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Cruises from USA to Italy

Are you looking for a cruise from USA to Italy? April is the most popular month to cruise between USA and Italy and there are 21 departures available from nine of the world's leading cruise lines.
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15 Days
128 Days
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21 Cruises (21 Cruise Departures)
17 Day Cosmopolitan Crossing with Oceania Cruises
Cruise

17 Days (16 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 25 March 2027
Countries Visited: USA, Portugal, Spain, France (+1 more), Italy
Exclusive Deal
INSIDE
$3,899
OCEANVIEW
$4,899
BALCONY
$5,749
SUITE
$7,199
Save (per person) 3,899
From (per person) 3,899
View Trip
24 Day Grand Atlantic To Adriatic with Oceania Cruises
Cruise

24 Days (23 Nights) Miami to Trieste
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 25 March 2027
Countries Visited: USA, Portugal, Spain, France (+5 more), Italy, Sicily, Greece, Montenegro, Croatia
Exclusive Deal
INSIDE
$6,499
OCEANVIEW
$7,599
BALCONY
$8,799
SUITE
$11,499
Save (per person) 6,499
From (per person) 6,499
View Trip
22 Day Mediterranean Grand Adventure with Princess
Cruise
 (3)

22 Days (21 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 28 March 2027
Countries Visited: USA, Spain, Gibraltar, France (+1 more), Italy
Exclusive DealBonus Instant Savings
INSIDE
$2,130
OCEANVIEW
$2,780
BALCONY
$3,730
SUITE
$4,580
From (per person) 2,130
View Trip
36 Day Crossing To Antiquity with Oceania Cruises
Cruise
 (1)

36 Days (35 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 March 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+6 more), Morocco, Gibraltar, France, Corsica, Sardinia, Italy
Exclusive Deal
INSIDE
$9,499
OCEANVIEW
$9,899
BALCONY
$13,699
SUITE
$18,999
Save (per person) 9,499
From (per person) 9,499
View Trip
20 Day Western Mediterranean & Adriatic Grand Adventure with Princess
Cruise
 (1)

20 Days (19 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Countries Visited: USA, Portugal, Gibraltar, Corsica (+3 more), Italy, Montenegro, Greece
Bonus Instant Savings
INSIDE
$1,527
OCEANVIEW
-
BALCONY
$1,982
SUITE
$2,292
From (per person) 1,527
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Miami to Genoa
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 April 2026
Countries Visited: USA, Saint Martin, Portugal, Spain (+2 more), France, Italy
Escape To Sea
INSIDE
$1,149
OCEANVIEW
$1,299
BALCONY
$1,509
SUITE
$4,809
From (per person) 1,149
View Trip
38 Day Miami To Venice Transatlantic Grand Voyage with Azamara Cruises
Cruise
 (1)

38 Days (37 Nights) Miami to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 29 March 2027
Countries Visited: USA, Bermuda, Portugal, Spain (+8 more), Morocco, Gibraltar, France, Monaco, Italy, Montenegro, Croatia, Slovenia
INSIDE
$8,669
OCEANVIEW
$10,079
BALCONY
$13,399
SUITE
$20,569
From (per person) 8,669
View Trip
21 Day Atlantic & Mediterranean Horizons with Viking Cruises
Cruise
 (8)

21 Days (20 Nights) Fort Lauderdale to Rome
Operated By: Viking Cruises
Ship: Viking Mars
Departure: 24 February 2026
Countries Visited: USA, Sint Maarten, Portugal, Spain (+3 more), France, Monaco, Italy
Viking $799 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$6,848
SUITE
-
Save (per person) 1,050
From (per person) 6,848
View Trip
24 Day New World To Ancient Shores with Oceania Cruises
Cruise

24 Days (23 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 31 March 2027
Countries Visited: USA, Bermuda, Portugal, Spain (+3 more), Gibraltar, France, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,099
SUITE
$11,799
Save (per person) 8,099
From (per person) 8,099
View Trip
15 Day Western Mediterranean Passage with Princess
Cruise
 (1)

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Countries Visited: USA, Portugal, Gibraltar, Corsica (+1 more), Italy
Bonus Instant Savings
INSIDE
$829
OCEANVIEW
$1,069
BALCONY
$1,046
SUITE
$1,239
From (per person) 829
View Trip
16 Day Western Mediterranean Passage with Princess
Cruise
 (1)

