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South America Cruises Starting In December 2025

If you're looking at joining a cruise around South America in December 2025, we have 90 unique expeditions and cruises with 1,553 departures from the world's leading cruise lines departing in December.
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Departures (December 2025)
< November 2025 January 2026 >
Duration
4 Days
78 Days
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Price
$300pp
$120,998pp
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90 Cruises (1,553 Cruise Departures)
10 Day Complete Galapagos (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Aug 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Exclusive Savings
Save (per person) 165
From (per person) 7,708
View Trip
7 Day Galapagos Explorer: Southern Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

7 Days (6 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jul 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Exclusive Deal
Save (per person) 854
From (per person) 4,451
View Trip
13 Day Treasures of Galapagos: Western & Central Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

13 Days (12 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Nov 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Exclusive Savings
Save (per person) 226
From (per person) 10,555
View Trip
10 Day Ultimate Galapagos: Central Islands (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jul 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Exclusive Deal
Save (per person) 1,656
From (per person) 6,209
View Trip
9 Day South America with MSC Cruises
Cruise

9 Days (8 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 27 December 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$1,537
OCEANVIEW
$1,657
BALCONY
$2,167
SUITE
$2,467
From (per person) 1,537
View Trip
17 Day Absolute Galapagos (Grand Daphne) with Intrepid Travel
Cruise

17 Days (16 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Nov 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Exclusive Savings
Save (per person) 297
From (per person) 13,877
View Trip
7 Day South America with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 16 December 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$908
OCEANVIEW
-
BALCONY
$1,211
SUITE
$2,102
From (per person) 908
View Trip
7 Day Galápagos - North & Central Islands aboard the Eden with G Adventures
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: G Adventures
Departures: Aug 2025 to Dec 2027
Countries Visited: Ecuador, Galapagos
Last Minute Offer
Save (per person) 1,240
From (per person) 2,709
View Trip
7 Day South America with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 13 December 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$761
OCEANVIEW
$911
BALCONY
$1,101
SUITE
$1,531
From (per person) 761
View Trip
8 Day San Cristóbal to San Cristóbal with Silversea
Cruise

8 Days (7 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departures: Sep 2025 to Mar 2027
Countries Visited: Ecuador, Galapagos
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
$12,900
SUITE
$18,300
From (per person) 12,900
View Trip
10 Day Galápagos - Central, South & East Islands aboard the Yolita with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jul 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Last Minute Offer
Save (per person) 2,103
From (per person) 4,527
View Trip
6 Day Galapagos at a Glance: Southern Islands (Grand Daphne) with Intrepid Travel
Cruise

6 Days (5 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Aug 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Exclusive Deal
Save (per person) 657
From (per person) 3,473
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departures: Dec 2025 to Dec 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$342
OCEANVIEW
$432
BALCONY
$512
SUITE
$772
From (per person) 342
View Trip
10 Day Galápagos – Central and East Islands aboard the Reina Silvia Voyager with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jul 2025 to Dec 2027
Countries Visited: Ecuador, Galapagos
Exclusive DealLast Minute Offer
Save (per person) 3,234
From (per person) 4,615
View Trip
9 Day Galapagos - Central & West Islands Aboard the Solaris with Explore!
Cruise

9 Days (8 Nights) Quito to Quito
Operated By: Explore!
Departures: Jul 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save (per person) 1,024
From (per person) 7,656
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 20 December 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$890
OCEANVIEW
$1,060
BALCONY
$1,500
SUITE
$1,770
From (per person) 890
View Trip
10 Day Galapagos - Central, South & East Islands aboard the Archipel I with Explore!
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: Explore!
Departures: Jul 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save (per person) 903
From (per person) 6,747
View Trip
11 Day Nine Of The Best Isles (Western And Northern Route) with HX Hurtigruten Expeditions
Cruise

11 Days (10 Nights) Quito to Quito
Ship: MS Santa Cruz II
Departures: Aug 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Anniversary Offers
INSIDE
-
OCEANVIEW
$9,314
BALCONY
-
SUITE
$12,665
Save (per person) 5,680
From (per person) 9,314
View Trip
11 Day South America with MSC Cruises
Cruise
 (1)

11 Days (10 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 25 December 2025
Countries Visited: Uruguay, Argentina, Brazil
Escape To Sea
INSIDE
$2,855
OCEANVIEW
$3,228
BALCONY
$3,468
SUITE
$4,918
From (per person) 2,855
View Trip
7 Day Galápagos Land & Sea - Central & South Islands aboard the Yolita with G Adventures
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jul 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Exclusive DealLast Minute Offer
Save (per person) 1,303
From (per person) 2,778
View Trip
17 Day Cape Horn & Strait of Magellan with Princess
Cruise

17 Days (16 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 06 December 2025
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Bonus Instant Savings
INSIDE
$2,409
OCEANVIEW
$3,659
BALCONY
$3,759
SUITE
$5,209
From (per person) 2,409
View Trip
7 Day Independent Galapagos Cruise Aboard the Galapagos Legend with Globus
New ReleaseTour + Cruise

7 Days Quito to Guayaquil
Operated By: Globus
Departures: Jul 2025 to Mar 2026
Trip Styles: Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Ecuador, Galapagos
Exclusive Savings
Save (per person) 154
From (per person) 4,864
View Trip
17 Day Complete Galápagos - Eden with G Adventures
Cruise

17 Days (16 Nights) Quito to Quito
Operated By: G Adventures
Departures: Aug 2025 to Dec 2027
Countries Visited: Ecuador, Galapagos
Exclusive Savings
Save (per person) 221
From (per person) 9,946
View Trip
10 Day Galápagos - East, Central, & West Islands aboard the Eden with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jul 2025 to Dec 2027
Countries Visited: Ecuador, Galapagos
Exclusive Savings
Save (per person) 122
From (per person) 5,516
View Trip
15 Day Patagonia & Argentina Cruise with Celebrity Cruises
Cruise

15 Days (14 Nights) Buenos Aires to Buenos Aires
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Dec 2025 to Feb 2027
Countries Visited: Argentina, Uruguay, Falkland Islands, Chile
Exclusive Deal
INSIDE
$1,953
OCEANVIEW
$2,191
BALCONY
$2,012
SUITE
$7,125
Save (per person) 1,315
From (per person) 1,953
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 26 December 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$1,693
OCEANVIEW
$1,965
BALCONY
$2,175
SUITE
$2,603
From (per person) 1,693
View Trip
7 Day South America with MSC Cruises
Cruise

7 Days (6 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 23 December 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$711
OCEANVIEW
$861
BALCONY
$991
SUITE
$1,401
From (per person) 711
View Trip
8 Day Galápagos - South & East Islands aboard the Eden with G Adventures
Cruise

8 Days (7 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jul 2025 to Dec 2027
Countries Visited: Ecuador, Galapagos
Exclusive DealLast Minute Offer
Save (per person) 1,344
From (per person) 2,935
View Trip
6 Day Galapagos Escape - Solaris (Itinerary C) with Exodus Adventure Travels
Cruise

6 Days (5 Nights) Quito to Guayaquil
Departures: Jul 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Sign Up SavingsEarly Booking Sale
Save (per person) 678
From (per person) 4,221
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Maceio to Maceio
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Dec 2025 to Apr 2026
Countries Visited: Brazil
Escape To Sea
INSIDE
$823
OCEANVIEW
$983
BALCONY
$1,163
SUITE
-
From (per person) 823
View Trip
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