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Tours from Santiago

Choose from 18 unique multi-day guided tours starting in Santiago, and traveling to Buenos Aires, Cusco, El Calafate, Lima, Rio de Janeiro and more. November is the most popular month to join a tour from Santiago and you can select from 289 departures available from eleven leading tour operators.
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18 Tours (289 Tour Departures)
20 Day Highlights of South America with Travelmarvel
Tour
 (4)

20 Days Santiago to Lima
Operated By: Travelmarvel
Departures: Aug 2026 to Sep 2026
Trip Styles: Coach, Small Group, Scenic
Visit: Chile, Argentina, Brazil, Peru
From
US$9,695
Per Person
View Trip
12 Day Chile, Argentina and Brazil Discovery with APT
Tour

12 Days Santiago to Rio de Janeiro
Operated By: APT
Departures: Apr 2026 to Oct 2026
Trip Styles: Coach, Scenic
Visit: Chile, Argentina, Brazil
From
US$8,895
Per Person
View Trip
18 Day Patagonia: Journey to the End of the World with Easter Island with Globus
Tour

18 Days Santiago to Buenos Aires
Operated By: Globus
Departures: Oct 2026 to Dec 2027
Trip Styles: Coach, Small Group, Scenic
Visit: Chile, Easter Island, Argentina
From
US$11,712
Per Person
View Trip
9 Day Premium Patagonia with Intrepid Travel
Tour

9 Days Santiago to Ushuaia
Operated By: Intrepid Travel
Departures: Nov 2026 to Dec 2027
Visit: Chile, Argentina
From
US$10,290
Per Person
View Trip
4 Day Independent Santiago City Stay with Globus
New ReleaseTour

4 Days Santiago to Santiago
Operated By: Globus
Departures: Apr 2026 to Mar 2027
Trip Styles: Short Break, Scenic
Visit: Chile
From
US$1,229
Per Person
View Trip
9 Day Patagonian Adventure with Scenic
Tour

9 Days Santiago to El Calafate
Operated By: Scenic
Departures: Nov 2026 to Feb 2028
Trip Styles: Small Group, Scenic
Visit: Chile, Argentina
From
US$17,665
Per Person
View Trip
15 Day Premium Chile, Argentina & Brazil with Intrepid Travel
Tour

15 Days Santiago to Rio de Janeiro
Operated By: Intrepid Travel
Departures: Jun 2026 to Dec 2027
Trip Styles: Adventure, Small Group
Visit: Chile, Argentina, Brazil
From
US$11,990
Per Person
View Trip
12 Day Classic South America with Luxury Gold
Tour

12 Days Santiago to Rio de Janeiro
Operated By: Luxury Gold
Departures: May 2026 to Nov 2026
Trip Styles: Coach, Small Group, Scenic
Visit: Chile, Argentina, Brazil
From
US$10,983
Per Person
View Trip
12 Day Heart of Patagonia (Small Group) with Insight Vacations
New ReleaseTour

12 Days Santiago to Buenos Aires
Operated By: Insight Vacations
Departure: 16 November 2026
Trip Styles: Coach, Small Group, Scenic
Visit: Chile, Argentina
Sign Up Savings
Exclusive Savings
From
US$9,575
Save 150
Per Person
View Trip
14 Day Chile & Argentina: Capital Cities & Hiking Patagonia with G Adventures
New ReleaseTour

14 Days Santiago to Buenos Aires
Operated By: G Adventures
Departures: Oct 2026 to Mar 2027
Visit: Chile, Argentina
From
US$9,999
Per Person
View Trip
12 Day Heart of Patagonia with Insight Vacations
New ReleaseTour

12 Days Santiago to Buenos Aires
Operated By: Insight Vacations
Departures: Oct 2026 to Nov 2027
Trip Styles: Coach, Scenic
Visit: Chile, Argentina
Sign Up Savings
Today's Deal
Exclusive Savings
From
US$7,694
Save 862
Per Person
View Trip
9 Day Premium Chile & Argentina with Intrepid Travel
Tour

9 Days Santiago to Buenos Aires
Operated By: Intrepid Travel
Departures: Apr 2026 to Dec 2027
Trip Styles: Adventure, Small Group
Visit: Chile, Argentina
From
US$6,690
Per Person
View Trip
13 Day Patagonia: Journey to the End of the World with Globus
Tour

13 Days Santiago to Buenos Aires
Operated By: Globus
Departures: Oct 2026 to Dec 2027
Trip Styles: Coach, Small Group, Scenic
Visit: Chile, Argentina
Exclusive Savings
From
US$8,384
Save 500
Per Person
View Trip
13 Day Highlights of Chile - Atacama to Paine with Explore Worldwide
Tour

13 Days Santiago to Santiago
Operated By: Explore Worldwide
Departures: Nov 2026 to Dec 2026
Trip Styles: Adventure, Small Group
Visit: Chile
From
US$7,050
Per Person
View Trip
19 Day Best of South America with APT
Tour

19 Days Santiago to Cusco
Operated By: APT
Departures: Apr 2026 to Oct 2026
Trip Styles: Coach, Scenic
Visit: Chile, Argentina, Brazil, Peru
From
US$13,395
Per Person
View Trip
11 Day Patagonia with Tauck
Tour

11 Days Santiago to Buenos Aires
Operated By: Tauck
Departures: Oct 2026 to Dec 2027
Trip Styles: Coach, Scenic
Visit: Chile, Argentina
From
US$9,990
Per Person
View Trip
9 Day Essential South America with Collette
New ReleaseTour

9 Days Santiago to Buenos Aires
Operated By: Collette
Departures: Apr 2026 to Jun 2028
Trip Styles: Coach, Small Group, Scenic
Visit: Chile, Argentina
Exclusive Savings
From
US$4,599
Save 300
Per Person
View Trip
11 Day South American Treasures with Travelmarvel
New ReleaseTour

11 Days Santiago to Rio de Janeiro
Operated By: Travelmarvel
Departures: Aug 2026 to Sep 2026
Trip Styles: Coach, Small Group, Scenic
Visit: Chile, Argentina, Brazil
From
US$5,395
Per Person
View Trip
Results: 18 results

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South America Tours

All South America Tours Amazon Tours Argentina Tours Brazil Tours Chile Tours Colombia Tours Ecuador Tours Galapagos Tours Patagonia Tours Peru Tours

Travel Styles

18-30's Tours Adventure Tours Coach Tours Luxury Tours Short Break Tours Small Group Tours Walking & Hiking Tours Wildlife Tours

Trip Lengths

10 Day 2 Week

Departure Months

April May June July August September October November December January February March

Cities

Santiago

Routes

Santiago to Buenos Aires

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