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Panama Tours & Cruises Starting In January 2027 and 2028

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113 Trips (844 Trip Departures)
45 Day Best of Central America with Intrepid Travel
Tour
 (1)

45 Days Playa del Carmen to Panama City
Operated By: Intrepid Travel
Departures: Apr 2026 to Nov 2028
Trip Styles: Adventure, Coach, Small Group, Scenic
Visit: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
US$6,097
Save 1,379
Per Person
View Trip
37 Day New York To Sydney with Cunard
Cruise
 (1)

37 Days (36 Nights) New York to Sydney
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 19 January 2027
Visit: USA, Aruba, Panama, El Salvador (+4 more), Mexico, Fiji, New Caledonia, Australia
Inside
$6,469
Oceanview
$6,369
Balcony
$8,304
Suite
-
From
US$6,369
Per Person
View Trip
13 Day Panama Canal From Miami To Miami with Norwegian Cruise Line
Cruise
 (1)

13 Days (12 Nights) Miami to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sun
Departures: Jan 2027 to Mar 2027
Visit: USA, Cayman Islands, Jamaica, Colombia (+4 more), Panama, Costa Rica, Belize, Mexico
Inside
$1,799
Oceanview
$2,188
Balcony
$3,488
Suite
$4,613
From
US$1,799
Per Person
View Trip
59 Day Ultimate Central America with Intrepid Travel
Tour

59 Days Mexico City to Panama City
Operated By: Intrepid Travel
Departures: Mar 2026 to Nov 2028
Trip Styles: Adventure, Small Group
Visit: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
US$8,377
Save 1,929
Per Person
View Trip
19 Day Discover Barbados, Panama & Costa Rica with Emerald Cruises
New ReleaseCruise
 (3)

19 Days (18 Nights) Bridgetown to Panama City
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 06 January 2028
Visit: Barbados, Saint Vincent, Grenada, Bonaire (+4 more), Curacao, Aruba, Colombia, Panama
Fly Free Economy
Fly Free Premium Economy
Exclusive Savings
Inside
-
Oceanview
$17,048
Balcony
-
Suite
$21,413
From
US$17,048
Save 17,932
Per Person
View Trip
13 Day Panama Canal From Miami To Miami with Norwegian Cruise Line
Cruise
 (1)

13 Days (12 Nights) Miami to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sun
Departures: Dec 2026 to Mar 2027
Visit: USA, Bahamas, Dominican Republic, Aruba (+4 more), Curacao, Colombia, Panama, Costa Rica
Exclusive Savings
Inside
$1,889
Oceanview
$2,323
Balcony
$3,730
Suite
$4,806
From
US$1,889
Save 71
Per Person
View Trip
62 Day Total Central America: Two Months of Wild with G Adventures
New ReleaseTour

62 Days Mexico City to Panama City
Operated By: G Adventures
Departures: May 2026 to Oct 2027
Trip Styles: Adventure, Small Group, 18-30's
Visit: Guatemala, Mexico, Nicaragua, Panama (+4 more), Belize, Honduras, Costa Rica, El Salvador
G's February Sale
Exclusive Savings
From
US$5,523
Save 1,176
Per Person
View Trip
30 Day Hamburg To Los Angeles with Cunard
Cruise

30 Days (29 Nights) Hamburg to Los Angeles
Cruise Line: Cunard
Ship: Queen Anne
Departure: 09 January 2028
Visit: Germany, England, Portugal, USA (+4 more), Colombia, Panama, Guatemala, Mexico
Inside
$6,329
Oceanview
$8,361
Balcony
$9,252
Suite
$18,261
From
US$6,329
Per Person
View Trip
15 Day Empires Of The Sun with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Lima
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 13 January 2028
Visit: USA, Cayman Islands, Jamaica, Colombia (+4 more), Costa Rica, Panama, Ecuador, Peru
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,095
Suite
$12,781
From
US$12,095
Save 19,503
Per Person
View Trip
26 Day Epic Caribbean Escape: Barbados to Costa Rica with Emerald Cruises
New ReleaseCruise
 (3)

26 Days (25 Nights) Bridgetown to San Jose
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 06 January 2028
Visit: Barbados, Saint Vincent, Grenada, Bonaire (+5 more), Curacao, Aruba, Colombia, Panama, Costa Rica
Fly Free Economy
Fly Free Premium Economy
Exclusive Savings
Inside
-
Oceanview
$24,098
Balcony
-
Suite
$30,161
From
US$24,098
Save 25,372
Per Person
View Trip
58 Day Panama Canal, Chilean Fjords, Antarctica & Falklands with Seabourn
Cruise
 (1)

