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249 Cruises (556 Cruise Departures)
19 Day Panama Canal Cruise: Colombia, Costa Rica & Mexico with Azamara Cruises
Cruise
 (5)

19 Days (18 Nights) Miami to San Francisco
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 18 December 2026
Visit: USA, Dominican Republic, Colombia, Panama, Costa Rica, Guatemala, Mexico
Azamara Always Included
Exclusive Savings
Inside
$4,514
Oceanview
$5,193
Balcony
$5,659
Suite
$8,792
From
US$4,514
Save 85
Per Person
View Trip
19 Day Panama Canal Eastbound Cruise with Celebrity Cruises
Cruise

19 Days (18 Nights) Los Angeles to Boston
Cruise Line: Celebrity Cruises
Ship: Celebrity Summit
Departure: 18 September 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia, Turks and Caicos Islands
Exclusive Savings
Inside
$4,134
Oceanview
$4,375
Balcony
$5,190
Suite
-
From
US$4,134
Save 2,359
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (2)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 15 January 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$6,320
Suite
$10,750
From
US$6,320
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 08 April 2027
Visit: USA, Colombia, Panama, Mexico
Inside
$1,817
Oceanview
$2,418
Balcony
$3,311
Suite
$9,878
From
US$1,817
Per Person
View Trip
8 Day Coastal Adventures: Panama & Costa Rica with Emerald Cruises
Cruise
 (3)

8 Days (7 Nights) Panama City to San Jose
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 24 January 2028
Visit: Panama, Costa Rica
Select Fare
Preferred Plus Fare + Air Credit
Exclusive Savings
Inside
-
Oceanview
$6,288
Balcony
-
Suite
$7,816
From
US$6,288
Save 807
Per Person
View Trip
15 Day Los Angeles To Miami with Cunard
Cruise
 (13)

15 Days (14 Nights) Los Angeles to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 13 April 2028
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Inside
$3,119
Oceanview
$3,619
Balcony
$4,309
Suite
-
From
US$3,119
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 23 April 2026
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Grand Voyages Sale
Inside
$1,511
Oceanview
$1,731
Balcony
$1,998
Suite
$8,721
From
US$1,511
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (6)

17 Days (16 Nights) San Diego to Fort Lauderdale
Cruise Line: Princess
Ship: Island Princess
Departure: 29 January 2027
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,687
Oceanview
$1,897
Balcony
$2,947
Suite
$3,744
From
US$1,687
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Star Princess
Departure: 04 October 2026
Visit: USA, Mexico, Panama, Aruba
Princess Standard
Inside
$1,479
Oceanview
$2,189
Balcony
$2,299
Suite
$3,694
From
US$1,479
Per Person
View Trip
8 Day Pacific Coast of Costa Rica with Ponant
Cruise
 (1)

8 Days (7 Nights) Puntarenas to Puntarenas
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Dec 2026 to Dec 2026
Visit: Costa Rica
Inside
-
Oceanview
-
Balcony
$6,920
Suite
$11,350
From
US$6,920
Per Person
View Trip
21 Day Seattle to Miami with Silversea
Cruise
 (1)

21 Days (20 Nights) Seattle to Miami
Cruise Line: Silversea
Ship: Silver Nova
Departure: 11 May 2026
Visit: USA, Mexico, Costa Rica, Panama, Colombia
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,000
Suite
-
From
US$11,000
Save 2,500
Per Person
View Trip
6 Day Caribbean And Antilles with MSC Cruises
Cruise

6 Days (5 Nights) Galveston to Galveston
Cruise Line: MSC Cruises
Ship: MSC Seascape
Departure: 24 October 2027
Visit: USA, Mexico
Inside
$549
Oceanview
$639
Balcony
$719
Suite
-
From
US$549
Per Person
View Trip
8 Day Central America - From Miami to Miami with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Miami to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Escape
Departures: May 2026 to Aug 2026
Visit: USA, Mexico, Honduras, Belize
Inside
$649
Oceanview
$699
Balcony
$849
Suite
$949
From
US$649
Per Person
View Trip
17 Day Panama Canal: Miami to Los Angeles with Virgin Voyages
Cruise
 (1)

17 Days (16 Nights) Miami to Los Angeles
Cruise Line: Virgin Voyages
Ship: Brilliant Lady
Departures: Mar 2026 to Mar 2027
Visit: USA, Colombia, Panama, Costa Rica, Guatemala, Mexico
Limited Time Offer
Inside
$1,584
Oceanview
$2,544
Balcony
$3,024
Suite
$9,104
From
US$1,584
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean Holiday with Princess
Cruise
 (6)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Island Princess
Departure: 28 December 2026
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,550
Oceanview
$1,657
Balcony
$2,137
Suite
$2,997
From
US$1,550
Per Person
View Trip
17 Day Halcyon Holidays with Oceania Cruises
Cruise

