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Cruises from Rome to Istanbul

Are you looking for a cruise from Rome to Istanbul? September is the most popular month to cruise between Rome and Istanbul and there are 39 departures available from seven of the world's leading cruise lines.
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24 Cruises (39 Departures)
24 Cruises (39 Departures)
Departures
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Duration
8 Days
22 Days
Regions
Ship Size
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Price
$1,800pp
$30,344pp
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10 Day Trojan Trek Revisited with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Sirena
Departure: 19 July 2027
Visits: Italy, Sicily, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$4,025
Oceanview
$4,374
Balcony
$6,644
Suite
$9,263
From (Per Person)
A$4,025
Save 2,085
Per Person
View Trip
8 Day Ancient Sites & Cities with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Sirena
Departure: 05 November 2026
Visits: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$1,857
Balcony
$2,716
Suite
$3,538
From (Per Person)
A$1,857
Save 3,563
Per Person
View Trip
15 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 14 September 2026
Visits: Italy, France, Greece, Turkey
Exclusive Savings
Inside
$4,112
Oceanview
$4,657
Balcony
$5,251
Suite
$10,795
From (Per Person)
A$4,112
Per Person
View Trip
10 Day Mysteries Of History with Oceania Cruises
Cruise
 (3)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Sirena
Departure: 24 May 2027
Visits: Italy, Sicily, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$3,311
Oceanview
$3,658
Balcony
$5,298
Suite
$7,524
From (Per Person)
A$3,311
Save 2,659
Per Person
View Trip
11 Day Eastbound Adventure with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Marina
Departure: 18 October 2027
Visits: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$4,393
Oceanview
$6,061
Balcony
$6,818
Suite
$9,311
From (Per Person)
A$4,393
Save 2,097
Per Person
View Trip
15 Day Mediterranean And Greece with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2027
Visits: Italy, France, Corsica, Spain, Sicily, Greece, Turkey
Exclusive Savings
Inside
$3,350
Oceanview
$3,677
Balcony
$4,231
Suite
$7,993
From (Per Person)
A$3,350
Per Person
View Trip
11 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 16 September 2026
Visits: Italy, Sicily, Greece, Turkey
Just Cruise Fare
Exclusive Savings
Inside
$4,012
Oceanview
$4,175
Balcony
$4,950
Suite
$6,140
From (Per Person)
A$4,012
Per Person
View Trip
10 Day Exploring Ancient Empires with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Sirena
Departure: 29 March 2027
Visits: Italy, Sicily, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$3,273
Balcony
$4,367
Suite
$6,726
From (Per Person)
A$3,273
Save 2,897
Per Person
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 02 July 2027
Visits: Italy, Sicily, Malta, Greece, Turkey
Just Cruise Fare
Exclusive Savings
Inside
$4,251
Oceanview
$4,727
Balcony
$5,620
Suite
$6,737
From (Per Person)
A$4,251
Per Person
View Trip
8 Day Greece And Turkiye with Cunard
Cruise
 (13)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 26 May 2028
Visits: Italy, Sicily, Greece, Turkey
Exclusive Savings
Inside
$2,625
Oceanview
$2,823
Balcony
$3,070
Suite
$6,733
From (Per Person)
A$2,625
Per Person
View Trip
8 Day Istanbul, Greek Isles And Italy with Cunard
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 21 September 2026
Visits: Italy, Greece, Turkey
Exclusive Savings
Inside
$1,981
Oceanview
$2,130
Balcony
$2,526
Suite
-
From (Per Person)
A$1,981
Per Person
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 22 July 2026
Visits: Italy, Sicily, Malta, Greece, Turkey
Just Cruise Fare
Exclusive Savings
Inside
$2,910
Oceanview
$3,536
Balcony
$3,983
Suite
$4,653
From (Per Person)
A$2,910
Per Person
View Trip
12 Day Ancient Empires with Oceania Cruises
Cruise
 (3)

