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Cruises from USA to Italy

Are you looking for a cruise from USA to Italy? April is the most popular month to cruise between USA and Italy and there are 27 departures available from nine of the world's leading cruise lines.
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128 Days
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27 Cruises (27 Cruise Departures)
20 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise

20 Days (19 Nights) New York to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Gem
Departure: 13 April 2027
Visit: USA, Portugal, Spain, Gibraltar, France, Italy
Exclusive Savings
Inside
$2,089
Oceanview
$2,166
Balcony
$3,563
Suite
$4,000
From
US$2,089
Save 50
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

16 Days (15 Nights) Miami to Genoa
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 April 2026
Visit: USA, Saint Martin, Portugal, Spain, France, Italy
Inside
$772
Oceanview
-
Balcony
$1,193
Suite
$2,873
From
US$772
Per Person
View Trip
26 Day Western Mediterranean & Adriatic Grand Adventure with Princess
Cruise
 (1)

26 Days (25 Nights) Fort Lauderdale to Trieste
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 16 April 2027
Visit: USA, Bermuda, Portugal, Gibraltar (+7 more), Spain, Corsica, Italy, Sardinia, Malta, Montenegro, Croatia
Princess Standard
Inside
$3,298
Oceanview
-
Balcony
-
Suite
$12,377
From
US$3,298
Per Person
View Trip
22 Day Atlantic & Italian Stars with Oceania Cruises
Cruise
 (3)

22 Days (21 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 07 April 2026
Visit: USA, Bermuda, Portugal, Gibraltar (+5 more), Spain, France, Italy, Corsica, Sardinia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,865
Suite
-
From
US$7,865
Save 8,233
Per Person
View Trip
24 Day New World To Ancient Shores with Oceania Cruises
Cruise

24 Days (23 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 31 March 2027
Visit: USA, Bermuda, Portugal, Spain, Gibraltar, France, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,525
Suite
$13,162
From
US$9,525
Save 9,973
Per Person
View Trip
24 Day Grand Atlantic To Adriatic with Oceania Cruises
Cruise
 (3)

24 Days (23 Nights) Miami to Trieste
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 25 March 2027
Visit: USA, Portugal, Spain, France (+5 more), Italy, Sicily, Greece, Montenegro, Croatia
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$6,508
Oceanview
$7,672
Balcony
$8,594
Suite
$11,407
From
US$6,508
Save 6,790
Per Person
View Trip
24 Day Springtime In Europe with Oceania Cruises
Cruise
 (1)

24 Days (23 Nights) Miami to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 10 March 2028
Visit: USA, Bermuda, Portugal, Gibraltar (+6 more), Spain, Sardinia, Sicily, Greece, Croatia, Italy
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$5,246
Oceanview
$5,828
Balcony
$8,350
Suite
$11,794
From
US$5,246
Save 5,452
Per Person
View Trip
82 Day World Cruise - Los Angeles to Rome with Princess
Cruise
 (4)

82 Days (81 Nights) Los Angeles to Rome
Cruise Line: Princess
Ship: Coral Princess
Departure: 18 January 2028
Visit: USA, Samoa, Fiji, New Zealand (+14 more), Australia, Mauritius, Reunion, South Africa, Namibia, Cape Verde, Spain, Gibraltar, Sicily, Greece, Croatia, Montenegro, Turkey, Italy
Princess Standard
Princess Premier
Exclusive Savings
Inside
$14,943
Oceanview
$15,816
Balcony
$17,383
Suite
$30,594
From
US$14,943
Save 236
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 04 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
$16,622
Oceanview
$19,493
Balcony
$28,272
Suite
-
From
US$16,622
Save 427
Per Person
View Trip
38 Day Miami To Venice Transatlantic Grand Voyage with Azamara Cruises
Cruise
 (3)

38 Days (37 Nights) Miami to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 29 March 2027
Visit: USA, Bermuda, Portugal, Spain (+8 more), Morocco, Gibraltar, France, Monaco, Italy, Montenegro, Croatia, Slovenia
Azamara Always Included
Exclusive Savings
Inside
$9,784
Oceanview
$10,570
Balcony
$14,013
Suite
$22,006
From
US$9,784
Save 215
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

16 Days (15 Nights) Miami to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 09 April 2026
Visit: USA, Virgin Islands, Spain, France, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$4,669
From
US$4,669
Save 132
Per Person
View Trip
15 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 19 April 2027
Visit: USA, Bermuda, Portugal, Spain, Italy
Exclusive Savings
Inside
$1,845
Oceanview
$2,035
Balcony
$2,209
Suite
$10,878
From
US$1,845
Save 1,030
Per Person
View Trip
16 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

16 Days (15 Nights) Tampa to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 12 April 2026
Visit: USA, Bermuda, Portugal, Spain, Italy
Exclusive Savings
Inside
-
Oceanview
$1,202
Balcony
$1,580
Suite
$5,188
From
US$1,385
Save 415
Per Person
View Trip
21 Day Atlantic & Mediterranean Horizons with Viking Cruises
New ReleaseCruise
 (8)

