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Cruises from Portugal to Italy

Are you looking for a cruise from Portugal to Italy? September is the most popular month to cruise between Portugal and Italy and there are 59 departures available from nine of the world's leading cruise lines.
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35 Cruises (59 Cruise Departures)
15 Day Iberia & Italian Treasures with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 21 December 2026
Visit: Portugal, Spain, France, Italy, Corsica
Your World Inclusions
Exclusive Savings
Inside
$3,904
Oceanview
$4,154
Balcony
$6,185
Suite
$8,711
From
A$3,904
Save 4,706
Per Person
View Trip
16 Day An Extended Journey To The Riviera For A New Year At Sea with Explora Journeys
Cruise
 (1)

16 Days (15 Nights) Lisbon to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 21 December 2026
Visit: Portugal, Gibraltar, Spain, France, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$15,469
From
A$15,469
Save 316
Per Person
View Trip
9 Day Mediterranean Sunrise with Oceania Cruises
Cruise
 (1)

9 Days (8 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 03 March 2027
Visit: Portugal, Spain, France, Italy
Your World Inclusions
Exclusive Savings
Inside
$2,285
Oceanview
$2,418
Balcony
$3,546
Suite
$4,895
From
A$2,285
Save 3,275
Per Person
View Trip
22 Day Spain & Italy Combination Cruise: Seville, Valencia & Florence with Azamara Cruises
Cruise
 (4)

22 Days (21 Nights) Lisbon to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 25 March 2028
Visit: Portugal, Spain, Morocco, Gibraltar, France, Monaco, Italy
Azamara Always Included
Exclusive Savings
Inside
$7,230
Oceanview
$7,788
Balcony
$9,552
Suite
$13,374
From
A$7,230
Per Person
View Trip
15 Day Spain, Portugal & the Mediterranean with Viking Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+7 more), Viking Libra, Viking Mira, Viking Neptune, Viking Saturn, Viking Sky, Viking Star, Viking Vela
Departures: Nov 2026 to Jun 2028
Visit: Portugal, Spain, Morocco, France, Monaco, Italy
Viking Savings Event
Bonus Shipboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,394
Suite
$11,804
From
A$7,394
Save 1,563
Per Person
View Trip
11 Day A Journey Of Golden Evenings & Southern Shores with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 23 February 2027
Visit: Portugal, Spain, Morocco, Sardinia, Sicily, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$9,001
From
A$9,001
Save 184
Per Person
View Trip
19 Day Mediterranean & North Africa Voyage: Portugal, Morocco & Italy with Azamara Cruises
Cruise
 (8)

19 Days (18 Nights) Lisbon to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 17 November 2026
Visit: Portugal, Morocco, Spain, Gibraltar, France, Italy
Azamara Always Included
Exclusive Savings
Inside
$9,601
Oceanview
$10,170
Balcony
$12,561
Suite
$17,010
From
A$9,601
Save 148
Per Person
View Trip
18 Day European Artistry with Oceania Cruises
Cruise
 (1)

18 Days (17 Nights) Lisbon to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 24 July 2026
Visit: Portugal, Spain, Gibraltar, Corsica (+6 more), Italy, Sicily, Greece, Montenegro, Croatia, Slovenia
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,589
Suite
$27,809
From
A$12,589
Save 2,311
Per Person
View Trip
22 Day Adriatic & Mediterranean Discovery with Viking Cruises
Cruise
 (1)

22 Days (21 Nights) Lisbon to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Neptune (+2 more), Viking Sky, Viking Vela
Departures: Feb 2027 to Jun 2028
Visit: Portugal, Spain, Morocco, France (+4 more), Monaco, Italy, Sicily, Croatia
Viking Savings Event
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,724
Suite
$24,152
From
A$15,724
Save 1,711
Per Person
View Trip
11 Day Lisbon to Civitavecchia (Rome) with Silversea
Cruise
 (1)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 06 April 2027
Visit: Portugal, Spain, France, Italy
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,408
Suite
$19,502
From
A$9,408
Save 6,592
Per Person
View Trip
15 Day Vibrant Cultural Tapestry with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 26 August 2027
Visit: Portugal, Spain, France, Sardinia, Tunisia, Sicily, Italy
Your World Inclusions
Exclusive Savings
Inside
$5,899
Oceanview
$6,452
Balcony
$10,759
Suite
$14,241
From
A$5,899
Save 2,121
Per Person
View Trip
11 Day Charming Mediterranean with Emerald Cruises
Cruise
 (3)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 30 April 2027
Visit: Portugal, Spain, Sardinia, Corsica, Italy
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$16,792
From
A$16,792
Save 2,803
Per Person
View Trip
11 Day Portrait Of Iberia with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 24 July 2026
Visit: Portugal, Spain, Gibraltar, Corsica, Italy
Your World Inclusions
Exclusive Savings
Inside
$3,354
Oceanview
$3,707
Balcony
$4,784
Suite
$6,481
From
A$3,354
Save 3,896
Per Person
View Trip
14 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

14 Days (13 Nights) Funchal to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 30 March 2027
Visit: Portugal, Spain, Morocco, Italy
Exclusive Savings
Inside
$2,198
Oceanview
$2,525
Balcony
$2,812
Suite
$4,624
From
A$2,198
Per Person
View Trip
25 Day Atlantic Sun & Latin Shores with Oceania Cruises
Cruise

