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Panama Tours & Cruises Starting In April 2026, 2027 and 2028

Are you planning a tour to Panama in April 2026, 2027 or 2028? Choose from 69 unique cruises, small group tours and adventures with 748 departures operated by Panama's leading tour operators. Easily compare prices, itineraries, inclusions and traveler reviews to find the Panama tour that best matches your travel style, budget and dates.
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69 Trips (748 Trip Departures)
6 Day Panama: Sandy Beaches & San Blas Sunsets with G Adventures
New ReleaseTour

6 Days Panama City to Panama City
Operated By: G Adventures
Departures: Apr 2026 to Jan 2028
Visit: Panama
From
US$899
Per Person
View Trip
6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operated By: Globus
Departures: Apr 2026 to Mar 2027
Trip Styles: Short Break, Scenic
Visit: Panama
Exclusive Savings
From
US$1,689
Save 89
Per Person
View Trip
18 Day Panama: Craters, Coasts & Highland Mountains with G Adventures
New ReleaseTour

18 Days San Jose to Panama City
Operated By: G Adventures
Departures: Jun 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama
Exclusive Savings
From
US$1,689
Save 386
Per Person
View Trip
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: Mar 2026 to Dec 2028
Trip Styles: Adventure, Small Group
Visit: Costa Rica, Panama
Exclusive Savings
From
US$1,769
Save 511
Per Person
View Trip
13 Day Costa Rica to Panama: Surf, Treks & Starry Skies with G Adventures
New ReleaseTour

13 Days San Jose to Panama City
Operated By: G Adventures
Departures: May 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama
Exclusive Savings
From
US$1,124
Save 125
Per Person
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 18 April 2026
Visit: Panama, Colombia
Exclusive Savings
Inside
$118
Oceanview
$127
Balcony
$133
Suite
$155
From
US$118
Save 117
Per Person
View Trip
27 Day Central and South American Adventure: From Costa Rica to Colombia with G Adventures
New ReleaseTour

27 Days San Jose to Medellin
Operated By: G Adventures
Departures: Oct 2026 to Dec 2027
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama, Colombia
Exclusive Savings
From
US$3,879
Save 133
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Mar 2028
Visit: Colombia, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$866
Oceanview
$965
Balcony
$1,179
Suite
$1,160
From
US$866
Save 1,106
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Apr 2028
Visit: Colombia, Curacao, Aruba, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$866
Oceanview
$997
Balcony
$1,406
Suite
$1,486
From
US$866
Save 572
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2027 to Apr 2028
Visit: Colombia, Curacao, Aruba, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$868
Oceanview
$998
Balcony
$1,408
Suite
$1,487
From
US$868
Save 627
Per Person
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Cartagena to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 19 April 2026
Visit: Colombia, Curacao, Aruba, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$2,712
From
US$2,712
Save 1,918
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Apr 2028
Visit: Panama, Colombia, Curacao, Aruba
Bonus Onboard Credit
Exclusive Savings
Inside
$839
Oceanview
$949
Balcony
$1,329
Suite
$1,398
From
US$839
Save 542
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2027 to Apr 2028
Visit: Panama, Colombia, Curacao, Aruba
Bonus Onboard Credit
Exclusive Savings
Inside
$841
Oceanview
$951
Balcony
$1,330
Suite
$1,400
From
US$841
Save 668
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 08 April 2027
Visit: USA, Colombia, Panama, Mexico
Grand Voyages Sale
Inside
$1,767
Oceanview
$2,370
Balcony
$3,122
Suite
$9,756
From
US$1,767
Per Person
View Trip
21 Day Panama Canal - Ocean to Ocean with Princess
Cruise

21 Days (20 Nights) Fort Lauderdale to Seattle
Cruise Line: Princess
Ship: Star Princess
Departure: 13 April 2026
Visit: USA, Aruba, Panama, Mexico
Princess Standard
Princess Premier
Inside
$1,799
Oceanview
$2,259
Balcony
$2,299
Suite
$2,399
From
US$1,799
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Apr 2028
Visit: Panama, Colombia, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$782
Oceanview
$843
Balcony
$1,026
Suite
$1,089
From
US$839
Save 908
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Mar 2026 to Jan 2028
Visit: Colombia, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$898
Oceanview
$1,028
Balcony
$1,448
Suite
$1,538
From
US$898
Save 640
Per Person
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

7 Days (6 Nights) Cartagena to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Nov 2026 to Apr 2028
Visit: Colombia, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$811
Oceanview
$932
Balcony
$1,249
Suite
$1,237
From
US$811
Save 578
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Star Princess
Departure: 03 April 2027
Visit: USA, Aruba, Panama, Mexico
Princess Standard
Inside
$1,399
Oceanview
$2,099
Balcony
$3,029
Suite
$5,242
From
US$1,399
Per Person
View Trip
11 Day Panama Canal Westward Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Colon to Los Angeles
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 25 April 2026
Visit: Panama, Costa Rica, Mexico, USA
Exclusive Savings
Inside
$757
Oceanview
$915
Balcony
$1,537
Suite
-
From
US$757
Save 311
Per Person
View Trip
15 Day Los Angeles To Miami with Cunard
Cruise
 (13)

15 Days (14 Nights) Los Angeles to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 13 April 2028
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Inside
$3,119
Oceanview
$3,619
Balcony
$4,309
Suite
-
From
US$3,119
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Sep 2026 to Apr 2028
Visit: Panama, Colombia, Bonaire, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$973
Oceanview
$1,065
Balcony
$1,543
Suite
$1,643
From
US$973
Save 591
Per Person
View Trip
12 Day A Journey Of Mayan Discovery & Mexican Exploration with Explora Journeys
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visit: Panama, El Salvador, Guatemala, Mexico, USA
Inside
-
Oceanview
-
Balcony
-
Suite
$6,535
From
US$6,535
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 11 April 2027
Visit: Colombia, Aruba, Bonaire, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$1,052
Oceanview
$1,122
Balcony
$1,705
Suite
$1,765
From
US$1,052
Save 571
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Sep 2026 to Apr 2028
Visit: Colombia, Bonaire, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$1,020
Oceanview
$1,160
Balcony
$1,640
Suite
$1,750
From
US$1,020
Save 703
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ships: Coral Princess, Island Princess
Departures: Sep 2026 to Apr 2027
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,397
Oceanview
$1,463
Balcony
$1,457
Suite
$1,997
From
US$1,397
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2028
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$2,971
Oceanview
$3,388
Balcony
$4,349
Suite
$11,915
From
US$2,971
Save 76
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (7)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ships: Crown Princess, Emerald Princess (+3 more), Grand Princess, Island Princess, Sapphire Princess
Departures: Apr 2026 to Apr 2028
Visit: USA, Aruba, Panama, Costa Rica, Mexico
Princess Standard
Inside
$1,297
Oceanview
$1,499
Balcony
$1,999
Suite
$3,007
From
US$1,297
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 23 April 2026
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Grand Voyages Sale
Inside
$1,461
Oceanview
$1,681
Balcony
$1,973
Suite
$6,980
From
US$1,461
Per Person
View Trip
15 Day Los Angeles To Miami with Cunard
Cruise

15 Days (14 Nights) Los Angeles to Miami
Cruise Line: Cunard
Ship: Queen Anne
Departure: 05 April 2026
Visit: USA, Guatemala, Panama, Curacao, Aruba
Inside
$1,689
Oceanview
-
Balcony
$2,909
Suite
$6,067
From
US$1,689
Per Person
View Trip
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