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265 Cruises (588 Cruise Departures)
17 Day Panama Canal - Ocean To Ocean with Princess
Cruise

17 Days (16 Nights) Los Angeles to Orlando
Cruise Line: Princess
Ship: Star Princess
Departure: 10 October 2027
Visit: USA, Mexico, Panama, Aruba
Princess Standard
Sanctuary Collection
Inside
$1,900
Oceanview
$2,300
Balcony
$3,550
Suite
$6,196
From
US$1,900
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Star Princess
Departure: 04 October 2026
Visit: USA, Mexico, Panama, Aruba
Princess Standard
Sanctuary Collection
Inside
$1,449
Oceanview
$1,609
Balcony
$2,609
Suite
$4,833
From
US$1,449
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Star Princess
Departure: 03 April 2027
Visit: USA, Aruba, Panama, Mexico
Princess Standard
Sanctuary Collection
Inside
$1,429
Oceanview
$1,929
Balcony
$3,429
Suite
$5,832
From
US$1,429
Per Person
View Trip
21 Day Panama Canal - Ocean to Ocean with Princess
Cruise

21 Days (20 Nights) Fort Lauderdale to Seattle
Cruise Line: Princess
Ship: Star Princess
Departure: 13 April 2026
Visit: USA, Aruba, Panama, Mexico
Princess Standard
Princess Premier
Inside
$1,649
Oceanview
$2,009
Balcony
$2,709
Suite
$4,248
From
US$1,649
Per Person
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America - with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 February 2026
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$8,730
Suite
-
From
US$8,730
Per Person
View Trip
8 Day Perfect Day Cococay & West Carib with Royal Caribbean
Cruise

8 Days (7 Nights) Miami to Miami
Cruise Line: Royal Caribbean
Ship: Icon Of The Seas
Departures: Jan 2026 to Jul 2027
Visit: USA, Mexico, Honduras, Bahamas
Bonus Onboard Credit
Exclusive Savings
Inside
$1,330
Oceanview
$1,445
Balcony
$1,545
Suite
$2,742
From
US$1,330
Save 1,132
Per Person
View Trip
11 Day Pristine islands of the Bahamas & the Panama Canal with Scenic
New ReleaseCruise

11 Days (10 Nights) Nassau to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 16 October 2026
Visit: Bahamas, Colombia, Panama
Wave Offer
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,263
Suite
$11,475
From
US$10,263
Save 14,827
Per Person
View Trip
24 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

24 Days (23 Nights) Fort Lauderdale to Honolulu
Cruise Line: Princess
Ship: Coral Princess
Departure: 06 January 2027
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Princess Standard
Inside
$2,853
Oceanview
$3,121
Balcony
$4,148
Suite
$6,745
From
US$2,853
Per Person
View Trip
24 Day Panama Canal & Pacific COast with Princess
Cruise

24 Days (23 Nights) Vancouver to Orlando
Cruise Line: Princess
Ship: Star Princess
Departure: 03 October 2027
Visit: Canada, USA, Mexico, Panama, Aruba
Princess Standard
Sanctuary Collection
Inside
$2,849
Oceanview
$3,746
Balcony
$5,030
Suite
$7,921
From
US$2,849
Per Person
View Trip
24 Day Panama Canal & Pacific Coast with Princess
Cruise

24 Days (23 Nights) Vancouver to Fort Lauderdale
Cruise Line: Princess
Ship: Star Princess
Departure: 27 September 2026
Visit: Canada, USA, Mexico, Panama, Aruba
Princess Standard
Sanctuary Collection
Inside
$2,408
Oceanview
$2,868
Balcony
$4,165
Suite
$6,762
From
US$2,408
Per Person
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Visit: USA, Bahamas, Colombia, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$47,076
Suite
$107,982
From
US$47,076
Save 1,314
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

20 Days (19 Nights) Seattle to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 27 September 2027
Visit: USA, Mexico, Panama, Colombia
Bonus Onboard Credit
Exclusive Savings
Inside
$3,167
Oceanview
$3,516
Balcony
$4,680
Suite
$11,771
From
US$3,167
Save 82
Per Person
View Trip
19 Day An Extended Journey of Ancient Mysteries & Pacific Coastal Wonders with Explora Journeys
Cruise

19 Days (18 Nights) Panama City to Vancouver
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visit: Panama, El Salvador, Guatemala, Mexico, USA, Canada
A Suite Invitation
Inside
-
Oceanview
-
Balcony
$10,795
Suite
$12,495
From
US$10,795
Per Person
View Trip
17 Day Holiday In Panama with Regent Seven Seas
Cruise

17 Days (16 Nights) Miami to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 20 December 2027
Visit: USA, Jamaica, Colombia, Panama, Costa Rica, Guatemala, Mexico
Upgrade Your Horizon
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,036
Suite
$10,771
From
US$10,036
Save 17,362
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (6)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Island Princess
Departure: 18 March 2028
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Princess Standard
Inside
$1,650
Oceanview
$1,869
Balcony
$3,009
Suite
$3,499
From
US$1,650
Per Person
View Trip
16 Day Treasures Of Two Oceans with Oceania Cruises
Cruise

16 Days (15 Nights) Miami to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 06 January 2027
Visit: USA, Cayman Islands, Colombia, Panama, Guatemala, Mexico
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,408
Suite
-
From
US$6,408
Save 7,390
Per Person
View Trip
16 Day Panama Canal Repositioning Cruise From Miami To Los Angeles with Norwegian Cruise Line
Cruise
 (1)

