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Panama Tours & Cruises Starting In April 2027, 2028 and 2029

Are you planning a tour to Panama in April 2027, 2028 or 2029? Choose from 70 unique cruises, small group tours and adventures with 773 departures operated by Panama's leading tour operators. Easily compare prices, itineraries, inclusions and traveller reviews to find the Panama tour that best matches your travel style, budget and dates.
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70 Trips (773 Departures)
70 Trips (773 Departures)
Departures
Duration
6 Days
62 Days
Types
Budget
Start & End Cities
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Price
$1,000pp
$147,495pp
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9 Day Independent Panama with the Pacific Coast with Globus
New ReleaseTour

9 Days Panama City to Pacific Coast
Operator: Globus
Departures: Nov 2026 to Mar 2028
Trip Style: Scenic
Visits: Panama
Exclusive Savings
From (Per Person)
A$4,393
Save 161
Per Person
View Trip
6 Day Panama: Sandy Beaches & San Blas Sunsets with G Adventures
New ReleaseTour

6 Days Panama City to Panama City
Operator: G Adventures
Departures: Nov 2026 to Feb 2028
Trip Styles: Adventure, Small Group, 18-30's, Short Break
Visits: Panama
Exclusive Savings
From (Per Person)
A$1,102
Save 437
Per Person
View Trip
6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operator: Globus
Departures: Nov 2026 to Mar 2028
Trip Styles: Short Break, Scenic
Visits: Panama
Exclusive Savings
From (Per Person)
A$2,890
Save 105
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Puntarenas to Colon
Operator: Ponant
Ships: Le Bellot, Le Bougainville, Le Laperouse
Departures: Dec 2026 to Apr 2028
Visits: Costa Rica, Panama
Exclusive Savings
Balcony
$10,789
Suite
$17,996
From (Per Person)
A$10,789
Save 433
Per Person
View Trip
16 Day Wonders of Colombia (MedellÍn, Cartagena & Panama Extensions) with AmaWaterways
New ReleaseTour + River Cruise

16 Days Medellin to Panama City
Operator: AmaWaterways
Ships: AmaMagdalena, AmaMelodia
Departures: Oct 2026 to Dec 2027
Rivers: Magdalena
Visits: Colombia, Panama
Exclusive Savings
Balcony
$11,708
Suite
$13,800
From (Per Person)
A$11,708
Save 1,929
Per Person
View Trip
11 Day Wonders of Colombia (Panama Extension) with AmaWaterways
New ReleaseTour + River Cruise

11 Days Cartagena to Panama City
Operator: AmaWaterways
Ships: AmaMagdalena, AmaMelodia
Departures: Oct 2026 to Dec 2027
Rivers: Magdalena
Visits: Colombia, Panama
Exclusive Savings
Balcony
$8,063
Suite
$10,155
From (Per Person)
A$8,063
Save 1,785
Per Person
View Trip
18 Day Panama: Craters, Coasts & Highland Mountains with G Adventures
New ReleaseTour

18 Days San Jose to Panama City
Operator: G Adventures
Departures: Dec 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visits: Costa Rica, Panama
Exclusive Savings
From (Per Person)
A$2,645
Save 954
Per Person
View Trip
14 Day Magic of Colombia (MedellÍn & Panama Extensions) with AmaWaterways
New ReleaseTour + River Cruise

14 Days Medellin to Panama City
Operator: AmaWaterways
Ships: AmaMagdalena, AmaMelodia
Departures: Oct 2026 to Dec 2027
Rivers: Magdalena
Visits: Colombia, Panama
Exclusive Savings
Balcony
$8,999
Suite
$12,568
From (Per Person)
A$8,999
Save 1,879
Per Person
View Trip
13 Day Costa Rica to Panama: Surf, Treks & Starry Skies with G Adventures
New ReleaseTour

13 Days San Jose to Panama City
Operator: G Adventures
Departures: Dec 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visits: Costa Rica, Panama
Exclusive Savings
From (Per Person)
A$1,469
Save 530
Per Person
View Trip
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operator: Intrepid
Departures: Dec 2026 to Dec 2028
Trip Styles: Adventure, Small Group
Visits: Costa Rica, Panama
Exclusive Savings
From (Per Person)
A$2,812
Save 219
Per Person
View Trip
12 Day Costa Rica & the Panama Canal with Aurora Expeditions
New ReleaseCruise

12 Days (11 Nights) San Jose to Panama City
Operator: Aurora Expeditions
Ships: Sylvia Earle, Douglas Mawson
Departures: Apr 2027 to Apr 2028
Visits: Costa Rica, Panama
Exclusive Savings
Oceanview
$24,346
Balcony
$24,448
Suite
$39,017
From (Per Person)
A$24,346
Per Person
View Trip
11 Day Magic of Colombia (Panama Extension) with AmaWaterways
New ReleaseTour + River Cruise

11 Days Barranquilla to Panama City
Operator: AmaWaterways
Ships: AmaMagdalena, AmaMelodia
Departures: Oct 2026 to Dec 2027
Rivers: Magdalena
Visits: Colombia, Panama
Exclusive Savings
Balcony
$7,923
Suite
$10,155
From (Per Person)
A$7,923
Save 1,785
Per Person
View Trip
27 Day Central and South American Adventure: From Costa Rica to Colombia with G Adventures
New ReleaseTour

