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Panama Tours & Cruises Starting In September 2026, 2027 and 2028

Are you planning a tour to Panama in September 2026, 2027 or 2028? Choose from 31 unique cruises, small group tours and adventures with 665 departures operated by Panama's leading tour operators. Easily compare prices, itineraries, inclusions and traveler reviews to find the Panama tour that best matches your travel style, budget and dates.
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31 Trips (665 Trip Departures)
6 Day Panama: Sandy Beaches & San Blas Sunsets with G Adventures
New ReleaseTour

6 Days Panama City to Panama City
Operated By: G Adventures
Departures: Jun 2026 to Jan 2028
Visit: Panama
Exclusive Savings
From
US$674
Save 225
Per Person
View Trip
6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operated By: Globus
Departures: Apr 2026 to Mar 2027
Trip Styles: Short Break, Scenic
Visit: Panama
Exclusive Savings
From
US$1,689
Save 89
Per Person
View Trip
13 Day Costa Rica to Panama: Surf, Treks & Starry Skies with G Adventures
New ReleaseTour

13 Days San Jose to Panama City
Operated By: G Adventures
Departures: May 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama
Exclusive Savings
From
US$959
Save 240
Per Person
View Trip
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: Apr 2026 to Dec 2028
Trip Styles: Adventure, Small Group
Visit: Costa Rica, Panama
Exclusive Savings
From
US$1,659
Save 621
Per Person
View Trip
18 Day Panama: Craters, Coasts & Highland Mountains with G Adventures
New ReleaseTour

18 Days San Jose to Panama City
Operated By: G Adventures
Departures: Jun 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama
Exclusive Savings
From
US$1,920
Save 279
Per Person
View Trip
27 Day Central and South American Adventure: From Costa Rica to Colombia with G Adventures
New ReleaseTour

27 Days San Jose to Medellin
Operated By: G Adventures
Departures: Oct 2026 to Dec 2027
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama, Colombia
Exclusive Savings
From
US$3,879
Save 133
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Mar 2028
Visit: Colombia, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$866
Oceanview
$970
Balcony
$1,236
Suite
$1,346
From
US$866
Save 1,097
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Apr 2028
Visit: Panama, Colombia, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$780
Oceanview
$789
Balcony
$1,175
Suite
$1,185
From
US$839
Save 908
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

20 Days (19 Nights) Seattle to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 27 September 2027
Visit: USA, Mexico, Panama, Colombia
Grand Voyages Sale
Inside
$1,939
Oceanview
$2,129
Balcony
$2,726
Suite
$8,720
From
US$1,939
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ships: Coral Princess, Island Princess
Departures: Sep 2026 to Apr 2027
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,499
Oceanview
$1,649
Balcony
$1,899
Suite
$2,249
From
US$1,499
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Sep 2026 to Apr 2028
Visit: Panama, Colombia, Bonaire, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$973
Oceanview
$1,065
Balcony
$1,543
Suite
$1,668
From
US$973
Save 591
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Sep 2026 to Apr 2028
Visit: Colombia, Bonaire, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$1,020
Oceanview
$1,160
Balcony
$1,640
Suite
$1,775
From
US$1,020
Save 707
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

20 Days (19 Nights) Seattle to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 28 September 2026
Visit: USA, Mexico, Costa Rica, Panama, Colombia
Grand Voyages Sale
Inside
$1,533
Oceanview
$1,749
Balcony
$2,183
Suite
$10,287
From
US$1,533
Per Person
View Trip
24 Day Panama Canal & Pacific Coast with Princess
Cruise

24 Days (23 Nights) Vancouver to Fort Lauderdale
Cruise Line: Princess
Ship: Star Princess
Departure: 27 September 2026
Visit: Canada, USA, Mexico, Panama, Aruba
Princess Standard
Inside
$2,106
Oceanview
$2,918
Balcony
$3,226
Suite
$4,545
From
US$2,106
Per Person
View Trip
22 Day Seattle To Miami with Cunard
Cruise
 (13)

22 Days (21 Nights) Seattle to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2026
Visit: USA, Mexico, Guatemala, Panama, Curacao, Aruba
Bonus Onboard Credit
Inside
$2,049
Oceanview
$2,149
Balcony
$3,299
Suite
$12,584
From
US$2,049
Per Person
View Trip
23 Day Panama Canal & Pacific Coast with Princess
Cruise
 (4)

23 Days (22 Nights) Vancouver to Fort Lauderdale
Cruise Line: Princess
Ship: Coral Princess
Departure: 23 September 2026
Visit: Canada, USA, Mexico, Costa Rica, Panama, Aruba
Princess Standard
Inside
$2,573
Oceanview
$2,396
Balcony
$3,331
Suite
$3,976
From
US$2,396
Per Person
View Trip
19 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

19 Days (18 Nights) Los Angeles to New York
Cruise Line: Princess
Ship: Coral Princess
Departure: 27 September 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,649
Oceanview
$1,895
Balcony
$2,857
Suite
$3,747
From
US$1,649
Per Person
View Trip
27 Day Amazing Central America with Intrepid Travel
Tour

