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Tours From Santiago

Choose from 18 unique multi-day guided tours starting in Santiago, and traveling to Buenos Aires, Cusco, El Calafate, Lima, Rio de Janeiro and more. October is the most popular month to join a tour from Santiago and you can select from 224 departures available from ten leading tour operators.
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28 Days
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18 Tours (224 Tour Departures)
20 Day Highlights of South America with Travelmarvel
Tour
 (4)

20 Days Santiago to Lima
Operated By: Travelmarvel
Departures: Apr 2026 to Oct 2026
Trip Styles: Coach, Scenic
Visit: Chile, Argentina, Brazil, Peru
Exclusive Savings
From
US$9,527
Save 468
Per Person
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14 Day Chile & Argentina: Capital Cities & Hiking Patagonia with G Adventures
New ReleaseTour

14 Days Santiago to Buenos Aires
Operated By: G Adventures
Departures: Jan 2026 to Mar 2027
Visit: Chile, Argentina
Exclusive Savings
From
US$9,699
Save 336
Per Person
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28 Day Chile to Brazil: Road Trippin’ Lake District & Beyond with G Adventures
New ReleaseTour

28 Days Santiago to Rio de Janeiro
Operated By: G Adventures
Departure: 09 February 2026
Trip Styles: Adventure, Small Group, 18-30's
Visit: Chile, Argentina, Uruguay, Brazil
Exclusive Savings
From
US$4,849
Save 150
Per Person
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18 Day Patagonia: Journey to the End of the World with Easter Island with Globus
Tour

18 Days Santiago to Buenos Aires
Operated By: Globus
Departures: Feb 2026 to Dec 2027
Trip Styles: Coach, Small Group, Scenic
Visit: Chile, Easter Island, Argentina
Exclusive Savings
From
US$11,324
Save 430
Per Person
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9 Day Premium Chile & Argentina with Intrepid Travel
Tour

9 Days Santiago to Buenos Aires
Operated By: Intrepid Travel
Departures: Oct 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Visit: Chile, Argentina
Exclusive Savings
From
US$4,769
Save 1,376
Per Person
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9 Day Essential South America with Collette
New ReleaseTour

9 Days Santiago to Buenos Aires
Operated By: Collette
Departures: Oct 2025 to May 2027
Trip Styles: Coach, Small Group, Scenic
Visit: Chile, Argentina
Exclusive Savings
From
US$4,123
Save 480
Per Person
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19 Day Best of South America with APT
Tour

19 Days Santiago to Cusco
Operated By: APT
Departures: Apr 2026 to Oct 2026
Trip Styles: Coach, Scenic
Visit: Chile, Argentina, Brazil, Peru
Exclusive Savings
From
US$13,169
Save 926
Per Person
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11 Day South American Treasures with Travelmarvel
New ReleaseTour

11 Days Santiago to Rio de Janeiro
Operated By: Travelmarvel
Departures: Apr 2026 to Oct 2026
Trip Styles: Coach, Scenic
Visit: Chile, Argentina, Brazil
Exclusive Savings
From
US$5,312
Save 183
Per Person
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9 Day Premium Patagonia with Intrepid Travel
Tour

9 Days Santiago to Ushuaia
Operated By: Intrepid Travel
Departures: Nov 2025 to Dec 2025
Visit: Chile, Argentina
Exclusive Savings
From
US$8,520
Save 1,269
Per Person
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13 Day Highlights of Chile - Atacama to Paine with Explore Worldwide
Tour

13 Days Santiago to Santiago
Operated By: Explore Worldwide
Departures: Oct 2025 to Dec 2026
Trip Styles: Adventure, Small Group
Visit: Chile
Sign Up Savings
Exclusive Savings
From
US$5,605
Save 917
Per Person
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4 Day Independent Santiago City Stay with Globus
New ReleaseTour

4 Days Santiago to Santiago
Operated By: Globus
Departures: Oct 2025 to Mar 2027
Trip Styles: Short Break, Scenic
Visit: Chile
Exclusive Savings
From
US$989
Save 150
Per Person
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12 Day Classic South America with Luxury Gold
Tour

12 Days Santiago to Rio de Janeiro
Operated By: Luxury Gold
Departures: Oct 2025 to Nov 2026
Trip Styles: Coach, Small Group, Scenic
Visit: Chile, Argentina, Brazil
Exclusive Savings
From
US$9,514
Save 404
Per Person
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9 Day Patagonian Adventure with Scenic
Tour

9 Days Santiago to El Calafate
Operated By: Scenic
Departures: Feb 2026 to Feb 2027
Trip Styles: Small Group, Scenic
Visit: Chile, Argentina
Exclusive Savings
From
US$15,590
Save 512
Per Person
View Trip
15 Day Premium Chile, Argentina & Brazil with Intrepid Travel
Tour

15 Days Santiago to Rio de Janeiro
Operated By: Intrepid Travel
Departures: Oct 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Visit: Chile, Argentina, Brazil
Exclusive Savings
From
US$9,629
Save 1,401
Per Person
View Trip
12 Day Chile, Argentina and Brazil Discovery with APT
Tour

12 Days Santiago to Rio de Janeiro
Operated By: APT
Departures: Apr 2026 to Oct 2026
Trip Styles: Coach, Scenic
Visit: Chile, Argentina, Brazil
Exclusive Savings
From
US$8,694
Save 551
Per Person
View Trip
11 Day Patagonia with Tauck
Tour

11 Days Santiago to Buenos Aires
Operated By: Tauck
Departures: Oct 2026 to Dec 2026
Trip Styles: Coach, Scenic
Visit: Chile, Argentina
Complimentary Hotel Night
From
US$9,990
Per Person
View Trip
16 Day Chile to Argentina: Patagonia Peaks & Campfire Nights with G Adventures
New ReleaseTour

16 Days Santiago to Buenos Aires
Operated By: G Adventures
Departures: Feb 2026 to Dec 2027
Trip Styles: Adventure, Small Group, 18-30's
Visit: Chile, Argentina
Exclusive Savings
From
US$4,122
Save 877
Per Person
View Trip
13 Day Patagonia: Journey to the End of the World with Globus
Tour

13 Days Santiago to Buenos Aires
Operated By: Globus
Departures: Jan 2026 to Dec 2027
Trip Styles: Coach, Small Group, Scenic
Visit: Chile, Argentina
Exclusive Savings
From
US$8,185
Save 809
Per Person
View Trip
Results: 18 results

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Tours found! Scroll up to view.

South America Tours

All South America Tours Amazon Tours Argentina Tours Brazil Tours Chile Tours Colombia Tours Ecuador Tours Galapagos Tours Patagonia Tours Peru Tours

Travel Styles

18-30's Tours Adventure Tours Coach Tours Luxury Tours Short Break Tours Small Group Tours Walking & Hiking Tours Wildlife Tours

Departure Months

October 2025 November 2025 December 2025 January 2026 February 2026 March 2026 April 2026 May 2026 June 2026 July 2026 August 2026 September 2026 October 2026 November 2026 December 2026 January 2027 February 2027 March 2027 April 2027 May 2027 October 2027 November 2027 December 2027

Cities

Santiago

Routes

Santiago to Buenos Aires

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