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3 Week Trips to Panama

Looking to explore Panama for 3 weeks? Then choose from our range of cruises, small group tours and adventures with 5 of the best tour operators to Panama. April is the most popular month to travel to Panama and we have 12 departures available.
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12 trips (12 trip Departures)
21 Day Panama Canal - Ocean to Ocean with Princess
Cruise

21 Days (20 Nights) Fort Lauderdale to Seattle
Cruise Line: Princess
Ship: Star Princess
Departure: 13 April 2026
Visit: USA, Aruba, Panama, Mexico
Princess Standard
Princess Premier
Inside
$1,649
Oceanview
$2,009
Balcony
$2,709
Suite
$4,246
From
US$1,649
Per Person
View Trip
21 Day Miami To Seattle with Cunard
Cruise
 (13)

21 Days (20 Nights) Miami to Seattle
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 14 April 2026
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Inside
$1,499
Oceanview
$1,699
Balcony
$1,999
Suite
$6,535
From
US$1,499
Per Person
View Trip
21 Day Seattle to Miami with Silversea
Cruise
 (1)

21 Days (20 Nights) Seattle to Miami
Cruise Line: Silversea
Ship: Silver Nova
Departure: 11 May 2026
Visit: USA, Mexico, Costa Rica, Panama, Colombia
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
-
Suite
$19,400
From
US$19,400
Per Person
View Trip
21 Day Panama Canal & Pacific Coast with Princess
Cruise
 (6)

21 Days (20 Nights) Vancouver to Fort Lauderdale
Cruise Line: Princess
Ship: Island Princess
Departure: 09 October 2027
Visit: Canada, USA, Mexico, Guatemala, Costa Rica, Panama, Aruba
Princess Standard
Inside
$2,137
Oceanview
$2,437
Balcony
$3,347
Suite
$3,845
From
US$2,137
Per Person
View Trip
21 Day Panama Canal with Holland America
Cruise

21 Days (20 Nights) Vancouver to Fort Lauderdale
Cruise Line: Holland America
Ship: Eurodam
Departure: 04 October 2026
Visit: Canada, USA, Mexico, Guatemala, Costa Rica, Panama, Aruba
Fare Saver
Inside
$2,139
Oceanview
$2,339
Balcony
$3,719
Suite
$5,923
From
US$2,139
Per Person
View Trip
21 Day Panama Canal with Holland America
Cruise

21 Days (20 Nights) Fort Lauderdale to Vancouver
Cruise Line: Holland America
Ship: Eurodam
Departure: 03 April 2027
Visit: USA, Colombia, Panama, Costa Rica, Guatemala, Mexico, Canada
Fare Saver
Inside
$2,599
Oceanview
$2,799
Balcony
$4,121
Suite
$6,669
From
US$2,599
Per Person
View Trip
21 Day Treasures Of The Tropics with Oceania Cruises
Cruise
 (2)

21 Days (20 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 March 2028
Visit: USA, Cayman Islands, Jamaica, Aruba (+7 more), Curacao, Colombia, Panama, Costa Rica, Honduras, Guatemala, Mexico
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$5,605
Oceanview
$7,448
Balcony
$8,952
Suite
$12,832
From
US$5,605
Save 5,793
Per Person
View Trip
21 Day Coastal Calm & Coconuts with Oceania Cruises
Cruise
 (2)

21 Days (20 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 06 January 2028
Visit: USA, Mexico, Belize, Honduras (+7 more), Costa Rica, Panama, Colombia, Curacao, Aruba, Jamaica, Cayman Islands
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$6,091
Oceanview
$7,643
Balcony
$9,147
Suite
$12,833
From
US$6,091
Save 6,307
Per Person
View Trip
21 Day Panama Canal Connoisseur with Oceania Cruises
Cruise
 (1)

21 Days (20 Nights) Tampa to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Visit: USA, Mexico, Belize, Honduras (+7 more), Costa Rica, Panama, Colombia, Curacao, Aruba, Jamaica, Cayman Islands
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$6,385
Oceanview
$6,918
Balcony
-
Suite
-
From
US$6,385
Save 6,613
Per Person
View Trip
21 Day Panama Canal Navigator with Oceania Cruises
Cruise
 (2)

21 Days (20 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 March 2027
Visit: USA, Mexico, Belize, Guatemala (+8 more), Honduras, Costa Rica, Panama, Colombia, Aruba, Curacao, Jamaica, Bahamas
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$6,046
Oceanview
$7,307
Balcony
$8,519
Suite
$12,060
From
US$6,046
Save 6,252
Per Person
View Trip
21 Day Panama Canal & Caribbean with Oceania Cruises
Cruise
 (2)

21 Days (20 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 January 2027
Visit: USA, Mexico, Belize, Guatemala (+8 more), Honduras, Costa Rica, Panama, Colombia, Aruba, Curacao, Jamaica, Cayman Islands
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$5,850
Oceanview
$7,208
Balcony
$8,469
Suite
$12,107
From
US$5,850
Save 6,048
Per Person
View Trip
21 Day Caribbean Kaleidoscope with Oceania Cruises
Cruise
 (1)

21 Days (20 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 17 January 2026
Visit: USA, Mexico, Belize, Guatemala (+8 more), Honduras, Costa Rica, Panama, Colombia, Bonaire, Curacao, Aruba, Jamaica
Your World Inclusions
Exclusive Savings
Inside
$5,905
Oceanview
$10,852
Balcony
-
Suite
-
From
US$5,905
Save 6,093
Per Person
View Trip
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