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Cruises from Rome to Istanbul

Are you looking for a cruise from Rome to Istanbul? September is the most popular month to cruise between Rome and Istanbul and there are 41 departures available from seven of the world's leading cruise lines.
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23 Cruises (41 Departures)
23 Cruises (41 Departures)
Departures
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Duration
8 Days
22 Days
Regions
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Price
$1,400pp
$37,098pp
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10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 02 July 2027
Visits: Italy, Sicily, Malta, Greece, Turkey
Just Cruise Fare
Exclusive Savings
Inside
$4,355
Oceanview
$4,653
Balcony
$5,620
Suite
$7,183
From (Per Person)
A$4,355
Per Person
View Trip
22 Day Italy, Croatia & Greece Combination Cruise: Florence, Dubrovnik & Crete with Azamara Cruises
Cruise
 (8)

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Azamara
Ship: Azamara Onward
Departure: 06 August 2028
Visits: Italy, Sicily, Montenegro, Slovenia, Croatia, Greece, Turkey
Azamara Always Included
Exclusive Savings
Inside
$9,629
Oceanview
$10,401
Balcony
$12,785
Suite
$18,017
From (Per Person)
A$9,629
Save 650
Per Person
View Trip
12 Day Ancient Empires with Oceania Cruises
Cruise
 (3)

12 Days (11 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Marina
Departure: 11 August 2028
Visits: Italy, Sardinia, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$5,017
Oceanview
$6,579
Balcony
$7,927
Suite
$10,973
From (Per Person)
A$5,017
Save 2,143
Per Person
View Trip
8 Day Ancient Sites & Cities with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Sirena
Departure: 05 November 2026
Visits: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$2,279
Balcony
$2,961
Suite
$3,804
From (Per Person)
A$2,279
Save 3,931
Per Person
View Trip
11 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 16 September 2026
Visits: Italy, Sicily, Greece, Turkey
Just Cruise Fare
Exclusive Savings
Inside
$3,535
Oceanview
$3,833
Balcony
$4,726
Suite
$5,842
From (Per Person)
A$3,535
Per Person
View Trip
8 Day Greece And Turkiye with Cunard
Cruise
 (13)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 26 May 2028
Visits: Italy, Sicily, Greece, Turkey
Exclusive Savings
Inside
$2,625
Oceanview
$2,823
Balcony
$3,070
Suite
$6,733
From (Per Person)
A$2,625
Per Person
View Trip
15 Day Mediterranean And Greece with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2027
Visits: Italy, France, Corsica, Spain, Sicily, Greece, Turkey
Exclusive Savings
Inside
$3,350
Oceanview
$3,677
Balcony
$4,231
Suite
-
From (Per Person)
A$3,350
Per Person
View Trip
15 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 14 September 2026
Visits: Italy, France, Greece, Turkey
Exclusive Savings
Inside
$2,835
Oceanview
$3,073
Balcony
$3,716
Suite
-
From (Per Person)
A$2,835
Per Person
View Trip
10 Day Trojan Trek Revisited with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Sirena
Departure: 19 July 2027
Visits: Italy, Sicily, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$3,773
Oceanview
$4,044
Balcony
$5,984
Suite
$8,341
From (Per Person)
A$3,773
Save 2,077
Per Person
View Trip
10 Day Exploring Ancient Empires with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Sirena
Departure: 29 March 2027
Visits: Italy, Sicily, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$3,583
Balcony
$4,414
Suite
$6,796
From (Per Person)
A$3,583
Save 2,987
Per Person
View Trip
10 Day Mysteries Of History with Oceania Cruises
Cruise
 (3)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Sirena
Departure: 24 May 2027
Visits: Italy, Sicily, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$3,311
Oceanview
$3,658
Balcony
$5,298
Suite
$7,524
From (Per Person)
A$3,311
Save 2,659
Per Person
View Trip
11 Day Eastbound Adventure with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Marina
Departure: 18 October 2027
Visits: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$4,393
Oceanview
$6,061
Balcony
$6,818
Suite
$9,311
From (Per Person)
A$4,393
Save 2,097
Per Person
View Trip
8 Day Istanbul, Greek Isles And Italy with Cunard
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 21 September 2026
Visits: Italy, Greece, Turkey
Exclusive Savings
Inside
$1,486
Oceanview
$1,684
Balcony
$1,981
Suite
-
From (Per Person)
A$1,486
Per Person
View Trip
22 Day Mediterranean Mosaic: Dalmatian Gems, Malta & Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 02 October 2027
Visits: Italy, Sicily, Malta, Montenegro +4 more, Croatia, Slovenia, Greece, Turkey
Exclusive Savings
Balcony
$34,052
Suite
-
From (Per Person)
A$34,052
Save 666
Per Person
View Trip
11 Day Ancient Civilizations with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Allura
Departure: 09 February 2028
Visits: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Balcony
$4,853
Suite
$8,616
From (Per Person)
A$4,853
Save 2,107
Per Person
View Trip
22 Day Adriatic & Mediterranean Sojourn with Viking Cruises
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Viking
Ships: Viking Jupiter, Viking Mars +3 more, Viking Neptune, Viking Sky, Viking Vesta
Departures: Mar 2027 to Jul 2028
Visits: Italy, Sicily, Croatia, Montenegro, Greece, Turkey
Exclusive Savings
Balcony
$16,900
Suite
$26,308
From (Per Person)
A$16,900
Save 1,707
Per Person
View Trip
22 Day Exploring Italy, Malta, Greece & Evening At Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departures: Apr 2028 to Aug 2028
Visits: Italy, Sicily, Malta, Montenegro, Croatia, Greece, Turkey
Exclusive Savings
Balcony
$22,093
Suite
$40,223
From (Per Person)
A$22,093
Save 503
Per Person
View Trip
15 Day Ancient Mediterranean Antiquities with Viking Cruises
Cruise