12 Days (11 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Marina
Departure: 11 August 2028
Visits: Italy, Sardinia, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$5,017
Oceanview
$6,579
Balcony
$7,927
Suite
$10,973
From (Per Person)
A$5,017
Save 2,143
Per Person
View Trip
22 Day Italy, Croatia & Greece Combination Cruise: Florence, Dubrovnik & Crete with Azamara Cruises
Cruise
 (8)

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Azamara
Ship: Azamara Onward
Departure: 06 August 2028
Visits: Italy, Sicily, Montenegro, Slovenia, Croatia, Greece, Turkey
Azamara Always Included
Exclusive Savings
Inside
$10,132
Oceanview
$10,946
Balcony
$13,455
Suite
$18,962
From (Per Person)
A$10,132
Per Person
View Trip
15 Day Ancient Mediterranean Antiquities with Viking Cruises
Cruise

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Viking
Ships: Viking Mira, Viking Neptune +2 more, Viking Vela, Viking Vesta
Departures: Dec 2026 to Feb 2028
Visits: Italy, Sicily, Greece, Turkey
Exclusive Savings
Balcony
$7,394
Suite
$11,804
From (Per Person)
A$7,394
Save 1,467
Per Person
View Trip
22 Day Exploring Italy, Malta, Greece & Evening At Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departures: Apr 2028 to Aug 2028
Visits: Italy, Sicily, Malta, Montenegro, Croatia, Greece, Turkey
Exclusive Savings
Balcony
$19,889
Suite
$32,854
From (Per Person)
A$19,889
Save 449
Per Person
View Trip
11 Day Hellenic Islands & Turkey with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Allura
Departure: 15 October 2028
Visits: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Balcony
$5,835
Suite
$9,628
From (Per Person)
A$5,835
Save 2,165
Per Person
View Trip
11 Day Ancient Civilizations with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Allura
Departure: 09 February 2028
Visits: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Balcony
$4,853
Suite
$8,616
From (Per Person)
A$4,853
Save 2,107
Per Person
View Trip
13 Day Artifacts & Antiquities with Oceania Cruises
Cruise

13 Days (12 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Allura
Departure: 14 September 2026
Visits: Italy, Sardinia, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Balcony
$11,579
Suite
$14,421
From (Per Person)
A$11,579
Save 2,311
Per Person
View Trip
22 Day Mediterranean Mosaic: Dalmatian Gems, Malta & Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 02 October 2027
Visits: Italy, Sicily, Malta, Montenegro +4 more, Croatia, Slovenia, Greece, Turkey
Exclusive Savings
Balcony
$29,037
Suite
$37,596
From (Per Person)
A$29,037
Save 563
Per Person
View Trip
8 Day A Journey Through Italy's Timeless Wonders to Istanbul's Vibrant Soul with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Explora Journeys
Ship: Explora V
Departure: 04 December 2027
Visits: Italy, Sicily, Greece, Turkey
Exclusive Savings
Suite
$6,840
From (Per Person)
A$6,840
Save 140
Per Person
View Trip
22 Day Adriatic & Mediterranean Sojourn with Viking Cruises
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Viking
Ships: Viking Jupiter, Viking Mars +3 more, Viking Neptune, Viking Sky, Viking Vesta
Departures: Mar 2027 to Jul 2028
Visits: Italy, Sicily, Croatia, Montenegro, Greece, Turkey
Exclusive Savings
Balcony
$16,900
Suite
$26,308
From (Per Person)
A$16,900
Save 1,707
Per Person
View Trip
11 Day Carthage To Constantinople with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Allura
Departure: 15 November 2028
Visits: Italy, Sicily, Tunisia, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Balcony
$5,564
Suite
$9,221
From (Per Person)
A$5,564
Save 2,156
Per Person
View Trip
22 Day Mediterranean Mosaic: Croatia, Greece & Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 08 May 2027
Visits: Italy, Sicily, Malta, Croatia, Montenegro, Greece, Turkey
Exclusive Savings
Balcony
$29,766
Suite
-
From (Per Person)
A$29,766
Save 578
Per Person
View Trip
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