Home > Cruises > South America Cruises > April 2026

South America Cruises Starting In April 2026

If you're looking at joining a cruise around South America in April 2026, we have 74 unique expeditions and cruises with 1,480 departures from the world's leading cruise lines departing in April.
Filter Results
Departures (April 2026)
< March 2026 May 2026 >
Duration
5 Days
32 Days
Regions
Start & End Cities
Ship Size
Cruise Lines
Price
$400pp
$120,998pp
Countries
Show More...
Filter Results
74 Cruises (1,480 Cruise Departures)
30 Day Ultimate South America with Brazil's Amazon & Galapagos Cruise with Cosmos
Tour + Cruise
 (3)

30 Days Manaus to Guayaquil
Operated By: Cosmos
Departures: Oct 2025 to Nov 2027
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador, Galapagos
Exclusive Savings
Save
263
From
9,478
per person
View Trip
10 Day Complete Galapagos (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Sep 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Save
1,656
From
6,209
per person
View Trip
7 Day Galapagos Explorer: Southern Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

7 Days (6 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Oct 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Save
1,602
From
3,704
per person
View Trip
13 Day Treasures of Galapagos: Western & Central Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

13 Days (12 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Oct 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Save
2,283
From
8,497
per person
View Trip
10 Day Ultimate Galapagos: Central Islands (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Sep 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Save
1,656
From
6,219
per person
View Trip
26 Day Ultimate South America with Galapagos Cruise with Cosmos
Tour + Cruise
 (1)

26 Days Rio de Janeiro to Guayaquil
Operated By: Cosmos
Departures: Oct 2025 to Nov 2027
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador, Galapagos
Save
470
From
10,012
per person
View Trip
21 Day South America Revealed with Galápagos Legend East Cruise with Trafalgar
Tour + Cruise

21 Days Rio de Janeiro to Quito
Operated By: Trafalgar
Departures: Feb 2026 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador, Galapagos
Sign Up SavingsPrice Drop Promise
Save
335
From
11,515
per person
View Trip
6 Day Galapagos Escape - Solaris (Itinerary C) with Exodus Adventure Travels
Cruise

6 Days (5 Nights) Quito to Guayaquil
Departures: Sep 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save
678
From
4,221
per person
View Trip
23 Day South American Discovery with Galápagos Cruise with Globus
Tour + Cruise

23 Days Rio de Janeiro to Guayaquil
Operated By: Globus
Departures: Mar 2026 to Nov 2027
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador, Galapagos
Save
779
From
11,856
per person
View Trip
8 Day San Cristóbal to San Cristóbal with Silversea
Cruise

8 Days (7 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departures: Apr 2026 to Mar 2027
Countries Visited: Ecuador, Galapagos
Port-to-PortDoor-to-Door Upgrade Option
Inside
-
Oceanview
-
Balcony
$12,300
Suite
$18,600
From
12,300
per person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Maceio to Maceio
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Dec 2025 to Apr 2026
Countries Visited: Brazil
Inside
$987
Oceanview
$1,249
Balcony
$1,395
Suite
-
From
987
per person
View Trip
7 Day Galápagos Islands – Iconic Wildlife & Sublime Scenery (Western Route) with HX Expeditions
Cruise

7 Days (6 Nights) Quito to Quito
Cruise Line: HX Expeditions
Ship: MS Santa Cruz II
Departures: Sep 2025 to Nov 2026
Countries Visited: Ecuador, Galapagos
Anniversary Offers
Inside
-
Oceanview
$6,003
Balcony
-
Suite
$7,897
Save
2,987
From
6,003
per person
View Trip
8 Day Pure Galapagos (Grand Daphne) with Intrepid Travel
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Operated By: Intrepid Travel
Departures: Sep 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Save
1,469
From
5,541
per person
View Trip
9 Day Island Hopping in the Galapagos with Exodus Adventure Travels
New ReleaseCruise

9 Days (8 Nights) Quito to Quito
Departures: Oct 2025 to Nov 2026
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save
624
From
3,924
per person
View Trip
16 Day Galápagos Islands - Nine Of The Best Isles Plus Machu Picchu with HX Expeditions
Cruise

16 Days (15 Nights) Lima to Quito
Cruise Line: HX Expeditions
Ship: MS Santa Cruz II
Departures: Mar 2026 to Dec 2026
Countries Visited: Peru, Ecuador, Galapagos
Anniversary Offers
Inside
-
Oceanview
$13,515
Balcony
-
Suite
$16,921
Save
5,680
From
13,515
per person
View Trip
10 Day Galápagos - Central, South & East Islands aboard the Yolita with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: Sep 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Save
1,749
From
4,850
per person
View Trip
7 Day Galapagos Express - Central & West Islands aboard the Archipel I with Explore Worldwide
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: Explore Worldwide
Departures: Sep 2025 to Dec 2026
Countries Visited: Galapagos, Ecuador
Sign Up Savings
Save
669
From
4,181
per person
View Trip
7 Day Galápagos - North & Central Islands aboard the Eden with G Adventures
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: G Adventures
Departures: Aug 2025 to Dec 2027
Countries Visited: Ecuador, Galapagos
Save
1,433
From
2,516
per person
View Trip
19 Day Legacy of the Incas with Galapagos Cruise with Globus
Tour + Cruise

