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Cruises from USA to Italy

Are you looking for a cruise from USA to Italy? April is the most popular month to cruise between USA and Italy and there are 27 departures available from nine of the world's leading cruise lines.
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15 Days
122 Days
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27 Cruises (27 Cruise Departures)
38 Day Miami To Venice Transatlantic Grand Voyage with Azamara Cruises
Cruise
 (3)

38 Days (37 Nights) Miami to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 29 March 2027
Visit: USA, Bermuda, Portugal, Spain (+8 more), Morocco, Gibraltar, France, Monaco, Italy, Montenegro, Croatia, Slovenia
Azamara Always Included
Exclusive Savings
Inside
$9,784
Oceanview
$10,570
Balcony
$14,013
Suite
$22,006
From
US$9,784
Save 215
Per Person
View Trip
15 Day Western Mediterranean Passage with Princess
Cruise
 (1)

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Visit: USA, Portugal, Gibraltar, Corsica, Italy
Princess Standard
Inside
$867
Oceanview
-
Balcony
$1,245
Suite
-
From
US$867
Per Person
View Trip
17 Day Cosmopolitan Crossing with Oceania Cruises
Cruise
 (3)

17 Days (16 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 25 March 2027
Visit: USA, Portugal, Spain, France, Italy
Your World Inclusions
Upgrade Your Experience
Exclusive Savings
Inside
$3,916
Oceanview
$4,789
Balcony
$5,614
Suite
$7,069
From
US$3,916
Save 4,082
Per Person
View Trip
15 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 19 April 2027
Visit: USA, Bermuda, Portugal, Spain, Italy
Exclusive Savings
Inside
$1,486
Oceanview
$1,747
Balcony
$2,020
Suite
$5,012
From
US$1,486
Save 855
Per Person
View Trip
21 Day Atlantic & Mediterranean Horizons with Viking Cruises
New ReleaseCruise
 (8)

21 Days (20 Nights) Fort Lauderdale to Rome
Cruise Line: Viking Cruises
Ship: Viking Mars
Departure: 23 February 2028
Visit: USA, Sint Maarten, Portugal, Spain, France, Monaco, Italy
Viking $1,299 Air Deal
Inside
-
Oceanview
-
Balcony
$7,298
Suite
$12,098
From
US$7,298
Per Person
View Trip
17 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise
 (1)

17 Days (16 Nights) Miami to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sun
Departure: 16 April 2027
Visit: USA, Bahamas, Portugal, Spain, France, Italy
Inside
$1,899
Oceanview
$2,069
Balcony
$3,235
Suite
$4,651
From
US$1,899
Per Person
View Trip
17 Day Passage To The Past with Oceania Cruises
Cruise
 (3)

17 Days (16 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 25 March 2028
Visit: USA, Bermuda, Portugal, Spain, France, Italy
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$3,236
Oceanview
$4,206
Balcony
$4,982
Suite
$7,019
From
US$3,236
Save 3,362
Per Person
View Trip
22 Day Atlantic & Italian Stars with Oceania Cruises
Cruise
 (3)

22 Days (21 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 07 April 2026
Visit: USA, Bermuda, Portugal, Gibraltar (+5 more), Spain, France, Italy, Corsica, Sardinia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,671
Suite
-
From
US$7,671
Save 8,027
Per Person
View Trip
16 Day Western Mediterranean Passage with Princess
Cruise
 (1)

16 Days (15 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 16 April 2027
Visit: USA, Bermuda, Portugal, Gibraltar, Spain, Corsica, Italy
Princess Standard
Inside
$1,200
Oceanview
$1,728
Balcony
$1,547
Suite
$2,539
From
US$1,200
Per Person
View Trip
24 Day Springtime In Europe with Oceania Cruises
Cruise
 (1)

24 Days (23 Nights) Miami to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 10 March 2028
Visit: USA, Bermuda, Portugal, Gibraltar (+6 more), Spain, Sardinia, Sicily, Greece, Croatia, Italy
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$5,246
Oceanview
$5,828
Balcony
$8,350
Suite
$11,794
From
US$5,246
Save 5,452
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Miami to Rome
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 April 2026
Visit: USA, Saint Martin, Portugal, Spain, France, Italy
Grand Voyages Sale
Inside
$1,014
Oceanview
$1,134
Balcony
$1,584
Suite
-
From
US$1,014
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Miami to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 09 April 2026
Visit: USA, Virgin Islands, Spain, France, Italy
Inside
$611
Oceanview
$799
Balcony
$930
Suite
$2,521
From
US$611
Per Person
View Trip
26 Day Western Mediterranean & Adriatic Grand Adventure with Princess
Cruise
 (1)

