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Cruises from USA to Italy

Are you looking for a cruise from USA to Italy? April is the most popular month to cruise between USA and Italy and there are 28 departures available from nine of the world's leading cruise lines.
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15 Days
128 Days
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28 Cruises (28 Cruise Departures)
15 Day Western Mediterranean Passage with Princess
Cruise
 (1)

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Visit: USA, Portugal, Gibraltar, Corsica, Italy
Black Friday Sale
Inside
$839
Oceanview
-
Balcony
$820
Suite
$1,627
From
US$820
Per Person
View Trip
24 Day New World To Ancient Shores with Oceania Cruises
Cruise

24 Days (23 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 31 March 2027
Visit: USA, Bermuda, Portugal, Spain, Gibraltar, France, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,720
Suite
$22,958
From
US$17,720
Save 478
Per Person
View Trip
25 Day Miami to Rome with Silversea
Cruise
 (1)

25 Days (24 Nights) Miami to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 31 May 2026
Visit: USA, Portugal, Spain, France, Monaco, Italy
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$11,900
Suite
$18,800
From
US$11,900
Per Person
View Trip
22 Day Mediterranean Grand Adventure with Princess
Cruise
 (6)

22 Days (21 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 28 March 2027
Visit: USA, Spain, France, Corsica, Italy
Black Friday Sale
Sanctuary Collection
Inside
$2,114
Oceanview
$2,824
Balcony
$3,658
Suite
$4,525
From
US$2,114
Per Person
View Trip
21 Day Atlantic & Mediterranean Horizons with Viking Cruises
Cruise
 (8)

21 Days (20 Nights) Fort Lauderdale to Rome
Cruise Line: Viking Cruises
Ship: Viking Mars
Departure: 24 February 2026
Visit: USA, Sint Maarten, Portugal, Spain, France, Monaco, Italy
Viking $799 Air Deal
Inside
-
Oceanview
-
Balcony
$8,448
Suite
-
From
US$8,448
Per Person
View Trip
22 Day Atlantic & Italian Stars with Oceania Cruises
Cruise
 (1)

22 Days (21 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 07 April 2026
Visit: USA, Bermuda, Portugal, Gibraltar (+5 more), Spain, France, Italy, Corsica, Sardinia
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,023
Suite
$19,843
From
US$14,023
Save 375
Per Person
View Trip
24 Day Springtime In Europe with Oceania Cruises
Cruise
 (3)

24 Days (23 Nights) Miami to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 10 March 2028
Visit: USA, Bermuda, Portugal, Gibraltar (+6 more), Spain, Sardinia, Sicily, Greece, Croatia, Italy
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$10,532
Oceanview
$11,696
Balcony
$16,740
Suite
$23,530
From
US$10,532
Save 266
Per Person
View Trip
15 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 20 April 2026
Visit: USA, Bermuda, Portugal, Spain, Italy
Exclusive Savings
Inside
-
Oceanview
$1,817
Balcony
$2,469
Suite
$10,025
From
US$1,817
Save 997
Per Person
View Trip
17 Day Cosmopolitan Crossing with Oceania Cruises
Cruise
 (1)

17 Days (16 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 25 March 2027
Visit: USA, Portugal, Spain, France, Italy
Your World Inclusions
Exclusive Savings
Inside
$7,601
Oceanview
$9,541
Balcony
$11,190
Suite
$14,003
From
US$7,601
Save 197
Per Person
View Trip
20 Day Western Mediterranean & Adriatic Grand Adventure with Princess
Cruise
 (1)

20 Days (19 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Visit: USA, Portugal, Gibraltar, Corsica, Italy, Montenegro, Greece
Black Friday Sale
Inside
$1,367
Oceanview
-
Balcony
$1,537
Suite
$2,082
From
US$1,367
Per Person
View Trip
16 Day Western Mediterranean Passage with Princess
Cruise
 (1)

16 Days (15 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 16 April 2027
Visit: USA, Bermuda, Portugal, Gibraltar, Spain, Corsica, Italy
Black Friday Sale
Inside
$1,300
Oceanview
$1,899
Balcony
$1,759
Suite
$2,925
From
US$1,300
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 04 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
$17,766
Oceanview
$19,493
Balcony
$28,272
Suite
-
From
US$17,766
Save 463
Per Person
View Trip
15 Day Spain, Italy, Azores Transatlantic with Royal Caribbean
Cruise

15 Days (14 Nights) New York to Rome
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 25 April 2027
Visit: USA, Portugal, Spain, Italy
Bonus Onboard Credit
Exclusive Savings
Inside
$1,546
Oceanview
$1,816
Balcony
$1,896
Suite
$3,098
From
US$1,546
Save 688
Per Person
View Trip
21 Day Atlantic & Mediterranean Horizons with Viking Cruises
New ReleaseCruise
 (8)

21 Days (20 Nights) Fort Lauderdale to Rome
Cruise Line: Viking Cruises
Ship: Viking Mars
Departure: 23 February 2028
Visit: USA, Sint Maarten, Portugal, Spain, France, Monaco, Italy
Viking $1,299 Air Deal
Inside
-
Oceanview
-
Balcony
$7,298
Suite
$12,098
From
US$7,298
Per Person
View Trip
24 Day Grand Atlantic To Adriatic with Oceania Cruises
Cruise
 (1)

