Home > Cruises > Europe Cruises > Western Europe Cruises > Cruises from Portugal to Italy

Cruises from Portugal to Italy

Are you looking for a cruise from Portugal to Italy? September is the most popular month to cruise between Portugal and Italy and there are 48 departures available from nine of the world's leading cruise lines.
Filter Results
Departures
Show More...
Duration
9 Days
23 Days
Start & End Cities
Ship Size
Ship Features
Operators
Show More...
Price
$1,200pp
$48,898pp
Countries
Show More...
Filter Results
24 Cruises (48 Cruise Departures)
15 Day Atlantic To Adriatic Sea with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 11 June 2026
Visit: Portugal, Spain, Italy, Sicily, Malta, Montenegro, Croatia
Your World Inclusions
Exclusive Savings
Inside
$3,332
Oceanview
$3,570
Balcony
$5,776
Suite
$7,032
From
US$3,332
Save 6,366
Per Person
View Trip
12 Day Western Mediterranean: Spain, Malta & Italy with Holland America
Cruise
 (3)

12 Days (11 Nights) Lisbon to Rome
Cruise Line: Holland America
Ship: Oosterdam
Departure: 03 June 2026
Visit: Portugal, Spain, Morocco, Malta, Italy, Sicily
Fare Saver
Inside
$1,299
Oceanview
$1,499
Balcony
$1,999
Suite
$2,799
From
US$1,299
Per Person
View Trip
11 Day Charming Mediterranean with Emerald Cruises
Cruise
 (3)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 30 April 2027
Visit: Portugal, Spain, Sardinia, Corsica, Italy
Select Fare
Preferred Plus Fare + Air Credit
Exclusive Savings
Inside
-
Oceanview
$9,148
Balcony
-
Suite
$11,854
From
US$9,148
Save 1,147
Per Person
View Trip
19 Day Mediterranean & North Africa Voyage: Portugal, Morocco & Italy with Azamara Cruises
Cruise
 (8)

19 Days (18 Nights) Lisbon to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 17 November 2026
Visit: Portugal, Morocco, Spain, Gibraltar, France, Italy
Azamara Always Included
Exclusive Savings
Inside
$3,852
Oceanview
$4,240
Balcony
$5,191
Suite
$8,130
From
US$3,852
Save 67
Per Person
View Trip
15 Day Vibrant Cultural Tapestry with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 26 August 2027
Visit: Portugal, Spain, France, Sardinia, Tunisia, Sicily, Italy
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$4,110
Oceanview
$4,498
Balcony
$7,311
Suite
$9,930
From
US$4,110
Save 4,288
Per Person
View Trip
11 Day Lisbon to Rome with Silversea
Cruise
 (1)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 14 June 2026
Visit: Portugal, Spain, France, Monaco, Italy
Last Minute Fare
All-Inclusive Plus Fare
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$6,950
Suite
$14,000
From
US$6,950
Per Person
View Trip
9 Day Mediterranean Sunrise with Oceania Cruises
Cruise
 (1)

9 Days (8 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 03 March 2027
Visit: Portugal, Spain, France, Italy
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$1,920
Oceanview
$2,120
Balcony
$3,431
Suite
$4,740
From
US$1,920
Save 2,878
Per Person
View Trip
22 Day Adriatic & Mediterranean Discovery with Viking Cruises
Cruise
 (1)

22 Days (21 Nights) Lisbon to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Neptune (+2 more), Viking Sky, Viking Vela
Departures: Feb 2027 to Jun 2028
Visit: Portugal, Spain, Morocco, France (+4 more), Monaco, Italy, Sicily, Croatia
Viking $999 Air Deal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,897
Suite
$15,797
From
US$11,897
Save 850
Per Person
View Trip
11 Day Portrait Of Iberia with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 24 July 2026
Visit: Portugal, Spain, Gibraltar, Corsica, Italy
Your World Inclusions
Exclusive Savings
Inside
$2,307
Oceanview
$2,470
Balcony
$3,692
Suite
$4,982
From
US$2,307
Save 4,791
Per Person
View Trip
14 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

14 Days (13 Nights) Funchal to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 30 March 2027
Visit: Portugal, Spain, Morocco, Italy
Inside
$1,434
Oceanview
$1,614
Balcony
$1,744
Suite
$2,838
From
US$1,434
Per Person
View Trip
15 Day Iberia & Italian Treasures with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 21 December 2026
Visit: Portugal, Spain, France, Italy, Corsica
Your World Inclusions
Exclusive Savings
Inside
$2,869
Oceanview
$3,152
Balcony
$5,415
Suite
$7,307
From
US$2,869
Save 6,129
Per Person
View Trip
15 Day Spain, Portugal & the Mediterranean with Viking Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+7 more), Viking Libra, Viking Mira, Viking Neptune, Viking Saturn, Viking Sky, Viking Star, Viking Vela
Departures: Nov 2026 to Jun 2028
Visit: Portugal, Spain, Morocco, France, Monaco, Italy
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$5,598
Suite
$8,998
From
US$5,598
Save 1,000
Per Person
View Trip
13 Day Iconic Cathedrals & Castles with Oceania Cruises
Cruise
 (1)

