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249 Cruises (556 Cruise Departures)
12 Day Pristine islands of the Caribbean & the Panama Canal with Scenic
New ReleaseCruise

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 03 April 2027
Visit: Panama, Colombia, Curacao, Saint Vincent, Saint Lucia, Barbados
Preferred Plus Fare + Air Credit
Select Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,110
Suite
$13,270
From
US$11,110
Save 1,320
Per Person
View Trip
8 Day Western Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Galveston to Galveston
Cruise Line: Royal Caribbean
Ship: Symphony of the Seas
Departures: Nov 2026 to Aug 2027
Visit: USA, Mexico, Honduras
Bonus Onboard Credit
Exclusive Savings
Inside
$657
Oceanview
$749
Balcony
$871
Suite
$1,782
From
US$657
Save 711
Per Person
View Trip
17 Day Panama Canal - Ocean To Ocean & Celebration Key with Princess
Cruise

17 Days (16 Nights) Orlando to Los Angeles
Cruise Line: Princess
Ship: Star Princess
Departure: 07 April 2028
Visit: USA, Bahamas, Aruba, Panama, Mexico
Princess Standard
Inside
$1,950
Oceanview
$2,300
Balcony
$3,549
Suite
$6,489
From
US$1,950
Per Person
View Trip
45 Day Sun, Sand & Seas Of Stars with Oceania Cruises
Cruise

45 Days (44 Nights) Los Angeles to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 06 January 2028
Visit: USA, Mexico, Guatemala, Costa Rica (+14 more), Panama, Colombia, Cayman Islands, Saint Martin, Martinique, Saint Lucia, Grenada, Aruba, Puerto Rico, Virgin Islands, Saint Kitts and Nevis, Guadeloupe, Honduras, Belize
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$42,625
Suite
$59,115
From
US$42,625
Save 1,173
Per Person
View Trip
21 Day Panama Canal with Holland America
Cruise

21 Days (20 Nights) Fort Lauderdale to Vancouver
Cruise Line: Holland America
Ship: Eurodam
Departure: 03 April 2027
Visit: USA, Colombia, Panama, Costa Rica, Guatemala, Mexico, Canada
Fare Saver
Inside
$2,384
Oceanview
$2,584
Balcony
$3,890
Suite
$6,605
From
US$2,384
Per Person
View Trip
15 Day A Festive Passage with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 22 December 2027
Visit: USA, Mexico, Guatemala, Belize (+5 more), Honduras, Costa Rica, Panama, Jamaica, Cayman Islands
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,283
Suite
$13,214
From
US$12,283
Save 12,715
Per Person
View Trip
20 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

20 Days (19 Nights) New York to San Francisco
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Bliss
Departure: 09 April 2027
Visit: USA, Dominican Republic, Colombia, Panama, Costa Rica, Guatemala, Mexico
Exclusive Savings
Inside
$2,482
Oceanview
$2,919
Balcony
$3,743
Suite
$4,422
From
US$2,482
Save 57
Per Person
View Trip
22 Day An Extended Journey from Majestic Horizons to Mayan Gems with Explora Journeys
Cruise

22 Days (21 Nights) Miami to Los Angeles
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 12 April 2027
Visit: USA, Jamaica, Curacao, Aruba (+5 more), Colombia, Panama, El Salvador, Guatemala, Mexico
Inside
-
Oceanview
-
Balcony
-
Suite
$12,840
From
US$12,840
Per Person
View Trip
21 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

21 Days (20 Nights) Los Angeles to New York
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Bliss
Departure: 19 October 2027
Visit: USA, Mexico, Guatemala, Costa Rica (+4 more), Panama, Colombia, Jamaica, Bahamas
Exclusive Savings
Inside
$2,368
Oceanview
$3,144
Balcony
$3,872
Suite
$4,454
From
US$2,368
Save 51
Per Person
View Trip
15 Day Tropical Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 12 January 2027
Visit: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,008
Suite
$17,694
From
US$17,008
Save 17,590
Per Person
View Trip
13 Day Caribbean with Costa Rica & Panama Canal Holiday with Princess
Cruise

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Princess
Ship: Caribbean Princess
Departures: Dec 2026 to Dec 2026
Visit: USA, Aruba, Colombia, Panama, Costa Rica, Cayman Islands
Princess Standard
Inside
$1,224
Oceanview
$1,414
Balcony
$1,749
Suite
$2,699
From
US$1,224
Per Person
View Trip
18 Day Panama Canal Eastbound Cruise with Celebrity Cruises
Cruise

