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Cruises from Portugal to Italy

Are you looking for a cruise from Portugal to Italy? September is the most popular month to cruise between Portugal and Italy and there are 55 departures available from ten of the world's leading cruise lines.
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31 Cruises (55 Cruise Departures)
21 Day Solar Eclipse Collectors' Voyage: Spain & Italy with Holland America
Cruise
 (3)

21 Days (20 Nights) Lisbon to Rome
Cruise Line: Holland America
Ship: Oosterdam
Departure: 09 August 2026
Visit: Portugal, Spain, Corsica, Italy, Montenegro, Greece, Sicily
Have It All Fare Option
Inside
$3,339
Oceanview
$3,639
Balcony
$6,039
Suite
-
From
US$3,339
Per Person
View Trip
9 Day Mediterranean Sunrise with Oceania Cruises
Cruise
 (1)

9 Days (8 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 03 March 2027
Visit: Portugal, Spain, France, Italy
Memorial Day Sale
Your World Inclusions
Exclusive Savings
Inside
$2,340
Oceanview
$2,475
Balcony
$3,645
Suite
$5,040
From
US$2,340
Save 2,858
Per Person
View Trip
15 Day Spain, Portugal & the Mediterranean with Viking Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+7 more), Viking Libra, Viking Mira, Viking Neptune, Viking Saturn, Viking Sky, Viking Star, Viking Vela
Departures: Nov 2026 to Jun 2028
Visit: Portugal, Spain, Morocco, France, Monaco, Italy
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$5,598
Suite
$8,998
From
US$5,598
Save 600
Per Person
View Trip
11 Day Portrait Of Iberia with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 24 July 2026
Visit: Portugal, Spain, Gibraltar, Corsica, Italy
Memorial Day Sale
Your World Inclusions
Exclusive Savings
Inside
$2,695
Oceanview
$2,975
Balcony
$3,850
Suite
$5,250
From
US$2,695
Save 5,003
Per Person
View Trip
22 Day Spain & Italy Combination Cruise: Seville, Valencia & Florence with Azamara Cruises
Cruise
 (3)

22 Days (21 Nights) Lisbon to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 25 March 2028
Visit: Portugal, Spain, Morocco, Gibraltar, France, Monaco, Italy
Azamara Always Included
Inside
$5,019
Oceanview
$5,409
Balcony
$6,639
Suite
$9,299
From
US$5,019
Per Person
View Trip
11 Day A Journey Of Golden Evenings & Southern Shores with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 23 February 2027
Visit: Portugal, Spain, Morocco, Sardinia, Sicily, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$5,775
From
US$5,775
Per Person
View Trip
15 Day Atlantic To Adriatic Sea with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 11 June 2026
Visit: Portugal, Spain, Italy, Sicily, Malta, Montenegro, Croatia
Your World Inclusions
Exclusive Savings
Inside
$4,080
Oceanview
$4,480
Balcony
$6,480
Suite
$16,699
From
US$4,080
Save 6,118
Per Person
View Trip
15 Day Vibrant Cultural Tapestry with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 26 August 2027
Visit: Portugal, Spain, France, Sardinia, Tunisia, Sicily, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$4,199
Oceanview
$4,599
Balcony
$7,699
Suite
$10,199
From
US$4,199
Save 4,199
Per Person
View Trip
19 Day Mediterranean & North Africa Voyage: Portugal, Morocco & Italy with Azamara Cruises
Cruise
 (8)

19 Days (18 Nights) Lisbon to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 17 November 2026
Visit: Portugal, Morocco, Spain, Gibraltar, France, Italy
Azamara Always Included
Inside
$4,299
Oceanview
$4,559
Balcony
$5,489
Suite
$8,889
From
US$4,299
Per Person
View Trip
16 Day An Extended Journey To The Riviera For A New Year At Sea with Explora Journeys
Cruise
 (1)

16 Days (15 Nights) Lisbon to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 21 December 2026
Visit: Portugal, Gibraltar, Spain, France, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$9,230
From
US$9,230
Per Person
View Trip
18 Day European Artistry with Oceania Cruises
Cruise
 (1)

18 Days (17 Nights) Lisbon to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 24 July 2026
Visit: Portugal, Spain, Gibraltar, Corsica (+6 more), Italy, Sicily, Greece, Montenegro, Croatia, Slovenia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$6,349
Oceanview
-
Balcony
$9,249
Suite
$20,499
From
US$6,349
Save 6,349
Per Person
View Trip
11 Day Charming Mediterranean with Emerald Cruises
Cruise
 (3)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 30 April 2027
Visit: Portugal, Spain, Sardinia, Corsica, Italy
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
$8,392
Balcony
-
Suite
$11,182
From
US$8,392
Save 1,903
Per Person
View Trip
22 Day Adriatic & Mediterranean Discovery with Viking Cruises
Cruise
 (1)

