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347 Cruises (2,121 Cruise Departures)
9 Day In Darwin’s Footsteps (Eastern Route) with HX Expeditions
Cruise

9 Days (8 Nights) Quito to Quito
Cruise Line: HX Expeditions
Ship: MS Santa Cruz II
Departures: Apr 2026 to Dec 2026
Visit: Ecuador, Galapagos
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
$6,652
Balcony
-
Suite
$8,748
From
US$6,652
Save 3,057
Per Person
View Trip
10 Day Galápagos - North, Central, & South Islands aboard the Eden with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: Feb 2026 to Dec 2027
Visit: Ecuador, Galapagos
Great Adventure Sale
Exclusive Savings
From
US$4,328
Save 1,621
Per Person
View Trip
11 Day Nine Of The Best Isles (Western And Northern Route) with HX Expeditions
Cruise

11 Days (10 Nights) Quito to Quito
Cruise Line: HX Expeditions
Ship: MS Santa Cruz II
Departures: Apr 2026 to Dec 2026
Visit: Ecuador, Galapagos
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
$8,360
Balcony
-
Suite
$12,339
From
US$8,360
Save 3,882
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Preziosa
Departures: Jan 2026 to Mar 2027
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$889
Oceanview
$959
Balcony
$1,089
Suite
$1,349
From
US$889
Per Person
View Trip
19 Day Around Cape Horn with Oceania Cruises
Cruise

19 Days (18 Nights) Buenos Aires to Lima
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 03 February 2026
Visit: Argentina, Uruguay, Falkland Islands, Chile, Peru
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,035
Suite
$18,481
From
US$7,035
Save 7,363
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

15 Days (14 Nights) Valencia to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 08 November 2027
Visit: Spain, Portugal, Brazil
Bonus Onboard Credit
Inside
$1,018
Oceanview
$1,188
Balcony
$1,478
Suite
-
From
US$1,018
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise

15 Days (14 Nights) Santos to Santiago De Compostela
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil, Portugal, Spain
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$2,754
From
US$2,754
Save 74
Per Person
View Trip
34 Day San Antonio To Southampton with Cunard
Cruise

34 Days (33 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Visit: Chile, Peru, Ecuador, Panama (+4 more), Aruba, USA, Portugal, England
Inside
$5,209
Oceanview
$7,216
Balcony
$8,048
Suite
$18,096
From
US$5,209
Per Person
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

14 Days (13 Nights) Lisbon to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 10 November 2027
Visit: Portugal, Brazil
Bonus Onboard Credit
Inside
$944
Oceanview
$1,104
Balcony
$1,384
Suite
-
From
US$944
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Valencia to Santos
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 07 November 2027
Visit: Spain, Brazil
Bonus Onboard Credit
Inside
$1,120
Oceanview
$1,670
Balcony
$2,486
Suite
$3,058
From
US$1,120
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (2)

20 Days (19 Nights) Buenos Aires to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 23 March 2026
Visit: Argentina, Brazil, Spain, Morocco
Bonus Onboard Credit
Inside
-
Oceanview
-
Balcony
$1,959
Suite
$3,206
From
US$1,959
Per Person
View Trip
21 Day South America with MSC Cruises
Cruise
 (2)

21 Days (20 Nights) Montevideo to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 22 March 2026
Visit: Uruguay, Argentina, Brazil, Spain, Morocco
Bonus Onboard Credit
Inside
$1,639
Oceanview
$1,849
Balcony
$2,079
Suite
$4,109
From
US$1,639
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Barcelona to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 01 November 2027
Visit: Spain, Brazil
Bonus Onboard Credit
Inside
$1,290
Oceanview
$1,540
Balcony
$1,790
Suite
$5,153
From
US$1,290
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Marseille to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 31 October 2027
Visit: France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,290
Oceanview
$1,540
Balcony
$1,790
Suite
$3,087
From
US$1,290
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Santos to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco
Bonus Onboard Credit
Inside
$1,394
Oceanview
$1,664
Balcony
$1,894
Suite
$5,265
From
US$1,394
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Barcelona to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 16 November 2027
Visit: Spain, Brazil
Bonus Onboard Credit
Inside
$1,607
Oceanview
$1,847
Balcony
$2,187
Suite
$5,736
From
US$1,607
Per Person
View Trip
22 Day South America, Canary Islands & Spain with Seabourn
Cruise

22 Days (21 Nights) Rio de Janeiro to Seville
Cruise Line: Seabourn
Ship: Seabourn Venture
Departure: 06 April 2027
Visit: Brazil, Cape Verde, Spain, Morocco
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$9,704
From
US$9,704
Save 155
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Barcelona to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 18 November 2027
Visit: Spain, Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$1,694
Oceanview
$2,073
Balcony
$2,219
Suite
$3,722
From
US$1,694
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Rio de Janeiro to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 04 April 2027
Visit: Brazil, Spain, Morocco
Bonus Onboard Credit
Inside
$1,289
Oceanview
$1,549
Balcony
$1,779
Suite
$6,008
From
US$1,289
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Marseille to Santos
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 05 November 2027
Visit: France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,284
Oceanview
$1,904
Balcony
$2,801
Suite
$3,461
From
US$1,284
Per Person
View Trip
34 Day Brazil Unbound with Oceania Cruises
Cruise
 (1)

