Home > Tours > Latin America Tours > Central America Tours > Panama Tours & Cruises > All Trips

All Panama Tours & Cruises

Explore the colors and natural beauty of Panama - a land between the seas. Travel via dugout canoe to meet the indigenous Emberá people, visit gorgeous islands, snorkel the Caribbean and cruise through the world-famous Panama Canal. Choose from 1,162 cruises, small group tours and adventures to Panama traveling with the world's leading tour operators.
Filter Results
Departures
Show More...
Duration
2 Days
181 Days
Types
Budget
Start & End Cities
Operators
Show More...
Price
$100pp
$182,995pp
Countries
Show More...
Filter Results
365 Trips (1,162 Trip Departures)
6 Day Panama: Sandy Beaches & San Blas Sunsets with G Adventures
New ReleaseTour

6 Days Panama City to Panama City
Operated By: G Adventures
Departures: Mar 2026 to Jan 2028
Visit: Panama
Great Adventure Sale
G's February Sale
Exclusive Savings
From
US$764
Save 135
Per Person
View Trip
6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operated By: Globus
Departures: Feb 2026 to Mar 2027
Trip Styles: Short Break, Scenic
Visit: Panama
Exclusive Savings
From
US$1,689
Save 89
Per Person
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Visit: Panama, Chile
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,806
Suite
$8,970
From
US$7,806
Save 11,184
Per Person
View Trip
13 Day Costa Rica, Panama from the Pacific to the Atlantic via the Panama Canal with Emerald Cruises
New ReleaseCruise
 (3)

13 Days (12 Nights) San Jose to San Jose
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 10 February 2028
Visit: Costa Rica, Panama
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$10,230
Balcony
-
Suite
$12,898
From
US$10,230
Save 12,760
Per Person
View Trip
18 Day Panama: Craters, Coasts & Highland Mountains with G Adventures
New ReleaseTour

18 Days San Jose to Panama City
Operated By: G Adventures
Departures: Jun 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama
Great Adventure Sale
G's February Sale
Exclusive Savings
From
US$1,689
Save 360
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Dec 2026 to Mar 2027
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$9,010
Suite
$14,480
From
US$9,010
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Nov 2026 to Jan 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$9,500
Suite
$15,340
From
US$9,500
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (1)

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Nov 2026 to Mar 2027
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$5,300
Suite
$8,950
From
US$5,300
Per Person
View Trip
12 Day The Panama Canal & Costa Rica - Eastbound with Tauck
Tour + Cruise

12 Days San Jose to Panama City or Puntarenas to Panama City
Operated By: Tauck
Ships: Le Champlain, Le Lapérouse
Departures: Feb 2026 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Costa Rica, Panama
From
US$8,990
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (1)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Nov 2026 to Feb 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$5,970
Suite
$10,140
From
US$5,970
Per Person
View Trip
8 Day Coastal Adventures: Costa Rica & Panama with Emerald Cruises
Cruise
 (3)

8 Days (7 Nights) San Jose to Panama City
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 22 February 2028
Visit: Costa Rica, Panama
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$6,070
Balcony
-
Suite
$7,768
From
US$6,070
Save 8,420
Per Person
View Trip
8 Day Coastal Adventures: Panama & Costa Rica with Emerald Cruises
Cruise
 (3)

8 Days (7 Nights) Panama City to San Jose
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 24 January 2028
Visit: Panama, Costa Rica
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$6,051
Balcony
-
Suite
$7,748
From
US$6,051
Save 8,439
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (2)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 15 January 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$5,980
Suite
$10,150
From
US$5,980
Per Person
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 18 April 2026
Visit: Panama, Colombia
Exclusive Savings
Inside
$101
Oceanview
$120
Balcony
$133
Suite
$183
From
US$101
Save 109
Per Person
View Trip
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: Feb 2026 to Dec 2028
Trip Styles: Adventure, Small Group
Visit: Costa Rica, Panama
Exclusive Savings
From
US$1,719
Save 440
Per Person
View Trip
12 Day The Panama Canal & Costa Rica - Westbound with Tauck
Tour + Cruise

12 Days Panama City to San Jose
Operated By: Tauck
Ship: Le Lapérouse
Departures: Jan 2027 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Panama, Costa Rica
From
US$9,290
Per Person
View Trip
13 Day Costa Rica to Panama: Surf, Treks & Starry Skies with G Adventures
New ReleaseTour

13 Days San Jose to Panama City
Operated By: G Adventures
Departures: May 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama
Great Adventure Sale
G's February Sale
Exclusive Savings
From
US$1,019
Save 180
Per Person
View Trip
11 Day From Panama’s Wild Beauty to Peruvian Shores with Ponant
Cruise

