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Panama Tours & Cruises Starting In September 2026, 2027, 2028 and 2029

Are you planning a tour to Panama in September 2026, 2027, 2028 or 2029? Choose from 32 unique cruises, small group tours and adventures with 637 departures operated by Panama's leading tour operators. Easily compare prices, itineraries, inclusions and traveler reviews to find the Panama tour that best matches your travel style, budget and dates.
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32 Trips (637 Trip Departures)
6 Day Panama: Sandy Beaches & San Blas Sunsets with G Adventures
New ReleaseTour

6 Days Panama City to Panama City
Operated By: G Adventures
Departures: Jun 2026 to Jan 2028
Visit: Panama
Exclusive Savings
From
US$809
Save 100
Per Person
View Trip
6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operated By: Globus
Departures: May 2026 to Mar 2027
Trip Styles: Short Break, Scenic
Visit: Panama
From
US$1,759
Per Person
View Trip
18 Day Panama: Craters, Coasts & Highland Mountains with G Adventures
New ReleaseTour

18 Days San Jose to Panama City
Operated By: G Adventures
Departures: Aug 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama
From
US$2,099
Per Person
View Trip
13 Day Costa Rica to Panama: Surf, Treks & Starry Skies with G Adventures
New ReleaseTour

13 Days San Jose to Panama City
Operated By: G Adventures
Departures: Jul 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama
Exclusive Savings
From
US$1,124
Save 125
Per Person
View Trip
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: May 2026 to Dec 2028
Trip Styles: Adventure, Small Group
Visit: Costa Rica, Panama
Exclusive Savings
From
US$1,738
Save 374
Per Person
View Trip
27 Day Central and South American Adventure: From Costa Rica to Colombia with G Adventures
New ReleaseTour

27 Days San Jose to Medellin
Operated By: G Adventures
Departures: Oct 2026 to Dec 2027
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama, Colombia
From
US$3,999
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Apr 2028
Visit: Panama, Colombia, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$888
Oceanview
$946
Balcony
$1,326
Suite
$1,316
From
US$888
Save 913
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

20 Days (19 Nights) Seattle to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 27 September 2027
Visit: USA, Mexico, Panama, Colombia
Inside
$1,939
Oceanview
$2,129
Balcony
$2,794
Suite
$8,974
From
US$1,939
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Mar 2028
Visit: Colombia, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$1,009
Oceanview
$1,074
Balcony
$1,337
Suite
$1,426
From
US$1,009
Save 1,525
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

20 Days (19 Nights) Seattle to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 28 September 2026
Visit: USA, Mexico, Costa Rica, Panama, Colombia
Inside
$1,434
Oceanview
$1,637
Balcony
$2,098
Suite
$10,589
From
US$1,434
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Sep 2026 to Apr 2028
Visit: Colombia, Bonaire, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$1,133
Oceanview
$1,273
Balcony
$1,790
Suite
$2,200
From
US$1,133
Save 758
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ships: Coral Princess, Island Princess
Departures: Sep 2026 to Apr 2027
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,354
Oceanview
$1,574
Balcony
$1,674
Suite
$2,174
From
US$1,354
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Sep 2026 to Apr 2028
Visit: Panama, Colombia, Bonaire, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$1,000
Oceanview
$1,110
Balcony
$1,693
Suite
$2,093
From
US$1,000
Save 612
Per Person
View Trip
22 Day Seattle To Miami with Cunard
Cruise
 (13)

22 Days (21 Nights) Seattle to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2026
Visit: USA, Mexico, Guatemala, Panama, Curacao, Aruba
Bonus Onboard Credit
Value Fare
Inside
$1,849
Oceanview
$1,949
Balcony
$2,799
Suite
$8,299
From
US$1,849
Per Person
View Trip
23 Day Panama Canal & Pacific Coast with Princess
Cruise
 (4)

23 Days (22 Nights) Vancouver to Fort Lauderdale
Cruise Line: Princess
Ship: Coral Princess
Departure: 23 September 2026
Visit: Canada, USA, Mexico, Costa Rica, Panama, Aruba
Princess Standard
Inside
$2,540
Oceanview
$2,665
Balcony
$3,487
Suite
$4,169
From
US$2,540
Per Person
View Trip
19 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

19 Days (18 Nights) Los Angeles to New York
Cruise Line: Princess
Ship: Coral Princess
Departure: 27 September 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,709
Oceanview
$1,939
Balcony
$2,719
Suite
$3,699
From
US$1,709
Per Person
View Trip
27 Day Amazing Central America with Intrepid Travel
Tour

27 Days Antigua to Panama City
Operated By: Intrepid Travel
Departures: May 2026 to Dec 2028
Trip Styles: Adventure, Small Group
Visit: Guatemala, Honduras, El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
US$3,516
Save 965
Per Person
View Trip
25 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

25 Days (24 Nights) Seattle to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 28 September 2026
Visit: USA, Mexico, Costa Rica, Panama, Colombia, Cayman Islands, Jamaica
Inside
$1,887
Oceanview
$2,160
Balcony
-
Suite
-
From
US$1,887
Per Person
View Trip
29 Day Seattle To Miami with Cunard
Cruise
 (13)

