Home > Tours > Latin America Tours > Central America Tours > Panama Tours & Cruises > All Trips

All Panama Tours & Cruises

Filter Results
Departures
Show More...
Duration
2 Days
181 Days
Types
Budget
Start & End Cities
Operators
Show More...
Price
$100pp
$182,995pp
Countries
Show More...
Filter Results
356 Trips (1,151 Trip Departures)
13 Day Flavors Of Cartagena with Regent Seven Seas
Cruise

13 Days (12 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 02 March 2028
Visit: USA, Cayman Islands, Jamaica, Dominican Republic, Colombia, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,655
Suite
$9,047
From
US$8,655
Save 14,943
Per Person
View Trip
21 Day Panama Canal with Holland America
Cruise

21 Days (20 Nights) Fort Lauderdale to Vancouver
Cruise Line: Holland America
Ship: Eurodam
Departure: 03 April 2027
Visit: USA, Colombia, Panama, Costa Rica, Guatemala, Mexico, Canada
Fare Saver
Inside
$2,384
Oceanview
$2,584
Balcony
$3,890
Suite
$6,605
From
US$2,384
Per Person
View Trip
17 Day Ultimate Panama Canal Transit with Regent Seven Seas
Cruise

17 Days (16 Nights) Los Angeles to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 24 January 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia, Cayman Islands
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,970
Suite
$13,950
From
US$12,970
Save 19,628
Per Person
View Trip
13 Day Southern Caribbean with Panama with Princess
Cruise

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Princess
Ship: Caribbean Princess
Departures: Jan 2028 to Mar 2028
Visit: USA, Aruba, Colombia, Panama, Costa Rica, Cayman Islands, Mexico
Princess Standard
Inside
$1,500
Oceanview
$1,748
Balcony
$1,750
Suite
$3,049
From
US$1,500
Per Person
View Trip
12 Day Panama Canal From Miami To Miami with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Miami to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jewel
Departure: 15 March 2026
Visit: USA, Cayman Islands, Colombia, Panama, Costa Rica, Belize, Mexico
Inside
$1,369
Oceanview
$1,419
Balcony
$2,269
Suite
$2,369
From
US$1,369
Per Person
View Trip
19 Day Transamerican Treasures with Oceania Cruises
Cruise

19 Days (18 Nights) Miami to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 24 October 2027
Visit: USA, Cayman Islands, Colombia, Panama, Costa Rica, Guatemala, Mexico
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,746
Suite
$11,790
From
US$6,746
Save 7,052
Per Person
View Trip
22 Day Panama Canal with Holland America
Cruise

22 Days (21 Nights) Seattle to Fort Lauderdale
Cruise Line: Holland America
Ship: Eurodam
Departures: Oct 2026 to Oct 2027
Visit: USA, Canada, Mexico, Guatemala, Costa Rica, Panama, Aruba
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,334
Oceanview
$2,434
Balcony
$3,734
Suite
$6,530
From
US$2,334
Per Person
View Trip
21 Day Panama Canal with Holland America
Cruise

21 Days (20 Nights) Vancouver to Fort Lauderdale
Cruise Line: Holland America
Ship: Eurodam
Departures: Oct 2026 to Oct 2027
Visit: Canada, USA, Mexico, Guatemala, Costa Rica, Panama, Aruba
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,109
Oceanview
$2,209
Balcony
$3,479
Suite
$5,845
From
US$2,109
Per Person
View Trip
20 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

20 Days (19 Nights) New York to San Francisco
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Bliss
Departure: 14 April 2028
Visit: USA, Dominican Republic, Colombia, Panama, Costa Rica, Guatemala, Mexico
Exclusive Savings
Inside
$2,375
Oceanview
$3,151
Balcony
$4,024
Suite
$4,606
From
US$2,375
Save 54
Per Person
View Trip
17 Day Panama Canal & Pacific Gems with Regent Seven Seas
Cruise

17 Days (16 Nights) Miami to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 29 December 2026
Visit: USA, Cayman Islands, Colombia, Panama, Costa Rica, Guatemala, Mexico
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,069
Suite
$13,657
From
US$13,069
Save 18,729
Per Person
View Trip
12 Day Central America From Miami To Miami with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Miami to Miami
Cruise Line: Norwegian Cruise Line
Ships: Norwegian Jewel, Norwegian Sun
Departures: Mar 2026 to Dec 2027
Visit: USA, Cayman Islands, Colombia, Panama, Costa Rica, Belize, Mexico
Inside
$1,369
Oceanview
$1,549
Balcony
$2,089
Suite
$3,246
From
US$1,369
Per Person
View Trip
29 Day Canal To Coral Reefs with Regent Seven Seas
Cruise

