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Panama Tours & Cruises Starting In May 2027 and 2028

Are you planning a tour to Panama in May 2027 or 2028? Choose from 18 unique cruises, small group tours and adventures with 647 departures operated by Panama's leading tour operators. Easily compare prices, itineraries, inclusions and traveller reviews to find the Panama tour that best matches your travel style, budget and dates.
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18 Trips (647 Departures)
18 Trips (647 Departures)
Departures
Duration
6 Days
62 Days
Types
Budget
Start & End Cities
Operators
Price
$1,100pp
$147,495pp
Countries
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6 Day Panama: Sandy Beaches & San Blas Sunsets with G Adventures
New ReleaseTour

6 Days Panama City to Panama City
Operator: G Adventures
Departures: Dec 2026 to Feb 2028
Interests: Adventure, Small Group, 18-30's, Short Break
Visits: Panama
Exclusive Savings
From (Per Person)
A$1,190
Save 437
Per Person
View Trip
9 Day Independent Panama with the Pacific Coast with Globus
New ReleaseTour

9 Days Panama City to Pacific Coast
Operator: Globus
Departures: Nov 2026 to Mar 2028
Interests:
Visits: Panama
Exclusive Savings
From (Per Person)
A$4,393
Save 161
Per Person
View Trip
6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operator: Globus
Departures: Nov 2026 to Mar 2028
Interests: Short Break
Visits: Panama
Exclusive Savings
From (Per Person)
A$2,890
Save 105
Per Person
View Trip
16 Day Wonders of Colombia (MedellÍn, Cartagena & Panama Extensions) with AmaWaterways
New ReleaseTour + River Cruise

16 Days Medellin to Panama City
Operator: AmaWaterways
Ships: AmaMagdalena, AmaMelodia
Departures: Nov 2026 to Dec 2027
Rivers: Magdalena
Visits: Colombia, Panama
Exclusive Savings
Balcony
$12,388
Suite
$13,921
From (Per Person)
A$12,388
Save 1,929
Per Person
View Trip
11 Day Wonders of Colombia (Panama Extension) with AmaWaterways
New ReleaseTour + River Cruise

11 Days Cartagena to Panama City
Operator: AmaWaterways
Ships: AmaMagdalena, AmaMelodia
Departures: Nov 2026 to Dec 2027
Rivers: Magdalena
Visits: Colombia, Panama
Exclusive Savings
Balcony
$8,564
Suite
$10,276
From (Per Person)
A$8,564
Save 1,785
Per Person
View Trip
14 Day Magic of Colombia (MedellÍn & Panama Extensions) with AmaWaterways
New ReleaseTour + River Cruise

14 Days Medellin to Panama City
Operator: AmaWaterways
Ships: AmaMagdalena, AmaMelodia
Departures: Nov 2026 to Dec 2027
Rivers: Magdalena
Visits: Colombia, Panama
Exclusive Savings
Balcony
$8,892
Suite
$12,690
From (Per Person)
A$9,120
Save 1,879
Per Person
View Trip
11 Day Magic of Colombia (Panama Extension) with AmaWaterways
New ReleaseTour + River Cruise

11 Days Barranquilla to Panama City
Operator: AmaWaterways
Ships: AmaMagdalena, AmaMelodia
Departures: Nov 2026 to Dec 2027
Rivers: Magdalena
Visits: Colombia, Panama
Exclusive Savings
Balcony
$8,044
Suite
$10,276
From (Per Person)
A$8,044
Save 1,785
Per Person
View Trip
18 Day Panama: Craters, Coasts & Highland Mountains with G Adventures
New ReleaseTour

18 Days San Jose to Panama City
Operator: G Adventures
Departures: Dec 2026 to Jan 2028
Interests: Adventure, Small Group, 18-30's
Visits: Costa Rica, Panama
Exclusive Savings
From (Per Person)
A$2,645
Save 954
Per Person
View Trip
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operator: Intrepid
Departures: Nov 2026 to Dec 2028
Interests: Adventure, Small Group
Visits: Costa Rica, Panama
Exclusive Savings
From (Per Person)
A$2,812
Save 224
Per Person
View Trip
13 Day Costa Rica to Panama: Surf, Treks & Starry Skies with G Adventures
New ReleaseTour

13 Days San Jose to Panama City
Operator: G Adventures
Departures: Dec 2026 to Jan 2028
Interests: Adventure, Small Group, 18-30's
Visits: Costa Rica, Panama
Exclusive Savings
From (Per Person)
A$1,469
Save 530
Per Person
View Trip
27 Day Central and South American Adventure: From Costa Rica to Colombia with G Adventures
New ReleaseTour

27 Days San Jose to Medellin
Operator: G Adventures
Departures: May 2027 to Dec 2027
Interests: Adventure, Small Group, 18-30's
Visits: Costa Rica, Panama, Colombia
Exclusive Savings
From (Per Person)
A$5,683
Save 130
Per Person
View Trip
20 Day Panama Canal Passage with Seabourn
Cruise
 (1)

20 Days (19 Nights) Los Angeles to Miami
Operator: Seabourn
Ship: Seabourn Quest
Departure: 11 May 2027
Visits: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia
Exclusive Savings
Oceanview
$21,001
Balcony
$24,132
Suite
$48,225
From (Per Person)
A$21,001
Save 402
Per Person
View Trip
28 Day World Cruise: Hawaii & Panama Canal with Seabourn
Cruise
 (1)

28 Days (27 Nights) Honolulu to Miami
Operator: Seabourn
Ship: Seabourn Quest
Departure: 03 May 2027
Visits: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia
Exclusive Savings
Oceanview
-
Balcony
$25,209
Suite
-
From (Per Person)
A$25,209
Save 454
Per Person
View Trip
27 Day Amazing Central America with Intrepid Travel
Tour

27 Days Antigua to Panama City
Operator: Intrepid
Departures: Nov 2026 to Dec 2028
Interests: Adventure, Small Group
Visits: Guatemala, Honduras, El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From (Per Person)
A$6,149
Save 455
Per Person
View Trip
32 Day Panama Canal & Atlantic Passage with Seabourn
Cruise
 (1)

32 Days (31 Nights) Los Angeles to Lisbon
Operator: Seabourn
Ship: Seabourn Quest
Departure: 11 May 2027
Visits: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia, Portugal
Exclusive Savings
Oceanview
-
Balcony
$27,604
Suite
$40,932
From (Per Person)
A$27,604
Save 494
Per Person
View Trip
45 Day Best of Central America with Intrepid Travel
Tour
 (1)

45 Days Playa del Carmen to Panama City
Operator: Intrepid
Departures: Nov 2026 to Nov 2028
Interests: Adventure, Coach, Small Group
Visits: Mexico, Belize, Guatemala, Honduras +4 more, El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From (Per Person)
A$10,540
Save 407
Per Person
View Trip
62 Day Total Central America: Two Months of Wild with G Adventures
New ReleaseTour

62 Days Mexico City to Panama City
Operator: G Adventures
Departures: Feb 2027 to Jul 2027
Interests: Adventure, Small Group, 18-30's
Visits: Mexico, Belize, Guatemala, Honduras +4 more, El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From (Per Person)
A$8,378
Save 1,770
Per Person
View Trip
59 Day Ultimate Central America with Intrepid Travel
Tour

59 Days Mexico City to Panama City
Operator: Intrepid
Departures: Nov 2026 to Nov 2028
Interests: Adventure, Small Group
Visits: Mexico, Belize, Guatemala, Honduras +4 more, El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From (Per Person)
A$14,808
Save 494
Per Person
View Trip
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