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Panama Tours & Cruises Starting In October 2026, 2027, 2028 and 2029

Are you planning a tour to Panama in October 2026, 2027, 2028 or 2029? Choose from 54 unique cruises, small group tours and adventures with 699 departures operated by Panama's leading tour operators. Easily compare prices, itineraries, inclusions and traveler reviews to find the Panama tour that best matches your travel style, budget and dates.
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54 Trips (699 Trip Departures)
6 Day Panama: Sandy Beaches & San Blas Sunsets with G Adventures
New ReleaseTour

6 Days Panama City to Panama City
Operated By: G Adventures
Departures: Jun 2026 to Jan 2028
Visit: Panama
Exclusive Savings
From
US$809
Save 100
Per Person
View Trip
6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operated By: Globus
Departures: May 2026 to Mar 2027
Trip Styles: Short Break, Scenic
Visit: Panama
From
US$1,759
Per Person
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Visit: Panama, Chile
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,494
Suite
$7,789
From
US$5,494
Save 2,351
Per Person
View Trip
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: May 2026 to Dec 2028
Trip Styles: Adventure, Small Group
Visit: Costa Rica, Panama
Exclusive Savings
From
US$1,738
Save 374
Per Person
View Trip
13 Day Costa Rica to Panama: Surf, Treks & Starry Skies with G Adventures
New ReleaseTour

13 Days San Jose to Panama City
Operated By: G Adventures
Departures: Jul 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama
Exclusive Savings
From
US$1,124
Save 125
Per Person
View Trip
11 Day From Panama’s Wild Beauty to Peruvian Shores with Ponant
Cruise

11 Days (10 Nights) Colon to Lima
Cruise Line: Ponant
Ship: L'Austral
Departure: 20 October 2026
Visit: Panama, Peru
Inside
-
Oceanview
$6,250
Balcony
$6,760
Suite
$10,670
From
US$6,250
Per Person
View Trip
18 Day Panama: Craters, Coasts & Highland Mountains with G Adventures
New ReleaseTour

18 Days San Jose to Panama City
Operated By: G Adventures
Departures: Aug 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama
From
US$2,099
Per Person
View Trip
11 Day Pristine islands of the Bahamas & the Panama Canal with Scenic
New ReleaseCruise

11 Days (10 Nights) Nassau to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 16 October 2026
Visit: Bahamas, Colombia, Panama
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,516
Suite
$12,653
From
US$10,516
Save 2,029
Per Person
View Trip
27 Day Central and South American Adventure: From Costa Rica to Colombia with G Adventures
New ReleaseTour

27 Days San Jose to Medellin
Operated By: G Adventures
Departures: Oct 2026 to Dec 2027
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama, Colombia
From
US$3,999
Per Person
View Trip
14 Day Cycle Nicaragua to the Panama Canal with Explore Worldwide
Tour

14 Days Granada to Panama City
Operated By: Explore Worldwide
Departures: Oct 2026 to Nov 2027
Trip Styles: Adventure, Small Group, Cycling
Visit: Costa Rica, Panama, Nicaragua
Exclusive Savings
From
US$4,720
Save 210
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Apr 2028
Visit: Panama, Colombia, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$840
Oceanview
$861
Balcony
$1,225
Suite
$1,177
From
US$840
Save 1,362
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Mar 2028
Visit: Colombia, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$904
Oceanview
$975
Balcony
$1,234
Suite
$1,383
From
US$904
Save 1,127
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Star Princess
Departure: 04 October 2026
Visit: USA, Mexico, Panama, Aruba
Princess Standard
Sanctuary Collection
Inside
$1,524
Oceanview
$2,314
Balcony
$2,274
Suite
$3,574
From
US$1,524
Per Person
View Trip
12 Day Voyage of the Tropics: Bahamas, Caribbean & Panama Canal with Scenic
New ReleaseCruise

12 Days (11 Nights) Miami to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 13 October 2028
Visit: USA, Bahamas, Colombia, Panama
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,683
Suite
$17,554
From
US$9,683
Save 2,412
Per Person
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Visit: USA, Bahamas, Colombia, Panama
Inside
-
Oceanview
-
Balcony
-
Suite
$56,695
From
US$56,695
Per Person
View Trip
17 Day Panama Canal - Ocean To Ocean with Princess
Cruise

17 Days (16 Nights) Los Angeles to Orlando
Cruise Line: Princess
Ship: Star Princess
Departure: 10 October 2027
Visit: USA, Mexico, Panama, Aruba
Princess Standard
Sanctuary Collection
Inside
$1,364
Oceanview
$1,704
Balcony
$2,174
Suite
$3,274
From
US$1,364
Per Person
View Trip
21 Day Ultimate Voyage: Caribbean Islands & the Panama Canal with Scenic
New ReleaseCruise