27 Days Antigua to Panama City
Operated By: Intrepid Travel
Departures: Apr 2026 to Dec 2028
Trip Styles: Adventure, Small Group
Visit: Guatemala, Honduras, El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
US$4,219
Save 148
Per Person
View Trip
24 Day Panama Canal & Pacific Coast with Princess
Cruise
 (4)

24 Days (23 Nights) Vancouver to New York
Cruise Line: Princess
Ship: Coral Princess
Departure: 22 September 2027
Visit: Canada, USA, Mexico, Guatemala, Costa Rica, Panama, Aruba
Princess Standard
Inside
$2,344
Oceanview
$2,600
Balcony
$3,908
Suite
$4,938
From
US$2,344
Per Person
View Trip
25 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

25 Days (24 Nights) Seattle to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 28 September 2026
Visit: USA, Mexico, Costa Rica, Panama, Colombia, Cayman Islands, Jamaica
Exclusive Savings
Inside
$2,328
Oceanview
$2,638
Balcony
-
Suite
-
From
US$2,328
Save 51
Per Person
View Trip
19 Day Panama Canal Eastbound Cruise with Celebrity Cruises
Cruise

19 Days (18 Nights) Los Angeles to Boston
Cruise Line: Celebrity Cruises
Ship: Celebrity Summit
Departure: 18 September 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia, Turks and Caicos Islands
Exclusive Savings
Inside
$4,036
Oceanview
$4,277
Balcony
$5,288
Suite
-
From
US$4,036
Save 2,297
Per Person
View Trip
29 Day Seattle To Miami with Cunard
Cruise
 (13)

29 Days (28 Nights) Seattle to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 17 September 2026
Visit: USA, Canada, Mexico, Guatemala, Panama, Curacao, Aruba
Bonus Onboard Credit
Inside
$2,681
Oceanview
$3,024
Balcony
$4,621
Suite
$14,038
From
US$2,681
Per Person
View Trip
45 Day Best of Central America with Intrepid Travel
Tour
 (1)

45 Days Playa del Carmen to Panama City
Operated By: Intrepid Travel
Departures: Apr 2026 to Nov 2028
Trip Styles: Adventure, Coach, Small Group, Scenic
Visit: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
US$7,173
Save 249
Per Person
View Trip
18 Day Panama Canal Cruise From Los Angeles To Miami with Norwegian Cruise Line
Cruise
 (1)

18 Days (17 Nights) Los Angeles to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Joy
Departure: 30 September 2027
Visit: USA, Mexico, Guatemala, Costa Rica (+4 more), Panama, Colombia, Jamaica, Cayman Islands
Inside
$2,239
Oceanview
$2,822
Balcony
$3,161
Suite
$3,501
From
US$2,239
Per Person
View Trip
22 Day Panama Canal with Holland America
Cruise
 (3)

22 Days (21 Nights) Vancouver to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 27 September 2026
Visit: Canada, USA, Mexico, Guatemala (+4 more), El Salvador, Panama, Colombia, Bahamas
Fare Saver
Inside
$2,199
Oceanview
$2,299
Balcony
$3,499
Suite
$5,712
From
US$2,199
Per Person
View Trip
59 Day Ultimate Central America with Intrepid Travel
Tour

59 Days Mexico City to Panama City
Operated By: Intrepid Travel
Departures: Apr 2026 to Nov 2028
Trip Styles: Adventure, Small Group
Visit: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
US$9,855
Save 343
Per Person
View Trip
62 Day Total Central America: Two Months of Wild with G Adventures
New ReleaseTour

62 Days Mexico City to Panama City
Operated By: G Adventures
Departures: May 2026 to Oct 2027
Trip Styles: Adventure, Small Group, 18-30's
Visit: Guatemala, Mexico, Nicaragua, Panama (+4 more), Belize, Honduras, Costa Rica, El Salvador
Exclusive Savings
From
US$6,013
Save 214
Per Person
View Trip
62 Day Longitudinal World Cruise IV with Viking Cruises
Cruise

62 Days (61 Nights) Milwaukee to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Octantis
Departure: 22 September 2028
Visit: USA, Canada, Mexico, Panama (+5 more), Ecuador, Peru, Chile, Argentina, Antarctica
Flights Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$52,995
Suite
$75,995
From
US$52,995
Save 2,100
Per Person
View Trip
34 Day Seattle To Miami with Cunard
Cruise
 (13)

34 Days (33 Nights) Seattle to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2026
Visit: USA, Mexico, Guatemala, Panama (+8 more), Curacao, Aruba, Puerto Rico, Antigua and Barbuda, Saint Lucia, Barbados, Saint Martin, Virgin Islands
Bonus Onboard Credit
Inside
$3,228
Oceanview
$3,561
Balcony
$4,923
Suite
$12,478
From
US$3,228
Per Person
View Trip
81 Day Arctic to Antarctic Explorer with Viking Cruises
Cruise
 (1)

81 Days (80 Nights) Nuuk to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 15 September 2028
Visit: Greenland, Cambodia, USA, Bahamas (+8 more), Jamaica, Panama, Peru, Chile, Argentina, Antarctica, South Georgia Island, Falkland Islands
Flights Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$74,995
Suite
$109,995
From
US$74,995
Save 2,800
Per Person
View Trip
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