22 Days (21 Nights) Lisbon to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Neptune (+2 more), Viking Sky, Viking Vela
Departures: Feb 2027 to Jun 2028
Visit: Portugal, Spain, Morocco, France (+4 more), Monaco, Italy, Sicily, Croatia
Viking $999 Air Deal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,197
Suite
$16,297
From
US$12,197
Save 550
Per Person
View Trip
15 Day Iberia & Italian Treasures with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 21 December 2026
Visit: Portugal, Spain, France, Italy, Corsica
Memorial Day Sale
Your World Inclusions
Exclusive Savings
Inside
$3,637
Oceanview
$3,862
Balcony
$5,775
Suite
$7,800
From
US$3,637
Save 6,061
Per Person
View Trip
11 Day Lisbon to Rome with Silversea
Cruise
 (1)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 14 June 2026
Visit: Portugal, Spain, France, Monaco, Italy
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,600
Suite
$13,600
From
US$8,600
Save 2,500
Per Person
View Trip
11 Day Lisbon to Civitavecchia (Rome) with Silversea
Cruise
 (1)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 06 April 2027
Visit: Portugal, Spain, France, Italy
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,200
Suite
$12,000
From
US$7,200
Save 2,500
Per Person
View Trip
14 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

14 Days (13 Nights) Funchal to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 30 March 2027
Visit: Portugal, Spain, Morocco, Italy
Inside
$1,432
Oceanview
$1,622
Balcony
$1,802
Suite
$2,914
From
US$1,432
Per Person
View Trip
18 Day Lisbon To Liguria with Regent Seven Seas
Cruise

18 Days (17 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 May 2027
Visit: Portugal, Spain, Morocco, France (+4 more), Monaco, Italy, Sicily, Sardinia
Inside
-
Oceanview
-
Balcony
$41,298
Suite
$43,898
From
US$41,298
Per Person
View Trip
23 Day Spanish Summer with Regent Seven Seas
Cruise

23 Days (22 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 11 August 2027
Visit: Portugal, Spain, Morocco, France (+4 more), Monaco, Italy, Corsica, Sardinia
Inside
-
Oceanview
-
Balcony
$47,198
Suite
$51,198
From
US$47,198
Per Person
View Trip
18 Day An Extended Journey Through Andalusian Energy, Catalan Creativity & Sicilian Flavours with Explora Journeys
Cruise

18 Days (17 Nights) Lisbon to Venice
Cruise Line: Explora Journeys
Ship: Explora IV
Departure: 14 October 2028
Visit: Portugal, Spain, Morocco, Malta (+4 more), Sicily, Italy, Montenegro, Slovenia
Inside
-
Oceanview
-
Balcony
-
Suite
$10,010
From
US$10,010
Per Person
View Trip
19 Day Timeless Shores with Regent Seven Seas
Cruise

19 Days (18 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 08 June 2027
Visit: Portugal, Spain, Morocco, Corsica, France, Italy, Sardinia
Inside
-
Oceanview
-
Balcony
$44,398
Suite
$44,798
From
US$44,398
Per Person
View Trip
15 Day Mediterranean with MSC Cruises
Cruise

15 Days (14 Nights) Lisbon to Rome
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 30 September 2027
Visit: Portugal, Spain, Sardinia, Italy, France, Morocco, Gibraltar
Inside
$2,282
Oceanview
$2,562
Balcony
$3,500
Suite
$3,808
From
US$2,282
Per Person
View Trip
11 Day Seville, Granada, Murcia And French Riviera with Seabourn
Cruise

11 Days (10 Nights) Lisbon to Genoa
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 08 April 2027
Visit: Portugal, Spain, France, Corsica, Italy
Inside
-
Oceanview
-
Balcony
$5,099
Suite
$9,009
From
US$5,099
Per Person
View Trip
13 Day Iberian & Italian Autumn with Oceania Cruises
Cruise

13 Days (12 Nights) Lisbon to Trieste
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 25 September 2027
Visit: Portugal, Spain, France, Italy, Sicily, Greece
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,099
Suite
$9,349
From
US$6,099
Save 6,099
Per Person
View Trip
11 Day Balearic Bliss with Oceania Cruises
Cruise

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 26 September 2027
Visit: Portugal, Spain, France, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,999
Suite
$6,799
From
US$3,999
Save 3,999
Per Person
View Trip
10 Day Lisbon to Civitavecchia (Rome) with Silversea
Cruise

10 Days (9 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 06 September 2027
Visit: Portugal, Spain, France, Italy
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$6,100
Balcony
$6,800
Suite
$6,300
From
US$6,100
Save 3,000
Per Person
View Trip
13 Day Lisbon to Civitavecchia (Rome) with Silversea
Cruise

13 Days (12 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 28 September 2027
Visit: Portugal, Spain, Gibraltar, Sardinia, Corsica, Italy
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$8,600
Balcony
$9,700
Suite
$19,500
From
US$8,600
Save 1,500
Per Person
View Trip
17 Day Hidden Gems Of Spain, Corsica & Sardinia with Seabourn
Cruise

17 Days (16 Nights) Lisbon to Rome
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 06 April 2028
Visit: Portugal, Spain, Morocco, France, Corsica, Sardinia, Italy
Inside
-
Oceanview
-
Balcony
$9,899
Suite
$16,649
From
US$9,899
Per Person
View Trip
15 Day Sublime Spain with Regent Seven Seas
Cruise

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 17 October 2027
Visit: Portugal, Spain, Morocco, France, Monaco, Italy, Corsica
Inside
-
Oceanview
-
Balcony
$29,998
Suite
$32,798
From
US$29,998
Per Person
View Trip
20 Day Woven By The Sea with Regent Seven Seas
Cruise

20 Days (19 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 17 March 2029
Visit: Portugal, Morocco, Spain, France (+4 more), Italy, Sardinia, Malta, Sicily
Inside
-
Oceanview
-
Balcony
$35,798
Suite
$40,598
From
US$35,798
Per Person
View Trip
Results: 1-30 of 31

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