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All Panama Tours & Cruises

Explore the colors and natural beauty of Panama - a land between the seas. Travel via dugout canoe to meet the indigenous Emberá people, visit gorgeous islands, snorkel the Caribbean and cruise through the world-famous Panama Canal. Choose from 1,114 cruises, small group tours and adventures to Panama traveling with the world's leading tour operators.
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331 Trips (1,114 Trip Departures)
6 Day Panama: Sandy Beaches & San Blas Sunsets with G Adventures
New ReleaseTour

6 Days Panama City to Panama City
Operated By: G Adventures
Departures: Apr 2026 to Jan 2028
Visit: Panama
G's February Sale
Exclusive Savings
From
US$749
Save 250
Per Person
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6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operated By: Globus
Departures: Apr 2026 to Mar 2027
Trip Styles: Short Break, Scenic
Visit: Panama
Exclusive Savings
From
US$1,689
Save 89
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Dec 2026 to Mar 2027
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$9,460
Suite
$14,480
From
US$9,460
Per Person
View Trip
13 Day Costa Rica to Panama: Surf, Treks & Starry Skies with G Adventures
New ReleaseTour

13 Days San Jose to Panama City
Operated By: G Adventures
Departures: May 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama
G's February Sale
Exclusive Savings
From
US$1,019
Save 180
Per Person
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise
 (2)

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 19 February 2027
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$7,020
Suite
$11,790
From
US$7,020
Per Person
View Trip
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: Mar 2026 to Dec 2028
Trip Styles: Adventure, Small Group
Visit: Costa Rica, Panama
Exclusive Savings
From
US$1,816
Save 524
Per Person
View Trip
18 Day Panama: Craters, Coasts & Highland Mountains with G Adventures
New ReleaseTour

18 Days San Jose to Panama City
Operated By: G Adventures
Departures: Jun 2026 to Jan 2028
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama
G's February Sale
Exclusive Savings
From
US$1,689
Save 360
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Nov 2026 to Jan 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$9,500
Suite
$15,340
From
US$9,500
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (1)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Nov 2026 to Feb 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$5,970
Suite
$10,140
From
US$5,970
Per Person
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 18 April 2026
Visit: Panama, Colombia
Exclusive Savings
Inside
$118
Oceanview
$127
Balcony
$133
Suite
$191
From
US$118
Save 117
Per Person
View Trip
8 Day Coastal Adventures: Costa Rica & Panama with Emerald Cruises
Cruise
 (3)

8 Days (7 Nights) San Jose to Panama City
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 22 February 2028
Visit: Costa Rica, Panama
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$6,070
Balcony
-
Suite
$7,768
From
US$6,070
Save 8,420
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (1)

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Nov 2026 to Mar 2027
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$5,300
Suite
$8,950
From
US$5,300
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (2)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 15 January 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$6,320
Suite
$10,750
From
US$6,320
Per Person
View Trip
11 Day From Panama’s Wild Beauty to Peruvian Shores with Ponant
Cruise

11 Days (10 Nights) Colon to Lima
Cruise Line: Ponant
Ship: L'Austral
Departure: 20 October 2026
Visit: Panama, Peru
Inside
-
Oceanview
$6,250
Balcony
$6,760
Suite
$10,670
From
US$6,250
Per Person
View Trip
13 Day Costa Rica, Panama from the Pacific to the Atlantic via the Panama Canal with Emerald Cruises
New ReleaseCruise
 (3)

13 Days (12 Nights) San Jose to San Jose
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 10 February 2028
Visit: Costa Rica, Panama
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$10,230
Balcony
-
Suite
$12,898
From
US$10,230
Save 12,760
Per Person
View Trip
8 Day Coastal Adventures: Panama & Costa Rica with Emerald Cruises
Cruise
 (3)

8 Days (7 Nights) Panama City to San Jose
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 24 January 2028
Visit: Panama, Costa Rica
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$6,051
Balcony
-
Suite
$7,748
From
US$6,051
Save 8,439
Per Person
View Trip
12 Day The Panama Canal & Costa Rica - Eastbound with Tauck
Tour + Cruise