11 Days (10 Nights) Colon to Lima
Cruise Line: Ponant
Ship: L'Austral
Departure: 20 October 2026
Visit: Panama, Peru
Inside
-
Oceanview
$6,250
Balcony
$6,760
Suite
$10,670
From
US$6,250
Per Person
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Champlain, Le Laperouse
Departures: Feb 2026 to Feb 2027
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$6,600
Suite
$11,050
From
US$6,600
Per Person
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America - with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 February 2026
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$8,280
Suite
$16,170
From
US$8,280
Per Person
View Trip
11 Day Pristine islands of the Bahamas & the Panama Canal with Scenic
New ReleaseCruise

11 Days (10 Nights) Nassau to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 16 October 2026
Visit: Bahamas, Colombia, Panama
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,748
Suite
$11,475
From
US$10,748
Save 14,342
Per Person
View Trip
14 Day Cycle Nicaragua to the Panama Canal with Explore Worldwide
Tour

14 Days Granada to Panama City
Operated By: Explore Worldwide
Departures: Feb 2026 to Nov 2026
Trip Styles: Adventure, Small Group, Cycling
Visit: Costa Rica, Panama, Nicaragua
Exclusive Savings
From
US$4,695
Save 145
Per Person
View Trip
20 Day Treasures of French Polynesia & the Marquesas Islands with Scenic
New ReleaseCruise

20 Days (19 Nights) Papeete to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 25 March 2026
Visit: French Polynesia, Costa Rica, Panama
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,457
Suite
$16,688
From
US$14,457
Save 18,333
Per Person
View Trip
27 Day Central and South American Adventure: From Costa Rica to Colombia with G Adventures
New ReleaseTour

27 Days San Jose to Medellin
Operated By: G Adventures
Departures: Jun 2026 to Dec 2027
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama, Colombia
Great Adventure Sale
Exclusive Savings
From
US$3,491
Save 565
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Mar 2026 to Jan 2028
Visit: Colombia, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$898
Oceanview
$1,028
Balcony
$1,210
Suite
$1,488
From
US$898
Save 611
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 14 February 2027
Visit: Colombia, Aruba, Bonaire, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$814
Oceanview
$934
Balcony
$1,344
Suite
$1,363
From
US$814
Save 476
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 07 March 2026
Visit: Panama, Colombia, Aruba, Curacao
Exclusive Savings
Inside
$1,052
Oceanview
$1,052
Balcony
$1,152
Suite
$1,862
From
US$1,052
Save 567
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Mar 2026 to Apr 2028
Visit: Colombia, Curacao, Aruba, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$868
Oceanview
$998
Balcony
$1,190
Suite
$1,437
From
US$868
Save 632
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Mar 2026 to Jan 2028
Visit: Panama, Colombia, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$861
Oceanview
$981
Balcony
$1,163
Suite
$1,390
From
US$861
Save 546
Per Person
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 20 December 2026
Visit: Colombia, Aruba, Bonaire, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$1,315
Oceanview
$1,326
Balcony
$1,658
Suite
$1,638
From
US$1,315
Save 648
Per Person
View Trip
Results: 1-30 of 365

No trips found. Try adjusting the search filters.




Trips found! Scroll up to view.

Central America Tours

All Central America Tours Belize Tours Chile Trips Colombia Trips Costa Rica Tours Guatemala Tours Mexico Tours Panama Tours Peru Trips

Travel Styles

18-30's Tours Active Adventures Coach Tours Cycling Tours Luxury Tours Small Group Tours Wildlife Tours

Trip Lengths

1 Month 10 Day 2 Week 3 Week 4 Week 7 Day

Departure Months

February March April May June July August September October November December January

Cities

Tours from Lima Tours from San Jose Tours from Santiago Tours from Santiago

Routes

Tours from Barcelona to Lisbon Tours from Lima to Lima Tours from London to Rome Tours from London to London Tours from Los Angeles to San Francisco Tours from Los Angeles to Los Angeles Tours from New York to Los Angeles Tours from New York to New York Tours from Rome to London Tours from Rome to Rome Tours from San Jose to San Jose Tours from Santiago to Buenos Aires Tours from Sydney to Sydney Tours from Vancouver to Vancouver

South & Central America Cruises

Central America Cruises South America Cruises Mexico Cruises Galapagos Cruises Bermunda Cruises Bahamas Cruises Caribbean Cruises Amazon Cruises Patagonia Cruises Cape Horn Cruises Falkland Island Cruises Panama Cruises

© 2010-2026. Global Journeys. You're viewing our site in US dollars.

    

About Us | View Your Booking | Operators | Terms & Conditions | Site Map | We're hiring!

Global Journeys Travel Inc. is a Member of the American Society of Travel Advisors (ASTA No: 900374670), CLIA (No. 00046729) & is TICO Accredited (No. 50027921).

Travel Industry Associations