25 Days (24 Nights) Lisbon to Trieste
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 27 December 2028
Visit: Portugal, Spain, Morocco, Sardinia (+5 more), Italy, Sicily, Tunisia, Malta, Croatia
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,258
Suite
$19,377
From
A$11,258
Save 2,322
Per Person
View Trip
23 Day Spanish Summer with Regent Seven Seas
Cruise

23 Days (22 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 11 August 2027
Visit: Portugal, Spain, Morocco, France (+4 more), Monaco, Italy, Corsica, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$31,727
Suite
$34,088
From
A$31,727
Save 2,573
Per Person
View Trip
15 Day Atlantic Isles To Italy with Oceania Cruises
Cruise

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 27 December 2028
Visit: Portugal, Spain, Morocco, Sardinia, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,188
Suite
$12,329
From
A$7,188
Save 2,212
Per Person
View Trip
17 Day Hidden Gems Of Spain, Corsica & Sardinia with Seabourn
Cruise

17 Days (16 Nights) Lisbon to Rome
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 06 April 2028
Visit: Portugal, Spain, Morocco, France, Corsica, Sardinia, Italy
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,616
Suite
$22,877
From
A$13,616
Save 243
Per Person
View Trip
19 Day Timeless Shores with Regent Seven Seas
Cruise

19 Days (18 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 08 June 2027
Visit: Portugal, Spain, Morocco, Corsica, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$32,321
Suite
$32,586
From
A$32,321
Save 2,599
Per Person
View Trip
18 Day Lisbon To Liguria with Regent Seven Seas
Cruise

18 Days (17 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 May 2027
Visit: Portugal, Spain, Morocco, France (+4 more), Monaco, Italy, Sicily, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$30,813
Suite
$32,695
From
A$30,813
Save 2,567
Per Person
View Trip
23 Day Balkan & Balearic Bliss with Oceania Cruises
Cruise

23 Days (22 Nights) Lisbon to Trieste
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 26 February 2029
Visit: Portugal, Spain, Gibraltar, Sardinia (+9 more), Sicily, Tunisia, Malta, Greece, Turkey, Montenegro, Croatia, Slovenia, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,000
Suite
$18,576
From
A$11,000
Save 2,300
Per Person
View Trip
15 Day Sublime Spain with Regent Seven Seas
Cruise

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 17 October 2027
Visit: Portugal, Spain, Morocco, France, Monaco, Italy, Corsica
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$19,843
Suite
$23,136
From
A$19,843
Save 2,357
Per Person
View Trip
21 Day Sea Of Stories with Regent Seven Seas
Cruise

21 Days (20 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Explorer
Departure: 16 August 2028
Visit: Portugal, Spain, Morocco, Sardinia (+4 more), Corsica, France, Monaco, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$34,263
Suite
$37,203
From
A$34,263
Save 2,637
Per Person
View Trip
10 Day Lisbon to Civitavecchia (Rome) with Silversea
Cruise

10 Days (9 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 06 September 2027
Visit: Portugal, Spain, France, Italy
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$8,232
Balcony
$9,055
Suite
$8,820
From
A$8,232
Save 5,768
Per Person
View Trip
18 Day An Extended Journey Through Andalusian Energy, Catalan Creativity & Sicilian Flavours with Explora Journeys
Cruise

18 Days (17 Nights) Lisbon to Venice
Cruise Line: Explora Journeys
Ship: Explora IV
Departure: 14 October 2028
Visit: Portugal, Spain, Morocco, Malta (+4 more), Sicily, Italy, Montenegro, Slovenia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$15,067
From
A$15,067
Save 308
Per Person
View Trip
15 Day Iberian Wanderlust & Sicilian Dream with Regent Seven Seas
Cruise

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 27 September 2027
Visit: Portugal, Spain, Morocco, Tunisia (+4 more), Sicily, Malta, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$20,382
Suite
$22,420
From
A$20,382
Save 2,368
Per Person
View Trip
11 Day Iberian & Italian Ballads with Oceania Cruises
Cruise

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 06 August 2028
Visit: Portugal, Spain, Gibraltar, Corsica, Sardinia, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,381
Suite
$10,232
From
A$6,381
Save 2,179
Per Person
View Trip
11 Day Balearic Bliss with Oceania Cruises
Cruise

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 26 September 2027
Visit: Portugal, Spain, France, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,383
Suite
$9,127
From
A$5,383
Save 2,117
Per Person
View Trip
20 Day Woven By The Sea with Regent Seven Seas
Cruise

20 Days (19 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 17 March 2029
Visit: Portugal, Morocco, Spain, France (+4 more), Italy, Sardinia, Malta, Sicily
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$25,173
Suite
$28,535
From
A$25,173
Save 2,447
Per Person
View Trip
16 Day Serenity Awaits with Regent Seven Seas
Cruise

16 Days (15 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 21 September 2028
Visit: Portugal, Spain, Morocco, France, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$22,043
Suite
$25,542
From
A$22,043
Save 2,397
Per Person
View Trip
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