony
$4,982
Suite
$7,019
From
US$3,236
Save 3,362
Per Person
View Trip
98 Day MSC World Cruise with MSC Cruises
Cruise

98 Days (97 Nights) Los Angeles to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 06 February 2026
Visit: USA, American Samoa, Samoa, Fiji (+17 more), New Zealand, Australia, Philippines, Taiwan, Japan, South Korea, China, Vietnam, Singapore, Malaysia, Seychelles, Mauritius, Reunion, South Africa, Namibia, Cape Verde, Italy
Exclusive Savings
Inside
-
Oceanview
$15,413
Balcony
-
Suite
-
From
US$15,413
Save 406
Per Person
View Trip
100 Day MSC World Cruise with MSC Cruises
Cruise

100 Days (99 Nights) Los Angeles to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 06 February 2026
Visit: USA, American Samoa, Samoa, Fiji (+17 more), New Zealand, Australia, Philippines, Taiwan, Japan, South Korea, China, Vietnam, Singapore, Malaysia, Seychelles, Mauritius, Reunion, South Africa, Namibia, Cape Verde, Italy
Exclusive Savings
Inside
$13,174
Oceanview
$15,725
Balcony
-
Suite
-
From
US$13,174
Save 335
Per Person
View Trip
24 Day Springtime In Europe with Oceania Cruises
Cruise

24 Days (23 Nights) Miami to Venice
Cruise Line: Oceania Cruises
Departure: 10 March 2028
Visit: USA, Bermuda, Portugal, Gibraltar (+6 more), Spain, Sardinia, Sicily, Greece, Croatia, Italy
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$5,246
Oceanview
$5,828
Balcony
$8,350
Suite
$11,794
From
US$5,246
Save 5,452
Per Person
View Trip
30 Day MSC World Cruise with MSC Cruises
Cruise

30 Days (29 Nights) Los Angeles to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 07 April 2027
Visit: USA, Mexico, Costa Rica, Panama (+5 more), Jamaica, Virgin Islands, Saint Martin, Spain, Italy
Exclusive Savings
Inside
$3,660
Oceanview
$4,349
Balcony
-
Suite
-
From
US$3,660
Save 89
Per Person
View Trip
20 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise

20 Days (19 Nights) New York to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Gem
Departure: 13 April 2027
Visit: USA, Portugal, Spain, Gibraltar, France, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,142
From
US$7,142
Save 207
Per Person
View Trip
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