12 Days Puntarenas to Panama City
Operated By: Tauck
Ship: Le Lapérouse
Departures: Jan 2027 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Costa Rica, Panama
From
US$9,290
Per Person
View Trip
12 Day The Panama Canal & Costa Rica - Westbound with Tauck
Tour + Cruise

12 Days Panama City to San Jose
Operated By: Tauck
Ship: Le Lapérouse
Departures: Jan 2027 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Panama, Costa Rica
From
US$9,290
Per Person
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Visit: Panama, Chile
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,806
Suite
$8,970
From
US$7,806
Save 11,184
Per Person
View Trip
27 Day Central and South American Adventure: From Costa Rica to Colombia with G Adventures
New ReleaseTour

27 Days San Jose to Medellin
Operated By: G Adventures
Departures: Oct 2026 to Dec 2027
Trip Styles: Adventure, Small Group, 18-30's
Visit: Costa Rica, Panama, Colombia
Exclusive Savings
From
US$3,879
Save 133
Per Person
View Trip
20 Day Treasures of French Polynesia & the Marquesas Islands with Scenic
New ReleaseCruise

20 Days (19 Nights) Papeete to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 25 March 2026
Visit: French Polynesia, Costa Rica, Panama
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,457
Suite
$16,688
From
US$14,457
Save 18,333
Per Person
View Trip
11 Day Pristine islands of the Bahamas & the Panama Canal with Scenic
New ReleaseCruise

11 Days (10 Nights) Nassau to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 16 October 2026
Visit: Bahamas, Colombia, Panama
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,729
Suite
$11,475
From
US$9,729
Save 13,261
Per Person
View Trip
14 Day Cycle Nicaragua to the Panama Canal with Explore Worldwide
Tour

14 Days Granada to Panama City
Operated By: Explore Worldwide
Departures: Oct 2026 to Nov 2026
Trip Styles: Adventure, Small Group, Cycling
Visit: Costa Rica, Panama, Nicaragua
Exclusive Savings
From
US$4,782
Save 148
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Mar 2026 to Jan 2028
Visit: Colombia, Aruba, Curacao, Panama
Exclusive Savings
Inside
$898
Oceanview
$1,028
Balcony
$1,448
Suite
$1,538
From
US$898
Save 2,097
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Star Princess
Departure: 04 October 2026
Visit: USA, Mexico, Panama, Aruba
Princess Standard
Sanctuary Collection
Inside
$1,529
Oceanview
$2,109
Balcony
$2,299
Suite
$3,645
From
US$1,529
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Apr 2028
Visit: Panama, Colombia, Curacao, Aruba
Exclusive Savings
Inside
$839
Oceanview
$949
Balcony
$1,329
Suite
$1,398
From
US$839
Save 542
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Mar 2026 to Jan 2028
Visit: Panama, Colombia, Aruba, Curacao
Exclusive Savings
Inside
$861
Oceanview
$981
Balcony
$1,203
Suite
$1,440
From
US$861
Save 2,214
Per Person
View Trip
8 Day Southern Caribbean Holiday Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 19 December 2026
Visit: Panama, Colombia, Aruba, Bonaire
Exclusive Savings
Inside
$1,032
Oceanview
$1,063
Balcony
$1,616
Suite
$1,717
From
US$1,032
Save 561
Per Person
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Cartagena to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 19 April 2026
Visit: Colombia, Curacao, Aruba, Panama
Exclusive Savings
Inside
$768
Oceanview
$788
Balcony
$908
Suite
$1,464
From
US$825
Save 485
Per Person
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 20 December 2026
Visit: Colombia, Aruba, Bonaire, Panama
Exclusive Savings
Inside
$1,835
Oceanview
$1,845
Balcony
$1,968
Suite
$1,738
From
US$1,738
Save 1,311
Per Person
View Trip
Results: 1-30 of 331

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