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Panama Tours & Cruises Starting In May 2027 and 2028

Are you planning a tour to Panama in May 2027 or 2028? Choose from 13 unique cruises, small group tours and adventures with 474 departures operated by Panama's leading tour operators. Easily compare prices, itineraries, inclusions and traveller reviews to find the Panama tour that best matches your travel style, budget and dates.
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59 Days
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$198,490pp
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13 Trips (474 Trip Departures)
6 Day Panama: Sandy Beaches & San Blas Sunsets with G Adventures
New ReleaseTour

6 Days Panama City to Panama City
Operated By: G Adventures
Departures: Aug 2026 to Jan 2028
Visit: Panama
Exclusive Savings
From
A$1,190
Save 182
Per Person
View Trip
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: Jun 2026 to Dec 2028
Trip Styles: Adventure, Small Group
Visit: Costa Rica, Panama
Exclusive Savings
From
A$1,999
Save 806
Per Person
View Trip
13 Day Costa Rica to Panama: Surf, Treks & Starry Skies with G Adventures
New ReleaseTour

13 Days San Jose to Panama City
Operated By: G Adventures
Departures: Aug 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama
Exclusive Savings
From
A$1,701
Save 228
Per Person
View Trip
18 Day Panama: Craters, Coasts & Highland Mountains with G Adventures
New ReleaseTour

18 Days San Jose to Panama City
Operated By: G Adventures
Departures: Aug 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama
Exclusive Savings
From
A$2,980
Save 399
Per Person
View Trip
27 Day Central and South American Adventure: From Costa Rica to Colombia with G Adventures
New ReleaseTour

27 Days San Jose to Medellin
Operated By: G Adventures
Departures: Dec 2026 to Dec 2027
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama, Colombia
Exclusive Savings
From
A$5,977
Save 136
Per Person
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28 Day World Cruise: Hawaii & Panama Canal with Seabourn
Cruise
 (1)

28 Days (27 Nights) Honolulu to Miami
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 03 May 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
$14,561
Balcony
$19,207
Suite
$33,701
From
A$14,561
Save 237
Per Person
View Trip
20 Day Panama Canal Passage with Seabourn
Cruise
 (1)

20 Days (19 Nights) Los Angeles to Miami
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 11 May 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
$12,862
Balcony
$18,448
Suite
$30,894
From
A$12,862
Save 236
Per Person
View Trip
27 Day Amazing Central America with Intrepid Travel
Tour

27 Days Antigua to Panama City
Operated By: Intrepid Travel
Departures: Jun 2026 to Dec 2028
Trip Styles: Adventure, Small Group
Visit: Guatemala, Honduras, El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
A$4,480
Save 1,723
Per Person
View Trip
18 Day Panama Canal & Latin America Cruise: Mexico, Costa Rica & Colombia with Azamara Cruises
Cruise
 (5)

18 Days (17 Nights) San Diego to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 24 May 2027
Visit: USA, Mexico, Guatemala, El Salvador, Costa Rica, Panama, Colombia
Azamara Always Included
Exclusive Savings
Inside
$8,414
Oceanview
$9,080
Balcony
$10,285
Suite
$16,891
From
A$8,414
Per Person
View Trip
32 Day Panama Canal & Atlantic Passage with Seabourn
Cruise
 (1)

32 Days (31 Nights) Los Angeles to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 11 May 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia, Portugal
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
$17,804
Balcony
$25,252
Suite
$41,520
From
A$17,804
Save 294
Per Person
View Trip
45 Day Best of Central America with Intrepid Travel
Tour
 (1)

45 Days Playa del Carmen to Panama City
Operated By: Intrepid Travel
Departures: Jul 2026 to Nov 2028
Trip Styles: Adventure, Coach, Small Group, Scenic
Visit: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
A$8,201
Save 2,359
Per Person
View Trip
59 Day Ultimate Central America with Intrepid Travel
Tour

59 Days Mexico City to Panama City
Operated By: Intrepid Travel
Departures: Jul 2026 to Nov 2028
Trip Styles: Adventure, Small Group
Visit: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
A$10,433
Save 3,947
Per Person
View Trip
36 Day San Diego To London Grand Voyage with Azamara Cruises
Cruise
 (5)

36 Days (35 Nights) San Diego to London
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 24 May 2027
Visit: USA, Mexico, Guatemala, El Salvador (+7 more), Costa Rica, Panama, Colombia, Canada, Ireland, England, France
Azamara Always Included
Exclusive Savings
Inside
-
Oceanview
$15,686
Balcony
$17,038
Suite
$30,964
From
A$15,686
Per Person
View Trip
Results: 13 results

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