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Panama Tours & Cruises Starting In March 2026, 2027 and 2028

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92 Trips (862 Trip Departures)
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Miami to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 29 March 2026
Visit: USA, Jamaica, Aruba, Colombia, Panama, Honduras, Bahamas
Bonus Onboard Credit
Inside
$1,172
Oceanview
$1,362
Balcony
$1,602
Suite
$2,826
From
US$1,172
Per Person
View Trip
39 Day Isles Of Polynesia, Hawaii & Panama Canal Passage with Seabourn
Cruise

39 Days (38 Nights) Tahiti to Miami
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 19 March 2026
Visit: French Polynesia, USA, Mexico, Guatemala, Costa Rica, Panama, Colombia
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,834
Suite
-
From
US$14,834
Per Person
View Trip
13 Day Southern Caribbean with Panama with Princess
Cruise

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Princess
Ship: Caribbean Princess
Departures: Jan 2028 to Mar 2028
Visit: USA, Aruba, Colombia, Panama, Costa Rica, Cayman Islands, Mexico
Princess Standard
Inside
$1,600
Oceanview
$1,839
Balcony
$1,850
Suite
$3,200
From
US$1,600
Per Person
View Trip
13 Day Southern Caribbean with Panama with Princess
Cruise

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Princess
Ship: Caribbean Princess
Departure: 17 March 2026
Visit: USA, Aruba, Curacao, Colombia, Panama, Costa Rica, Cayman Islands
Princess Standard
Inside
$1,049
Oceanview
$1,199
Balcony
$1,859
Suite
$3,099
From
US$1,049
Per Person
View Trip
45 Day Best of Central America with Intrepid Travel
Tour
 (1)

45 Days Playa del Carmen to Panama City
Operated By: Intrepid Travel
Departures: Jan 2026 to Nov 2028
Trip Styles: Adventure, Coach, Small Group, Scenic
Visit: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
US$7,173
Save 628
Per Person
View Trip
59 Day Ultimate Central America with Intrepid Travel
Tour

59 Days Mexico City to Panama City
Operated By: Intrepid Travel
Departures: Jan 2026 to Nov 2028
Trip Styles: Adventure, Small Group
Visit: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
US$9,855
Save 364
Per Person
View Trip
34 Day Sydney To Miami with Cunard
Cruise

34 Days (33 Nights) Sydney to Miami
Cruise Line: Cunard
Ship: Queen Anne
Departure: 17 March 2026
Visit: Australia, Vanuatu, Fiji, USA (+4 more), Guatemala, Panama, Curacao, Aruba
Inside
$3,599
Oceanview
-
Balcony
$5,099
Suite
$11,511
From
US$3,599
Per Person
View Trip
17 Day Machu Picchu & Mayan Ruins with Regent Seven Seas
Cruise

17 Days (16 Nights) Lima to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 10 March 2027
Visit: Peru, Ecuador, Costa Rica, Panama (+4 more), Honduras, Belize, Mexico, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,991
Suite
$13,559
From
US$11,991
Save 18,407
Per Person
View Trip
13 Day Bon Bini Aruba with Regent Seven Seas
Cruise

13 Days (12 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 14 March 2028
Visit: Panama, Colombia, Aruba, Curacao (+4 more), Grenada, Dominica, Virgin Islands, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,968
Suite
$8,360
From
US$7,968
Save 14,230
Per Person
View Trip
13 Day Panama Canal From Miami To Miami with Norwegian Cruise Line
Cruise
 (1)

13 Days (12 Nights) Miami to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sun
Departures: Dec 2026 to Mar 2027
Visit: USA, Bahamas, Dominican Republic, Aruba (+4 more), Curacao, Colombia, Panama, Costa Rica
Exclusive Savings
Inside
$1,919
Oceanview
-
Balcony
$3,746
Suite
$8,364
From
US$1,919
Save 285
Per Person
View Trip
13 Day Panama Canal From Miami To Miami with Norwegian Cruise Line
Cruise
 (1)

13 Days (12 Nights) Miami to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sun
Departures: Jan 2027 to Mar 2027
Visit: USA, Cayman Islands, Jamaica, Colombia (+4 more), Panama, Costa Rica, Belize, Mexico
Inside
$1,829
Oceanview
-
Balcony
$3,650
Suite
$8,277
From
US$1,829
Per Person
View Trip
30 Day Caribbean And Antilles with MSC Cruises
Cruise
 (3)