19 Days Lima to Guayaquil
Operated By: Globus
Departures: Mar 2026 to Nov 2027
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Peru, Ecuador, Galapagos
Save
766
From
10,644
per person
View Trip
8 Day Galapagos Outer Loop Cruise with Celebrity Cruises
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Cruise Line: Celebrity Cruises
Ship: Celebrity Flora
Departures: Oct 2025 to Dec 2027
Countries Visited: Galapagos
Inside
-
Oceanview
-
Balcony
-
Suite
$8,329
Save
4,917
From
8,329
per person
View Trip
6 Day Galapagos Escape (Itinerary B) with Exodus Adventure Travels
Cruise

6 Days (5 Nights) Quito to Guayaquil
Departures: Sep 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save
678
From
4,221
per person
View Trip
7 Day Galápagos - South & East Islands aboard the Yolita with G Adventures
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: G Adventures
Departures: Aug 2025 to Dec 2026
Countries Visited: Ecuador
Save
1,205
From
3,344
per person
View Trip
17 Day Peru Splendors with Peru's Amazon & Galapagos Cruise with Globus
Tour + Cruise

17 Days Lima to Guayaquil
Operated By: Globus
Departures: Nov 2025 to Nov 2027
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Peru, Ecuador, Galapagos
Save
224
From
8,436
per person
View Trip
18 Day Land of the Incas with Galápagos Legend North and Central Cruise with Trafalgar
Tour + Cruise

18 Days Lima to Quito
Operated By: Trafalgar
Departures: Feb 2026 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Peru, Ecuador, Galapagos
Sign Up SavingsPrice Drop Promise
Save
286
From
9,545
per person
View Trip
8 Day Galápagos - West & Central Islands aboard the Reina Silvia Voyager (Cruise Only) with G Adventures
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Operated By: G Adventures
Departures: Sep 2025 to Dec 2027
Countries Visited: Ecuador, Galapagos
Save
2,182
From
4,767
per person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Nov 2025 to Apr 2026
Countries Visited: Brazil
Inside
$599
Oceanview
$701
Balcony
$839
Suite
$1,127
From
599
per person
View Trip
15 Day Peru & the Galapagos Islands with Tauck
Tour + Cruise

15 Days Lima to Guayaquil
Operated By: Tauck
Departure: 11 September 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Peru, Ecuador, Galapagos
From
14,190
per person
View Trip
17 Day Complete Galápagos - Yolita with G Adventures
Cruise

17 Days (16 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jan 2026 to Dec 2026
Countries Visited: Ecuador, Galapagos
Exclusive Savings
Save
255
From
11,955
per person
View Trip
17 Day Complete Galápagos - Eden with G Adventures
Cruise

17 Days (16 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jan 2026 to Dec 2027
Countries Visited: Ecuador, Galapagos
Exclusive Savings
Save
221
From
10,240
per person
View Trip
8 Day San Cristóbal to San Cristóbal with Silversea
Cruise

8 Days (7 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departures: Oct 2025 to Mar 2027
Countries Visited: Ecuador, Galapagos
Port-to-PortDoor-to-Door Upgrade Option
Inside
-
Oceanview
-
Balcony
$12,400
Suite
$18,300
From
12,400
per person
View Trip
Results: 1-30 of 74

No results found. Try amending the search filters.




Cruises found! Scroll up to view.

South & Central America Cruises

Central America Cruises South America Cruises Mexico Cruises Galapagos Cruises Bermunda Cruises Bahamas Cruises Caribbean Cruises Amazon Cruises Patagonia Cruises Cape Horn Cruises Falkland Island Cruises Panama Cruises

Travel Styles

Active Adventures Coach Cruises Locally Guided Tours Luxury Cruises Short Cruise Breaks Wildlife Cruises

Countries

Antarctica Argentina Barbados Brazil Chile Ecuador Falkland Islands French Polynesia Galapagos Panama Peru Portugal Spain Uruguay

Cities

Baltra Island Lima Manaus Quito Rio de Janeiro Santos Sao Paulo

Routes

Cruises from Baltra Island to Baltra Island Cruises from Lima to Quito Cruises from Quito to Guayaquil Cruises from Quito to Quito Cruises from Rio de Janeiro to Rio de Janeiro Cruises from Rio de Janeiro to Barcelona Cruises from Santos to Santos Cruises from Sao Paulo to Sao Paulo

Country Routes

Cruises from Brazil to France Cruises from Brazil to Portugal Cruises from Brazil to Spain Cruises from Brazil to Italy Cruises from Peru to Ecuador

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

South America Tours

All South America Tours Amazon Tours Argentina Tours Brazil Tours Chile Tours Colombia Tours Ecuador Tours Galapagos Tours Patagonia Tours Peru Tours

© 2010-2025. Global Journeys. You're viewing our site in US dollars.

    

About Us | View Your Booking | Terms & Conditions | Site Map

Global Journeys Travel Inc. is a Member of the American Society of Travel Advisors (ASTA No: 900374670), CLIA (No. 00046729) & is TICO Accredited (No. 50027921).

Travel Industry Associations