58 Days (57 Nights) Miami to Buenos Aires
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 07 January 2028
Visit: USA, Panama, Ecuador, Peru (+5 more), Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Exclusive Savings
Inside
-
Oceanview
$37,371
Balcony
$42,271
Suite
-
From
US$37,371
Save 628
Per Person
View Trip
20 Day Panama, Peru & Chile Cruise: Panama Canal, Lima & Coquimbo with Azamara Cruises
Cruise
 (4)

20 Days (19 Nights) Miami to Valparaiso
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 05 January 2028
Visit: USA, Mexico, Belize, Honduras (+5 more), Costa Rica, Panama, Ecuador, Peru, Chile
Azamara Always Included
Exclusive Savings
Inside
$6,711
Oceanview
$7,594
Balcony
$9,223
Suite
$13,210
From
US$6,711
Save 148
Per Person
View Trip
22 Day Southern Caribbean & Panama Canal: ABC Islands with Holland America
Cruise
 (3)

22 Days (21 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departures: Jan 2027 to Feb 2027
Visit: USA, Bonaire, Curacao, Aruba (+5 more), Bahamas, Colombia, Panama, Costa Rica, Cayman Islands
Fare Saver
Inside
$2,494
Oceanview
$2,784
Balcony
$3,734
Suite
$7,500
From
US$2,494
Per Person
View Trip
19 Day Discover the Secrets of Panama and Costa Rica with Emerald Cruises
New ReleaseCruise
 (3)

19 Days (18 Nights) Bridgetown to San Jose
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 13 January 2028
Visit: Barbados, Saint Vincent, Grenada, Bonaire (+5 more), Curacao, Aruba, Colombia, Panama, Costa Rica
Fly Free Economy
Fly Free Premium Economy
Exclusive Savings
Inside
-
Oceanview
$18,269
Balcony
-
Suite
$22,634
From
US$18,269
Save 19,211
Per Person
View Trip
15 Day Tropical Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 12 January 2027
Visit: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,774
Suite
$14,215
From
US$13,774
Save 20,624
Per Person
View Trip
22 Day Eastern Caribbean & Panama Canal: U.S. Virgin Islands with Holland America
Cruise
 (3)

22 Days (21 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departures: Jan 2027 to Mar 2027
Visit: USA, Antigua and Barbuda, Virgin Islands, Puerto Rico (+6 more), Bahamas, Aruba, Colombia, Panama, Costa Rica, Cayman Islands
Fare Saver
Inside
$2,539
Oceanview
$2,819
Balcony
$3,819
Suite
$7,593
From
US$2,539
Per Person
View Trip
42 Day Grand South America & Antarctica Voyage with Holland America
Cruise
 (3)

42 Days (41 Nights) Fort Lauderdale to Buenos Aires
Cruise Line: Holland America
Ship: Zaandam
Departure: 03 January 2027
Visit: USA, Cayman Islands, Panama, Ecuador (+6 more), Peru, Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Advantage Fare
Exclusive Savings
Inside
$10,137
Oceanview
$11,264
Balcony
$19,839
Suite
-
From
US$10,137
Per Person
View Trip
22 Day Panama Canal & Eastern Caribbean: U.S. Virgin Islands with Holland America
Cruise
 (3)

22 Days (21 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departures: Jan 2027 to Feb 2027
Visit: USA, Bahamas, Aruba, Colombia (+6 more), Panama, Costa Rica, Cayman Islands, Antigua and Barbuda, Virgin Islands, Puerto Rico
Fare Saver
Inside
$2,499
Oceanview
$2,789
Balcony
$3,739
Suite
$7,603
From
US$2,499
Per Person
View Trip
64 Day World Cruise: Panama Canal, Polynesia & New Zealand with Seabourn
Cruise
 (1)

64 Days (63 Nights) Miami to Sydney
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 05 January 2027
Visit: USA, Panama, Ecuador, Peru (+6 more), Chile, French Polynesia, Cook Islands, Tonga, New Zealand, Australia
Explore More
Exclusive Savings
Inside
-
Oceanview
$28,077
Balcony
$33,064
Suite
$142,981
From
US$28,077
Save 426
Per Person
View Trip
22 Day Caribbean And Antilles with MSC Cruises
Cruise
 (3)

22 Days (21 Nights) Miami to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 14 January 2027
Visit: USA, Curacao, Aruba, Jamaica (+7 more), Cayman Islands, Mexico, Colombia, Panama, Costa Rica, Honduras, Belize
Bonus Onboard Credit
Inside
$2,139
Oceanview
$2,328
Balcony
$3,007
Suite
-
From
US$2,139
Per Person
View Trip
22 Day Caribbean And Antilles with MSC Cruises
Cruise
 (3)

