All Panama Tours & Cruises

Explore the colors and natural beauty of Panama - a land between the seas. Travel via dugout canoe to meet the indigenous Emberá people, visit gorgeous islands, snorkel the Caribbean and cruise through the world-famous Panama Canal. Choose from 174 cruises, small gropup tours and adventures to Panama. Compare trips, read past passenger reviews and enjoy exclusive savings on every departure.

  174 Trips Found
Cruise  

8 Days Puerto Caldera to Colon
Operated By: Peregrine Adventures (Adventure Cruise)
Embark on a 7 night adventure cruise with Peregrine Adventures visiting Costa Rica & Panama, beginning your journey in Puerto Caldera and travelling through to Colon...
Departures: Jan 2022 to Feb 2022 (2 Departures)
Regions: Central America
Save
$ 82
From
$ 4,038
Cruise  

11 Days Puerto Caldera to Colon
Operated By: Ponant (Cruise)
Ship: Le Champlain
Embark on a 10 night cruise with Ponant visiting Costa Rica & Panama, beginning your journey in Puerto Caldera and travelling through to Colon.
Departs: 14 January 2022
Regions: Central America
 
From
$ 7,300
Cruise  

10 Days Halifax to Colon
Operated By: Hurtigruten (Expedition Cruise)
Ship: MS Fram
Embark on a 9 night expedition cruise with Hurtigruten visiting Canada & Panama, beginning your journey in Halifax and travelling through to Colon.
Departs: 21 September 2022
Regions: Transatlantic
 
From
$ 2,385
Cruise  

8 Days Colon to Puerto Caldera
Operated By: Peregrine Adventures (Adventure Cruise)
Embark on a 7 night adventure cruise with Peregrine Adventures visiting Costa Rica & Panama, beginning your journey in Colon and travelling through to Puerto Caldera...
Departures: Jan 2022 to Mar 2022 (4 Departures)
Regions: Central America
Save
$ 82
From
$ 4,038
Tour  

13 Days San Jose to Panama City
Operated By: Intrepid Travel (Small Group Adventure)
Discover Costa Rica & Panama on this 13 day small group adventure with Intrepid Travel, beginning your journey in San Jose and travelling through to Panama City....
Departures: Jul 2021 to Dec 2022 (44 Departures)
Countries Visited: Costa Rica, Panama
Save
$ 77
From
$ 1,627
Cruise  

11 Days Colón to Puerto Caldera
Operated By: Ponant (Cruise)
Ship: Le Champlain
Embark on a 10 night cruise with Ponant visiting Panama & Costa Rica, beginning your journey in Colón and travelling through to Puerto Caldera.
Departs: 04 January 2022
Regions: Central America
 
From
$ 7,300
Cruise  

9 Days Lima to Panama City
Operated By: Scenic (Cruise)
Embark on a 8 night cruise with Scenic visiting Colombia, Panama & Peru, beginning your journey in Lima and travelling through to Panama City.
Exclusive: Mutiple Deals Available
Departs: 27 March 2023
Regions: Central America
Save
$ 732
From
$ 9,603
Tour  

14 Days Granada to Panama City
Operated By: Explore! (Small Group Adventure)
Travel to South & Central America and journey through Nicaragua, Costa Rica & Panama on this 14 day small group adventure with Explore!.
Departures: Oct 2021 to Nov 2022 (8 Departures)
Countries Visited: Nicaragua, Costa Rica, Panama
Save
$ 397
From
$ 4,483
Tour  

15 Days Granada to Panama City
Operated By: Exodus Travels (Small Group Adventure)
Travel to South & Central America and journey through Costa Rica, Nicaragua & Panama on this 15 day small group adventure with Exodus Travels.
Departures: Sep 2021 to Dec 2022 (19 Departures)
Countries Visited: Costa Rica, Nicaragua, Panama
Save
$ 279
From
$ 5,903
Cruise  