13 Days (12 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 17 July 2027
Visit: Portugal, Spain, France, Monaco, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,864
Oceanview
$4,155
Balcony
$6,531
Suite
$8,956
From
US$3,864
Save 4,034
Per Person
View Trip
18 Day Lisbon To Liguria with Regent Seven Seas
Cruise

18 Days (17 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 May 2027
Visit: Portugal, Spain, Morocco, France (+4 more), Monaco, Italy, Sicily, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$18,854
Suite
$20,324
From
US$18,854
Save 19,544
Per Person
View Trip
18 Day European Artistry with Oceania Cruises
Cruise
 (1)

18 Days (17 Nights) Lisbon to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 24 July 2026
Visit: Portugal, Spain, Gibraltar, Corsica (+6 more), Italy, Sicily, Greece, Montenegro, Croatia, Slovenia
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$5,863
Oceanview
-
Balcony
$8,919
Suite
$11,780
From
US$5,863
Save 6,135
Per Person
View Trip
11 Day Lisbon to Civitavecchia (Rome) with Silversea
Cruise
 (1)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 06 April 2027
Visit: Portugal, Spain, France, Italy
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$8,800
Suite
$13,600
From
US$8,800
Per Person
View Trip
13 Day Lisbon to Civitavecchia (Rome) with Silversea
Cruise

13 Days (12 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 28 September 2027
Visit: Portugal, Spain, Gibraltar, Sardinia, Corsica, Italy
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$8,400
Balcony
$9,500
Suite
$19,500
From
US$8,400
Save 1,500
Per Person
View Trip
15 Day Iberian Wanderlust & Sicilian Dream with Regent Seven Seas
Cruise

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 27 September 2027
Visit: Portugal, Spain, Morocco, Tunisia (+4 more), Sicily, Malta, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,190
Suite
$15,807
From
US$14,190
Save 14,708
Per Person
View Trip
11 Day Balearic Bliss with Oceania Cruises
Cruise

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 26 September 2027
Visit: Portugal, Spain, France, Italy
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,910
Suite
$6,432
From
US$3,910
Save 4,088
Per Person
View Trip
19 Day Timeless Shores with Regent Seven Seas
Cruise

19 Days (18 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 08 June 2027
Visit: Portugal, Spain, Morocco, Corsica, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$20,764
Suite
$21,205
From
US$20,764
Save 21,534
Per Person
View Trip
23 Day Spanish Summer with Regent Seven Seas
Cruise

23 Days (22 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 11 August 2027
Visit: Portugal, Spain, Morocco, France (+4 more), Monaco, Italy, Corsica, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$24,006
Suite
$26,505
From
US$24,006
Save 24,892
Per Person
View Trip
11 Day Seville, Granada, Murcia And French Riviera with Seabourn
Cruise

11 Days (10 Nights) Lisbon to Genoa
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 08 April 2027
Visit: Portugal, Spain, France, Corsica, Italy
Yours to Explore
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,368
Suite
$10,798
From
US$7,368
Save 131
Per Person
View Trip
10 Day Lisbon to Civitavecchia (Rome) with Silversea
Cruise

10 Days (9 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 06 September 2027
Visit: Portugal, Spain, France, Italy
All-Inclusive Fare
Inside
-
Oceanview
$8,700
Balcony
$9,200
Suite
$8,900
From
US$8,700
Per Person
View Trip
13 Day Iberian & Italian Autumn with Oceania Cruises
Cruise

13 Days (12 Nights) Lisbon to Trieste
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 25 September 2027
Visit: Portugal, Spain, France, Italy, Sicily, Greece
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,953
Suite
$9,105
From
US$5,953
Save 6,245
Per Person
View Trip
Results: 24 results

No trips found. Try adjusting the search filters.




Cruises found! Scroll up to view.

Europe Cruises

All Europe Cruises Adriatic Cruises Aegean Cruises Baltic Cruises Croatia Cruises Med Cruises Greek Islands Cruises UK Cruises Western Europe Cruises

Travel Styles

Festivals & Events Luxury Cruises

Countries

Cape Verde England France Germany Gibraltar Guernsey Italy Malta Morocco Portugal Puerto Rico Senegal Spain USA

Cities

Cruises from Funchal Cruises from Lisbon

Routes

Cruises from Lisbon to Rome

Country Routes

Cruises from Portugal to Italy

Cruise Lines Exploring Europe

APT Europe Cruises Azamara Europe Cruises Celebrity Europe Cruises Cunard Europe Cruises Emerald Europe Cruises G Adventures Europe Cruises Intrepid Europe Cruises MSC Europe Cruises NCL Europe Cruises Oceania Europe Cruises Ponant Europe Cruises Princess Europe Cruises Regent Seven Seas Europe Cruises Royal Caribbean Europe Cruises Scenic Europe Cruises Silversea Europe Cruises Viking Europe Cruises Virgin Voyages Europe Cruises

Western Europe Tours

France Tours Morocco Tours Portugal Tours Provence Tours Spain & Portugal Tours Spain Tours Western Europe Tours

© 2010-2026. Global Journeys. You're viewing our site in US dollars.

    

Global Journeys | Terms & Conditions

Global Journeys Travel Inc. is a Member of the American Society of Travel Advisors (ASTA No: 900374670), CLIA (No. 00046729) & is TICO Accredited (No. 50027921).

Travel Industry Associations