34 Days (33 Nights) Buenos Aires to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 07 March 2027
Visit: Argentina, Uruguay, Brazil, Barbados, Antigua and Barbuda, Virgin Islands, USA
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$8,834
Oceanview
$9,610
Balcony
$12,811
Suite
$18,534
From
US$8,834
Save 9,164
Per Person
View Trip
22 Day Amazonian Spirit with Oceania Cruises
Cruise
 (1)

22 Days (21 Nights) Rio de Janeiro to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 19 March 2027
Visit: Brazil, Barbados, Antigua and Barbuda, Virgin Islands, USA
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$5,500
Oceanview
$6,053
Balcony
$7,896
Suite
$10,844
From
US$5,500
Save 6,298
Per Person
View Trip
22 Day Amazonian Exploration with Oceania Cruises
Cruise
 (1)

22 Days (21 Nights) Rio de Janeiro to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 February 2028
Visit: Brazil, Barbados, Guadeloupe, Virgin Islands, USA
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$6,854
Oceanview
$7,145
Balcony
$9,376
Suite
$13,062
From
US$6,854
Save 7,144
Per Person
View Trip
11 Day A Journey Through Amazonian Mesmerising Wonders to the Caribbean Sunlit Landscapes with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Manaus to San Juan
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 17 February 2028
Visit: Brazil, Trinidad and Tobago, Saint Lucia, Dominica, Saint Martin, Puerto Rico
A Suite Invitation
Inside
-
Oceanview
-
Balcony
$7,675
Suite
$8,660
From
US$7,675
Per Person
View Trip
18 Day Fort Lauderdale To Rio De Janeiro with Cunard
Cruise

18 Days (17 Nights) Fort Lauderdale to Rio de Janeiro
Cruise Line: Cunard
Ship: Queen Anne
Departure: 22 January 2027
Visit: USA, Turks and Caicos Islands, Barbados, Brazil
Inside
$3,149
Oceanview
$4,489
Balcony
$5,109
Suite
$11,619
From
US$3,149
Per Person
View Trip
31 Day Legendary Amazon Explorer with Holland America
Cruise

31 Days (30 Nights) New York to Fort Lauderdale
Cruise Line: Holland America
Ship: Volendam
Departure: 22 November 2026
Visit: USA, Saint Martin, Martinique, Barbados, Brazil, French Guiana, Curacao
Fare Saver
Exclusive Savings
Inside
$4,995
Oceanview
$5,191
Balcony
$11,561
Suite
-
From
US$4,995
Per Person
View Trip
20 Day Amazon To Caribbean Gems with Oceania Cruises
Cruise
 (1)

20 Days (19 Nights) Bridgetown to Bridgetown
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 27 January 2026
Visit: Barbados, Brazil, French Guiana, Trinidad and Tobago, Grenada, Saint Vincent, Saint Lucia
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,464
Suite
-
From
US$9,464
Save 9,934
Per Person
View Trip
36 Day Buenos Aires To Miami Grand Voyage with Azamara Cruises
Cruise
 (4)

36 Days (35 Nights) Buenos Aires to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 16 February 2028
Visit: Argentina, Uruguay, Brazil, French Guiana (+9 more), Trinidad and Tobago, Barbados, Grenada, Saint Lucia, Martinique, Dominica, Saint Martin, Virgin Islands, USA
Azamara Always Included
Exclusive Savings
Inside
$12,145
Oceanview
$13,503
Balcony
$16,316
Suite
$23,581
From
US$12,145
Save 284
Per Person
View Trip
19 Day Brazilian Adventure with Princess
Cruise
 (7)

19 Days (18 Nights) Fort Lauderdale to Buenos Aires
Cruise Line: Princess
Ship: Majestic Princess
Departure: 19 November 2026
Visit: USA, Saint Martin, Saint Lucia, Barbados, Brazil, Uruguay, Argentina
Princess Standard
Inside
$2,134
Oceanview
-
Balcony
$2,616
Suite
$2,930
From
US$2,134
Per Person
View Trip
22 Day From the Caribbean to the Amazon with Viking Cruises
Cruise
 (5)

22 Days (21 Nights) San Juan to San Juan
Cruise Line: Viking Cruises
Ship: Viking Sea
Departure: 15 December 2026
Visit: Puerto Rico, Barbados, French Guiana, Brazil (+4 more), Trinidad and Tobago, Saint Lucia, Antigua and Barbuda, Virgin Islands
Viking $799 Air Deal
Inside
-
Oceanview
-
Balcony
$11,999
Suite
-
From
US$11,999
Per Person
View Trip
Results: 181-210 of 347

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South & Central America Cruises

