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South America Cruises Starting In December 2026 and 2027

Are you planning a cruise around South America in December 2026 or 2027? Choose from 84 unique expeditions and cruises with 1,274 departures operated by South America's leading cruise lines. Easily compare prices, itineraries, inclusions and traveler reviews to find the South America cruise that best matches your travel style, budget and dates.
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84 Cruises (1,274 Cruise Departures)
15 Day Patagonia & Argentina Cruise with Celebrity Cruises
Cruise
 (1)

15 Days (14 Nights) Buenos Aires to Buenos Aires
Cruise Line: Celebrity Cruises
Ships: Celebrity Equinox
Departures: Dec 2026 to Feb 2028
Visit: Argentina, Uruguay, Falkland Islands, Chile
Exclusive Savings
Inside
$2,435
Oceanview
$2,756
Balcony
$2,681
Suite
$6,763
From
US$2,830
Save 1,508
Per Person
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (7)

18 Days (17 Nights) Buenos Aires to Santiago
Cruise Line: Viking Cruises
Ship: Viking Jupiter
Departures: Dec 2026 to Feb 2028
Visit: Argentina, Uruguay, Falkland Islands, Chile
Viking $1,799 Air Deal
Inside
-
Oceanview
-
Balcony
$8,499
Suite
$12,999
From
US$8,499
Per Person
View Trip
10 Day Complete Galapagos (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$6,994
Save 1,256
Per Person
View Trip
7 Day Galapagos Explorer: Southern Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

7 Days (6 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$4,117
Save 764
Per Person
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (7)

18 Days (17 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Jupiter
Departures: Dec 2026 to Feb 2028
Visit: Chile, Argentina, Falkland Islands, Uruguay
Viking $1,799 Air Deal
Inside
-
Oceanview
-
Balcony
$8,299
Suite
$12,999
From
US$8,299
Per Person
View Trip
13 Day Treasures of Galapagos: Western & Central Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

13 Days (12 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jul 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$9,491
Save 1,634
Per Person
View Trip
10 Day Ultimate Galapagos: Central Islands (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jun 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$6,596
Save 1,196
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 05 December 2026
Visit: Brazil, Uruguay, Argentina
Inside
$1,114
Oceanview
$1,314
Balcony
$1,524
Suite
$1,404
From
US$1,114
Per Person
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (3)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ships: Nieuw Amsterdam, Oosterdam
Departures: Dec 2026 to Dec 2027
Visit: Chile, Argentina, Falkland Islands, Uruguay
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,124
Oceanview
$2,324
Balcony
$3,224
Suite
$4,599
From
US$2,124
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Nov 2026 to Dec 2026
Visit: Brazil
Inside
$525
Oceanview
$595
Balcony
$765
Suite
-
From
US$525
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 06 December 2026
Visit: Brazil, Uruguay, Argentina
Inside
$1,099
Oceanview
$1,229
Balcony
$1,509
Suite
$2,099
From
US$1,099
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Musica
Departures: Nov 2026 to Mar 2027
Visit: Brazil
Inside
$433
Oceanview
$503
Balcony
$593
Suite
$948
From
US$433
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Dec 2026 to Feb 2027
Visit: Brazil, Uruguay, Argentina
Inside
$899
Oceanview
$1,079
Balcony
$1,279
Suite
$1,329
From
US$899
Per Person
View Trip
16 Day Cape Horn & Glaciers of Patagonia with Princess
Cruise
 (8)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Majestic Princess
Departures: Dec 2026 to Dec 2027
Visit: Chile, Argentina, Falkland Islands, Uruguay
Princess Standard
Inside
$1,972
Oceanview
-
Balcony
$2,370
Suite
$2,972
From
US$1,972
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Dec 2026 to Feb 2027
Visit: Argentina, Brazil, Uruguay
Inside
$908
Oceanview
$1,088
Balcony
$1,348
Suite
$1,868
From
US$908
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 02 December 2026
Visit: Brazil
Inside
$559
Oceanview
$619
Balcony
$719
Suite
$959
From
US$559
Per Person
View Trip
15 Day Patagonia & Argentina Holiday with Celebrity Cruises
Cruise
 (1)

15 Days (14 Nights) Buenos Aires to Buenos Aires
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 19 December 2027
Visit: Argentina, Uruguay, Falkland Islands, Chile
Exclusive Savings
Inside
$2,590
Oceanview
$2,924
Balcony
$3,325
Suite
$11,066
From
US$3,009
Save 888
Per Person
View Trip
16 Day Cape Horn & Glaciers of Patagonia with Princess
Cruise
 (8)

16 Days (15 Nights) Buenos Aires to Santiago
Cruise Line: Princess
Ship: Majestic Princess
Departures: Dec 2026 to Nov 2027
Visit: Argentina, Uruguay, Falkland Islands, Chile
Princess Standard
Inside
$2,022
Oceanview
-
Balcony
$2,254
Suite
$2,922
From
US$2,022
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Mar 2027
Visit: Brazil
Inside
$525
Oceanview
$595
Balcony
$715
Suite
-
From
US$525
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Dec 2026 to Feb 2027
Visit: Brazil, Uruguay, Argentina
Inside
$869
Oceanview
$1,049
Balcony
$1,299
Suite
$1,329
From
US$869
Per Person
View Trip
17 Day Absolute Galapagos (Grand Daphne) with Intrepid Travel
Cruise

17 Days (16 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Aug 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$12,721
Save 2,204
Per Person
View Trip
9 Day Cruising the Galapagos Islands with Tauck
Tour + Cruise

9 Days Guayaquil to Guayaquil
Operated By: Tauck
Departures: Nov 2026 to Dec 2027
Visit: Ecuador, Galapagos
From
US$9,490
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise

9 Days (8 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departures: Dec 2026 to Mar 2027
Visit: Argentina, Brazil, Uruguay
Inside
$1,249
Oceanview
$1,557
Balcony
$1,689
Suite
$2,338
From
US$1,249
Per Person
View Trip
7 Day Galápagos Land & Sea - Central & South Islands aboard the Yolita with G Adventures
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jun 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$3,074
Save 1,062
Per Person
View Trip
10 Day Classic Galapagos: Central Eastern Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jul 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$6,812
Save 1,225
Per Person
View Trip
7 Day Galápagos - North & Central Islands aboard the Eden with G Adventures
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jun 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$3,037
Save 1,045
Per Person
View Trip
8 Day Galápagos - West & Central Islands aboard the Reina Silvia Voyager (Cruise Only) with G Adventures
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Operated By: G Adventures
Departures: Jun 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$5,399
Save 1,800
Per Person
View Trip
10 Day Galápagos – Central and East Islands aboard the Reina Silvia Voyager with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$6,319
Save 1,630
Per Person
View Trip
14 Day Patagonia: Edge of the World with Collette
Tour + Cruise

14 Days Buenos Aires to Buenos Aires
Operated By: Collette
Departures: Oct 2026 to Mar 2027
Visit: Argentina, Chile
Flash Sale
Exclusive Savings
From
US$9,799
Save 400
Per Person
View Trip
8 Day Galápagos – Central and East Islands aboard the Reina Silvia Voyager (Cruise Only) with G Adventures
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Operated By: G Adventures
Departures: May 2026 to Dec 2027
Visit: Galapagos
Exclusive Savings
From
US$5,759
Save 1,490
Per Person
View Trip
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