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Cruises from Portugal to Italy

Are you looking for a cruise from Portugal to Italy? September is the most popular month to cruise between Portugal and Italy and there are 51 departures available from nine of the world's leading cruise lines.
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23 Days
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27 Cruises (51 Cruise Departures)
15 Day Lisbon to Civitavecchia with Silversea
Cruise

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 25 October 2026
Visit: Portugal, Spain, Gibraltar, Sardinia, Tunisia, Sicily, Italy
All-Inclusive Fare
Inside
-
Oceanview
$8,000
Balcony
$9,100
Suite
$16,000
From
US$8,000
Per Person
View Trip
15 Day Vibrant Cultural Tapestry with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 26 August 2027
Visit: Portugal, Spain, France, Sardinia, Tunisia, Sicily, Italy
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$4,110
Oceanview
$4,498
Balcony
$7,117
Suite
$10,124
From
US$4,110
Save 4,288
Per Person
View Trip
18 Day European Artistry with Oceania Cruises
Cruise
 (1)

18 Days (17 Nights) Lisbon to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 24 July 2026
Visit: Portugal, Spain, Gibraltar, Corsica (+6 more), Italy, Sicily, Greece, Montenegro, Croatia, Slovenia
Your World Inclusions
Exclusive Savings
Inside
$5,475
Oceanview
$10,713
Balcony
$8,773
Suite
$12,071
From
US$5,475
Save 5,723
Per Person
View Trip
10 Day Lisbon to Civitavecchia (Rome) with Silversea
Cruise

10 Days (9 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 06 September 2027
Visit: Portugal, Spain, France, Italy
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$6,240
Balcony
$6,720
Suite
$6,400
From
US$6,240
Save 1,560
Per Person
View Trip
9 Day Mediterranean Sunrise with Oceania Cruises
Cruise
 (3)

9 Days (8 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 03 March 2027
Visit: Portugal, Spain, France, Italy
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$2,399
Oceanview
$2,595
Balcony
$3,808
Suite
$5,263
From
US$2,399
Save 2,399
Per Person
View Trip
11 Day Charming Mediterranean with Emerald Cruises
Cruise
 (3)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 30 April 2027
Visit: Portugal, Spain, Sardinia, Corsica, Italy
Wave Offer
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$7,968
Balcony
-
Suite
$10,975
From
US$7,968
Save 11,322
Per Person
View Trip
22 Day Adriatic & Mediterranean Discovery with Viking Cruises
Cruise
 (1)

22 Days (21 Nights) Lisbon to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Neptune (+2 more), Viking Sky, Viking Vela
Departures: Feb 2027 to Jun 2028
Visit: Portugal, Spain, Morocco, France (+4 more), Monaco, Italy, Sicily, Croatia
Viking $999 Air Deal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Inside
-
Oceanview
-
Balcony
$11,347
Suite
$16,797
From
US$11,347
Per Person
View Trip
11 Day Lisbon to Rome with Silversea
Cruise
 (1)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 14 June 2026
Visit: Portugal, Spain, France, Monaco, Italy
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,600
Suite
$10,010
From
US$10,010
Save 4,290
Per Person
View Trip
19 Day Timeless Shores with Regent Seven Seas
Cruise

19 Days (18 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 08 June 2027
Visit: Portugal, Spain, Morocco, Corsica, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,717
Suite
$16,109
From
US$15,717
Save 24,281
Per Person
View Trip
15 Day Iberia & Italian Treasures with Oceania Cruises
Cruise
 (3)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 21 December 2026
Visit: Portugal, Spain, France, Italy, Corsica
Black Friday Deal
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$3,786
Oceanview
$4,135
Balcony
$6,317
Suite
$8,762
From
US$3,786
Save 4,812
Per Person
View Trip
11 Day Seville, Granada, Murcia And French Riviera with Seabourn
Cruise

11 Days (10 Nights) Lisbon to Genoa
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 08 April 2027
Visit: Portugal, Spain, France, Corsica, Italy
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,516
Suite
$9,181
From
US$5,516
Save 93
Per Person
View Trip
13 Day Iconic Cathedrals & Castles with Oceania Cruises
Cruise
 (1)

13 Days (12 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 17 July 2027
Visit: Portugal, Spain, France, Monaco, Italy
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$3,815
Oceanview
$4,155
Balcony
$6,434
Suite
$8,956
From
US$3,815
Save 3,983
Per Person
View Trip
14 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

14 Days (13 Nights) Funchal to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 30 March 2027
Visit: Portugal, Spain, Morocco, Italy
Inside
$1,434
Oceanview
$1,614
Balcony
$1,794
Suite
$2,838
From
US$1,434
Per Person
View Trip
23 Day Spanish Summer with Regent Seven Seas
Cruise