21 Days (20 Nights) Fort Lauderdale to Rome
Cruise Line: Viking Cruises
Ship: Viking Mars
Departure: 23 February 2028
Visit: USA, Sint Maarten, Portugal, Spain, France, Monaco, Italy
Viking $1,299 Air Deal
Inside
-
Oceanview
-
Balcony
$7,298
Suite
$12,098
From
US$7,298
Per Person
View Trip
17 Day Passage To The Past with Oceania Cruises
Cruise
 (3)

17 Days (16 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 25 March 2028
Visit: USA, Bermuda, Portugal, Spain, France, Italy
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$3,236
Oceanview
$4,206
Balcony
$4,982
Suite
$7,019
From
US$3,236
Save 3,362
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Miami to Rome
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 April 2026
Visit: USA, Saint Martin, Portugal, Spain, France, Italy
Inside
$912
Oceanview
-
Balcony
-
Suite
$3,286
From
US$912
Per Person
View Trip
15 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 20 April 2026
Visit: USA, Bermuda, Portugal, Spain, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,130
Suite
$7,680
From
US$3,130
Save 1,905
Per Person
View Trip
17 Day Cosmopolitan Crossing with Oceania Cruises
Cruise
 (3)

17 Days (16 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 25 March 2027
Visit: USA, Portugal, Spain, France, Italy
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$3,916
Oceanview
$4,789
Balcony
$5,420
Suite
$7,069
From
US$3,916
Save 4,082
Per Person
View Trip
22 Day Mediterranean Grand Adventure with Princess
Cruise
 (6)

22 Days (21 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 28 March 2027
Visit: USA, Spain, France, Corsica, Italy
Princess Standard
Inside
$2,408
Oceanview
$2,738
Balcony
$3,318
Suite
$3,749
From
US$2,408
Per Person
View Trip
97 Day World Cruise - Ft. Lauderdale to Rome with Princess
Cruise
 (4)

97 Days (96 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Coral Princess
Departure: 03 January 2028
Visit: USA, Colombia, Panama, El Salvador (+18 more), Mexico, Samoa, Fiji, New Zealand, Australia, Mauritius, Reunion, South Africa, Namibia, Cape Verde, Spain, Gibraltar, Sicily, Greece, Croatia, Montenegro, Turkey, Italy
Princess Standard
Princess Premier
Exclusive Savings
Inside
$17,873
Oceanview
$18,913
Balcony
$20,774
Suite
$36,463
From
US$17,873
Save 276
Per Person
View Trip
17 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise
 (1)

17 Days (16 Nights) Miami to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sun
Departure: 16 April 2027
Visit: USA, Bahamas, Portugal, Spain, France, Italy
Inside
$1,849
Oceanview
$2,099
Balcony
$3,235
Suite
$4,787
From
US$1,849
Per Person
View Trip
16 Day Western Mediterranean Passage with Princess
Cruise
 (1)

16 Days (15 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 16 April 2027
Visit: USA, Bermuda, Portugal, Gibraltar, Spain, Corsica, Italy
Princess Standard
Inside
$1,099
Oceanview
-
Balcony
$1,421
Suite
$2,079
From
US$1,099
Per Person
View Trip
15 Day Spain, Italy, Azores Transatlantic with Royal Caribbean
Cruise

15 Days (14 Nights) New York to Rome
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 25 April 2027
Visit: USA, Portugal, Spain, Italy
Bonus Onboard Credit
Exclusive Savings
Inside
$1,563
Oceanview
$1,793
Balcony
$1,912
Suite
$3,542
From
US$1,563
Save 695
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Genoa to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 05 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
$16,622
Oceanview
$19,493
Balcony
$28,272
Suite
-
From
US$16,622
Save 427
Per Person
View Trip
128 Day Navigate The World with Regent Seven Seas
Cruise

128 Days (127 Nights) Miami to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 11 January 2027
Visit: USA, Mexico, Belize, Honduras (+32 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama, El Salvador, Guatemala, French Polynesia, American Samoa, Samoa, Fiji, Vanuatu, New Caledonia, Australia, Indonesia, Singapore, Malaysia, Thailand, Sri Lanka, Maldives, India, Oman, United Arab Emirates, Qatar, Saudi Arabia, Egypt, Jordan, Israel, Cyprus, Greece, Turkey, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$119,152
From
US$119,152
Save 123,446
Per Person
View Trip
22 Day Old Country In Bloom with Oceania Cruises
Cruise

22 Days (21 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 18 March 2028
Visit: USA, Spain, France, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,300
Suite
$11,113
From
US$8,300
Save 8,698
Per Person
View Trip
17 Day Transoceanic Salute with Oceania Cruises
Cruise

17 Days (16 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 14 April 2026
Visit: USA, Bermuda, Portugal, Spain, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,987
Suite
$14,396
From
US$4,987
Save 5,211
Per Person
View Trip
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