30 Days (29 Nights) Miami to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 28 March 2027
Visit: USA, Jamaica, Colombia, Panama (+4 more), Costa Rica, Honduras, Belize, Mexico
Bonus Onboard Credit
Exclusive Savings
Inside
$2,913
Oceanview
$3,505
Balcony
$4,485
Suite
-
From
US$2,913
Save 66
Per Person
View Trip
62 Day Total Central America: Two Months of Wild with G Adventures
New ReleaseTour

62 Days Mexico City to Panama City
Operated By: G Adventures
Departures: Feb 2026 to Nov 2026
Trip Styles: Adventure, Small Group, 18-30's
Visit: Guatemala, Mexico, Nicaragua, Panama (+4 more), Belize, Honduras, Costa Rica, El Salvador
Exclusive Savings
From
US$6,013
Save 214
Per Person
View Trip
50 Day Yokohama To Miami with Cunard
Cruise
 (13)

50 Days (49 Nights) Tokyo to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 09 March 2028
Visit: Japan, Papua New Guinea, Australia, Tonga (+5 more), USA, Mexico, Costa Rica, Panama, Aruba
Exclusive Savings
Inside
$9,827
Oceanview
$11,708
Balcony
$14,876
Suite
$34,082
From
US$9,827
Per Person
View Trip
22 Day Panama Canal & Southern Caribbean: ABC Islands with Holland America
Cruise
 (3)

22 Days (21 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Rotterdam
Departures: Feb 2026 to Mar 2026
Visit: USA, Bahamas, Curacao, Colombia (+5 more), Panama, Costa Rica, Cayman Islands, Bonaire, Aruba
Have It All Fare Option
Inside
$2,524
Oceanview
$3,519
Balcony
$4,482
Suite
-
From
US$2,524
Per Person
View Trip
63 Day Longitudinal World Cruise VII with Viking Cruises
Cruise
 (1)

63 Days (62 Nights) Buenos Aires to Milwaukee
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2028 to Mar 2028
Visit: Argentina, Antarctica, Chile, Peru (+5 more), Panama, Jamaica, Bahamas, USA, Canada
Flights Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$49,995
Suite
$72,995
From
US$49,995
Save 2,100
Per Person
View Trip
32 Day South America, Inca & Panama Canal Discovery with Holland America
Cruise
 (2)

32 Days (31 Nights) Buenos Aires to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departure: 08 March 2026
Visit: Argentina, Uruguay, Falkland Islands, Chile (+5 more), Peru, Ecuador, Panama, Cayman Islands, USA
Have It All Fare Option
Inside
$3,994
Oceanview
$4,134
Balcony
$6,676
Suite
$9,077
From
US$3,994
Per Person
View Trip
32 Day Panama Canal, Inca & South America: Chilean Fjords with Holland America
Cruise
 (2)

32 Days (31 Nights) Buenos Aires to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departures: Mar 2027 to Mar 2028
Visit: Argentina, Uruguay, Falkland Islands, Chile (+5 more), Peru, Ecuador, Panama, Cayman Islands, USA
Fare Saver
Book Early & Have It All Fare Option
Exclusive Savings
Inside
$4,771
Oceanview
$5,310
Balcony
$6,927
Suite
$9,426
From
US$4,771
Per Person
View Trip
25 Day Ultimate South America to the Caribbean Through the Panama Canal with Scenic
New ReleaseCruise

25 Days (24 Nights) Santiago to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 21 March 2027
Visit: Chile, Peru, Ecuador, Colombia (+5 more), Panama, Curacao, Saint Vincent, Saint Lucia, Barbados
Fly Free Premium Economy
Fly Free Business Class
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$27,213
Suite
$37,059
From
US$27,213
Save 28,667
Per Person
View Trip
22 Day Eastern Caribbean & Panama Canal: U.S. Virgin Islands with Holland America
Cruise
 (3)

22 Days (21 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departures: Jan 2027 to Mar 2027
Visit: USA, Antigua and Barbuda, Virgin Islands, Puerto Rico (+6 more), Bahamas, Aruba, Colombia, Panama, Costa Rica, Cayman Islands
Fare Saver
Inside
$3,009
Oceanview
$3,908
Balcony
$4,565
Suite
$7,750
From
US$3,009
Per Person
View Trip
15 Day Carnival Of Caribbean Colors with Regent Seven Seas
Cruise

