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Cruises from Portugal to Italy

Are you looking for a cruise from Portugal to Italy? September is the most popular month to cruise between Portugal and Italy and there are 53 departures available from ten of the world's leading cruise lines.
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29 Cruises (53 Cruise Departures)
15 Day Iberia & Italian Treasures with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 21 December 2026
Visit: Portugal, Spain, France, Italy, Corsica
Your World Inclusions
Exclusive Savings
Inside
$3,375
Oceanview
$3,712
Balcony
$5,550
Suite
$7,500
From
US$3,375
Save 5,623
Per Person
View Trip
18 Day European Artistry with Oceania Cruises
Cruise
 (1)

18 Days (17 Nights) Lisbon to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 24 July 2026
Visit: Portugal, Spain, Gibraltar, Corsica (+6 more), Italy, Sicily, Greece, Montenegro, Croatia, Slovenia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$6,199
Oceanview
-
Balcony
$9,049
Suite
$11,799
From
US$6,199
Save 6,199
Per Person
View Trip
15 Day Atlantic To Adriatic Sea with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 11 June 2026
Visit: Portugal, Spain, Italy, Sicily, Malta, Montenegro, Croatia
Your World Inclusions
Exclusive Savings
Inside
$3,465
Oceanview
$3,640
Balcony
$5,915
Suite
$7,420
From
US$3,465
Save 6,433
Per Person
View Trip
11 Day Lisbon to Civitavecchia (Rome) with Silversea
Cruise
 (1)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 06 April 2027
Visit: Portugal, Spain, France, Italy
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,900
Suite
$11,700
From
US$6,900
Save 2,500
Per Person
View Trip
19 Day Mediterranean & North Africa Voyage: Portugal, Morocco & Italy with Azamara Cruises
Cruise
 (8)

19 Days (18 Nights) Lisbon to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 17 November 2026
Visit: Portugal, Morocco, Spain, Gibraltar, France, Italy
Azamara Always Included
Inside
$4,209
Oceanview
$4,699
Balcony
$5,649
Suite
$9,119
From
US$4,209
Per Person
View Trip
13 Day Iconic Cathedrals & Castles with Oceania Cruises
Cruise
 (1)

13 Days (12 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 17 July 2027
Visit: Portugal, Spain, France, Monaco, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,949
Oceanview
$4,249
Balcony
$6,699
Suite
$9,199
From
US$3,949
Save 3,949
Per Person
View Trip
21 Day Solar Eclipse Collectors' Voyage: Spain & Italy with Holland America
Cruise
 (3)

21 Days (20 Nights) Lisbon to Rome
Cruise Line: Holland America
Ship: Oosterdam
Departure: 09 August 2026
Visit: Portugal, Spain, Corsica, Italy, Montenegro, Greece, Sicily
Fare Saver
Inside
$3,639
Oceanview
$3,889
Balcony
$6,689
Suite
$8,139
From
US$3,639
Per Person
View Trip
9 Day Mediterranean Sunrise with Oceania Cruises
Cruise
 (1)

9 Days (8 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 03 March 2027
Visit: Portugal, Spain, France, Italy
Your World Inclusions
Exclusive Savings
Inside
$2,160
Oceanview
$2,385
Balcony
$3,510
Suite
$4,860
From
US$2,160
Save 2,638
Per Person
View Trip
11 Day Balearic Bliss with Oceania Cruises
Cruise

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 26 September 2027
Visit: Portugal, Spain, France, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,999
Suite
$6,799
From
US$3,999
Save 3,999
Per Person
View Trip
22 Day Adriatic & Mediterranean Discovery with Viking Cruises
Cruise
 (1)

22 Days (21 Nights) Lisbon to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Neptune (+2 more), Viking Sky, Viking Vela
Departures: Feb 2027 to Jun 2028
Visit: Portugal, Spain, Morocco, France (+4 more), Monaco, Italy, Sicily, Croatia
Viking $999 Air Deal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,897
Suite
$15,797
From
US$11,897
Save 850
Per Person
View Trip
15 Day Vibrant Cultural Tapestry with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 26 August 2027
Visit: Portugal, Spain, France, Sardinia, Tunisia, Sicily, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$4,199
Oceanview
$4,599
Balcony
$7,699
Suite
$10,199
From
US$4,199
Save 4,199
Per Person
View Trip
11 Day Portrait Of Iberia with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 24 July 2026
Visit: Portugal, Spain, Gibraltar, Corsica, Italy
Your World Inclusions
Exclusive Savings
Inside
$2,520
Oceanview
$2,730
Balcony
$3,710
Suite
$4,970
From
US$2,520
Save 4,678
Per Person
View Trip
19 Day Timeless Shores with Regent Seven Seas
Cruise

