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Panama Tours & Cruises Starting In March 2026, 2027 and 2028

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93 Trips (859 Trip Departures)
17 Day Miami to LA via Panama Canal with Virgin Voyages
Cruise
 (1)

17 Days (16 Nights) Miami to Los Angeles
Cruise Line: Virgin Voyages
Ship: Brilliant Lady
Departures: Mar 2026 to Mar 2027
Visit: USA, Colombia, Panama, Costa Rica, Guatemala, Mexico
With Love From the World
Inside
$2,851
Oceanview
$3,664
Balcony
$3,687
Suite
$9,280
From
US$2,851
Per Person
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 22 March 2027
Visit: Chile, Peru, Ecuador, Panama, Mexico, USA
Flights Included
Inside
-
Oceanview
-
Balcony
$11,195
Suite
$29,995
From
US$11,195
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (6)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Island Princess
Departures: Oct 2027 to Apr 2028
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,700
Oceanview
$1,909
Balcony
$2,819
Suite
$3,329
From
US$1,700
Per Person
View Trip
19 Day Valparaiso to Miami with Silversea
Cruise
 (1)

19 Days (18 Nights) Valparaiso to Miami
Cruise Line: Silversea
Ship: Silver Nova
Departure: 05 March 2027
Visit: Chile, Peru, Ecuador, Panama, Mexico, USA
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,900
Suite
$17,000
From
US$17,000
Save 3,000
Per Person
View Trip
15 Day Panama Canal with Holland America
Cruise
 (3)

15 Days (14 Nights) Fort Lauderdale to San Diego
Cruise Line: Holland America
Ship: Zaandam
Departure: 14 March 2027
Visit: USA, Colombia, Panama, Costa Rica, Guatemala, Mexico
Fare Saver
Inside
$2,299
Oceanview
$2,599
Balcony
$4,233
Suite
$8,349
From
US$2,299
Per Person
View Trip
11 Day Palms & Panama Canal with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Tampa to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,450
Oceanview
$2,590
Balcony
-
Suite
-
From
US$2,450
Save 4,548
Per Person
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (2)

17 Days (16 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departures: Mar 2027 to Mar 2028
Visit: Chile, Peru, Ecuador, Panama, Cayman Islands, USA
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,724
Oceanview
$3,024
Balcony
$3,724
Suite
$5,148
From
US$2,724
Per Person
View Trip
18 Day Inca & Panama Canal Discovery with Holland America
Cruise
 (2)

18 Days (17 Nights) San Antonio to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departure: 22 March 2026
Visit: Chile, Peru, Ecuador, Panama, Cayman Islands, USA
Have It All Fare Option
Fare Saver
Inside
$1,944
Oceanview
$2,044
Balcony
$3,414
Suite
$4,972
From
US$1,944
Per Person
View Trip
11 Day Spanish Lullaby with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 March 2028
Visit: Panama, Costa Rica, Honduras, Guatemala, Mexico, USA
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$2,946
Oceanview
$3,916
Balcony
$4,692
Suite
$6,729
From
US$2,946
Save 3,052
Per Person
View Trip
23 Day Journey To The Amazon with Regent Seven Seas
Cruise

23 Days (22 Nights) Panama City to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 March 2027
Visit: Panama, Aruba, Trinidad and Tobago, Brazil, Grenada, Curacao
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,904
Suite
$15,639
From
US$14,904
Save 21,594
Per Person
View Trip
27 Day Amazing Central America with Intrepid Travel
Tour

27 Days Antigua to Panama City
Operated By: Intrepid Travel
Departures: Feb 2026 to Dec 2028
Trip Styles: Adventure, Small Group
Visit: Guatemala, Honduras, El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
US$4,219
Save 156
Per Person
View Trip
12 Day Panama Canal & Southern Caribbean with Celebrity Cruises
Cruise

12 Days (11 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departures: Mar 2026 to Mar 2027
Visit: USA, Colombia, Panama, Aruba, Curacao, Bonaire
Exclusive Savings
Inside
$1,707
Oceanview
$2,246
Balcony
$2,646
Suite
$6,824
From
US$1,707
Save 1,516
Per Person
View Trip
25 Day Central American Explorer with Explore Worldwide
Tour

25 Days Panama City to Antigua
Operated By: Explore Worldwide
Departures: Jan 2026 to Nov 2026
Trip Styles: Adventure, Small Group
Visit: Costa Rica, Panama, Guatemala, Honduras, El Salvador, Nicaragua
Exclusive Savings
From
US$4,957
Save 1,457
Per Person
View Trip
12 Day Panama Canal & Southern Caribbean with Celebrity Cruises
Cruise

12 Days (11 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 27 March 2028
Visit: USA, Dominican Republic, Aruba, Curacao, Panama, Cayman Islands
Exclusive Savings
Inside
$2,154
Oceanview
$2,354
Balcony
$2,704
Suite
$7,193
From
US$2,154
Save 1,094
Per Person
View Trip
12 Day Panama Canal From Miami To Miami with Norwegian Cruise Line
Cruise
 (1)

12 Days (11 Nights) Miami to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sun
Departures: Dec 2026 to Apr 2027
Visit: USA, Jamaica, Colombia, Panama, Costa Rica, Belize, Mexico
Exclusive Savings
Inside
$1,669
Oceanview
-
Balcony
$3,280
Suite
$7,034
From
US$1,669
Save 195
Per Person
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Miami to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 29 March 2026
Visit: USA, Jamaica, Aruba, Colombia, Panama, Honduras, Bahamas
Bonus Onboard Credit
Inside
$1,172
Oceanview
$1,362
Balcony
$1,602
Suite
$2,826
From
US$1,172
Per Person
View Trip
34 Day Sydney To Miami with Cunard
Cruise
 (13)

