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Italy Cruises Starting In April 2026, 2027 and 2028

If you're looking at joining a cruise to Italy in April 2026, 2027 or 2028, we have 250 unique cruise itineraries and 3,630 departures available, operated by nineteen of the world's leading cruise lines departing in April.
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250 Cruises (3,630 Cruise Departures)
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Venice to Brindisi
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 27 April 2027
Visit: Italy, Montenegro
Inside
$279
Oceanview
$349
Balcony
$529
Suite
$629
From
US$279
Per Person
View Trip
6 Day A Journey From Ancient Whispers To Aegean Wonders with Explora Journeys
Cruise
 (1)

6 Days (5 Nights) Rome to Athens
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 29 April 2026
Visit: Italy, Greece
Inside
-
Oceanview
-
Balcony
-
Suite
$3,485
From
US$3,485
Per Person
View Trip
5 Day Mediterranean with MSC Cruises
Cruise
 (2)

5 Days (4 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 25 April 2026
Visit: Spain, Italy
Inside
-
Oceanview
-
Balcony
$563
Suite
$1,013
From
US$563
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (2)

4 Days (3 Nights) Marseille to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 20 April 2026
Visit: France, Italy
Inside
-
Oceanview
-
Balcony
$509
Suite
-
From
US$509
Per Person
View Trip
3 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Rome to Marseille
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 20 April 2026
Visit: Italy, France
Inside
-
Oceanview
$189
Balcony
$289
Suite
-
From
US$189
Per Person
View Trip
5 Day A Journey Through Riviera Elegance & Coastal Splendour with Explora Journeys
Cruise
 (1)

5 Days (4 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 25 April 2026
Visit: Spain, Monaco, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$2,640
From
US$2,640
Per Person
View Trip
3 Day Mediterranean with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Genoa to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 28 April 2026
Visit: Italy, Spain
Inside
$209
Oceanview
$269
Balcony
$339
Suite
$689
From
US$209
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Bari to Athens
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 04 April 2026
Visit: Italy, Greece
Inside
$341
Oceanview
$471
Balcony
$631
Suite
$751
From
US$341
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Athens to Athens
Cruise Line: MSC Cruises
Ships: MSC Orchestra, MSC Sinfonia
Departures: May 2026 to Oct 2027
Visit: Greece, Italy
Inside
$764
Oceanview
$997
Balcony
$1,288
Suite
$1,558
From
US$764
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Bari to Bari
Cruise Line: MSC Cruises
Ships: MSC Orchestra, MSC Sinfonia
Departures: Apr 2026 to Oct 2027
Visit: Italy, Greece
Inside
$606
Oceanview
$854
Balcony
$1,264
Suite
$1,461
From
US$606
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (2)

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 24 April 2026
Visit: Italy, Spain
Inside
$339
Oceanview
$429
Balcony
$519
Suite
$1,259
From
US$339
Per Person
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise
 (8)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+11 more), Viking Libra, Viking Lyra, Viking Mars, Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Apr 2026 to Sep 2028
Visit: Italy, Monaco, France, Spain
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$2,599
Suite
$3,499
From
US$2,599
Save 600
Per Person
View Trip
8 Day Italian Sojourn with Viking Cruises
Cruise
 (8)

8 Days (7 Nights) Venice to Rome
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+9 more), Viking Lyra, Viking Mars, Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Vela, Viking Vesta
Departures: Apr 2026 to Sep 2028
Visit: Italy, Croatia, Sicily
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,799
Suite
$4,999
From
US$3,799
Save 900
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Valencia to Valencia
Cruise Line: MSC Cruises
Ships: MSC Lirica, MSC Orchestra, MSC Sinfonia
Departures: Apr 2026 to Mar 2028
Visit: Spain, France, Italy
Inside
$519
Oceanview
$719
Balcony
$999
Suite
$1,279
From
US$519
Per Person
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Venice to Venice
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 27 April 2027
Visit: Italy, Montenegro, Croatia
Inside
$712
Oceanview
$842
Balcony
$1,192
Suite
$1,362
From
US$712
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Palma de Mallorca to Palma de Mallorca
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departures: Apr 2027 to Oct 2027
Visit: Spain, France, Italy
Inside
$1,256
Oceanview
$1,466
Balcony
$1,586
Suite
$2,316
From
US$1,256
Per Person
View Trip
9 Day Mediterranean with MSC Cruises
Cruise