29 Days (28 Nights) Panama City to Tahiti
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 26 January 2027
Visit: Panama, Costa Rica, El Salvador, Guatemala, Mexico, USA, French Polynesia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$21,043
Suite
$22,219
From
US$21,043
Save 30,155
Per Person
View Trip
45 Day Best of Central America with Intrepid Travel
Tour
 (1)

45 Days Playa del Carmen to Panama City
Operated By: Intrepid Travel
Departures: Apr 2026 to Nov 2028
Trip Styles: Adventure, Coach, Small Group, Scenic
Visit: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
US$6,097
Save 1,379
Per Person
View Trip
22 Day Panama Canal with Holland America
Cruise
 (3)

22 Days (21 Nights) Fort Lauderdale to Vancouver
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 11 April 2027
Visit: USA, Aruba, Panama, Costa Rica (+4 more), El Salvador, Guatemala, Mexico, Canada
Fare Saver
Inside
$2,534
Oceanview
$2,734
Balcony
$4,076
Suite
$6,820
From
US$2,534
Per Person
View Trip
37 Day New York To Sydney with Cunard
Cruise
 (1)

37 Days (36 Nights) New York to Sydney
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 19 January 2027
Visit: USA, Aruba, Panama, El Salvador (+4 more), Mexico, Fiji, New Caledonia, Australia
Inside
$6,469
Oceanview
$6,369
Balcony
$8,304
Suite
-
From
US$6,369
Per Person
View Trip
22 Day Panama Canal with Holland America
Cruise
 (3)

22 Days (21 Nights) Vancouver to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 27 September 2026
Visit: Canada, USA, Mexico, Guatemala (+4 more), El Salvador, Panama, Colombia, Bahamas
Fare Saver
Inside
$2,234
Oceanview
$2,334
Balcony
$3,634
Suite
$5,844
From
US$2,234
Per Person
View Trip
13 Day Panama Canal From Miami To Miami with Norwegian Cruise Line
Cruise
 (1)

13 Days (12 Nights) Miami to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sun
Departure: 06 November 2026
Visit: USA, Bahamas, Dominican Republic, Aruba (+4 more), Curacao, Panama, Costa Rica, Cayman Islands
Inside
$2,019
Oceanview
$2,169
Balcony
$3,478
Suite
-
From
US$2,019
Per Person
View Trip
23 Day Panama Canal with Holland America
Cruise
 (2)

23 Days (22 Nights) Fort Lauderdale to Vancouver
Cruise Line: Holland America
Ship: Koningsdam
Departure: 10 April 2026
Visit: USA, Colombia, Panama, Costa Rica (+4 more), El Salvador, Guatemala, Mexico, Canada
Have It All Fare Option
Inside
$2,409
Oceanview
$2,859
Balcony
$3,409
Suite
-
From
US$2,409
Per Person
View Trip
42 Day Antarctic Explorer & the Americas with Viking Cruises
Cruise
 (1)

42 Days (41 Nights) Buenos Aires to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 26 February 2027
Visit: Argentina, Antarctica, Chile, Peru (+4 more), Ecuador, Panama, Mexico, USA
Viking $1,499 Air Deal
Inside
-
Oceanview
-
Balcony
$40,985
Suite
-
From
US$40,985
Per Person
View Trip
12 Day Panama Canal Transit, Colombia & the Grenadines with Emerald Cruises
New ReleaseCruise
 (3)

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 29 February 2028
Visit: Panama, Colombia, Aruba, Curacao (+4 more), Bonaire, Saint Vincent, Grenada, Barbados
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$10,249
Balcony
-
Suite
$12,917
From
US$10,249
Save 12,741
Per Person
View Trip
13 Day Panama Canal From Miami To Miami with Norwegian Cruise Line
Cruise
 (1)

13 Days (12 Nights) Miami to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sun
Departures: Jan 2027 to Mar 2027
Visit: USA, Cayman Islands, Jamaica, Colombia (+4 more), Panama, Costa Rica, Belize, Mexico
Inside
$1,799
Oceanview
$2,188
Balcony
$3,488
Suite
$4,613
From
US$1,799
Per Person
View Trip
59 Day Ultimate Central America with Intrepid Travel
Tour

59 Days Mexico City to Panama City
Operated By: Intrepid Travel
Departures: Mar 2026 to Nov 2028
Trip Styles: Adventure, Small Group
Visit: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
From
US$8,377
Save 1,929
Per Person
View Trip
23 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

23 Days (22 Nights) New York to Seattle
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Bliss
Departure: 14 April 2028
Visit: USA, Dominican Republic, Colombia, Panama (+4 more), Costa Rica, Guatemala, Mexico, Canada
Exclusive Savings
Inside
$2,485
Oceanview
$3,261
Balcony
$4,134
Suite
$4,716
From
US$2,485
Save 54
Per Person
View Trip
19 Day Discover Barbados, Panama & Costa Rica with Emerald Cruises
New ReleaseCruise
 (3)

