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Panama Tours & Cruises Starting In March 2026, 2027 and 2028

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89 Trips (825 Trip Departures)
12 Day Panama Canal From Miami To Miami with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Miami to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jewel
Departure: 15 March 2026
Visit: USA, Cayman Islands, Colombia, Panama, Costa Rica, Belize, Mexico
Inside
$1,369
Oceanview
$1,419
Balcony
$2,269
Suite
$2,369
From
US$1,369
Per Person
View Trip
12 Day Central America From Miami To Miami with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Miami to Miami
Cruise Line: Norwegian Cruise Line
Ships: Norwegian Jewel, Norwegian Sun
Departures: Mar 2026 to Dec 2027
Visit: USA, Cayman Islands, Colombia, Panama, Costa Rica, Belize, Mexico
Inside
$1,369
Oceanview
$1,549
Balcony
$2,089
Suite
$3,246
From
US$1,369
Per Person
View Trip
45 Day Best of Central America with Intrepid Travel
Tour
 (1)

45 Days Playa del Carmen to Panama City
Operated By: Intrepid Travel
Departures: Apr 2026 to Nov 2028
Trip Styles: Adventure, Coach, Small Group, Scenic
Visit: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
US$6,097
Save 1,379
Per Person
View Trip
13 Day Panama Canal From Miami To Miami with Norwegian Cruise Line
Cruise
 (1)

13 Days (12 Nights) Miami to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sun
Departures: Jan 2027 to Mar 2027
Visit: USA, Cayman Islands, Jamaica, Colombia (+4 more), Panama, Costa Rica, Belize, Mexico
Inside
$1,799
Oceanview
$2,188
Balcony
$3,488
Suite
$4,613
From
US$1,799
Per Person
View Trip
59 Day Ultimate Central America with Intrepid Travel
Tour

59 Days Mexico City to Panama City
Operated By: Intrepid Travel
Departures: Mar 2026 to Nov 2028
Trip Styles: Adventure, Small Group
Visit: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
US$8,377
Save 1,929
Per Person
View Trip
30 Day Caribbean And Antilles with MSC Cruises
Cruise
 (3)

30 Days (29 Nights) Miami to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 28 March 2027
Visit: USA, Jamaica, Colombia, Panama (+4 more), Costa Rica, Honduras, Belize, Mexico
Bonus Onboard Credit
Exclusive Savings
Inside
$2,913
Oceanview
$3,505
Balcony
$4,485
Suite
-
From
US$2,913
Save 66
Per Person
View Trip
13 Day Bon Bini Aruba with Regent Seven Seas
Cruise

13 Days (12 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 14 March 2028
Visit: Panama, Colombia, Aruba, Curacao (+4 more), Grenada, Dominica, Virgin Islands, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,458
Suite
$8,850
From
US$8,458
Save 14,740
Per Person
View Trip
13 Day Panama Canal From Miami To Miami with Norwegian Cruise Line
Cruise
 (1)

13 Days (12 Nights) Miami to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sun
Departures: Dec 2026 to Mar 2027
Visit: USA, Bahamas, Dominican Republic, Aruba (+4 more), Curacao, Colombia, Panama, Costa Rica
Exclusive Savings
Inside
$1,889
Oceanview
$2,323
Balcony
$3,730
Suite
$4,806
From
US$1,889
Save 71
Per Person
View Trip
62 Day Total Central America: Two Months of Wild with G Adventures
New ReleaseTour

62 Days Mexico City to Panama City
Operated By: G Adventures
Departures: May 2026 to Oct 2027
Trip Styles: Adventure, Small Group, 18-30's
Visit: Guatemala, Mexico, Nicaragua, Panama (+4 more), Belize, Honduras, Costa Rica, El Salvador
G's February Sale
Exclusive Savings
From
US$5,523
Save 1,176
Per Person
View Trip
17 Day Machu Picchu & Mayan Ruins with Regent Seven Seas
Cruise

17 Days (16 Nights) Lima to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 10 March 2027
Visit: Peru, Ecuador, Costa Rica, Panama (+4 more), Honduras, Belize, Mexico, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,677
Suite
$13,755
From
US$12,677
Save 19,121
Per Person
View Trip
31 Day Treasures of French Polynesia & South Pacific Islands with Scenic
New ReleaseCruise