18 Days (17 Nights) Los Angeles to Tampa
Cruise Line: Celebrity Cruises
Ship: Celebrity Summit
Departure: 01 October 2026
Visit: USA, Mexico, Guatemala, Costa Rica (+4 more), Panama, Colombia, Jamaica, Cayman Islands
Exclusive Savings
Inside
$1,535
Oceanview
$2,582
Balcony
$4,006
Suite
$14,926
From
US$1,743
Save 466
Per Person
View Trip
34 Day Grand World Voyage with Holland America
Cruise

34 Days (33 Nights) Tokyo to Fort Lauderdale
Cruise Line: Holland America
Ship: Volendam
Departure: 14 April 2026
Visit: Japan, USA, Mexico, El Salvador, Panama, Colombia
Advantage Fare
Exclusive Savings
Inside
$5,925
Oceanview
$7,395
Balcony
$15,132
Suite
-
From
US$5,925
Per Person
View Trip
55 Day Grand World Voyage with Holland America
Cruise

55 Days (54 Nights) Singapore to Fort Lauderdale
Cruise Line: Holland America
Ship: Volendam
Departure: 24 March 2026
Visit: Singapore, Vietnam, China, Taiwan (+6 more), Japan, USA, Mexico, El Salvador, Panama, Colombia
Advantage Fare
Exclusive Savings
Inside
$10,740
Oceanview
$12,798
Balcony
-
Suite
-
From
US$10,740
Per Person
View Trip
22 Day Inca Coast Discovery Segment with Holland America
Cruise
 (3)

22 Days (21 Nights) San Diego to Santiago
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 12 October 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Ecuador, Peru, Chile
Book Early & Have It All Fare Option
Inside
$2,909
Oceanview
$3,109
Balcony
$4,444
Suite
$6,796
From
US$2,909
Per Person
View Trip
20 Day Southern America & Panama Canal Cruise: Lima, Panama City & Cozumel with Azamara Cruises
Cruise
 (3)

20 Days (19 Nights) Santiago to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 March 2027
Visit: Chile, Peru, Panama, Costa Rica, Colombia, Mexico, USA
Azamara Always Included
Exclusive Savings
Inside
$6,145
Oceanview
$6,892
Balcony
$7,697
Suite
$12,751
From
US$6,145
Save 134
Per Person
View Trip
42 Day Inca Coast Discovery Collectors' Voyage with Holland America
Cruise
 (3)

42 Days (41 Nights) Vancouver to Buenos Aires
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 07 October 2027
Visit: Canada, USA, Mexico, Guatemala (+7 more), Costa Rica, Ecuador, Peru, Chile, Argentina, Falkland Islands, Uruguay
Book Early & Have It All Fare Option
Exclusive Savings
Inside
$5,364
Oceanview
$5,756
Balcony
$8,010
Suite
$11,832
From
US$5,364
Per Person
View Trip
37 Day New York To Sydney with Cunard
Cruise
 (1)

37 Days (36 Nights) New York to Sydney
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 19 January 2027
Visit: USA, Aruba, Panama, El Salvador (+4 more), Mexico, Fiji, New Caledonia, Australia
Bonus Onboard Credit
Inside
$6,419
Oceanview
$6,659
Balcony
$8,680
Suite
$22,708
From
US$6,419
Per Person
View Trip
32 Day Panama Canal, Inca & South America: Chilean Fjords with Holland America
Cruise
 (3)

32 Days (31 Nights) Buenos Aires to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departure: 09 March 2027
Visit: Argentina, Uruguay, Falkland Islands, Chile (+5 more), Peru, Ecuador, Panama, Cayman Islands, USA
Fare Saver
Inside
$4,504
Oceanview
$4,604
Balcony
$6,507
Suite
$9,202
From
US$4,504
Per Person
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (3)

17 Days (16 Nights) Fort Lauderdale to Santiago
Cruise Line: Holland America
Ship: Oosterdam
Departure: 18 November 2026
Visit: USA, Cayman Islands, Panama, Ecuador, Peru, Chile
Fare Saver
Inside
$2,159
Oceanview
$2,259
Balcony
$3,059
Suite
$4,692
From
US$2,159
Per Person
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 22 March 2027
Visit: Chile, Peru, Ecuador, Panama, Mexico, USA
Flights Included
Inside
-
Oceanview
-
Balcony
$12,495
Suite
$29,995
From
US$12,495
Per Person
View Trip
32 Day Panama Canal, Inca & South America: Chilean Fjords with Holland America
Cruise
 (3)

32 Days (31 Nights) Fort Lauderdale to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 18 November 2026
Visit: USA, Cayman Islands, Panama, Ecuador (+5 more), Peru, Chile, Argentina, Falkland Islands, Uruguay
Fare Saver
Inside
$4,399
Oceanview
$4,599
Balcony
$6,030
Suite
$8,637
From
US$4,399
Per Person
View Trip
20 Day Panama, Peru & Chile Cruise: Panama Canal, Lima & Coquimbo with Azamara Cruises
Cruise
 (5)

