Home > Cruises > Europe Cruises > Mediterranean Cruises > Cruises from Rome to Istanbul

Cruises from Rome to Istanbul

Are you looking for a cruise from Rome to Istanbul? September is the most popular month to cruise between Rome and Istanbul and there are 40 departures available from seven of the world's leading cruise lines.
Filter Results
Departures
Show More...
Duration
8 Days
22 Days
Regions
Ship Size
Ship Features
Operators
Show More...
Price
$1,900pp
$29,239pp
Countries
Show More...
Filter Results
24 Cruises (40 Cruise Departures)
15 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 14 September 2026
Visit: Italy, France, Greece, Turkey
Exclusive Savings
Inside
$4,112
Oceanview
$4,657
Balcony
$5,251
Suite
$10,795
From
A$4,112
Per Person
View Trip
10 Day Exploring Ancient Empires with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 29 March 2027
Visit: Italy, Sicily, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$2,691
Oceanview
$2,970
Balcony
$4,685
Suite
$6,796
From
A$2,691
Save 2,729
Per Person
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: Jul 2027 to Aug 2027
Visit: Italy, Sicily, Malta, Greece, Turkey
Just Cruise Fare
Exclusive Savings
Inside
$3,744
Oceanview
$4,503
Balcony
$5,025
Suite
$6,618
From
A$3,744
Per Person
View Trip
12 Day Ancient Empires with Oceania Cruises
Cruise
 (3)

12 Days (11 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 11 August 2028
Visit: Italy, Sardinia, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$5,017
Oceanview
$6,579
Balcony
$7,927
Suite
$10,973
From
A$5,017
Save 2,143
Per Person
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 22 July 2026
Visit: Italy, Sicily, Malta, Greece, Turkey
Just Cruise Fare
Exclusive Savings
Inside
$2,910
Oceanview
$3,312
Balcony
$4,101
Suite
$5,174
From
A$2,910
Per Person
View Trip
11 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 16 September 2026
Visit: Italy, Sicily, Greece, Turkey
Just Cruise Fare
Exclusive Savings
Inside
$4,354
Oceanview
$4,652
Balcony
$4,950
Suite
$6,826
From
A$4,354
Per Person
View Trip
11 Day Eastbound Adventure with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 18 October 2027
Visit: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$4,296
Oceanview
$5,576
Balcony
$6,391
Suite
$9,097
From
A$4,296
Save 2,094
Per Person
View Trip
22 Day Adriatic & Mediterranean Sojourn with Viking Cruises
Cruise
 (1)

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+3 more), Viking Neptune, Viking Sky, Viking Vesta
Departures: Mar 2027 to Jul 2028
Visit: Italy, Sicily, Croatia, Montenegro, Greece, Turkey
Viking Savings Event
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,900
Suite
$26,308
From
A$16,900
Save 1,707
Per Person
View Trip
10 Day Mysteries Of History with Oceania Cruises
Cruise
 (3)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 24 May 2027
Visit: Italy, Sicily, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$3,118
Oceanview
$3,444
Balcony
$4,988
Suite
$7,084
From
A$3,118
Save 2,852
Per Person
View Trip
15 Day Mediterranean And Greece with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2027
Visit: Italy, France, Corsica, Spain, Sicily, Greece, Turkey
Exclusive Savings
Inside
$3,964
Oceanview
$4,459
Balcony
$5,152
Suite
$9,706
From
A$3,964
Per Person
View Trip
8 Day Istanbul, Greek Isles And Italy with Cunard
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 21 September 2026
Visit: Italy, Greece, Turkey
Exclusive Savings
Inside
$1,981
Oceanview
$2,130
Balcony
$2,526
Suite
$5,991
From
A$1,981
Per Person
View Trip
8 Day Ancient Sites & Cities with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 November 2026
Visit: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$2,307
Oceanview
$2,354
Balcony
$3,447
Suite
$4,493
From
A$2,307
Save 3,043
Per Person
View Trip
22 Day Italy, Croatia & Greece Combination Cruise: Florence, Dubrovnik & Crete with Azamara Cruises
Cruise
 (8)