22 Days (21 Nights) Miami to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 24 January 2027
Visit: USA, Jamaica, Colombia, Panama (+7 more), Costa Rica, Honduras, Belize, Cayman Islands, Aruba, Bonaire, Dominican Republic
Bonus Onboard Credit
Inside
$2,139
Oceanview
$2,328
Balcony
$2,813
Suite
$11,746
From
US$2,139
Per Person
View Trip
21 Day Coastal Calm & Coconuts with Oceania Cruises
Cruise
 (3)

21 Days (20 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 06 January 2028
Visit: USA, Mexico, Belize, Honduras (+7 more), Costa Rica, Panama, Colombia, Curacao, Aruba, Jamaica, Cayman Islands
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$6,091
Oceanview
$7,643
Balcony
$9,147
Suite
$12,833
From
US$6,091
Save 6,307
Per Person
View Trip
22 Day Caribbean And Antilles with MSC Cruises
Cruise
 (3)

22 Days (21 Nights) Miami to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 03 January 2027
Visit: USA, Jamaica, Colombia, Panama (+7 more), Costa Rica, Honduras, Belize, Curacao, Aruba, Cayman Islands, Mexico
Bonus Onboard Credit
Inside
$2,139
Oceanview
$2,328
Balcony
$2,813
Suite
$11,746
From
US$2,139
Per Person
View Trip
57 Day South America Discovery From Fort Lauderdale with Cunard
Cruise

57 Days (56 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Anne
Departure: 22 January 2027
Visit: USA, Turks and Caicos Islands, Barbados, Brazil (+7 more), Uruguay, Argentina, Chile, Peru, Ecuador, Panama, Aruba
Exclusive Savings
Inside
$11,019
Oceanview
$14,682
Balcony
$15,375
Suite
$35,175
From
US$11,019
Per Person
View Trip
83 Day South America, Antarctica, South Atlantic & Africa with Seabourn
Cruise
 (1)

83 Days (82 Nights) Miami to Cape Town
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 07 January 2028
Visit: USA, Panama, Ecuador, Peru (+8 more), Chile, Argentina, Antarctica, Falkland Islands, Uruguay, Saint Helena, South Africa, Mozambique
Exclusive Savings
Inside
-
Oceanview
$54,079
Balcony
$60,939
Suite
$111,899
From
US$54,079
Save 920
Per Person
View Trip
21 Day Panama Canal & Caribbean with Oceania Cruises
Cruise
 (3)

21 Days (20 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 January 2027
Visit: USA, Mexico, Belize, Guatemala (+8 more), Honduras, Costa Rica, Panama, Colombia, Aruba, Curacao, Jamaica, Cayman Islands
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$5,850
Oceanview
-
Balcony
$8,663
Suite
$12,107
From
US$5,850
Save 6,048
Per Person
View Trip
37 Day Grand World Voyage with Holland America
Cruise

37 Days (36 Nights) Fort Lauderdale to Sydney
Cruise Line: Holland America
Ship: Volendam
Departure: 05 January 2027
Visit: USA, Panama, Ecuador, Peru (+8 more), Chile, Easter Island, Pitcairn Islands, French Polynesia, Samoa, Fiji, New Caledonia, Australia
Advantage Fare
Exclusive Savings
Inside
$8,533
Oceanview
$9,415
Balcony
$15,981
Suite
-
From
US$8,533
Save 131
Per Person
View Trip
43 Day Tides To Tahiti with Regent Seven Seas
Cruise

43 Days (42 Nights) Miami to Tahiti
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 12 January 2027
Visit: USA, Mexico, Belize, Honduras (+8 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama, El Salvador, Guatemala, French Polynesia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$33,739
Suite
$34,621
From
US$33,739
Save 50,059
Per Person
View Trip
43 Day Miami To Buenos Aires Grand Voyage with Azamara Cruises
Cruise
 (4)

43 Days (42 Nights) Miami to Buenos Aires
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 05 January 2028
Visit: USA, Mexico, Belize, Honduras (+9 more), Costa Rica, Panama, Ecuador, Peru, Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Azamara Always Included
Exclusive Savings
Inside
$14,374
Oceanview
$16,217
Balcony
$20,194
Suite
$28,351
From
US$14,374
Save 335
Per Person
View Trip
83 Day South America Discovery with Cunard
Cruise

83 Days (82 Nights) London to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 10 January 2027
Visit: England, Bermuda, USA, Turks and Caicos Islands (+10 more), Barbados, Brazil, Uruguay, Argentina, Chile, Peru, Ecuador, Panama, Aruba, Portugal
Exclusive Savings
Inside
$13,068
Oceanview
$18,117
Balcony
$20,058
Suite
$40,016
From
US$13,068
Per Person
View Trip
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