20 Days (19 Nights) Miami to Valparaiso
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 05 January 2028
Visit: USA, Mexico, Belize, Honduras (+5 more), Costa Rica, Panama, Ecuador, Peru, Chile
Azamara Always Included
Exclusive Savings
Inside
$6,119
Oceanview
$6,915
Balcony
$8,379
Suite
$11,968
From
US$6,119
Save 130
Per Person
View Trip
19 Day Valparaiso to Miami with Silversea
Cruise
 (1)

19 Days (18 Nights) Valparaiso to Miami
Cruise Line: Silversea
Ship: Silver Nova
Departure: 05 March 2027
Visit: Chile, Peru, Ecuador, Panama, Mexico, USA
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$16,500
Suite
$22,000
From
US$16,500
Per Person
View Trip
27 Day Inca Coast: Mexico & Latin America Legendary Voyage with Holland America
Cruise
 (3)

27 Days (26 Nights) Vancouver to Santiago
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 07 October 2027
Visit: Canada, USA, Mexico, Guatemala (+4 more), Costa Rica, Ecuador, Peru, Chile
Book Early & Have It All Fare Option
Inside
$3,479
Oceanview
$3,679
Balcony
$5,107
Suite
$7,753
From
US$3,479
Per Person
View Trip
17 Day Machu Picchu & Mayan Ruins with Regent Seven Seas
Cruise

17 Days (16 Nights) Lima to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 10 March 2027
Visit: Peru, Ecuador, Costa Rica, Panama (+4 more), Honduras, Belize, Mexico, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,617
Suite
$16,597
From
US$15,617
Save 16,181
Per Person
View Trip
13 Day Miami, Fl to Lima (Callao) with Silversea
Cruise

13 Days (12 Nights) Miami to Lima
Cruise Line: Silversea
Ship: Silver Ray
Departure: 15 January 2028
Visit: USA, Mexico, Costa Rica, Panama, Ecuador, Peru
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$11,100
Suite
$16,900
From
US$11,100
Per Person
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise

18 Days (17 Nights) Fort Lauderdale to Santiago
Cruise Line: Viking Cruises
Ship: Viking Octantis
Departure: 06 November 2026
Visit: USA, Mexico, Panama, Ecuador, Peru, Chile
Viking $999 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,995
Suite
$14,995
From
US$8,995
Save 1,000
Per Person
View Trip
29 Day Seattle To Miami with Cunard
Cruise
 (13)

29 Days (28 Nights) Seattle to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 17 September 2026
Visit: USA, Canada, Mexico, Guatemala, Panama, Curacao, Aruba
Bonus Onboard Credit
Inside
$2,681
Oceanview
$3,024
Balcony
$4,621
Suite
$14,038
From
US$2,681
Per Person
View Trip
41 Day Seattle To Miami with Cunard
Cruise
 (13)

41 Days (40 Nights) Seattle to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 17 September 2026
Visit: USA, Canada, Mexico, Guatemala (+9 more), Panama, Curacao, Aruba, Puerto Rico, Antigua and Barbuda, Saint Lucia, Barbados, Saint Martin, Virgin Islands
Bonus Onboard Credit
Inside
$3,760
Oceanview
$4,309
Balcony
$6,230
Suite
$14,654
From
US$3,760
Per Person
View Trip
Results: 181-210 of 249

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South & Central America Cruises

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Routes

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Country Routes

Cruises from USA to Germany Cruises from Germany to England Cruises from France to Spain Cruises from Puerto Rico to USA Cruises from Chile to USA Cruises from France to Brazil Cruises from England to Canada Cruises from England to Germany Cruises from Dominican Republic to USA Cruises from USA to Puerto Rico Cruises from Argentina to Brazil Cruises from USA to Brazil Cruises from Argentina to Chile Cruises from Argentina to USA Cruises from Peru to USA Cruises from Australia to USA Cruises from Barbados to USA Cruises from Canada to USA Cruises from Chile to Argentina Cruises from England to USA Cruises from France to Italy Cruises from USA to Dominican Republic Cruises from Italy to Brazil Cruises from Italy to France Cruises from Italy to Greece Cruises from Italy to Spain Cruises from Italy to USA Cruises from Japan to USA Cruises from Panama to USA Cruises from Spain to Brazil Cruises from Singapore to Australia Cruises from Spain to France Cruises from Spain to Greece Cruises from Spain to Italy Cruises from Spain to USA Cruises from USA to Argentina Cruises from USA to Australia Cruises from USA to Barbados Cruises from USA to Canada Cruises from USA to Chile Cruises from USA to England Cruises from USA to French Polynesia Cruises from USA to Italy Cruises from USA to Panama Cruises from USA to Peru Cruises from USA to Spain Cruises from Japan to Canada

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

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