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Cruises from Rome to Istanbul

Are you looking for a cruise from Rome to Istanbul? September is the most popular month to cruise between Rome and Istanbul and there are 45 departures available from seven of the world's leading cruise lines.
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32 Days
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20 Cruises (45 Cruise Departures)
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: May 2026 to Aug 2027
Visit: Italy, Sicily, Malta, Greece, Turkey
Exclusive Savings
Inside
$2,341
Oceanview
-
Balcony
$3,457
Suite
$5,203
From
US$2,341
Save 163
Per Person
View Trip
32 Day The Best of the Mediterranean with Princess
Cruise
 (1)

32 Days (31 Nights) Rome to Istanbul
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 25 September 2027
Visit: Italy, Corsica, Sardinia, Malta (+6 more), Montenegro, Croatia, Greece, Cyprus, Turkey, Sicily
Princess Standard
Exclusive Savings
Inside
$6,514
Oceanview
$9,206
Balcony
$8,700
Suite
$11,399
From
US$6,514
Save 100
Per Person
View Trip
15 Day Ancient Mediterranean Antiquities with Viking Cruises
Cruise
 (5)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mira (+5 more), Viking Neptune, Viking Saturn, Viking Star, Viking Vela, Viking Vesta
Departures: Apr 2026 to Feb 2028
Visit: Italy, Sicily, Greece, Turkey
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$5,148
Suite
$7,998
From
US$5,148
Save 1,300
Per Person
View Trip
10 Day Exploring Ancient Empires with Oceania Cruises
Cruise
 (3)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 29 March 2027
Visit: Italy, Sicily, Greece, Turkey
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$2,399
Oceanview
$2,594
Balcony
$4,098
Suite
$5,941
From
US$2,399
Save 2,399
Per Person
View Trip
10 Day Mysteries Of History with Oceania Cruises
Cruise
 (3)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 24 May 2027
Visit: Italy, Sicily, Greece, Turkey
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$2,643
Oceanview
$2,885
Balcony
$4,389
Suite
$6,232
From
US$2,643
Save 2,755
Per Person
View Trip
32 Day The Best of the Mediterranean with Princess
Cruise
 (1)

32 Days (31 Nights) Rome to Istanbul
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 14 August 2027
Visit: Italy, Corsica, Malta, Sicily (+5 more), Montenegro, Croatia, Greece, Cyprus, Turkey
Princess Standard
Exclusive Savings
Inside
$6,213
Oceanview
$7,317
Balcony
$6,905
Suite
$9,442
From
US$6,213
Per Person
View Trip
22 Day Adriatic & Mediterranean Sojourn with Viking Cruises
Cruise
 (2)

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+5 more), Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Vesta
Departures: Mar 2026 to Jul 2028
Visit: Italy, Sicily, Croatia, Montenegro, Greece, Turkey
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,997
Suite
$16,997
From
US$11,997
Save 2,849
Per Person
View Trip
32 Day The Best of the Mediterranean with Princess
Cruise
 (1)

32 Days (31 Nights) Rome to Istanbul
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 01 May 2027
Visit: Italy, Corsica, Sardinia, Malta (+6 more), Montenegro, Croatia, Greece, Cyprus, Turkey, Sicily
Princess Standard
Exclusive Savings
Inside
$6,740
Oceanview
$7,913
Balcony
$8,169
Suite
$9,557
From
US$6,740
Save 104
Per Person
View Trip
8 Day Istanbul, Greek Isles And Italy with Cunard
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 21 September 2026
Visit: Italy, Greece, Turkey
Inside
$899
Oceanview
$1,009
Balcony
$1,159
Suite
$3,459
From
US$899
Per Person
View Trip
15 Day Mediterranean And Greece with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2027
Visit: Italy, France, Corsica, Spain, Sicily, Greece, Turkey
Inside
$1,979
Oceanview
$2,219
Balcony
$2,459
Suite
$5,797
From
US$1,979
Per Person
View Trip
10 Day Trojan Trek Revisited with Oceania Cruises
Cruise
 (3)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 19 July 2027
Visit: Italy, Sicily, Greece, Turkey
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$2,837
Oceanview
$3,080
Balcony
$4,680
Suite
$6,523
From
US$2,837
Save 2,961
Per Person
View Trip
11 Day Eastbound Adventure with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 18 October 2027
Visit: Italy, Sicily, Malta, Greece, Turkey
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$3,031
Oceanview
$3,855
Balcony
$4,583
Suite
$6,523
From
US$3,031
Save 3,167
Per Person
View Trip
8 Day Ancient Sites & Cities with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 November 2026
Visit: Italy, Sicily, Malta, Greece, Turkey
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$1,890
Oceanview
$2,070
Balcony
$2,987
Suite
$4,122
From
US$1,890
Save 2,308
Per Person
View Trip
11 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 16 September 2026
Visit: Italy, Sicily, Greece, Turkey
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$5,737
From
US$5,737
Save 162
Per Person
View Trip
15 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 14 September 2026
Visit: Italy, France, Greece, Turkey
Inside
$1,619
Oceanview
$1,809
Balcony
$2,159
Suite
$6,045
From
US$1,619
Per Person
View Trip
22 Day Mediterranean Mosaic: Dalmatian Gems, Malta & Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 02 October 2027
Visit: Italy, Sicily, Malta, Montenegro (+4 more), Croatia, Slovenia, Greece, Turkey
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,033
Suite
$22,695
From
US$13,033
Save 226
Per Person
View Trip
22 Day Mediterranean Mosaic: Croatia, Greece & Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 08 May 2027
Visit: Italy, Sicily, Malta, Croatia, Montenegro, Greece, Turkey
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,032
Suite
-
From
US$15,032
Save 267
Per Person
View Trip
11 Day Ancient Civilizations with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 09 February 2028
Visit: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,129
Suite
$5,554
From
US$3,129
Save 3,269
Per Person
View Trip
10 Day Spellbinding Mediterranean with Regent Seven Seas
Cruise

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 31 October 2027
Visit: Italy, Croatia, Greece, Turkey
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,681
Suite
$7,563
From
US$6,681
Save 11,917
Per Person
View Trip
13 Day Artifacts & Antiquities with Oceania Cruises
Cruise

13 Days (12 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 14 September 2026
Visit: Italy, Sardinia, Sicily, Malta, Greece, Turkey
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,404
Suite
-
From
US$7,404
Save 7,794
Per Person
View Trip
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