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 06 August 2028
Visit: Italy, Sicily, Montenegro, Slovenia, Croatia, Greece, Turkey
Azamara Always Included
Exclusive Savings
Inside
$10,132
Oceanview
$10,946
Balcony
$13,455
Suite
$18,962
From
A$10,132
Per Person
View Trip
15 Day Ancient Mediterranean Antiquities with Viking Cruises
Cruise
 (1)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Viking Cruises
Ships: Viking Mira, Viking Neptune (+2 more), Viking Vela, Viking Vesta
Departures: Dec 2026 to Feb 2028
Visit: Italy, Sicily, Greece, Turkey
Viking Savings Event
Bonus Shipboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,904
Suite
$11,804
From
A$6,904
Save 1,467
Per Person
View Trip
8 Day Greece And Turkiye with Cunard
Cruise
 (13)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 26 May 2028
Visit: Italy, Sicily, Greece, Turkey
Exclusive Savings
Inside
$2,625
Oceanview
$2,823
Balcony
$3,070
Suite
$6,733
From
A$2,625
Per Person
View Trip
10 Day Trojan Trek Revisited with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 19 July 2027
Visit: Italy, Sicily, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$4,025
Oceanview
$4,374
Balcony
$6,644
Suite
$9,263
From
A$4,025
Save 2,085
Per Person
View Trip
13 Day Artifacts & Antiquities with Oceania Cruises
Cruise

13 Days (12 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 14 September 2026
Visit: Italy, Sardinia, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,579
Suite
$14,421
From
A$11,579
Save 2,311
Per Person
View Trip
22 Day Exploring Italy, Malta, Greece & Evening At Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departures: Apr 2028 to Aug 2028
Visit: Italy, Sicily, Malta, Montenegro, Croatia, Greece, Turkey
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$18,918
Suite
$32,413
From
A$18,918
Save 429
Per Person
View Trip
8 Day A Journey Through Italy's Timeless Wonders to Istanbul's Vibrant Soul with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Explora Journeys
Ship: Explora V
Departure: 04 December 2027
Visit: Italy, Sicily, Greece, Turkey
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$6,840
From
A$6,840
Save 140
Per Person
View Trip
11 Day Carthage To Constantinople with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 15 November 2028
Visit: Italy, Sicily, Tunisia, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,564
Suite
$9,221
From
A$5,564
Save 2,156
Per Person
View Trip
22 Day Mediterranean Mosaic: Dalmatian Gems, Malta & Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 02 October 2027
Visit: Italy, Sicily, Malta, Montenegro (+4 more), Croatia, Slovenia, Greece, Turkey
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$27,883
Suite
$35,930
From
A$27,883
Save 540
Per Person
View Trip
11 Day Hellenic Islands & Turkey with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 15 October 2028
Visit: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,835
Suite
$9,628
From
A$5,835
Save 2,165
Per Person
View Trip
11 Day Ancient Civilizations with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 09 February 2028
Visit: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,853
Suite
$8,616
From
A$4,853
Save 2,107
Per Person
View Trip
22 Day Mediterranean Mosaic: Croatia, Greece & Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 08 May 2027
Visit: Italy, Sicily, Malta, Croatia, Montenegro, Greece, Turkey
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$28,683
Suite
-
From
A$28,683
Save 556
Per Person
View Trip
Results: 24 results

No trips found. Try adjusting the search filters.




Cruises found! Scroll up to view.

Europe Cruises

All Europe Cruises Adriatic Cruises Aegean Cruises Baltic Cruises Croatia Cruises Med Cruises Greek Islands Cruises UK Cruises Western Europe Cruises

Travel Styles

Festivals & Events Luxury Cruises Short Cruise Breaks

Countries

Albania Corsica Croatia Cyprus Egypt England France Gibraltar Italy Malta Mexico Monaco Montenegro Morocco Portugal Sardinia Sicily Slovenia Spain Tunisia Turkey USA

Cities

Cruises from Rome

Routes

Cruises from Rome to Istanbul Cruises from Venice to Istanbul

Country Routes

Cruises from Italy to Turkey

Cruise Lines Exploring The Med

APT Med Cruises Azamara Med Cruises Celebrity Med Cruises Cunard Med Cruises Emerald Med Cruises G Adventures Med Cruises Intrepid Med Cruises MSC Med Cruises NCL Med Cruises Oceania Med Cruises P&O (UK) Med Cruises Ponant Med Cruises Princess Med Cruises Regent Seven Seas Med Cruises Royal Caribbean Med Cruises Scenic Med Cruises Silversea Med Cruises Viking Med Cruises Virgin Voyages Med Cruises

© 2010-2026. Global Journeys. You're viewing our site in Australian dollars.

    

Global Journeys | Terms & Conditions

Global Journeys Pty Ltd. Accredited Member of The Australian Travel Industry Association (ATIA). No. A11351.

Travel Industry Associations