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Cruises from Rome to Istanbul

Are you looking for a cruise from Rome to Istanbul? October is the most popular month to cruise between Rome and Istanbul and there are 38 departures available from seven of the world's leading cruise lines.
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32 Days
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19 Cruises (38 Cruise Departures)
8 Day Istanbul, Greek Isles And Italy with Cunard
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 21 September 2026
Visit: Italy, Greece, Turkey
Inside
$1,539
Oceanview
$1,649
Balcony
$2,099
Suite
$3,589
From
US$1,539
Per Person
View Trip
32 Day The Best of the Mediterranean with Princess
Cruise
 (1)

32 Days (31 Nights) Rome to Istanbul
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 14 August 2027
Visit: Italy, Corsica, Malta, Sicily (+5 more), Montenegro, Croatia, Greece, Cyprus, Turkey
Princess Standard
Exclusive Savings
Inside
$5,143
Oceanview
$7,002
Balcony
$6,467
Suite
$7,862
From
US$5,143
Per Person
View Trip
10 Day Spellbinding Mediterranean with Regent Seven Seas
Cruise

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 31 October 2027
Visit: Italy, Croatia, Greece, Turkey
Upgrade Your Horizon
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,877
Suite
$7,759
From
US$6,877
Save 12,121
Per Person
View Trip
22 Day Adriatic & Mediterranean Sojourn with Viking Cruises
Cruise
 (1)

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+4 more), Viking Neptune, Viking Sea, Viking Sky, Viking Vesta
Departures: Jul 2026 to Jul 2028
Visit: Italy, Sicily, Croatia, Montenegro, Greece, Turkey
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,397
Suite
$17,497
From
US$12,397
Save 1,150
Per Person
View Trip
32 Day The Best of the Mediterranean with Princess
Cruise
 (1)

32 Days (31 Nights) Rome to Istanbul
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 01 May 2027
Visit: Italy, Corsica, Sardinia, Malta (+6 more), Montenegro, Croatia, Greece, Cyprus, Turkey, Sicily
Princess Standard
Exclusive Savings
Inside
$5,576
Oceanview
$7,190
Balcony
$6,649
Suite
$7,869
From
US$5,576
Per Person
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: Jul 2027 to Aug 2027
Visit: Italy, Sicily, Malta, Greece, Turkey
Exclusive Savings
Inside
$2,296
Oceanview
$2,791
Balcony
$3,392
Suite
$4,061
From
US$2,296
Save 65
Per Person
View Trip
15 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 14 September 2026
Visit: Italy, France, Greece, Turkey
Inside
$2,959
Oceanview
$3,189
Balcony
$3,629
Suite
$5,995
From
US$2,959
Per Person
View Trip
22 Day Mediterranean Mosaic: Croatia, Greece & Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 08 May 2027
Visit: Italy, Sicily, Malta, Croatia, Montenegro, Greece, Turkey
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$18,114
Suite
-
From
US$18,114
Save 330
Per Person
View Trip
10 Day Trojan Trek Revisited with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 19 July 2027
Visit: Italy, Sicily, Greece, Turkey
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$2,837
Oceanview
$3,080
Balcony
$4,680
Suite
$6,523
From
US$2,837
Save 2,961
Per Person
View Trip
10 Day Exploring Ancient Empires with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 29 March 2027
Visit: Italy, Sicily, Greece, Turkey
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,399
Oceanview
$2,594
Balcony
$4,098
Suite
$5,941
From
US$2,399
Save 2,399
Per Person
View Trip
15 Day Ancient Mediterranean Antiquities with Viking Cruises
Cruise
 (6)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Viking Cruises
Ships: Viking Mira, Viking Neptune (+4 more), Viking Saturn, Viking Star, Viking Vela, Viking Vesta
Departures: Oct 2026 to Feb 2028
Visit: Italy, Sicily, Greece, Turkey
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$5,198
Suite
$7,198
From
US$5,198
Save 1,700
Per Person
View Trip
10 Day Mysteries Of History with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 24 May 2027
Visit: Italy, Sicily, Greece, Turkey
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,643
Oceanview
$2,885
Balcony
$4,389
Suite
$6,232
From
US$2,643
Save 2,755
Per Person
View Trip
8 Day Ancient Sites & Cities with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 November 2026
Visit: Italy, Sicily, Malta, Greece, Turkey
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$1,827
Oceanview
$1,955
Balcony
$2,822
Suite
$3,894
From
US$1,827
Save 2,471
Per Person
View Trip
11 Day Eastbound Adventure with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 18 October 2027
Visit: Italy, Sicily, Malta, Greece, Turkey
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,031
Oceanview
$3,855
Balcony
$4,583
Suite
$6,523
From
US$3,031
Save 3,167
Per Person
View Trip
15 Day Mediterranean And Greece with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2027
Visit: Italy, France, Corsica, Spain, Sicily, Greece, Turkey
Inside
$1,979
Oceanview
$2,219
Balcony
$2,459
Suite
$5,797
From
US$1,979
Per Person
View Trip
32 Day The Best of the Mediterranean with Princess
Cruise
 (1)

32 Days (31 Nights) Rome to Istanbul
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 25 September 2027
Visit: Italy, Corsica, Sardinia, Malta (+6 more), Montenegro, Croatia, Greece, Cyprus, Turkey, Sicily
Princess Standard
Exclusive Savings
Inside
$6,291
Oceanview
$9,669
Balcony
$9,053
Suite
$11,417
From
US$6,291
Save 98
Per Person
View Trip
22 Day Mediterranean Mosaic: Dalmatian Gems, Malta & Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 02 October 2027
Visit: Italy, Sicily, Malta, Montenegro (+4 more), Croatia, Slovenia, Greece, Turkey
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,615
Suite
$24,028
From
US$15,615
Save 279
Per Person
View Trip
13 Day Artifacts & Antiquities with Oceania Cruises
Cruise

13 Days (12 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 14 September 2026
Visit: Italy, Sardinia, Sicily, Malta, Greece, Turkey
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,064
Suite
-
From
US$7,064
Save 7,434
Per Person
View Trip
11 Day Ancient Civilizations with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 09 February 2028
Visit: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,129
Suite
$5,554
From
US$3,129
Save 3,269
Per Person
View Trip
Results: 19 results

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