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Travel Styles

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Cities

Cruises from Baltra Island Cruises from Barcelona Cruises from Bridgetown Cruises from Buenos Aires Cruises from Colon Cruises from Lima Cruises from Lisbon Cruises from Maceio Cruises from Manaus Cruises from Marseille Cruises from Montevideo Cruises from Panama City Cruises from Puerto Williams Cruises from Quito Cruises from Rio de Janeiro Cruises from Salvador Cruises from San Antonio Cruises from San Cristobal Island Cruises from Santiago Cruises from Santiago Cruises from Santos Cruises from Sao Paulo Cruises from Tahiti Cruises from Valencia Cruises from Valparaiso

Routes

Cruises from Baltra Island to Baltra Island Cruises from Barcelona to Fort Lauderdale Cruises from Barcelona to Trieste Cruises from Barcelona to Athens Cruises from Barcelona to Lisbon Cruises from Barcelona to Rome Cruises from Barcelona to Barcelona Cruises from Barcelona to Miami Cruises from Bridgetown to Miami Cruises from Bridgetown to Bridgetown Cruises from Buenos Aires to Rio de Janeiro Cruises from Buenos Aires to Buenos Aires Cruises from Fort Lauderdale to Los Angeles Cruises from Fort Lauderdale to Barcelona Cruises from Fort Lauderdale to Fort Lauderdale Cruises from Genoa to Genoa Cruises from Hamburg to London Cruises from Hamburg to Hamburg Cruises from Lima to Buenos Aires Cruises from Lima to Quito Cruises from Lisbon to Lisbon Cruises from Lisbon to London Cruises from Lisbon to Barcelona Cruises from Lisbon to Rome Cruises from London to Hamburg Cruises from London to Barcelona Cruises from London to Fort Lauderdale Cruises from London to London Cruises from London to Lisbon Cruises from London to New York Cruises from Marseille to Marseille Cruises from Miami to San Juan Cruises from Miami to Lisbon Cruises from Miami to Los Angeles Cruises from Miami to Rome Cruises from Miami to Bridgetown Cruises from Miami to Panama City Cruises from Miami to Barcelona Cruises from Miami to Miami Cruises from Miami to London Cruises from New York to New York Cruises from New York to London Cruises from Panama City to Miami Cruises from Quito to Guayaquil Cruises from Quito to Quito Cruises from Rio de Janeiro to Rio de Janeiro Cruises from Rio de Janeiro to Barcelona Cruises from Rome to Trieste Cruises from Rome to Lisbon Cruises from Rome to Miami Cruises from Rome to Athens Cruises from Rome to Barcelona Cruises from Rome to Fort Lauderdale Cruises from Rome to Rome Cruises from San Antonio to Buenos Aires Cruises from San Cristobal Island to San Cristobal Island Cruises from San Juan to Miami Cruises from San Juan to San Juan Cruises from Santiago to Buenos Aires Cruises from Santiago to Santiago Cruises from Santos to Santos Cruises from Sao Paulo to Sao Paulo Cruises from Tahiti to Tahiti Cruises from Ushuaia to Ushuaia Cruises from Venice to Athens Cruises from Venice to Barcelona Cruises from Venice to Rome

Country Routes

Cruises from Peru to Argentina Cruises from USA to Portugal Cruises from Germany to England Cruises from Canada to Japan Cruises from France to Spain Cruises from Portugal to England Cruises from Puerto Rico to USA Cruises from Chile to USA Cruises from France to Brazil Cruises from Brazil to France Cruises from England to Germany Cruises from Dominican Republic to USA Cruises from Brazil to Spain Cruises from USA to Puerto Rico Cruises from Argentina to Brazil Cruises from USA to Brazil Cruises from Argentina to Chile Cruises from Brazil to Italy Cruises from Argentina to USA Cruises from Peru to USA Cruises from Barbados to USA Cruises from Canada to USA Cruises from Chile to Argentina Cruises from England to Spain Cruises from England to USA Cruises from France to Italy Cruises from French Polynesia to USA Cruises from USA to Dominican Republic Cruises from England to Norway Cruises from Italy to Brazil Cruises from Italy to France Cruises from Italy to Greece Cruises from Italy to Portugal Cruises from Italy to Spain Cruises from Italy to USA Cruises from Panama to USA Cruises from Spain to Brazil Cruises from Peru to Ecuador Cruises from Portugal to Italy Cruises from Portugal to Spain Cruises from Portugal to USA Cruises from Spain to France Cruises from Spain to Greece Cruises from Spain to Italy Cruises from Spain to Portugal Cruises from Spain to USA Cruises from USA to Australia Cruises from USA to Barbados Cruises from USA to Canada Cruises from England to Portugal Cruises from USA to Chile Cruises from USA to England Cruises from USA to French Polynesia Cruises from USA to Italy Cruises from USA to Japan Cruises from Spain to England Cruises from USA to Panama Cruises from USA to Peru Cruises from USA to Spain

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant South America Cruises Ponant Central America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking Central America Cruises Viking South America Cruises

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