29 Days (28 Nights) Seattle to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 17 September 2026
Visit: USA, Canada, Mexico, Guatemala, Panama, Curacao, Aruba
Bonus Onboard Credit
Value Fare
Inside
$2,513
Oceanview
$2,855
Balcony
$4,508
Suite
$15,432
From
US$2,513
Per Person
View Trip
24 Day Panama Canal & Pacific Coast with Princess
Cruise
 (4)

24 Days (23 Nights) Vancouver to New York
Cruise Line: Princess
Ship: Coral Princess
Departure: 22 September 2027
Visit: Canada, USA, Mexico, Guatemala, Costa Rica, Panama, Aruba
Princess Standard
Inside
$2,758
Oceanview
$2,881
Balcony
$4,137
Suite
$5,657
From
US$2,758
Per Person
View Trip
19 Day Panama Canal Eastbound Cruise with Celebrity Cruises
Cruise

19 Days (18 Nights) Los Angeles to Boston
Cruise Line: Celebrity Cruises
Ship: Celebrity Summit
Departure: 18 September 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia, Turks and Caicos Islands
Exclusive Savings
Inside
$2,997
Oceanview
$3,043
Balcony
$4,547
Suite
-
From
US$2,997
Save 1,576
Per Person
View Trip
45 Day Best of Central America with Intrepid Travel
Tour
 (1)

45 Days Playa del Carmen to Panama City
Operated By: Intrepid Travel
Departures: Jun 2026 to Nov 2028
Trip Styles: Adventure, Coach, Small Group, Scenic
Visit: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
US$6,286
Save 1,220
Per Person
View Trip
22 Day Panama Canal with Holland America
Cruise
 (3)

22 Days (21 Nights) Vancouver to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 27 September 2026
Visit: Canada, USA, Mexico, Guatemala (+4 more), El Salvador, Panama, Colombia, Bahamas
Fare Saver
Inside
$1,999
Oceanview
$2,199
Balcony
$3,299
Suite
$5,799
From
US$1,999
Per Person
View Trip
18 Day Panama Canal Cruise From Los Angeles To Miami with Norwegian Cruise Line
Cruise
 (1)

18 Days (17 Nights) Los Angeles to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Joy
Departure: 30 September 2027
Visit: USA, Mexico, Guatemala, Costa Rica (+4 more), Panama, Colombia, Jamaica, Cayman Islands
Inside
$2,319
Oceanview
$2,889
Balcony
$3,369
Suite
$3,589
From
US$2,319
Per Person
View Trip
59 Day Ultimate Central America with Intrepid Travel
Tour

59 Days Mexico City to Panama City
Operated By: Intrepid Travel
Departures: Jul 2026 to Nov 2028
Trip Styles: Adventure, Small Group
Visit: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
US$8,128
Save 2,199
Per Person
View Trip
25 Day Atlantic Crossing: Halifax To South America with Seabourn
Cruise

25 Days (24 Nights) Halifax to Valparaiso
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 24 September 2028
Visit: Canada, Bermuda, Puerto Rico, Aruba (+4 more), Panama, Ecuador, Peru, Chile
Inside
-
Oceanview
-
Balcony
$13,048
Suite
$17,998
From
US$13,048
Per Person
View Trip
62 Day Total Central America: Two Months of Wild with G Adventures
New ReleaseTour

62 Days Mexico City to Panama City
Operated By: G Adventures
Departures: Aug 2026 to Jun 2027
Trip Styles: Adventure, Small Group, 18-30's
Visit: Guatemala, Mexico, Nicaragua, Panama (+4 more), Belize, Honduras, Costa Rica, El Salvador
From
US$6,199
Per Person
View Trip
62 Day Longitudinal World Cruise IV with Viking Cruises
Cruise

62 Days (61 Nights) Milwaukee to Buenos Aires
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Sep 2028 to Sep 2029
Visit: USA, Canada, Mexico, Panama (+5 more), Ecuador, Peru, Chile, Argentina, Antarctica
Flights Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$52,995
Suite
$75,995
From
US$52,995
Save 2,100
Per Person
View Trip
43 Day Exploring Greenland, Labrador Coast & Panama Canal with Seabourn
Cruise

43 Days (42 Nights) Reykjavik to Valparaiso
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 06 September 2028
Visit: Iceland, Greenland, Canada, Bermuda (+6 more), Puerto Rico, Aruba, Panama, Ecuador, Peru, Chile
Inside
-
Oceanview
-
Balcony
$31,047
Suite
$44,997
From
US$31,047
Per Person
View Trip
34 Day Seattle To Miami with Cunard
Cruise
 (13)

34 Days (33 Nights) Seattle to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2026
Visit: USA, Mexico, Guatemala, Panama (+8 more), Curacao, Aruba, Puerto Rico, Antigua and Barbuda, Saint Lucia, Barbados, Saint Martin, Virgin Islands
Inside
$2,967
Oceanview
$3,147
Balcony
$4,449
Suite
$12,714
From
US$2,967
Per Person
View Trip
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