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Panama Tours & Cruises Starting In March 2027 and 2028

Are you planning a tour to Panama in March 2027 or 2028? Choose from 72 unique cruises, small group tours and adventures with 763 departures operated by Panama's leading tour operators. Easily compare prices, itineraries, inclusions and traveler reviews to find the Panama tour that best matches your travel style, budget and dates.
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72 Trips (763 Trip Departures)
6 Day Panama: Sandy Beaches & San Blas Sunsets with G Adventures
New ReleaseTour

6 Days Panama City to Panama City
Operated By: G Adventures
Departures: Apr 2026 to Jan 2028
Visit: Panama
From
US$899
Per Person
View Trip
6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operated By: Globus
Departures: Apr 2026 to Mar 2027
Trip Styles: Short Break, Scenic
Visit: Panama
Exclusive Savings
From
US$1,689
Save 89
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (1)

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Nov 2026 to Mar 2027
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$5,300
Suite
$8,950
From
US$5,300
Per Person
View Trip
18 Day Panama: Craters, Coasts & Highland Mountains with G Adventures
New ReleaseTour

18 Days San Jose to Panama City
Operated By: G Adventures
Departures: Jun 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama
Exclusive Savings
From
US$1,689
Save 386
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Dec 2026 to Mar 2027
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$8,530
Suite
$14,480
From
US$8,530
Per Person
View Trip
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: Mar 2026 to Dec 2028
Trip Styles: Adventure, Small Group
Visit: Costa Rica, Panama
Exclusive Savings
From
US$1,769
Save 511
Per Person
View Trip
13 Day Costa Rica to Panama: Surf, Treks & Starry Skies with G Adventures
New ReleaseTour

13 Days San Jose to Panama City
Operated By: G Adventures
Departures: May 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama
Exclusive Savings
From
US$1,124
Save 125
Per Person
View Trip
27 Day Central and South American Adventure: From Costa Rica to Colombia with G Adventures
New ReleaseTour

27 Days San Jose to Medellin
Operated By: G Adventures
Departures: Oct 2026 to Dec 2027
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama, Colombia
Exclusive Savings
From
US$3,879
Save 133
Per Person
View Trip
20 Day Treasures of French Polynesia & the Marquesas Islands with Scenic
New ReleaseCruise

20 Days (19 Nights) Papeete to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 25 March 2026
Visit: French Polynesia, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,261
Suite
$20,131
From
US$16,261
Save 444
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Mar 2028
Visit: Colombia, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$866
Oceanview
$965
Balcony
$1,179
Suite
$1,160
From
US$866
Save 1,106
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 19 March 2028
Visit: Colombia, Curacao, Aruba, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$966
Oceanview
$1,097
Balcony
$1,556
Suite
$1,656
From
US$966
Save 538
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Apr 2028
Visit: Colombia, Curacao, Aruba, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$866
Oceanview
$997
Balcony
$1,406
Suite
$1,486
From
US$866
Save 572
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Apr 2028
Visit: Panama, Colombia, Curacao, Aruba
Bonus Onboard Credit
Exclusive Savings
Inside
$839
Oceanview
$949
Balcony
$1,329
Suite
$1,398
From
US$839
Save 542
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 18 March 2028
Visit: Panama, Colombia, Curacao, Aruba
Bonus Onboard Credit
Exclusive Savings
Inside
$919
Oceanview
$1,049
Balcony
$1,469
Suite
$1,549
From
US$919
Save 508
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Apr 2028
Visit: Panama, Colombia, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$782
Oceanview
$843
Balcony
$1,026
Suite
$1,089
From
US$839
Save 908
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Mar 2026 to Jan 2028
Visit: Colombia, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$898
Oceanview
$1,028
Balcony
$1,448
Suite
$1,538
From
US$898
Save 640
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Mar 2027 to Mar 2027
Visit: Colombia, Curacao, Bonaire, Aruba, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$1,041
Oceanview
$1,060
Balcony
$1,483
Suite
$1,683
From
US$1,041
Save 566
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (6)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Island Princess
Departure: 18 March 2027
Visit: USA, Aruba, Panama, Costa Rica, Mexico
Princess Standard
Inside
$1,477
Oceanview
$1,497
Balcony
$1,997
Suite
$2,997
From
US$1,477
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ships: Coral Princess, Island Princess
Departures: Sep 2026 to Apr 2027
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,397
Oceanview
$1,463
Balcony
$1,457
Suite
$1,997
From
US$1,397
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (6)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Island Princess
Departure: 18 March 2028
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Princess Standard
Inside
$1,550
Oceanview
$1,769
Balcony
$2,909
Suite
$3,499
From
US$1,550
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Mar 2027 to Mar 2027
Visit: Panama, Colombia, Curacao, Bonaire, Aruba
Bonus Onboard Credit
Exclusive Savings
Inside
$896
Oceanview
$1,066
Balcony
$1,499
Suite
$1,629
From
US$896
Save 549
Per Person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Chile to Panama with Scenic
New ReleaseCruise

