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Panama Tours & Cruises Starting In May 2027 and 2028

Are you planning a tour to Panama in May 2027 or 2028? Choose from 16 unique cruises, small group tours and adventures with 559 departures operated by Panama's leading tour operators. Easily compare prices, itineraries, inclusions and traveller reviews to find the Panama tour that best matches your travel style, budget and dates.
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16 Trips (559 Departures)
16 Trips (559 Departures)
Departures
Duration
6 Days
62 Days
Types
Budget
Start & End Cities
Operators
Price
$900pp
$198,460pp
Countries
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6 Day Panama: Sandy Beaches & San Blas Sunsets with G Adventures
New ReleaseTour

6 Days Panama City to Panama City
Operator: G Adventures
Departures: Oct 2026 to Feb 2028
Trip Styles: Adventure, Small Group, 18-30's, Short Break
Visits: Panama
Exclusive Savings
From (Per Person)
A$1,322
Save 177
Per Person
View Trip
9 Day Independent Panama with the Pacific Coast with Globus
New ReleaseTour

9 Days Panama City to Pacific Coast
Operator: Globus
Departures: Nov 2026 to Mar 2028
Trip Style: Scenic
Visits: Panama
Exclusive Savings
From (Per Person)
A$4,393
Save 161
Per Person
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6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operator: Globus
Departures: Nov 2026 to Mar 2028
Trip Styles: Short Break, Scenic
Visits: Panama
Exclusive Savings
From (Per Person)
A$2,890
Save 105
Per Person
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18 Day Panama: Craters, Coasts & Highland Mountains with G Adventures
New ReleaseTour

18 Days San Jose to Panama City
Operator: G Adventures
Departures: Nov 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visits: Costa Rica, Panama
Exclusive Savings
From (Per Person)
A$3,086
Save 72
Per Person
View Trip
13 Day Costa Rica to Panama: Surf, Treks & Starry Skies with G Adventures
New ReleaseTour

13 Days San Jose to Panama City
Operator: G Adventures
Departures: Nov 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visits: Costa Rica, Panama
Exclusive Savings
From (Per Person)
A$1,812
Save 40
Per Person
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12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operator: Intrepid
Departures: Dec 2026 to Dec 2028
Trip Styles: Adventure, Small Group
Visits: Costa Rica, Panama
Exclusive Savings
From (Per Person)
A$2,788
Save 217
Per Person
View Trip
27 Day Central and South American Adventure: From Costa Rica to Colombia with G Adventures
New ReleaseTour

27 Days San Jose to Medellin
Operator: G Adventures
Departures: Dec 2026 to Dec 2027
Trip Styles: Adventure, Small Group, 18-30's
Visits: Costa Rica, Panama, Colombia
Exclusive Savings
From (Per Person)
A$5,683
Save 802
Per Person
View Trip
28 Day World Cruise: Hawaii & Panama Canal with Seabourn
Cruise
 (1)

28 Days (27 Nights) Honolulu to Miami
Operator: Seabourn
Ship: Seabourn Quest
Departure: 03 May 2027
Visits: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia
Exclusive Savings
Oceanview
-
Balcony
$20,875
Suite
$29,463
From (Per Person)
A$20,875
Save 365
Per Person
View Trip
20 Day Panama Canal Passage with Seabourn
Cruise
 (1)

20 Days (19 Nights) Los Angeles to Miami
Operator: Seabourn
Ship: Seabourn Quest
Departure: 11 May 2027
Visits: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia
Exclusive Savings
Oceanview
$12,774
Balcony
$17,855
Suite
$26,931
From (Per Person)
A$12,774
Save 234
Per Person
View Trip
27 Day Amazing Central America with Intrepid Travel
Tour

27 Days Antigua to Panama City
Operator: Intrepid
Departures: Oct 2026 to Dec 2028
Trip Styles: Adventure, Small Group
Visits: Guatemala, Honduras, El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From (Per Person)
A$6,149
Save 1,317
Per Person
View Trip
32 Day Panama Canal & Atlantic Passage with Seabourn
Cruise
 (1)

32 Days (31 Nights) Los Angeles to Lisbon
Operator: Seabourn
Ship: Seabourn Quest
Departure: 11 May 2027
Visits: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia, Portugal
Exclusive Savings
Oceanview
$16,777
Balcony
$22,058
Suite
$36,136
From (Per Person)
A$16,777
Save 273
Per Person
View Trip
18 Day Panama Canal & Latin America Cruise: Mexico, Costa Rica & Colombia with Azamara Cruises
Cruise
 (6)

18 Days (17 Nights) San Diego to Miami
Operator: Azamara
Ship: Azamara Quest
Departure: 24 May 2027
Visits: USA, Mexico, Guatemala, El Salvador, Costa Rica, Panama, Colombia
Exclusive Savings
Inside
$6,692
Oceanview
$7,204
Balcony
$8,126
Suite
$13,200
From (Per Person)
A$6,692
Save 447
Per Person
View Trip
45 Day Best of Central America with Intrepid Travel
Tour
 (1)

45 Days Playa del Carmen to Panama City
Operator: Intrepid
Departures: Oct 2026 to Nov 2028
Trip Styles: Adventure, Coach, Small Group, Scenic
Visits: Mexico, Belize, Guatemala, Honduras +4 more, El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From (Per Person)
A$10,540
Save 397
Per Person
View Trip
62 Day Total Central America: Two Months of Wild with G Adventures
New ReleaseTour

62 Days Mexico City to Panama City
Operator: G Adventures
Departures: Jan 2027 to Jun 2027
Trip Styles: Adventure, Small Group, 18-30's
Visits: Guatemala, Mexico, Nicaragua, Panama +4 more, Belize, Honduras, Costa Rica, El Salvador
Exclusive Savings
From (Per Person)
A$9,799
Save 213
Per Person
View Trip
59 Day Ultimate Central America with Intrepid Travel
Tour

59 Days Mexico City to Panama City
Operator: Intrepid
Departures: Sep 2026 to Nov 2028
Trip Styles: Adventure, Small Group
Visits: Mexico, Belize, Guatemala, Honduras +4 more, El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From (Per Person)
A$14,715
Save 494
Per Person
View Trip
36 Day San Diego To London Grand Voyage with Azamara Cruises
Cruise
 (6)

36 Days (35 Nights) San Diego to London
Operator: Azamara
Ship: Azamara Quest
Departure: 24 May 2027
Visits: USA, Mexico, Guatemala, El Salvador +7 more, Costa Rica, Panama, Colombia, Canada, Ireland, England, France
Azamara Always Included
Exclusive Savings
Inside
-
Oceanview
$12,756
Balcony
$13,548
Suite
$26,935
From (Per Person)
A$12,756
Save 853
Per Person
View Trip
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