31 Days (30 Nights) Lautoka to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 14 March 2026
Visit: Fiji, Tonga, Niue, Cook Islands (+4 more), Bora Bora, French Polynesia, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$66,171
Suite
-
From
US$66,171
Save 1,949
Per Person
View Trip
50 Day Yokohama To Miami with Cunard
Cruise
 (13)

50 Days (49 Nights) Tokyo to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 09 March 2028
Visit: Japan, Papua New Guinea, Australia, Tonga (+5 more), USA, Mexico, Costa Rica, Panama, Aruba
Exclusive Savings
Inside
$9,825
Oceanview
$11,706
Balcony
$14,874
Suite
$34,080
From
US$9,825
Per Person
View Trip
32 Day South America, Inca & Panama Canal Discovery with Holland America
Cruise
 (2)

32 Days (31 Nights) Buenos Aires to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departure: 08 March 2026
Visit: Argentina, Uruguay, Falkland Islands, Chile (+5 more), Peru, Ecuador, Panama, Cayman Islands, USA
Have It All Fare Option
Inside
$3,944
Oceanview
$4,184
Balcony
$6,489
Suite
$9,077
From
US$3,944
Per Person
View Trip
25 Day Ultimate South America to the Caribbean Through the Panama Canal with Scenic
New ReleaseCruise

25 Days (24 Nights) Santiago to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 21 March 2027
Visit: Chile, Peru, Ecuador, Colombia (+5 more), Panama, Curacao, Saint Vincent, Saint Lucia, Barbados
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$54,300
Suite
$73,991
From
US$54,300
Save 1,580
Per Person
View Trip
63 Day Longitudinal World Cruise VII with Viking Cruises
Cruise
 (1)

63 Days (62 Nights) Buenos Aires to Milwaukee
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2028 to Mar 2028
Visit: Argentina, Antarctica, Chile, Peru (+5 more), Panama, Jamaica, Bahamas, USA, Canada
Flights Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$49,995
Suite
$72,995
From
US$49,995
Save 2,100
Per Person
View Trip
32 Day Panama Canal, Inca & South America: Chilean Fjords with Holland America
Cruise
 (2)

32 Days (31 Nights) Buenos Aires to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departures: Mar 2027 to Mar 2028
Visit: Argentina, Uruguay, Falkland Islands, Chile (+5 more), Peru, Ecuador, Panama, Cayman Islands, USA
Fare Saver
Book Early & Have It All Fare Option
Exclusive Savings
Inside
$4,404
Oceanview
$4,604
Balcony
$6,507
Suite
$9,202
From
US$4,404
Per Person
View Trip
15 Day Carnival Of Caribbean Colors with Regent Seven Seas
Cruise

15 Days (14 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 31 March 2027
Visit: Panama, Colombia, Aruba, Curacao (+6 more), Bonaire, Grenada, Saint Lucia, Saint Barthelemy, Virgin Islands, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,199
Suite
$9,689
From
US$9,199
Save 16,499
Per Person
View Trip
22 Day Eastern Caribbean & Panama Canal: U.S. Virgin Islands with Holland America
Cruise
 (3)

22 Days (21 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departures: Jan 2027 to Mar 2027
Visit: USA, Antigua and Barbuda, Virgin Islands, Puerto Rico (+6 more), Bahamas, Aruba, Colombia, Panama, Costa Rica, Cayman Islands
Fare Saver
Inside
$2,539
Oceanview
$2,819
Balcony
$3,819
Suite
$7,593
From
US$2,539
Per Person
View Trip
22 Day Panama Canal & Southern Caribbean: ABC Islands with Holland America
Cruise
 (3)

22 Days (21 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 21 March 2027
Visit: USA, Bahamas, Aruba, Colombia (+6 more), Panama, Costa Rica, Cayman Islands, Bonaire, Curacao, Dominican Republic
Fare Saver
Inside
$2,649
Oceanview
$2,929
Balcony
$3,879
Suite
$7,789
From
US$2,649
Per Person
View Trip
21 Day Treasures Of The Tropics with Oceania Cruises
Cruise
 (3)

21 Days (20 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 March 2028
Visit: USA, Cayman Islands, Jamaica, Aruba (+7 more), Curacao, Colombia, Panama, Costa Rica, Honduras, Guatemala, Mexico
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$5,605
Oceanview
$7,448
Balcony
$8,952
Suite
$12,832
From
US$5,605
Save 5,793
Per Person
View Trip
27 Day Azure To Iberia with Regent Seven Seas
Cruise