16 Days (15 Nights) Miami to Los Angeles
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Joy
Departures: Apr 2026 to Apr 2028
Visit: USA, Colombia, Panama, Costa Rica, Guatemala, Mexico
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$3,024
From
US$3,024
Save 109
Per Person
View Trip
18 Day New York To Los Angeles with Cunard
Cruise
 (1)

18 Days (17 Nights) New York to Los Angeles
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 19 January 2027
Visit: USA, Aruba, Panama, El Salvador, Mexico
Inside
$2,519
Oceanview
$3,429
Balcony
$3,609
Suite
-
From
US$2,519
Per Person
View Trip
18 Day Panama Canal & Latin America Cruise: Mexico, Costa Rica & Colombia with Azamara Cruises
Cruise
 (4)

18 Days (17 Nights) San Diego to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 24 May 2027
Visit: USA, Mexico, Guatemala, El Salvador, Costa Rica, Panama, Colombia
Azamara Always Included
Exclusive Savings
Inside
$5,994
Oceanview
$6,459
Balcony
$7,323
Suite
$12,017
From
US$5,994
Save 135
Per Person
View Trip
15 Day Panama Canal with Holland America
Cruise

15 Days (14 Nights) Fort Lauderdale to San Diego
Cruise Line: Holland America
Ship: Eurodam
Departure: 03 April 2027
Visit: USA, Colombia, Costa Rica, Guatemala, Mexico
Fare Saver
Inside
$2,209
Oceanview
$2,409
Balcony
$3,536
Suite
$6,133
From
US$2,209
Per Person
View Trip
19 Day Panama Canal Cruise From Miami To Seattle with Norwegian Cruise Line
Cruise
 (1)

19 Days (18 Nights) Miami to Seattle
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Joy
Departure: 25 April 2026
Visit: USA, Colombia, Panama, Costa Rica, Guatemala, Mexico
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$3,453
From
US$3,453
Save 76
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (6)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Crown Princess
Departure: 03 December 2026
Visit: USA, Mexico, Costa Rica, Panama, Curacao
Princess Standard
Inside
$1,379
Oceanview
$1,709
Balcony
$1,979
Suite
$2,979
From
US$1,379
Per Person
View Trip
20 Day Panama Canal Repositioning Cruise From Los Angeles To New York with Norwegian Cruise Line
Cruise

20 Days (19 Nights) Los Angeles to New York
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Bliss
Departure: 13 October 2026
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia, Jamaica
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$14,231
From
US$14,231
Save 418
Per Person
View Trip
15 Day Panama Canal with Holland America
Cruise
 (3)

15 Days (14 Nights) Fort Lauderdale to San Diego
Cruise Line: Holland America
Ship: Zaandam
Departure: 14 March 2027
Visit: USA, Colombia, Panama, Costa Rica, Guatemala, Mexico
Fare Saver
Inside
$2,189
Oceanview
$2,239
Balcony
$4,028
Suite
$8,144
From
US$2,189
Per Person
View Trip
16 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

16 Days (15 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Coral Princess
Departure: 06 January 2027
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Princess Standard
Inside
$2,052
Oceanview
$2,278
Balcony
$2,902
Suite
$3,087
From
US$2,052
Per Person
View Trip
17 Day Panama Canal & Pacific Gems with Regent Seven Seas
Cruise

17 Days (16 Nights) Miami to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 29 December 2026
Visit: USA, Cayman Islands, Colombia, Panama, Costa Rica, Guatemala, Mexico
Upgrade Your Horizon
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,138
Suite
$12,922
From
US$12,138
Save 17,760
Per Person
View Trip
17 Day Panama Canal Repositioning Cruise From Los Angeles To Miami with Norwegian Cruise Line
Cruise

17 Days (16 Nights) Los Angeles to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Bliss
Departure: 13 October 2026
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia, Jamaica
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$14,161
From
US$14,161
Save 418
Per Person
View Trip
20 Day Panama Canal Passage with Seabourn
Cruise
 (1)

20 Days (19 Nights) Los Angeles to Miami
Cruise Line: Seabourn
Ship: Seabourn Quest
Departures: Apr 2026 to May 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia
Explore More
Exclusive Savings
Inside
-
Oceanview
$7,547
Balcony
$9,213
Suite
$15,048
From
US$7,547
Save 153
Per Person
View Trip
18 Day Panama Canal Westward Cruise with Celebrity Cruises
Cruise

18 Days (17 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Celebrity Cruises
Ship: Celebrity Summit
Departure: 13 April 2026
Visit: USA, Cayman Islands, Colombia, Panama, Costa Rica, Guatemala, Mexico
Exclusive Savings
Inside
$1,493
Oceanview
$1,636
Balcony
$4,379
Suite
-
From
US$1,493
Save 721
Per Person
View Trip
8 Day Harvest Caye, Cozumel & Roatan with Norwegian Cruise Line
Cruise

8 Days (7 Nights) Miami to Miami
Cruise Line: Norwegian Cruise Line
Ships: Norwegian Aqua, Norwegian Luna
Departures: Oct 2026 to Mar 2027
Visit: USA, Honduras, Belize, Mexico
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$2,595
From
US$2,595
Save 114
Per Person
View Trip
Results: 61-90 of 265

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Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant South America Cruises Ponant Central America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking Central America Cruises Viking South America Cruises

Central America Tours

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