10 or 9 Days Cartagena to Lima or Panama City to Lima
Operated By: Scenic (Cruise)
Visit 4 different countries on this 9 night cruise with Scenic, beginning your journey in Cartagena and travelling through to Lima.
Exclusive: Mutiple Deals Available
Departures: Oct 2021 to Oct 2023 (2 Departures)
Regions: Central America
Save
$ 1,252
From
$ 9,888
Tour + Cruise  

18 Days Bogota to Lima
Operated By: Scenic (Discovery Voyage)
Travel to South & Central America and journey through Colombia, Panama & Peru on this 18 day discovery voyage with Scenic.
Departs: 08 October 2021
Countries Visited: Colombia, Panama, Peru
Save
$ 494
From
$ 18,126
Tour + Cruise  

16 Days Panama City to Cusco
Operated By: Scenic (Discovery Voyage)
Tour through 4 different countries on this 16 day discovery voyage with Scenic, beginning your journey in Panama City and travelling through to Cusco.
Exclusive: Mutiple Deals Available
Departs: 26 October 2023
Countries Visited: Panama, Colombia, Ecuador, Peru
Save
$ 1,931
From
$ 17,804
Cruise  

12 Days Puntarenas to Guayaquil
Operated By: Silversea (Cruise)
Ship: Silver Wind
Visit 4 different countries on this 11 night cruise with Silversea, beginning your journey in Puntarenas and travelling through to Guayaquil.
Exclusive: Early Booking Bonus
Departs: 27 October 2022
Regions: South America
 
From
$ 9,270
Cruise  

16 Days Panama City to Valparaiso
Operated By: Hurtigruten (Expedition Cruise)
Visit 4 different countries on this 15 night expedition cruise with Hurtigruten, beginning your journey in Panama City and travelling through to Valparaiso.
Departs: 08 October 2021
Regions: South America
 
From
$ 7,033
Cruise  

10 Days Fort Lauderdale to Fort Lauderdale
Operated By: Royal Caribbean (Cruise)
Visit 4 different countries on this 9 night cruise with Royal Caribbean, beginning and ending your journey in Fort Lauderdale.
Exclusive: Flash Sale
Departs: 16 November 2022
Regions: Caribbean
 
From
$ 1,243
Cruise  

15 Days Colon to Valparaiso
Operated By: Hurtigruten (Expedition Cruise)
Ship: MS Fram
Visit 4 different countries on this 14 night expedition cruise with Hurtigruten, beginning your journey in Colon and travelling through to Valparaiso.
Departs: 01 October 2021
Regions: South America
 
From
$ 6,435
Cruise  

16 Days Panama City to Valparaiso
Operated By: Hurtigruten (Expedition Cruise)
Visit 4 different countries on this 15 night expedition cruise with Hurtigruten, beginning your journey in Panama City and travelling through to Valparaiso.
Departs: 18 October 2021
Regions: South America
 
From
$ 7,334
Cruise  

15 Days Colon to Valparaiso
Operated By: Hurtigruten (Expedition Cruise)
Visit 4 different countries on this 14 night expedition cruise with Hurtigruten, beginning your journey in Colon and travelling through to Valparaiso.
Departures: Oct 2022 to Oct 2022 (2 Departures)
Regions: Central America, South America
 
From
$ 6,584
Cruise  

12 Days Nassau to Cartagena
Operated By: Scenic (Cruise)
Visit 5 different countries on this 11 night cruise with Scenic, beginning your journey in Nassau and travelling through to Cartagena.
Exclusive: Mutiple Deals Available
Departs: 05 October 2021
Regions: Caribbean
Save
$ 1,720
From
$ 12,170
Cruise  

12 Days Fort Lauderdale to Fort Lauderdale
Operated By: Royal Caribbean (Cruise)
Visit 5 different countries on this 11 night cruise with Royal Caribbean, beginning and ending your journey in Fort Lauderdale.
Exclusive: Flash Sale
Departs: 22 November 2021
Regions: Caribbean
 