9 Days (8 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 10 April 2027
Visit: Spain, France, Italy
Inside
$969
Oceanview
$1,149
Balcony
-
Suite
$1,749
From
US$969
Per Person
View Trip
8 Day Italian Sojourn with Viking Cruises
Cruise
 (5)

8 Days (7 Nights) Rome to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+7 more), Viking Mira, Viking Neptune, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Apr 2026 to Jul 2028
Visit: Italy, Sicily, Croatia
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,599
Suite
$4,999
From
US$3,599
Save 800
Per Person
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (2)

6 Days (5 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Apr 2026 to Apr 2026
Visit: Italy, Spain, France
Inside
$514
Oceanview
$594
Balcony
$664
Suite
$894
From
US$514
Per Person
View Trip
10 Day Greek Isles Cruise with Royal Caribbean
Cruise

10 Days (9 Nights) Rome to Rome
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 24 April 2026
Visit: Italy, Greece, Turkey
Exclusive Savings
Inside
$1,364
Oceanview
$1,541
Balcony
$1,566
Suite
$3,324
From
US$1,959
Save 50
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departures: Apr 2026 to Oct 2027
Visit: Italy, Greece, Turkey
Inside
$524
Oceanview
$694
Balcony
$834
Suite
$1,294
From
US$524
Per Person
View Trip
8 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Lanzarote to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 13 April 2026
Visit: Spain, Morocco, Italy
Inside
$612
Oceanview
-
Balcony
$1,042
Suite
-
From
US$612
Per Person
View Trip
5 Day Mediterranean with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Marseille to Marseille
Cruise Line: MSC Cruises
Ships: MSC Euribia, MSC Seaview
Departures: Apr 2026 to Oct 2026
Visit: France, Italy, Spain
Inside
$424
Oceanview
$544
Balcony
$614
Suite
$1,164
From
US$424
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Marseille to Marseille
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departures: Apr 2026 to Oct 2026
Visit: France, Spain, Italy
Inside
$676
Oceanview
$796
Balcony
$1,006
Suite
$1,766
From
US$676
Per Person
View Trip
7 Day Nice to Valletta with Silversea
Cruise

7 Days (6 Nights) Nice to Valletta
Cruise Line: Silversea
Ship: Silver Shadow
Departures: Apr 2026 to Aug 2026
Visit: France, Italy, Malta
All-Inclusive Plus Fare
All-Inclusive Fare
Last Minute Fare
Exclusive Savings
Inside
-
Oceanview
$3,300
Balcony
$3,450
Suite
$9,900
From
US$3,300
Save 2,500
Per Person
View Trip
3 Day Mediterranean with MSC Cruises
Cruise
 (2)

3 Days (2 Nights) Barcelona to Genoa
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 11 April 2026
Visit: Spain, France, Italy
Inside
$149
Oceanview
$209
Balcony
$279
Suite
$559
From
US$149
Per Person
View Trip
5 Day Mediterranean with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Barcelona to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Euribia
Departures: Oct 2026 to Apr 2028
Visit: Spain, France, Italy
Inside
$527
Oceanview
$653
Balcony
$718
Suite
$1,165
From
US$527
Per Person
View Trip
9 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santa Cruz De Tenerife to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 12 April 2026
Visit: Spain, Morocco, Italy
Inside
-
Oceanview
$632
Balcony
$1,029
Suite
-
From
US$632
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Marseille to Marseille
Cruise Line: MSC Cruises
Ships: MSC Lirica, MSC Orchestra, MSC Sinfonia
Departures: Apr 2026 to Mar 2028
Visit: France, Italy, Spain
Inside
$562
Oceanview
$762
Balcony
$1,010
Suite
$1,322
From
US$562
Per Person
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (2)

6 Days (5 Nights) Marseille to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 22 April 2026
Visit: France, Italy, Spain
Inside
$612
Oceanview
$692
Balcony
$762
Suite
$1,162
From
US$612
Per Person
View Trip
Results: 1-30 of 250

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