34 Days (33 Nights) Sydney to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 25 March 2028
Visit: Australia, Tonga, USA, Mexico, Costa Rica, Panama, Aruba
Exclusive Savings
Inside
$6,928
Oceanview
$8,116
Balcony
$10,096
Suite
$23,857
From
US$6,928
Per Person
View Trip
13 Day Flavors Of Cartagena with Regent Seven Seas
Cruise

13 Days (12 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 02 March 2028
Visit: USA, Cayman Islands, Jamaica, Dominican Republic, Colombia, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,165
Suite
$8,557
From
US$8,165
Save 14,433
Per Person
View Trip
13 Day Panama Canal Sunfarer with Holland America
Cruise
 (3)

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Rotterdam
Departures: Feb 2026 to Mar 2026
Visit: USA, Bahamas, Curacao, Colombia, Panama, Costa Rica, Cayman Islands
Advantage Fare
Have It All Fare Option
Fare Saver
Inside
$1,299
Oceanview
$2,249
Balcony
$2,899
Suite
$4,086
From
US$1,299
Per Person
View Trip
13 Day Southern Caribbean with Panama with Princess
Cruise

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Princess
Ship: Caribbean Princess
Departure: 28 March 2027
Visit: USA, Cayman Islands, Jamaica, Costa Rica, Panama, Aruba, Dominican Republic
Princess Standard
Inside
$1,470
Oceanview
$1,689
Balcony
$1,900
Suite
$2,850
From
US$1,470
Per Person
View Trip
12 Day Panama Canal & Southern Caribbean Cruise: Cartagena, Aruba & Curacao with Azamara Cruises
Cruise
 (4)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 15 March 2026
Visit: Panama, Colombia, Aruba, Curacao, Bonaire, Dominican Republic, USA
Azamara Always Included
Exclusive Savings
Inside
$2,644
Oceanview
-
Balcony
$5,234
Suite
$13,586
From
US$2,644
Save 55
Per Person
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 March 2028
Visit: USA, Cayman Islands, Jamaica, Aruba, Curacao, Colombia, Panama
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$2,949
Oceanview
$3,919
Balcony
$4,695
Suite
$6,732
From
US$2,949
Save 3,049
Per Person
View Trip
13 Day Panama Canal Discovery: Costa Rica & Greater Antilles with Holland America
Cruise
 (3)

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departures: Oct 2026 to Mar 2027
Visit: USA, Bahamas, Aruba, Colombia, Panama, Costa Rica, Cayman Islands
Fare Saver
Inside
$1,494
Oceanview
$2,094
Balcony
$2,444
Suite
$4,424
From
US$1,494
Per Person
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Miami to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 01 March 2026
Visit: USA, Jamaica, Colombia, Panama, Costa Rica, Honduras, Bahamas
Inside
$1,319
Oceanview
$1,609
Balcony
$1,849
Suite
$3,222
From
US$1,319
Per Person
View Trip
12 Day Central America From Miami To Miami with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Miami to Miami
Cruise Line: Norwegian Cruise Line
Ships: Norwegian Jewel, Norwegian Sun
Departures: Jan 2026 to Feb 2027
Visit: USA, Cayman Islands, Colombia, Panama, Costa Rica, Belize, Mexico
Exclusive Savings
Inside
$1,019
Oceanview
-
Balcony
$3,397
Suite
$5,747
From
US$1,019
Save 152
Per Person
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise
 (3)

12 Days (11 Nights) Miami to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departures: Nov 2026 to Mar 2027
Visit: USA, Jamaica, Colombia, Panama, Costa Rica, Honduras, Belize
Bonus Onboard Credit
Inside
$1,066
Oceanview
$1,196
Balcony
$1,466
Suite
$5,387
From
US$1,066
Per Person
View Trip
20 Day Southern America & Panama Canal Cruise: Lima, Panama City & Cozumel with Azamara Cruises
Cruise
 (3)

20 Days (19 Nights) Santiago to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 March 2027
Visit: Chile, Peru, Panama, Costa Rica, Colombia, Mexico, USA
Azamara Always Included
Exclusive Savings
Inside
$7,008
Oceanview
$7,852
Balcony
$8,793
Suite
$14,681
From
US$7,008
Save 161
Per Person
View Trip
11 Day Panama & Pristine Isles with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 March 2027
Visit: Panama, Colombia, Aruba, Curacao, Jamaica, Bahamas, USA
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$2,999
Oceanview
$3,725
Balcony
$4,404
Suite
$6,344
From
US$2,999
Save 2,999
Per Person
View Trip
13 Day Panama Canal with Costa Rica & Caribbean with Princess
Cruise

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Princess
Ship: Caribbean Princess
Departures: Nov 2027 to Mar 2028
Visit: USA, Aruba, Colombia, Panama, Costa Rica, Cayman Islands, Mexico
Princess Standard
Inside
$1,400
Oceanview
$1,549
Balcony
$2,300
Suite
$3,050
From
US$1,400
Per Person
View Trip
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departures: Jan 2027 to Mar 2027
Visit: USA, Mexico, Belize, Guatemala, Honduras, Costa Rica, Panama
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,999
Oceanview
$3,726
Balcony
$4,405
Suite
$6,345
From
US$2,999
Save 2,999
Per Person
View Trip
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