19 Days (18 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 08 June 2027
Visit: Portugal, Spain, Morocco, Corsica, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$21,149
Suite
$21,749
From
US$21,149
Save 21,149
Per Person
View Trip
15 Day Spain, Portugal & the Mediterranean with Viking Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+7 more), Viking Libra, Viking Mira, Viking Neptune, Viking Saturn, Viking Sky, Viking Star, Viking Vela
Departures: Nov 2026 to Jun 2028
Visit: Portugal, Spain, Morocco, France, Monaco, Italy
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$5,598
Suite
$8,998
From
US$5,598
Save 800
Per Person
View Trip
11 Day Lisbon to Rome with Silversea
Cruise
 (1)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 14 June 2026
Visit: Portugal, Spain, France, Monaco, Italy
Last Minute Fare
All-Inclusive Plus Fare
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$6,950
Suite
$13,800
From
US$6,950
Per Person
View Trip
18 Day Lisbon To Liguria with Regent Seven Seas
Cruise

18 Days (17 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 May 2027
Visit: Portugal, Spain, Morocco, France (+4 more), Monaco, Italy, Sicily, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$19,649
Suite
$21,199
From
US$19,649
Save 19,649
Per Person
View Trip
11 Day Charming Mediterranean with Emerald Cruises
Cruise
 (3)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 30 April 2027
Visit: Portugal, Spain, Sardinia, Corsica, Italy
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
$8,392
Balcony
-
Suite
$11,182
From
US$8,392
Save 1,903
Per Person
View Trip
14 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

14 Days (13 Nights) Funchal to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 30 March 2027
Visit: Portugal, Spain, Morocco, Italy
Inside
$1,492
Oceanview
$1,672
Balcony
$1,852
Suite
$2,914
From
US$1,492
Per Person
View Trip
13 Day Iberian & Italian Autumn with Oceania Cruises
Cruise

13 Days (12 Nights) Lisbon to Trieste
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 25 September 2027
Visit: Portugal, Spain, France, Italy, Sicily, Greece
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,099
Suite
$9,349
From
US$6,099
Save 6,099
Per Person
View Trip
11 Day Spain's Southern Coast & Riviera Gems with Seabourn
Cruise
 (1)

11 Days (10 Nights) Lisbon to Genoa
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 10 May 2026
Visit: Portugal, Gibraltar, Spain, France, Italy
Yours to Explore
Inside
-
Oceanview
$7,099
Balcony
$8,999
Suite
$13,999
From
US$7,099
Per Person
View Trip
15 Day Mediterranean with MSC Cruises
Cruise

15 Days (14 Nights) Lisbon to Rome
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 30 September 2027
Visit: Portugal, Spain, Sardinia, Italy, France, Morocco, Gibraltar
Inside
$2,282
Oceanview
$2,562
Balcony
$3,500
Suite
$3,808
From
US$2,282
Per Person
View Trip
11 Day A Journey Of Golden Evenings & Southern Shores with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 23 February 2027
Visit: Portugal, Spain, Morocco, Sardinia, Sicily, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$5,775
From
US$5,775
Per Person
View Trip
10 Day Lisbon to Civitavecchia (Rome) with Silversea
Cruise

10 Days (9 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 06 September 2027
Visit: Portugal, Spain, France, Italy
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$6,600
Balcony
$7,100
Suite
$6,800
From
US$6,600
Save 2,500
Per Person
View Trip
17 Day Hidden Gems Of Spain, Corsica & Sardinia with Seabourn
Cruise

17 Days (16 Nights) Lisbon to Rome
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 06 April 2028
Visit: Portugal, Spain, Morocco, France, Corsica, Sardinia, Italy
Inside
-
Oceanview
-
Balcony
$10,599
Suite
$16,699
From
US$10,599
Per Person
View Trip
15 Day Sublime Spain with Regent Seven Seas
Cruise

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 17 October 2027
Visit: Portugal, Spain, Morocco, France, Monaco, Italy, Corsica
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,999
Suite
$16,399
From
US$14,999
Save 14,999
Per Person
View Trip
11 Day Seville, Granada, Murcia And French Riviera with Seabourn
Cruise

11 Days (10 Nights) Lisbon to Genoa
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 08 April 2027
Visit: Portugal, Spain, France, Corsica, Italy
Yours to Explore
Inside
-
Oceanview
-
Balcony
$6,999
Suite
$10,999
From
US$6,999
Per Person
View Trip
13 Day Lisbon to Civitavecchia (Rome) with Silversea
Cruise

13 Days (12 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 28 September 2027
Visit: Portugal, Spain, Gibraltar, Sardinia, Corsica, Italy
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$8,400
Balcony
$9,500
Suite
$19,500
From
US$8,400
Save 1,500
Per Person
View Trip
15 Day Iberian Wanderlust & Sicilian Dream with Regent Seven Seas
Cruise

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 27 September 2027
Visit: Portugal, Spain, Morocco, Tunisia (+4 more), Sicily, Malta, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,999
Suite
$16,549
From
US$14,999
Save 14,999
Per Person
View Trip
23 Day Spanish Summer with Regent Seven Seas
Cruise

23 Days (22 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 11 August 2027
Visit: Portugal, Spain, Morocco, France (+4 more), Monaco, Italy, Corsica, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$24,449
Suite
$26,349
From
US$24,449
Save 24,449
Per Person
View Trip
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