14 Days (13 Nights) Santiago to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 21 March 2027
Visit: Chile, Peru, Ecuador, Colombia, Panama
Preferred Plus Fare + Air Credit
Select Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,691
Suite
$13,103
From
US$10,691
Save 1,959
Per Person
View Trip
17 Day Panama Canal: Miami to Los Angeles with Virgin Voyages
Cruise
 (1)

17 Days (16 Nights) Miami to Los Angeles
Cruise Line: Virgin Voyages
Ship: Brilliant Lady
Departures: Mar 2027 to Feb 2028
Visit: USA, Colombia, Panama, Costa Rica, Guatemala, Mexico
Limited Time Offer
Inside
$1,905
Oceanview
$2,385
Balcony
$2,865
Suite
$9,104
From
US$1,905
Per Person
View Trip
11 Day Palms & Panama Canal with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Tampa to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Your World Inclusions
Exclusive Savings
Inside
$3,054
Oceanview
$3,272
Balcony
-
Suite
-
From
US$3,054
Save 3,844
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (6)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Island Princess
Departures: Oct 2027 to Apr 2028
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,299
Oceanview
$1,499
Balcony
$1,999
Suite
$3,439
From
US$1,299
Per Person
View Trip
12 Day Panama Canal & Southern Caribbean with Celebrity Cruises
Cruise

12 Days (11 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departures: Nov 2026 to Mar 2027
Visit: USA, Colombia, Panama, Aruba, Curacao, Bonaire
Exclusive Savings
Inside
$2,279
Oceanview
$2,726
Balcony
$3,979
Suite
$10,232
From
US$2,279
Save 1,291
Per Person
View Trip
11 Day Spanish Lullaby with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 March 2028
Visit: Panama, Costa Rica, Honduras, Guatemala, Mexico, USA
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$2,946
Oceanview
$3,916
Balcony
$4,692
Suite
$6,729
From
US$2,946
Save 3,052
Per Person
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (3)

17 Days (16 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 March 2027
Visit: Chile, Peru, Ecuador, Panama, Cayman Islands, USA
Fare Saver
Inside
$2,299
Oceanview
$2,399
Balcony
$3,299
Suite
$4,829
From
US$2,299
Per Person
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 22 March 2027
Visit: Chile, Peru, Ecuador, Panama, Mexico, USA
Flights Included
Inside
-
Oceanview
-
Balcony
$12,495
Suite
$16,995
From
US$12,495
Per Person
View Trip
19 Day Valparaiso to Miami with Silversea
Cruise
 (1)

19 Days (18 Nights) Valparaiso to Miami
Cruise Line: Silversea
Ship: Silver Nova
Departure: 05 March 2027
Visit: Chile, Peru, Ecuador, Panama, Mexico, USA
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$16,500
Suite
$22,000
From
US$16,500
Per Person
View Trip
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