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Viking
Ships: Viking Astrea, Viking Libra +4 more, Viking Mira, Viking Neptune, Viking Vela, Viking Vesta
Departures: Dec 2026 to Jan 2029
Visits: Italy, Sicily, Greece, Turkey
Exclusive Savings
Balcony
$6,904
Suite
$11,804
From (Per Person)
A$6,904
Save 1,499
Per Person
View Trip
8 Day A Journey Through Italy's Timeless Wonders to Istanbul's Vibrant Soul with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Explora Journeys
Ship: Explora V
Departure: 04 December 2027
Visits: Italy, Sicily, Greece, Turkey
Exclusive Savings
Suite
$6,840
From (Per Person)
A$6,840
Save 140
Per Person
View Trip
22 Day Mediterranean Mosaic: Croatia, Greece & Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 08 May 2027
Visits: Italy, Sicily, Malta, Croatia, Montenegro, Greece, Turkey
Exclusive Savings
Balcony
$36,385
Suite
-
From (Per Person)
A$36,385
Save 713
Per Person
View Trip
11 Day Hellenic Islands & Turkey with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Allura
Departure: 15 October 2028
Visits: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Balcony
$5,835
Suite
$9,628
From (Per Person)
A$5,835
Save 2,165
Per Person
View Trip
13 Day Artifacts & Antiquities with Oceania Cruises
Cruise

13 Days (12 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Allura
Departure: 14 September 2026
Visits: Italy, Sardinia, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Balcony
$11,646
Suite
$14,683
From (Per Person)
A$11,646
Save 2,314
Per Person
View Trip
11 Day Carthage To Constantinople with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania
Ship: Oceania Allura
Departure: 15 November 2028
Visits: Italy, Sicily, Tunisia, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Balcony
$5,564
Suite
$9,221
From (Per Person)
A$5,564
Save 2,156
Per Person
View Trip
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