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Cruises from Portugal to Italy

Are you looking for a cruise from Portugal to Italy? October and June are the most popular months to cruise between Portugal and Italy and there are 27 departures available from eight of the world's leading cruise lines.
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6 Days
22 Days
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17 Cruises (27 Cruise Departures)
19 Day Mediterranean & North Africa Voyage: Portugal, Morocco & Italy with Azamara Cruises
Cruise
 (3)

19 Days (18 Nights) Lisbon to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 17 November 2026
Countries Visited: Portugal, Morocco, Spain, Gibraltar (+2 more), France, Italy
INSIDE
$4,659
OCEANVIEW
$4,999
BALCONY
$6,359
SUITE
$9,459
From (per person) 4,659
View Trip
15 Day Lisbon to Civitavecchia with Silversea
Cruise

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 25 October 2026
Countries Visited: Portugal, Spain, Gibraltar, Sardinia (+3 more), Tunisia, Sicily, Italy
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$6,400
BALCONY
$7,700
SUITE
$12,000
From (per person) 6,400
View Trip
11 Day Lisbon to Rome with Silversea
Cruise

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 14 June 2026
Countries Visited: Portugal, Spain, France, Monaco (+1 more), Italy
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$10,700
From (per person) 10,700
View Trip
11 Day Lisbon to Rome with Silversea
Cruise

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Muse
Departure: 04 January 2026
Countries Visited: Portugal, Morocco, Spain, France (+1 more), Italy
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$6,900
BALCONY
$7,500
SUITE
$14,100
From (per person) 6,900
View Trip
18 Day European Artistry with Oceania Cruises
Cruise
 (1)

18 Days (17 Nights) Lisbon to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 24 July 2026
Countries Visited: Portugal, Spain, Gibraltar, Corsica (+6 more), Italy, Sicily, Greece, Montenegro, Croatia, Slovenia
Exclusive Deal
INSIDE
$5,399
OCEANVIEW
$5,899
BALCONY
$8,799
SUITE
$11,999
Save (per person) 5,399
From (per person) 5,399
View Trip
11 Day Portrait Of Iberia with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 24 July 2026
Countries Visited: Portugal, Spain, Gibraltar, Corsica (+1 more), Italy
Exclusive Deal
INSIDE
$3,299
OCEANVIEW
$3,649
BALCONY
$5,499
SUITE
$7,499
Save (per person) 3,299
From (per person) 3,299
View Trip
13 Day Moorish Majesty with Oceania Cruises
Cruise
 (1)

13 Days (12 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 17 October 2025
Countries Visited: Portugal, Spain, Morocco, Tunisia (+4 more), Malta, Greece, Sicily, Italy
Fleetwide SaleExclusive Deal
INSIDE
$3,799
OCEANVIEW
$4,099
BALCONY
$6,399
SUITE
$8,399
Save (per person) 3,799
From (per person) 3,799
View Trip
15 Day Flamenco Fascination with Oceania Cruises
Cruise
 (3)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 04 October 2025
Countries Visited: Portugal, Morocco, Spain, France (+1 more), Italy
Fleetwide SaleExclusive Deal
INSIDE
$4,099
OCEANVIEW
$4,499
BALCONY
$6,999
SUITE
$9,399
Save (per person) 4,099
From (per person) 4,099
View Trip
15 Day Spain, Portugal & the Mediterranean with Viking Cruises
Cruise

15 Days (14 Nights) Lisbon to Rome
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mira (+2 more), Viking Neptune, Viking Saturn
Departures: Oct 2026 to Sep 2027
Countries Visited: Portugal, Spain, Morocco, France (+2 more), Monaco, Italy
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$6,198
SUITE
$9,198
Save (per person) 200
From (per person) 6,198
View Trip
15 Day Atlantic To Adriatic Sea with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 11 June 2026
Countries Visited: Portugal, Spain, Italy, Sicily (+3 more), Malta, Montenegro, Croatia
Exclusive Deal
INSIDE
$4,599
OCEANVIEW
$4,999
BALCONY
$7,499
SUITE
$10,299
Save (per person) 4,599
From (per person) 4,599
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (1)

6 Days (5 Nights) Lisbon to Genoa
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 28 October 2025
Countries Visited: Portugal, Spain, Sardinia, Italy
One Way Cruise Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$659
SUITE
-
From (per person) 659
View Trip
15 Day Iberia & Italian Treasures with Oceania Cruises
Cruise
 (3)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 21 December 2026
Countries Visited: Portugal, Spain, France, Italy (+1 more), Corsica
Exclusive Deal
INSIDE
$4,299
OCEANVIEW
$4,699
BALCONY
$7,199
SUITE
$9,999
Save (per person) 4,299
From (per person) 4,299
View Trip
12 Day Western Mediterranean: Spain, Malta & Italy with Holland America
Cruise
 (2)

12 Days (11 Nights) Lisbon to Rome
Cruise Line: Holland America
Ship: Oosterdam
Departure: 03 June 2026
Countries Visited: Portugal, Spain, Morocco, Malta (+2 more), Sicily, Italy
Exclusive Deal
INSIDE
$1,874
OCEANVIEW
$2,174
BALCONY
$2,724
SUITE
$3,824
From (per person) 1,874
View Trip
9 Day Mediterranean Sunrise with Oceania Cruises
Cruise
 (3)

9 Days (8 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 03 March 2027
Countries Visited: Portugal, Spain, France, Italy
Exclusive Deal
INSIDE
$2,399
OCEANVIEW
$2,649
BALCONY
$3,899
SUITE
$5,399
Save (per person) 2,399
From (per person) 2,399
View Trip
22 Day Adriatic & Mediterranean Discovery with Viking Cruises
Cruise

22 Days (21 Nights) Lisbon to Venice
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mira, Viking Neptune
Departures: Oct 2026 to Jun 2027
Countries Visited: Portugal, Spain, Morocco, France (+4 more), Monaco, Italy, Sicily, Croatia
Viking $999 Air DealViking $1,499 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,297
SUITE
$16,197
From (per person) 10,297
View Trip
11 Day Mediterranean Cruise From Lisbon To Rome with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sky
Departure: 02 September 2025
Countries Visited: Portugal, Spain, Gibraltar, France (+1 more), Italy
INSIDE
$1,361
OCEANVIEW
$1,860
BALCONY
$3,541
SUITE
$4,531
From (per person) 1,361
View Trip
11 Day Spain's Southern Coast & Riviera Gems with Seabourn
Cruise

11 Days (10 Nights) Lisbon to Genoa
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 10 May 2026
Countries Visited: Portugal, Gibraltar, Spain, France (+1 more), Italy
A Sail To Remember
INSIDE
-
OCEANVIEW
$5,354
BALCONY
$6,204
SUITE
$11,049
From (per person) 5,354
View Trip
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