From
$ 1,585
Cruise  

15 Days Los Angeles to Fort Lauderdale
Operated By: Cunard (Cruise)
Visit 5 different countries on this 14 night cruise with Cunard, beginning your journey in Los Angeles and travelling through to Fort Lauderdale.
Exclusive: Gift for You
Departs: 26 July 2022
Regions: Central America
 
From
$ 2,799
Cruise  

9 Days Panama City to Panama City
Operated By: Norwegian Cruise Line (Cruise)
Visit 5 different countries on this 8 night cruise with Norwegian Cruise Line, beginning and ending your journey in Panama City.
Exclusive: Great Getaway Sale
Departs: 02 March 2022
Regions: Caribbean
 
From
$ 1,153
Cruise  

22 Days Miami to San Antonio
Operated By: Seabourn (Cruise)
Visit 5 different countries on this 21 night cruise with Seabourn, beginning your journey in Miami and travelling through to San Antonio.
Exclusive: Advantage Fares
Departs: 06 January 2023
Regions: Central America, South America
 
From
$ 19,427
Cruise  

10 Days Panama City to Panama City
Operated By: Norwegian Cruise Line (Cruise)
Visit 5 different countries on this 9 night cruise with Norwegian Cruise Line, beginning and ending your journey in Panama City.
Exclusive: Great Getaway Sale
Departs: 02 November 2021
Regions: Caribbean
 
From
$ 1,637
Tour + Cruise  

28 Days Guayaquil to Panama City
Operated By: Scenic (Discovery Voyage)
Tour through 5 different countries on this 28 day discovery voyage with Scenic, beginning your journey in Guayaquil and travelling through to Panama City.
Exclusive: Mutiple Deals Available
Departs: 08 March 2023
Countries Visited: Ecuador, Galapagos, Peru, Colombia, Panama
Save
$ 3,887
From
$ 26,843
Cruise  

16 Days Miami to Colon
Operated By: Hurtigruten (Expedition Cruise)
Ship: MS Fram
Visit 5 different countries on this 15 night expedition cruise with Hurtigruten, beginning your journey in Miami and travelling through to Colon.
Departs: 16 September 2021
Regions: Central America
 
From
$ 5,684
Cruise  

18 Days Colon to Valparaiso
Operated By: Hurtigruten (Expedition Cruise)
Ship: MS Fram
Visit 5 different countries on this 17 night expedition cruise with Hurtigruten, beginning your journey in Colon and travelling through to Valparaiso.
Exclusive: Mothers Day Sale
Departs: 29 September 2022
Regions: Central America, South America
 
From
$ 7,035
Tour  

25 Days Panama City to Antigua
Operated By: Explore! (Small Group Adventure)
Tour through 5 different countries on this 25 day small group adventure with Explore!, beginning your journey in Panama City and travelling through to Antigua.
Departures: Nov 2021 to Nov 2022 (5 Departures)
Countries Visited: Costa Rica, Panama, Guatemala, Honduras, Nicaragua
Save
$ 455
From
$ 5,770
Cruise  

15 Days Bridgetown to Lima
Operated By: Seabourn (Expedition Cruise)
Visit 5 different countries on this 14 night expedition cruise with Seabourn, beginning your journey in Bridgetown and travelling through to Lima.
Exclusive: Advantage Fares
Departs: 12 October 2022
Regions: Central America
 
From
$ 15,951
Cruise  

18 Days Valparaiso to Puntarenas
Operated By: Hurtigruten (Expedition Cruise)
Visit 5 different countries on this 17 night expedition cruise with Hurtigruten, beginning your journey in Valparaiso and travelling through to Puntarenas.
Exclusive: Mothers Day Sale
Departs: 03 April 2022
Regions: South America
 
From
$ 7,185

Results 1-30 of 174