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Cruises from USA to Spain

Are you looking for a cruise from USA to Spain? April is the most popular month to cruise between USA and Spain and there are 35 departures available from ten of the world's leading cruise lines.
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34 Cruises (35 Cruise Departures)
15 Day South Beach To Sant Sebasti with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Miami to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 10 March 2028
Visit: USA, Bermuda, Portugal, Gibraltar, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,999
Oceanview
$3,399
Balcony
$4,599
Suite
$6,399
From
US$2,999
Save 2,999
Per Person
View Trip
15 Day Spain & Morocco Transatlantic with Virgin Voyages
Cruise
 (5)

15 Days (14 Nights) Miami to Barcelona
Cruise Line: Virgin Voyages
Ship: Resilient Lady
Departure: 02 May 2027
Visit: USA, Spain, Morocco
Limited Time Offer
Inside
$1,386
Oceanview
$1,526
Balcony
$1,806
Suite
$5,530
From
US$1,386
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) New York to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 19 April 2026
Visit: USA, Canada, Portugal, Spain, France
Drinks & WiFi Package
Inside
-
Oceanview
-
Balcony
-
Suite
$7,085
From
US$7,085
Per Person
View Trip
17 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise
 (1)

17 Days (16 Nights) New York to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Escape
Departure: 26 September 2026
Visit: USA, Canada, Portugal, Gibraltar, Spain
Inside
$2,319
Oceanview
$2,619
Balcony
$2,819
Suite
$3,319
From
US$2,319
Per Person
View Trip
15 Day Transatlantic to Spain & Morocco with Virgin Voyages
Cruise
 (1)

15 Days (14 Nights) Miami to Barcelona
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 26 April 2026
Visit: USA, Spain, Morocco
Limited Time Offer
Inside
$1,246
Oceanview
$1,386
Balcony
$1,526
Suite
$4,550
From
US$1,246
Per Person
View Trip
16 Day Spain & Portugal Transatlantic with Celebrity Cruises
Cruise

16 Days (15 Nights) Fort Lauderdale to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Xcel
Departure: 26 April 2026
Visit: USA, Bermuda, Portugal, Spain
Exclusive Savings
Inside
$2,778
Oceanview
-
Balcony
$3,026
Suite
$13,249
From
US$2,778
Save 1,691
Per Person
View Trip
15 Day Gilded Crossing with Regent Seven Seas
Cruise

15 Days (14 Nights) New York to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 27 April 2027
Visit: USA, Bermuda, Portugal, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$13,499
From
US$13,499
Save 13,499
Per Person
View Trip
13 Day Transatlantic Repositioning Cruise From Miami To Barcelona with Norwegian Cruise Line
Cruise
 (1)

13 Days (12 Nights) Miami to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 23 May 2027
Visit: USA, Portugal, Spain
Inside
$1,599
Oceanview
$1,929
Balcony
$2,009
Suite
$3,079
From
US$1,599
Per Person
View Trip
15 Day Transatlantic Miami to Morocco & Spain with Virgin Voyages
Cruise
 (1)

15 Days (14 Nights) Miami to Barcelona
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 24 April 2027
Visit: USA, Spain, Morocco
Limited Time Offer
Inside
$1,386
Oceanview
$1,526
Balcony
$1,666
Suite
$6,300
From
US$1,386
Per Person
View Trip
15 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise
 (1)

15 Days (14 Nights) Philadelphia to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Pearl
Departure: 09 April 2028
Visit: USA, Portugal, Spain, France
Inside
$1,569
Oceanview
$1,719
Balcony
$2,569
Suite
$2,919
From
US$1,569
Per Person
View Trip
16 Day Spain & Morocco Transatlantic with Royal Caribbean
Cruise
 (2)

16 Days (15 Nights) Fort Lauderdale to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 23 April 2027
Visit: USA, Bahamas, Morocco, Spain
Bonus Onboard Credit
Exclusive Savings
Inside
$1,062
Oceanview
$1,192
Balcony
$1,664
Suite
$3,987
From
US$1,062
Save 523
Per Person
View Trip
24 Day A Grand Journey Into Island Whispers & Beauty-Rich Shores with Explora Journeys
Cruise

24 Days (23 Nights) San Juan to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 01 March 2027
Visit: Puerto Rico, Antigua and Barbuda, Anguilla, Virgin Islands (+5 more), Turks and Caicos Islands, USA, Saint Martin, Portugal, Spain
Inside
-
Oceanview
-
Balcony
-
Suite
$11,480
From
US$11,480
Per Person
View Trip
17 Day A Journey Through Vibrant Cultures Across The Atlantic & The Mediterranean with Explora Journeys
Cruise
 (1)

17 Days (16 Nights) Miami to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 19 March 2028
Visit: USA, Puerto Rico, Antigua and Barbuda, Portugal, Spain
Inside
-
Oceanview
-
Balcony
-
Suite
$8,340
From
US$8,340
Per Person
View Trip
15 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise
 (1)

15 Days (14 Nights) Orlando to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 18 April 2027
Visit: USA, Portugal, Spain
Inside
$1,389
Oceanview
-
Balcony
$2,239
Suite
$2,279
From
US$1,389
Per Person
View Trip
14 Day Atlantic Ocean Passage with Viking Cruises
Cruise
 (8)