15 Days (14 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 31 March 2027
Visit: Panama, Colombia, Aruba, Curacao (+6 more), Bonaire, Grenada, Saint Lucia, Saint Barthelemy, Virgin Islands, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,807
Suite
$9,297
From
US$8,807
Save 16,091
Per Person
View Trip
22 Day Panama Canal & Southern Caribbean: ABC Islands with Holland America
Cruise
 (3)

22 Days (21 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 21 March 2027
Visit: USA, Bahamas, Aruba, Colombia (+6 more), Panama, Costa Rica, Cayman Islands, Bonaire, Curacao, Dominican Republic
Fare Saver
Inside
$3,149
Oceanview
$4,094
Balcony
$4,633
Suite
$8,004
From
US$3,149
Per Person
View Trip
21 Day Treasures Of The Tropics with Oceania Cruises
Cruise
 (1)

21 Days (20 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 March 2028
Visit: USA, Cayman Islands, Jamaica, Aruba (+7 more), Curacao, Colombia, Panama, Costa Rica, Honduras, Guatemala, Mexico
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$5,896
Oceanview
$7,448
Balcony
$8,952
Suite
$12,832
From
US$5,896
Save 6,102
Per Person
View Trip
22 Day Caribbean And Antilles with MSC Cruises
Cruise
 (3)

22 Days (21 Nights) Miami to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departures: Feb 2027 to Mar 2027
Visit: USA, Jamaica, Colombia, Panama (+7 more), Costa Rica, Honduras, Belize, Curacao, Bonaire, Aruba, Dominican Republic
Bonus Onboard Credit
Inside
$2,239
Oceanview
$2,425
Balcony
$2,910
Suite
$11,688
From
US$2,239
Per Person
View Trip
22 Day Caribbean And Antilles with MSC Cruises
Cruise
 (3)

22 Days (21 Nights) Miami to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departures: Feb 2027 to Mar 2027
Visit: USA, Curacao, Bonaire, Aruba (+7 more), Dominican Republic, Jamaica, Colombia, Panama, Costa Rica, Honduras, Belize
Bonus Onboard Credit
Inside
$2,209
Oceanview
$2,396
Balcony
$3,075
Suite
-
From
US$2,209
Per Person
View Trip
21 Day Panama Canal Connoisseur with Oceania Cruises
Cruise
 (1)

21 Days (20 Nights) Tampa to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Visit: USA, Mexico, Belize, Honduras (+7 more), Costa Rica, Panama, Colombia, Curacao, Aruba, Jamaica, Cayman Islands
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$5,900
Oceanview
$6,385
Balcony
$9,780
Suite
-
From
US$5,900
Save 6,098
Per Person
View Trip
27 Day Eastern Caribbean Explorer & Panama Canal with Holland America
Cruise

27 Days (26 Nights) Fort Lauderdale to Vancouver
Cruise Line: Holland America
Ship: Eurodam
Departure: 29 March 2026
Visit: USA, Bahamas, Turks and Caicos Islands, Dominican Republic (+7 more), Colombia, Panama, Costa Rica, El Salvador, Guatemala, Mexico, Canada
Fare Saver
Inside
$2,894
Oceanview
$3,074
Balcony
$4,367
Suite
-
From
US$2,894
Per Person
View Trip
27 Day Azure To Iberia with Regent Seven Seas
Cruise

27 Days (26 Nights) Panama City to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 14 March 2028
Visit: Panama, Colombia, Aruba, Curacao (+7 more), Grenada, Dominica, Virgin Islands, USA, Bermuda, Portugal, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,830
Suite
$16,761
From
US$15,830
Save 29,368
Per Person
View Trip
22 Day Caribbean And Antilles with MSC Cruises
Cruise

22 Days (21 Nights) Miami to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 01 March 2026
Visit: USA, Jamaica, Colombia, Panama (+7 more), Costa Rica, Honduras, Bahamas, Mexico, Cayman Islands, Curacao, Aruba
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,822
Suite
$4,811
From
US$2,822
Save 67
Per Person
View Trip
83 Day World Cruise: Australia In-depth & Panama Canal with Seabourn
Cruise

83 Days (82 Nights) Sydney to Miami
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 09 March 2027
Visit: Australia, Papua New Guinea, New Caledonia, Vanuatu (+8 more), Fiji, Samoa, USA, Mexico, Guatemala, Costa Rica, Panama, Colombia
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$46,098
Suite
-
From
US$46,098
Save 736
Per Person
View Trip
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