26 Days (25 Nights) Fort Lauderdale to Trieste
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 16 April 2027
Visit: USA, Bermuda, Portugal, Gibraltar (+7 more), Spain, Corsica, Italy, Sardinia, Malta, Montenegro, Croatia
Princess Standard
Exclusive Savings
Inside
$3,519
Oceanview
-
Balcony
$4,936
Suite
$12,550
From
US$3,519
Per Person
View Trip
22 Day Old Country In Bloom with Oceania Cruises
Cruise

22 Days (21 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 18 March 2028
Visit: USA, Spain, France, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,300
Suite
$11,113
From
US$8,300
Save 8,698
Per Person
View Trip
24 Day Grand Atlantic To Adriatic with Oceania Cruises
Cruise
 (3)

24 Days (23 Nights) Miami to Trieste
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 25 March 2027
Visit: USA, Portugal, Spain, France (+5 more), Italy, Sicily, Greece, Montenegro, Croatia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$6,363
Oceanview
$7,478
Balcony
$8,642
Suite
$11,261
From
US$6,363
Save 6,635
Per Person
View Trip
25 Day Miami to Rome with Silversea
Cruise
 (1)

25 Days (24 Nights) Miami to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 31 May 2026
Visit: USA, Portugal, Spain, France, Monaco, Italy
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$12,500
Suite
$19,500
From
US$12,500
Per Person
View Trip
22 Day Mediterranean Grand Adventure with Princess
Cruise
 (6)

22 Days (21 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 28 March 2027
Visit: USA, Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Inside
$2,178
Oceanview
$2,773
Balcony
$3,474
Suite
$4,288
From
US$2,178
Per Person
View Trip
98 Day MSC World Cruise with MSC Cruises
Cruise

98 Days (97 Nights) Los Angeles to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 06 February 2026
Visit: USA, American Samoa, Samoa, Fiji (+17 more), New Zealand, Australia, Philippines, Taiwan, Japan, South Korea, China, Vietnam, Singapore, Malaysia, Seychelles, Mauritius, Reunion, South Africa, Namibia, Cape Verde, Italy
Exclusive Savings
Inside
-
Oceanview
$15,413
Balcony
-
Suite
-
From
US$15,413
Save 406
Per Person
View Trip
16 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

16 Days (15 Nights) Tampa to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 12 April 2026
Visit: USA, Bermuda, Portugal, Spain, Italy
Exclusive Savings
Inside
$1,065
Oceanview
-
Balcony
-
Suite
-
From
US$1,065
Save 556
Per Person
View Trip
20 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise

20 Days (19 Nights) New York to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Gem
Departure: 13 April 2027
Visit: USA, Portugal, Spain, Gibraltar, France, Italy
Exclusive Savings
Inside
$2,157
Oceanview
$2,351
Balcony
$3,757
Suite
$4,388
From
US$2,157
Save 52
Per Person
View Trip
15 Day Spain, Italy, Azores Transatlantic with Royal Caribbean
Cruise

15 Days (14 Nights) New York to Rome
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 25 April 2027
Visit: USA, Portugal, Spain, Italy
Bonus Onboard Credit
Exclusive Savings
Inside
$1,553
Oceanview
$1,816
Balcony
$1,896
Suite
$3,145
From
US$1,553
Save 691
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Genoa to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 05 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
$16,622
Oceanview
$20,065
Balcony
$28,272
Suite
-
From
US$16,622
Save 427
Per Person
View Trip
100 Day MSC World Cruise with MSC Cruises
Cruise

100 Days (99 Nights) Los Angeles to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 06 February 2026
Visit: USA, American Samoa, Samoa, Fiji (+17 more), New Zealand, Australia, Philippines, Taiwan, Japan, South Korea, China, Vietnam, Singapore, Malaysia, Seychelles, Mauritius, Reunion, South Africa, Namibia, Cape Verde, Italy
Exclusive Savings
Inside
-
Oceanview
$15,725
Balcony
-
Suite
-
From
US$15,725
Save 414
Per Person
View Trip
15 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 20 April 2026
Visit: USA, Bermuda, Portugal, Spain, Italy
Exclusive Savings
Inside
$1,873
Oceanview
$2,229
Balcony
$2,682
Suite
$7,280
From
US$1,873
Save 1,070
Per Person
View Trip
24 Day New World To Ancient Shores with Oceania Cruises
Cruise

24 Days (23 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 31 March 2027
Visit: USA, Bermuda, Portugal, Spain, Gibraltar, France, Italy
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,476
Suite
$12,629
From
US$9,476
Save 9,922
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 04 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
-
Oceanview
$20,065
Balcony
$28,272
Suite
$43,937
From
US$20,065
Save 534
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Miami to Genoa
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 April 2026
Visit: USA, Saint Martin, Portugal, Spain, France, Italy
Grand Voyages Sale
Inside
-
Oceanview
$949
Balcony
$1,139
Suite
$2,873
From
US$949
Per Person
View Trip
Results: 27 results

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