19 Days (18 Nights) Bridgetown to Panama City
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 06 January 2028
Visit: Barbados, Saint Vincent, Grenada, Bonaire (+4 more), Curacao, Aruba, Colombia, Panama
Fly Free Economy
Fly Free Premium Economy
Exclusive Savings
Inside
-
Oceanview
$17,048
Balcony
-
Suite
$21,413
From
US$17,048
Save 17,932
Per Person
View Trip
30 Day Caribbean And Antilles with MSC Cruises
Cruise
 (3)

30 Days (29 Nights) Miami to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 28 March 2027
Visit: USA, Jamaica, Colombia, Panama (+4 more), Costa Rica, Honduras, Belize, Mexico
Bonus Onboard Credit
Exclusive Savings
Inside
$2,913
Oceanview
$3,505
Balcony
$4,485
Suite
-
From
US$2,913
Save 66
Per Person
View Trip
13 Day Bon Bini Aruba with Regent Seven Seas
Cruise

13 Days (12 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 14 March 2028
Visit: Panama, Colombia, Aruba, Curacao (+4 more), Grenada, Dominica, Virgin Islands, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,458
Suite
$8,850
From
US$8,458
Save 14,740
Per Person
View Trip
13 Day Panama Canal From Miami To Miami with Norwegian Cruise Line
Cruise
 (1)

13 Days (12 Nights) Miami to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sun
Departures: Dec 2026 to Mar 2027
Visit: USA, Bahamas, Dominican Republic, Aruba (+4 more), Curacao, Colombia, Panama, Costa Rica
Exclusive Savings
Inside
$1,889
Oceanview
$2,323
Balcony
$3,730
Suite
$4,806
From
US$1,889
Save 71
Per Person
View Trip
62 Day Total Central America: Two Months of Wild with G Adventures
New ReleaseTour

62 Days Mexico City to Panama City
Operated By: G Adventures
Departures: May 2026 to Oct 2027
Trip Styles: Adventure, Small Group, 18-30's
Visit: Guatemala, Mexico, Nicaragua, Panama (+4 more), Belize, Honduras, Costa Rica, El Salvador
G's February Sale
Exclusive Savings
From
US$5,523
Save 1,176
Per Person
View Trip
34 Day San Antonio To Southampton with Cunard
Cruise

34 Days (33 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Visit: Chile, Peru, Ecuador, Panama (+4 more), Aruba, USA, Portugal, England
Inside
$5,209
Oceanview
$7,216
Balcony
$8,048
Suite
$18,096
From
US$5,209
Per Person
View Trip
17 Day Machu Picchu & Mayan Ruins with Regent Seven Seas
Cruise

17 Days (16 Nights) Lima to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 10 March 2027
Visit: Peru, Ecuador, Costa Rica, Panama (+4 more), Honduras, Belize, Mexico, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,677
Suite
$13,755
From
US$12,677
Save 19,121
Per Person
View Trip
Results: 211-240 of 356

No trips found. Try adjusting the search filters.




Trips found! Scroll up to view.

Central America Tours

All Central America Tours Belize Tours Chile Trips Colombia Trips Costa Rica Tours Guatemala Tours Mexico Tours Panama Tours Peru Trips

Travel Styles

18-30's Tours Active Adventures Coach Tours Cycling Tours Luxury Tours Small Group Tours Wildlife Tours

Trip Lengths

1 Month 10 Day 2 Week 3 Week 4 Week 7 Day

Departure Months

February March April May June July August September October November December January

Cities

Tours from Lima Tours from San Jose Tours from Santiago Tours from Santiago

Routes

Tours from Barcelona to Lisbon Tours from Lima to Lima Tours from London to Rome Tours from London to London Tours from Los Angeles to San Francisco Tours from Los Angeles to Los Angeles Tours from New York to Los Angeles Tours from New York to New York Tours from Rome to London Tours from Rome to Rome Tours from San Jose to San Jose Tours from Santiago to Buenos Aires Tours from Sydney to Sydney Tours from Vancouver to Vancouver

South & Central America Cruises

Central America Cruises South America Cruises Mexico Cruises Galapagos Cruises Bermunda Cruises Bahamas Cruises Caribbean Cruises Amazon Cruises Patagonia Cruises Cape Horn Cruises Falkland Island Cruises Panama Cruises

© 2010-2026. Global Journeys. You're viewing our site in US dollars.

    

About Us | View Your Booking | Operators | Terms & Conditions | Site Map | We're hiring!

Global Journeys Travel Inc. is a Member of the American Society of Travel Advisors (ASTA No: 900374670), CLIA (No. 00046729) & is TICO Accredited (No. 50027921).

Travel Industry Associations