14 Days (13 Nights) Fort Lauderdale to Barcelona
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Jan 2027 to Feb 2028
Visit: USA, Sint Maarten, Portugal, Spain
Viking $799 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,299
Suite
$5,799
From
US$3,299
Save 350
Per Person
View Trip
16 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise
 (1)

16 Days (15 Nights) Miami to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Star
Departure: 01 March 2027
Visit: USA, Dominican Republic, Puerto Rico, Portugal, Spain
Inside
$2,179
Oceanview
$2,439
Balcony
$3,579
Suite
$4,259
From
US$2,179
Per Person
View Trip
15 Day Transatlantic Aspirations with Oceania Cruises
Cruise

15 Days (14 Nights) Miami to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 18 March 2028
Visit: USA, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,149
Suite
$6,599
From
US$5,149
Save 5,149
Per Person
View Trip
15 Day Spain & Gibraltar Transatlantic with Royal Caribbean
Cruise
 (1)

15 Days (14 Nights) Miami to Barcelona
Cruise Line: Royal Caribbean
Ship: Rhapsody of the Seas
Departure: 19 April 2027
Visit: USA, Bahamas, Gibraltar, Spain
Bonus Onboard Credit
Exclusive Savings
Inside
$867
Oceanview
$958
Balcony
$1,770
Suite
$2,460
From
US$867
Save 438
Per Person
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

14 Days (13 Nights) Miami to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 April 2026
Visit: USA, Saint Martin, Portugal, Spain
Inside
-
Oceanview
-
Balcony
-
Suite
$2,488
From
US$2,488
Per Person
View Trip
24 Day Across The Atlantic with Oceania Cruises
Cruise
 (3)

24 Days (23 Nights) Miami to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 25 March 2028
Visit: USA, Bermuda, Portugal, Spain (+4 more), France, Italy, Corsica, Monaco
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$5,449
Oceanview
$6,799
Balcony
$8,199
Suite
$11,399
From
US$5,449
Save 5,449
Per Person
View Trip
15 Day Exuberant Bermuda & Azores with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 18 March 2028
Visit: USA, Bermuda, Portugal, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,999
Suite
$11,499
From
US$9,999
Save 9,999
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Miami to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 25 March 2028
Visit: USA, Saint Martin, Portugal, Spain, France
Inside
$1,379
Oceanview
$1,789
Balcony
$2,189
Suite
$3,549
From
US$1,379
Per Person
View Trip
15 Day Spanish Passage with Princess
Cruise
 (7)

15 Days (14 Nights) Fort Lauderdale to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 28 March 2027
Visit: USA, Spain
Princess Standard
Sanctuary Collection
Inside
$986
Oceanview
$1,049
Balcony
$1,339
Suite
$1,629
From
US$986
Per Person
View Trip
18 Day Spain & Morocco Transatlantic with Royal Caribbean
Cruise

18 Days (17 Nights) New Orleans to Barcelona
Cruise Line: Royal Caribbean
Ship: Mariner of the Seas
Departure: 24 April 2027
Visit: USA, Morocco, Spain
Bonus Onboard Credit
Exclusive Savings
Inside
$1,192
Oceanview
$1,342
Balcony
$1,991
Suite
$3,372
From
US$1,192
Save 590
Per Person
View Trip
23 Day Caribbean And Antilles with MSC Cruises
Cruise

23 Days (22 Nights) Miami to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 19 March 2028
Visit: USA, Turks and Caicos Islands, Bahamas, Saint Martin, Portugal, Spain, France
Inside
$1,845
Oceanview
$2,405
Balcony
$2,965
Suite
$5,945
From
US$1,845
Per Person
View Trip
15 Day Spain & Portugal Transatlantic with Royal Caribbean
Cruise

15 Days (14 Nights) Orlando to Barcelona
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 23 April 2026
Visit: USA, Portugal, Spain
Exclusive Savings
Inside
$894
Oceanview
$1,485
Balcony
-
Suite
-
From
US$894
Save 476
Per Person
View Trip
17 Day A Grand Journey From Atlantic Exploration To Mediterranean Delights with Explora Journeys
Cruise

17 Days (16 Nights) Miami to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 08 March 2027
Visit: USA, Puerto Rico, Saint Martin, Portugal, Spain
Inside
-
Oceanview
-
Balcony
-
Suite
$6,910
From
US$6,910
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise

15 Days (14 Nights) Miami to Malaga
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 10 April 2027
Visit: USA, Saint Martin, Portugal, Spain
Inside
$1,208
Oceanview
$1,408
Balcony
$1,828
Suite
-
From
US$1,208
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Miami to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 10 April 2027
Visit: USA, Saint Martin, Portugal, Spain, France
Inside
$1,504
Oceanview
$1,984
Balcony
$2,494
Suite
$8,174
From
US$1,504
Per Person
View Trip
28 Day Springtime Atlantic Crossing with Regent Seven Seas
Cruise

28 Days (27 Nights) Miami to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 20 March 2028
Visit: USA, Dominican Republic, Puerto Rico, Saint Barthelemy (+8 more), Dominica, Guadeloupe, Saint Kitts and Nevis, Virgin Islands, Bahamas, Portugal, Spain, Morocco
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$19,399
Suite
$21,399
From
US$19,399
Save 19,399
Per Person
View Trip
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