24 Days (23 Nights) Miami to Trieste
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 25 March 2027
Visit: USA, Portugal, Spain, France (+5 more), Italy, Sicily, Greece, Montenegro, Croatia
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$12,667
Oceanview
$14,801
Balcony
$17,129
Suite
$22,367
From
US$12,667
Save 331
Per Person
View Trip
17 Day Passage To The Past with Oceania Cruises
Cruise
 (1)

17 Days (16 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 25 March 2028
Visit: USA, Bermuda, Portugal, Spain, France, Italy
Your World Inclusions
Exclusive Savings
Inside
$6,824
Oceanview
$8,376
Balcony
$9,928
Suite
$14,002
From
US$6,824
Save 174
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Genoa to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 05 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
$16,622
Oceanview
$19,493
Balcony
$28,272
Suite
-
From
US$16,622
Save 427
Per Person
View Trip
26 Day Western Mediterranean & Adriatic Grand Adventure with Princess
Cruise
 (1)

26 Days (25 Nights) Fort Lauderdale to Trieste
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 16 April 2027
Visit: USA, Bermuda, Portugal, Gibraltar (+7 more), Spain, Corsica, Italy, Sardinia, Malta, Montenegro, Croatia
Black Friday Sale
Exclusive Savings
Inside
$4,018
Oceanview
$4,915
Balcony
$5,097
Suite
$6,461
From
US$4,018
Per Person
View Trip
98 Day MSC World Cruise with MSC Cruises
Cruise

98 Days (97 Nights) Los Angeles to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 06 February 2026
Visit: USA, American Samoa, Samoa, Fiji (+17 more), New Zealand, Australia, Philippines, Taiwan, Japan, South Korea, China, Vietnam, Singapore, Malaysia, Seychelles, Mauritius, Reunion, South Africa, Namibia, Cape Verde, Italy
Exclusive Savings
Inside
$12,913
Oceanview
-
Balcony
-
Suite
-
From
US$12,913
Save 329
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Miami to Genoa
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 April 2026
Visit: USA, Saint Martin, Portugal, Spain, France, Italy
Inside
-
Oceanview
$930
Balcony
$1,320
Suite
-
From
US$930
Per Person
View Trip
25 Day Atlantic Crossing & Spain's Southern Coast with Seabourn
Cruise

25 Days (24 Nights) Miami to Genoa
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 26 April 2026
Visit: USA, Portugal, Morocco, Gibraltar, Spain, France, Italy
Black Friday Sail
Exclusive Savings
Inside
-
Oceanview
$10,329
Balcony
$12,877
Suite
$25,029
From
US$10,329
Save 169
Per Person
View Trip
36 Day Crossing To Antiquity with Oceania Cruises
Cruise
 (1)

36 Days (35 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 March 2026
Visit: USA, Bermuda, Portugal, Spain (+6 more), Morocco, Gibraltar, France, Corsica, Sardinia, Italy
Your World Inclusions
Exclusive Savings
Inside
$18,526
Oceanview
$21,048
Balcony
$28,614
Suite
$70,906
From
US$18,526
Save 472
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Miami to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 09 April 2026
Visit: USA, Virgin Islands, Spain, France, Italy
Inside
-
Oceanview
$750
Balcony
$920
Suite
$2,350
From
US$750
Per Person
View Trip
100 Day MSC World Cruise with MSC Cruises
Cruise

100 Days (99 Nights) Los Angeles to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 06 February 2026
Visit: USA, American Samoa, Samoa, Fiji (+17 more), New Zealand, Australia, Philippines, Taiwan, Japan, South Korea, China, Vietnam, Singapore, Malaysia, Seychelles, Mauritius, Reunion, South Africa, Namibia, Cape Verde, Italy
Exclusive Savings
Inside
$13,174
Oceanview
$15,725
Balcony
-
Suite
-
From
US$13,174
Save 335
Per Person
View Trip
16 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

16 Days (15 Nights) Tampa to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 12 April 2026
Visit: USA, Bermuda, Portugal, Spain, Italy
Exclusive Savings
Inside
$883
Oceanview
$1,191
Balcony
$1,570
Suite
$4,651
From
US$883
Save 407
Per Person
View Trip
128 Day Navigate The World with Regent Seven Seas
Cruise

128 Days (127 Nights) Miami to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 11 January 2027
Visit: USA, Mexico, Belize, Honduras (+32 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama, El Salvador, Guatemala, French Polynesia, American Samoa, Samoa, Fiji, Vanuatu, New Caledonia, Australia, Indonesia, Singapore, Malaysia, Thailand, Sri Lanka, Maldives, India, Oman, United Arab Emirates, Qatar, Saudi Arabia, Egypt, Jordan, Israel, Cyprus, Greece, Turkey, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$211,173
Suite
-
From
US$211,173
Save 4,025
Per Person
View Trip
15 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 19 April 2027
Visit: USA, Bermuda, Portugal, Spain, Italy
Exclusive Savings
Inside
$1,363
Oceanview
$1,600
Balcony
$1,817
Suite
$4,914
From
US$1,363
Save 821
Per Person
View Trip
17 Day Transoceanic Salute with Oceania Cruises
Cruise

17 Days (16 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 14 April 2026
Visit: USA, Bahamas, Bermuda, Portugal, Spain, Italy
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,933
Suite
-
From
US$9,933
Save 265
Per Person
View Trip
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