21 Days (20 Nights) Nassau to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 04 October 2028
Visit: Bahamas, Turks and Caicos Islands, USA, Colombia, Panama
Inside
-
Oceanview
-
Balcony
$20,890
Suite
$32,605
From
US$20,890
Per Person
View Trip
24 Day Panama Canal & Pacific COast with Princess
Cruise

24 Days (23 Nights) Vancouver to Orlando
Cruise Line: Princess
Ship: Star Princess
Departure: 03 October 2027
Visit: Canada, USA, Mexico, Panama, Aruba
Princess Standard
Sanctuary Collection
Inside
$2,486
Oceanview
-
Balcony
$3,498
Suite
$5,990
From
US$2,486
Per Person
View Trip
17 Day Panama Canal & Historic Coasts Of South America with Seabourn
Cruise

17 Days (16 Nights) Oranjestad to Valparaiso
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 02 October 2028
Visit: Aruba, Panama, Ecuador, Peru, Chile
Inside
-
Oceanview
-
Balcony
$10,999
Suite
$14,999
From
US$10,999
Per Person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Panama to Chile with Scenic
New ReleaseCruise

14 Days (13 Nights) Panama City to Santiago
Cruise Line: Scenic
Ships: Scenic Eclipse I
Departures: Oct 2027 to Oct 2028
Visit: Panama, Colombia, Ecuador, Peru, Chile
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,650
Suite
$15,511
From
US$11,650
Save 2,745
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (6)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Island Princess
Departures: Oct 2027 to Apr 2028
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,324
Oceanview
$1,622
Balcony
$2,134
Suite
$3,534
From
US$1,324
Per Person
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise
 (1)

20 Days (19 Nights) New York to Santiago
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2026 to Oct 2029
Visit: USA, Bahamas, Jamaica, Panama, Peru, Chile
Flights Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,995
Suite
$14,995
From
US$8,995
Save 2,000
Per Person
View Trip
18 Day Panama Canal: LA to Miami Halloween with Virgin Voyages
Cruise
 (1)

18 Days (17 Nights) Los Angeles to Miami
Cruise Line: Virgin Voyages
Ship: Brilliant Lady
Departure: 29 October 2026
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia
Inside
$1,854
Oceanview
$2,363
Balcony
$2,534
Suite
$9,503
From
US$1,854
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (1)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Emerald Princess
Departure: 24 October 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,232
Oceanview
$1,472
Balcony
$2,352
Suite
$3,022
From
US$1,232
Per Person
View Trip
13 Day Panama Canal with Costa Rica & Caribbean with Princess
Cruise

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Princess
Ship: Caribbean Princess
Departures: Oct 2026 to Jan 2027
Visit: USA, Curacao, Colombia, Panama, Costa Rica, Bahamas
Princess Standard
Inside
$860
Oceanview
$1,000
Balcony
$1,518
Suite
$2,141
From
US$860
Per Person
View Trip
17 Day Panama Canal with Holland America
Cruise

17 Days (16 Nights) San Diego to Fort Lauderdale
Cruise Line: Holland America
Ship: Eurodam
Departures: Oct 2026 to Oct 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Aruba
Fare Saver
Book Early & Have It All Fare Option
Inside
$1,899
Oceanview
$1,969
Balcony
$3,069
Suite
$5,239
From
US$1,899
Per Person
View Trip
27 Day Amazing Central America with Intrepid Travel
Tour

27 Days Antigua to Panama City
Operated By: Intrepid Travel
Departures: May 2026 to Dec 2028
Trip Styles: Adventure, Small Group
Visit: Guatemala, Honduras, El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
US$3,516
Save 965
Per Person
View Trip
12 Day Pristine Islands of the Caribbean & the Panama Canal with Scenic
New ReleaseCruise

12 Days (11 Nights) Bridgetown to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 20 October 2027
Visit: Barbados, Saint Lucia, Saint Vincent, Curacao, Colombia, Panama
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,863
Suite
$12,090
From
US$9,863
Save 2,567
Per Person
View Trip
13 Day Panama, Colombia & Caribbean Islands with Ponant
Cruise
 (1)

13 Days (12 Nights) Fort-de-France to Colon
Cruise Line: Ponant
Ship: Le Bellot
Departure: 26 October 2026
Visit: Martinique, Guadeloupe, Saint Lucia, Saint Vincent, Bonaire, Colombia, Panama
Inside
-
Oceanview
-
Balcony
$7,550
Suite
$11,910
From
US$7,550
Per Person
View Trip
13 Day Panama Canal Discovery: Costa Rica & Greater Antilles with Holland America
Cruise
 (3)

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departures: Oct 2026 to Mar 2027
Visit: USA, Bahamas, Aruba, Colombia, Panama, Costa Rica, Cayman Islands
Fare Saver
Inside
$1,199
Oceanview
$1,349
Balcony
$1,899
Suite
$3,999
From
US$1,199
Per Person
View Trip
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