27 Days (26 Nights) Panama City to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 14 March 2028
Visit: Panama, Colombia, Aruba, Curacao (+7 more), Grenada, Dominica, Virgin Islands, USA, Bermuda, Portugal, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,761
Suite
$17,692
From
US$16,761
Save 30,337
Per Person
View Trip
21 Day Panama Canal Connoisseur with Oceania Cruises
Cruise
 (1)

21 Days (20 Nights) Tampa to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Visit: USA, Mexico, Belize, Honduras (+7 more), Costa Rica, Panama, Colombia, Curacao, Aruba, Jamaica, Cayman Islands
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$6,579
Oceanview
$6,918
Balcony
-
Suite
-
From
US$6,579
Save 6,819
Per Person
View Trip
22 Day Caribbean And Antilles with MSC Cruises
Cruise
 (3)

22 Days (21 Nights) Miami to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 05 March 2028
Visit: USA, Jamaica, Colombia, Panama (+7 more), Costa Rica, Honduras, Belize, Aruba, Curacao, Dominican Republic, Cayman Islands
Bonus Onboard Credit
Inside
$2,154
Oceanview
-
Balcony
$2,856
Suite
-
From
US$2,154
Per Person
View Trip
22 Day Caribbean And Antilles with MSC Cruises
Cruise
 (3)

22 Days (21 Nights) Miami to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departures: Feb 2027 to Mar 2027
Visit: USA, Curacao, Bonaire, Aruba (+7 more), Dominican Republic, Jamaica, Colombia, Panama, Costa Rica, Honduras, Belize
Bonus Onboard Credit
Inside
$2,209
Oceanview
$2,396
Balcony
$3,075
Suite
-
From
US$2,209
Per Person
View Trip
22 Day Caribbean And Antilles with MSC Cruises
Cruise
 (3)

22 Days (21 Nights) Miami to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departures: Feb 2027 to Mar 2027
Visit: USA, Jamaica, Colombia, Panama (+7 more), Costa Rica, Honduras, Belize, Curacao, Bonaire, Aruba, Dominican Republic
Bonus Onboard Credit
Inside
$2,239
Oceanview
$2,425
Balcony
$2,910
Suite
$11,931
From
US$2,239
Per Person
View Trip
22 Day Caribbean And Antilles with MSC Cruises
Cruise
 (3)

22 Days (21 Nights) Miami to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 16 March 2028
Visit: USA, Aruba, Curacao, Dominican Republic (+7 more), Jamaica, Cayman Islands, Colombia, Panama, Costa Rica, Honduras, Belize
Bonus Onboard Credit
Inside
$2,184
Oceanview
$2,352
Balcony
$2,885
Suite
-
From
US$2,184
Per Person
View Trip
22 Day Caribbean And Antilles with MSC Cruises
Cruise

22 Days (21 Nights) Miami to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 01 March 2026
Visit: USA, Jamaica, Colombia, Panama (+7 more), Costa Rica, Honduras, Bahamas, Mexico, Cayman Islands, Curacao, Aruba
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,745
Suite
$4,811
From
US$2,745
Save 64
Per Person
View Trip
21 Day Panama Canal Navigator with Oceania Cruises
Cruise
 (3)

21 Days (20 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 March 2027
Visit: USA, Mexico, Belize, Guatemala (+8 more), Honduras, Costa Rica, Panama, Colombia, Aruba, Curacao, Jamaica, Bahamas
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$6,046
Oceanview
$7,307
Balcony
$8,616
Suite
$12,060
From
US$6,046
Save 6,252
Per Person
View Trip
30 Day Panama Canal & Eastern Caribbean with Holland America
Cruise
 (2)

30 Days (29 Nights) Fort Lauderdale to San Diego
Cruise Line: Holland America
Ship: Koningsdam
Departure: 29 March 2026
Visit: USA, Puerto Rico, Virgin Islands, Antigua and Barbuda (+10 more), Dominica, Saint Lucia, Saint Kitts and Nevis, Bahamas, Colombia, Panama, Costa Rica, El Salvador, Guatemala, Mexico
Have It All Fare Option
Inside
$3,374
Oceanview
$4,180
Balcony
$4,964
Suite
-
From
US$3,374
Per Person
View Trip
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