23 Days (22 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 11 August 2027
Visit: Portugal, Spain, Morocco, France (+4 more), Monaco, Italy, Corsica, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,293
Suite
$19,841
From
US$17,293
Save 29,905
Per Person
View Trip
11 Day Portrait Of Iberia with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 24 July 2026
Visit: Portugal, Spain, Gibraltar, Corsica, Italy
Black Friday Deal
Your World Inclusions
Exclusive Savings
Inside
$1,980
Oceanview
$2,190
Balcony
$3,226
Suite
$4,390
From
US$1,980
Save 4,618
Per Person
View Trip
15 Day Atlantic To Adriatic Sea with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 11 June 2026
Visit: Portugal, Spain, Italy, Sicily, Malta, Montenegro, Croatia
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$4,694
Oceanview
$5,082
Balcony
$7,701
Suite
$10,514
From
US$4,694
Save 4,904
Per Person
View Trip
19 Day Mediterranean & North Africa Voyage: Portugal, Morocco & Italy with Azamara Cruises
Cruise
 (8)

19 Days (18 Nights) Lisbon to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 17 November 2026
Visit: Portugal, Morocco, Spain, Gibraltar, France, Italy
Azamara Always Included
Exclusive Savings
Inside
$5,123
Oceanview
$5,656
Balcony
$6,966
Suite
$11,040
From
US$5,123
Save 106
Per Person
View Trip
15 Day Sublime Spain with Regent Seven Seas
Cruise

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 17 October 2027
Visit: Portugal, Spain, Morocco, France, Monaco, Italy, Corsica
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,103
Suite
$12,475
From
US$11,103
Save 18,495
Per Person
View Trip
18 Day Lisbon To Liguria with Regent Seven Seas
Cruise

18 Days (17 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 May 2027
Visit: Portugal, Spain, Morocco, France (+4 more), Monaco, Italy, Sicily, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,484
Suite
$13,660
From
US$12,484
Save 19,914
Per Person
View Trip
15 Day Iberian Wanderlust & Sicilian Dream with Regent Seven Seas
Cruise

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 27 September 2027
Visit: Portugal, Spain, Morocco, Tunisia (+4 more), Sicily, Malta, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,103
Suite
$12,475
From
US$11,103
Save 18,495
Per Person
View Trip
15 Day Spain, Portugal & the Mediterranean with Viking Cruises
Cruise
 (1)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+7 more), Viking Libra, Viking Mira, Viking Neptune, Viking Saturn, Viking Sky, Viking Star, Viking Vela
Departures: Nov 2026 to Jun 2028
Visit: Portugal, Spain, Morocco, France, Monaco, Italy
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$5,498
Suite
$8,998
From
US$5,498
Save 100
Per Person
View Trip
11 Day MSC Grand Voyages with MSC Cruises
Cruise

11 Days (10 Nights) Lisbon to Amalfi
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 29 April 2026
Visit: Portugal, Spain, France, Tunisia, Sicily, Italy
Inside
$1,159
Oceanview
$1,409
Balcony
$1,649
Suite
-
From
US$1,159
Per Person
View Trip
12 Day Western Mediterranean: Spain, Malta & Italy with Holland America
Cruise
 (2)

12 Days (11 Nights) Lisbon to Rome
Cruise Line: Holland America
Ship: Oosterdam
Departure: 03 June 2026
Visit: Portugal, Spain, Morocco, Malta, Sicily, Italy
Fare Saver
Inside
$1,994
Oceanview
$2,184
Balcony
$2,969
Suite
$3,577
From
US$1,994
Per Person
View Trip
11 Day Lisbon to Rome with Silversea
Cruise

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Muse
Departure: 04 January 2026
Visit: Portugal, Morocco, Spain, France, Italy
Last Minute Fare
Inside
-
Oceanview
$5,250
Balcony
$5,750
Suite
-
From
US$5,250
Per Person
View Trip
13 Day Lisbon to Civitavecchia (Rome) with Silversea
Cruise

13 Days (12 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 28 September 2027
Visit: Portugal, Spain, Gibraltar, Sardinia, Corsica, Italy
All-Inclusive Fare
Inside
-
Oceanview
$8,400
Balcony
$9,200
Suite
$18,000
From
US$8,400
Per Person
View Trip
11 Day Spain's Southern Coast & Riviera Gems with Seabourn
Cruise

11 Days (10 Nights) Lisbon to Genoa
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 10 May 2026
Visit: Portugal, Gibraltar, Spain, France, Italy
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,431
Suite
$12,929
From
US$7,431
Save 133
Per Person
View Trip
11 Day Balearic Bliss with Oceania Cruises
Cruise

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 26 September 2027
Visit: Portugal, Spain, France, Italy
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,910
Suite
$6,432
From
US$3,910
Save 4,088
Per Person
View Trip
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