16 Days (15 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 16 April 2027
Countries Visited: USA, Bermuda, Portugal, Gibraltar (+3 more), Spain, Corsica, Italy
Bonus Instant Savings
INSIDE
$1,250
OCEANVIEW
$1,849
BALCONY
$1,709
SUITE
$2,850
From (per person) 1,250
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Miami to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 09 April 2026
Countries Visited: USA, Virgin Islands, Spain, France (+1 more), Italy
Grand Voyages Sale
INSIDE
$980
OCEANVIEW
$1,180
BALCONY
$1,370
SUITE
$2,770
From (per person) 980
View Trip
26 Day Western Mediterranean & Adriatic Grand Adventure with Princess
Cruise
 (1)

26 Days (25 Nights) Fort Lauderdale to Trieste
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 16 April 2027
Countries Visited: USA, Bermuda, Portugal, Gibraltar (+7 more), Spain, Corsica, Italy, Sardinia, Malta, Montenegro, Croatia
Bonus Instant Savings
INSIDE
$3,069
OCEANVIEW
$3,967
BALCONY
$4,133
SUITE
$5,769
From (per person) 3,069
View Trip
25 Day Atlantic Crossing & Spain's Southern Coast with Seabourn
Cruise

25 Days (24 Nights) Miami to Genoa
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 26 April 2026
Countries Visited: USA, Portugal, Morocco, Gibraltar (+3 more), Spain, France, Italy
A Sail To Remember
INSIDE
-
OCEANVIEW
$9,349
BALCONY
$11,559
SUITE
$19,379
From (per person) 9,349
View Trip
128 Day Navigate The World with Regent Seven Seas
Cruise

128 Days (127 Nights) Miami to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 11 January 2027
Countries Visited: USA, Mexico, Belize, Honduras (+32 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama, El Salvador, Guatemala, French Polynesia, American Samoa, Samoa, Fiji, Vanuatu, New Caledonia, Australia, Indonesia, Singapore, Malaysia, Thailand, Sri Lanka, Maldives, India, Oman, United Arab Emirates, Qatar, Saudi Arabia, Egypt, Jordan, Israel, Cyprus, Greece, Turkey, Italy
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$94,799
Save (per person) 140,799
From (per person) 94,799
View Trip
22 Day Atlantic & Italian Stars with Oceania Cruises
Cruise

22 Days (21 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 07 April 2026
Countries Visited: USA, Bermuda, Portugal, Gibraltar (+5 more), Spain, France, Italy, Corsica, Sardinia
Exclusive Deal
INSIDE
$5,399
OCEANVIEW
$6,299
BALCONY
$7,099
SUITE
$9,999
Save (per person) 5,399
From (per person) 5,399
View Trip
16 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

16 Days (15 Nights) Tampa to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 12 April 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+1 more), Italy
Exclusive Deal
INSIDE
$924
OCEANVIEW
$1,064
BALCONY
$1,588
SUITE
$6,475
Save (per person) 450
From (per person) 924
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Miami to Rome
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 April 2026
Countries Visited: USA, Saint Martin, Portugal, Spain (+2 more), France, Italy
Escape To Sea
INSIDE
$1,319
OCEANVIEW
$1,539
BALCONY
$1,749
SUITE
-
From (per person) 1,319
View Trip
15 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 20 April 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+1 more), Italy
Exclusive DealExclusive Solo Offer
INSIDE
$1,055
OCEANVIEW
$1,429
BALCONY
$1,429
SUITE
$5,546
Save (per person) 554
From (per person) 1,055
View Trip
17 Day Transoceanic Salute with Oceania Cruises
Cruise

17 Days (16 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 14 April 2026
Countries Visited: USA, Bahamas, Bermuda, Portugal (+2 more), Spain, Italy
Fleetwide SaleExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$4,799
SUITE
$7,449
Save (per person) 4,799
From (per person) 4,799
View Trip
25 Day Miami to Rome with Silversea
Cruise

25 Days (24 Nights) Miami to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 31 May 2026
Countries Visited: USA, Portugal, Spain, France (+2 more), Monaco, Italy
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$11,400
From (per person) 11,400
View Trip
Results: 21 results

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Cruises from USA to Italy

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