17 Days (16 Nights) Miami to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 19 December 2027
Visit: USA, Cayman Islands, Colombia, Panama, Costa Rica, Guatemala, Mexico
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,923
Suite
$23,131
From
US$16,923
Save 475
Per Person
View Trip
16 Day Panama Canal Holiday with Holland America
Cruise
 (3)

16 Days (15 Nights) San Diego to Miami
Cruise Line: Holland America
Ship: Zaandam
Departure: 18 December 2027
Visit: USA, Mexico, Costa Rica, Panama, Colombia
Book Early & Have It All Fare Option
Inside
$2,674
Oceanview
$2,974
Balcony
$4,897
Suite
$9,405
From
US$2,674
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean Holiday with Princess
Cruise
 (6)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Island Princess
Departure: 29 December 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,599
Oceanview
$1,799
Balcony
$2,347
Suite
$3,899
From
US$1,599
Per Person
View Trip
19 Day Transamerican Treasures with Oceania Cruises
Cruise

19 Days (18 Nights) Miami to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 24 October 2027
Visit: USA, Cayman Islands, Colombia, Panama, Costa Rica, Guatemala, Mexico
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,438
Suite
$23,526
From
US$13,438
Save 360
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2027 to Jan 2028
Visit: Panama, Costa Rica, Belize, Mexico, USA
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$3,799
Suite
$6,499
From
US$3,799
Per Person
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise
 (2)

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 19 February 2027
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$7,020
Suite
$11,790
From
US$7,020
Per Person
View Trip
23 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

23 Days (22 Nights) New York to Seattle
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Bliss
Departure: 14 April 2028
Visit: USA, Dominican Republic, Colombia, Panama (+4 more), Costa Rica, Guatemala, Mexico, Canada
Exclusive Savings
Inside
$2,485
Oceanview
$3,261
Balcony
$4,134
Suite
$4,716
From
US$2,485
Save 54
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (1)

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Nov 2026 to Mar 2027
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$5,300
Suite
$8,950
From
US$5,300
Per Person
View Trip
17 Day Holiday In Panama with Regent Seven Seas
Cruise

17 Days (16 Nights) Miami to San Francisco
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 20 December 2027
Visit: USA, Jamaica, Colombia, Panama, Costa Rica, Guatemala, Mexico
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,368
Suite
$14,201
From
US$13,368
Save 13,830
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (1)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Nov 2026 to Feb 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$5,970
Suite
$10,140
From
US$5,970
Per Person
View Trip
19 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

19 Days (18 Nights) Los Angeles to New York
Cruise Line: Princess
Ship: Coral Princess
Departure: 27 September 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,649
Oceanview
$1,895
Balcony
$2,857
Suite
$3,747
From
US$1,649
Per Person
View Trip
15 Day Panama Canal & Central America with Viking Cruises
Cruise
 (8)

15 Days (14 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Oct 2026 to Feb 2028
Visit: USA, Jamaica, Panama, Costa Rica, Honduras, Belize, Mexico
Flights Included
Viking $499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,099
Suite
$7,999
From
US$5,099
Save 500
Per Person
View Trip
8 Day Western Caribbean Holiday Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Tampa to Tampa
Cruise Line: Royal Caribbean
Ships: Enchantment of the Seas, Grandeur of the Seas (+2 more), Radiance of the Seas, Rhapsody of the Seas
Departures: Mar 2026 to Apr 2027
Visit: USA, Mexico, Honduras, Belize
Bonus Onboard Credit
Exclusive Savings
Inside
$516
Oceanview
$573
Balcony
$784
Suite
$1,205
From
US$516
Save 586
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (1)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Emerald Princess
Departure: 24 October 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,499
Oceanview
$1,699
Balcony
$2,799
Suite
$3,695
From
US$1,499
Per Person
View Trip
7 Day Western Caribbean with Royal Caribbean
Cruise

7 Days (6 Nights) Galveston to Galveston
Cruise Line: Royal Caribbean
Ships: Icon Of The Seas, Symphony of the Seas
Departures: Jun 2026 to Sep 2027
Visit: USA, Mexico, Honduras
Bonus Onboard Credit
Exclusive Savings
Inside
$639
Oceanview
$759
Balcony
$713
Suite
$1,902
From
US$639
Save 642
Per Person
View Trip
Results: 31-60 of 249

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Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant South America Cruises Ponant Central America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking Central America Cruises Viking South America Cruises

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