27 Days San Jose to Medellin
Operator: G Adventures
Departures: Apr 2027 to Dec 2027
Trip Styles: Adventure, Small Group, 18-30's
Visits: Costa Rica, Panama, Colombia
Exclusive Savings
From (Per Person)
A$5,683
Save 130
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Dec 2026 to Mar 2028
Visits: Colombia, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,484
Oceanview
$1,614
Balcony
$2,015
Suite
$2,419
From (Per Person)
A$1,484
Save 3,345
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Apr 2028
Visits: Panama, Colombia, Curacao, Aruba
Exclusive Savings
Inside
$1,429
Oceanview
$1,529
Balcony
$2,079
Suite
$2,390
From (Per Person)
A$1,429
Save 926
Per Person
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

7 Days (6 Nights) Cartagena to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Nov 2026 to Apr 2028
Visits: Colombia, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,342
Oceanview
$1,584
Balcony
$2,259
Suite
$2,691
From (Per Person)
A$1,342
Save 2,505
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Apr 2028
Visits: Colombia, Curacao, Aruba, Panama
Exclusive Savings
Inside
$1,466
Oceanview
$1,621
Balcony
$2,219
Suite
$2,763
From (Per Person)
A$1,466
Save 972
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2027 to Apr 2028
Visits: Panama, Colombia, Curacao, Aruba
Exclusive Savings
Inside
$1,386
Oceanview
$1,502
Balcony
$2,065
Suite
$2,550
From (Per Person)
A$1,386
Save 1,308
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Nov 2026 to Apr 2028
Visits: Panama, Colombia, Aruba, Curacao
Exclusive Savings
Inside
$1,369
Oceanview
$1,500
Balcony
$2,009
Suite
$2,388
From (Per Person)
A$1,369
Save 1,970
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Operator: MSC Cruises
Ship: MSC Poesia
Departure: 08 April 2027
Visits: USA, Colombia, Panama, Mexico
Exclusive Savings
Inside
$2,773
Oceanview
$3,060
Balcony
$4,228
Suite
$15,929
From (Per Person)
A$2,773
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2027 to Apr 2028
Visits: Colombia, Curacao, Aruba, Panama
Exclusive Savings
Inside
$1,506
Oceanview
$1,603
Balcony
$2,113
Suite
$2,461
From (Per Person)
A$1,506
Save 1,277
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Operator: Princess
Ship: Star Princess
Departure: 03 April 2027
Visits: USA, Aruba, Panama, Mexico
Sanctuary Collection
Exclusive Savings
Inside
$2,446
Oceanview
$2,917
Balcony
$3,570
Suite
$7,035
From (Per Person)
A$2,446
Per Person
View Trip
15 Day Los Angeles To Miami with Cunard
Cruise
 (13)

15 Days (14 Nights) Los Angeles to Miami
Operator: Cunard
Ship: Queen Elizabeth
Departure: 13 April 2028
Visits: USA, Mexico, Costa Rica, Panama, Aruba
Exclusive Savings
Inside
$4,261
Oceanview
$5,053
Balcony
$6,488
Suite
$14,161
From (Per Person)
A$4,261
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 01 April 2028
Visits: Panama, Colombia, Bonaire, Aruba, Curacao
Exclusive Savings
Inside
$1,646
Oceanview
$1,785
Balcony
$2,390
Suite
$2,959
From (Per Person)
A$1,646
Save 924
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Operator: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2028
Visits: USA, Colombia, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$3,050
Oceanview
$3,337
Balcony
$4,248
Suite
$13,533
From (Per Person)
A$3,050
Per Person
View Trip
16 Day World Cruise Segment - Panama Canal with Princess
Cruise
 (4)

16 Days (15 Nights) Fort Lauderdale to Los Angeles
Operator: Princess
Ship: Coral Princess
Departures: Jan 2028 to Apr 2028
Visits: USA, Colombia, Panama, El Salvador, Mexico
Exclusive Savings
Inside
$2,458
Oceanview
$2,696
Balcony
$3,107
Suite
$5,725
From (Per Person)
A$2,458
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 10 April 2027
Visits: Panama, Colombia, Aruba, Bonaire, Curacao
Exclusive Savings
Inside
$1,690
Oceanview
$1,835
Balcony
$4,257
Suite
$3,313
From (Per Person)
A$1,690
Save 1,182
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (6)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Operator: Princess
Ship: Island Princess
Departures: Mar 2027 to Apr 2027
Visits: USA, Mexico, Costa Rica, Panama, Aruba
Exclusive Savings
Inside
$2,350
Oceanview
$2,631
Balcony
$3,750
Suite
$5,829
From (Per Person)
A$2,350
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 02 April 2028
Visits: Colombia, Bonaire, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,725
Oceanview
$1,862
Balcony
$2,537
Suite
$2,956
From (Per Person)
A$1,725
Save 976
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (12)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Operator: Princess
Ship: Crown Princess
Departure: 04 April 2027
Visits: USA, Colombia, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$2,047
Oceanview
$2,364
Balcony
$3,918
Suite
$6,720
From (Per Person)
A$2,047
Per Person
View Trip
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