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Cruises from Rome to Istanbul

Are you looking for a cruise from Rome to Istanbul? August is the most popular month to cruise between Rome and Istanbul and there are 45 departures available from eight of the world's leading cruise lines.
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24 Cruises (45 Departures)
24 Cruises (45 Departures)
Departures
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Duration
8 Days
22 Days
Regions
Ship Size
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Price
$1,400pp
$37,998pp
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10 Day Exploring Ancient Empires with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Operator: Oceania
Ship: Oceania Sirena
Departure: 29 March 2027
Visits: Italy, Sicily, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$3,583
Balcony
$4,414
Suite
$6,796
From (Per Person)
A$3,583
Save 2,987
Per Person
View Trip
11 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Rome to Istanbul
Operator: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 16 September 2026
Visits: Italy, Sicily, Greece, Turkey
Just Cruise Fare
Exclusive Savings
Inside
$2,836
Oceanview
$3,238
Balcony
$4,131
Suite
$4,950
From (Per Person)
A$2,836
Per Person
View Trip
8 Day Greece And Turkiye with Cunard
Cruise
 (13)

8 Days (7 Nights) Rome to Istanbul
Operator: Cunard
Ship: Queen Elizabeth
Departure: 26 May 2028
Visits: Italy, Sicily, Greece, Turkey
Exclusive Savings
Inside
$2,625
Oceanview
$2,823
Balcony
$3,070
Suite
$6,733
From (Per Person)
A$2,625
Per Person
View Trip
15 Day Mediterranean And Greece with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Istanbul
Operator: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2027
Visits: Italy, France, Corsica, Spain, Sicily, Greece, Turkey
Exclusive Savings
Inside
$3,350
Oceanview
$3,677
Balcony
$4,231
Suite
-
From (Per Person)
A$3,350
Per Person
View Trip
10 Day Mysteries Of History with Oceania Cruises
Cruise
 (3)

10 Days (9 Nights) Rome to Istanbul
Operator: Oceania
Ship: Oceania Sirena
Departure: 24 May 2027
Visits: Italy, Sicily, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$4,004
Oceanview
$4,473
Balcony
$6,337
Suite
$9,025
From (Per Person)
A$4,004
Save 2,806
Per Person
View Trip
12 Day Ancient Empires with Oceania Cruises
Cruise
 (3)

12 Days (11 Nights) Rome to Istanbul
Operator: Oceania
Ship: Oceania Marina
Departure: 11 August 2028
Visits: Italy, Sardinia, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$5,017
Oceanview
$6,579
Balcony
$7,927
Suite
$10,973
From (Per Person)
A$5,017
Save 2,143
Per Person
View Trip
22 Day Italy, Croatia & Greece Combination Cruise: Florence, Dubrovnik & Crete with Azamara Cruises
Cruise
 (8)

22 Days (21 Nights) Rome to Istanbul
Operator: Azamara
Ship: Azamara Onward
Departure: 06 August 2028
Visits: Italy, Sicily, Montenegro, Slovenia, Croatia, Greece, Turkey
Azamara Always Included
Exclusive Savings
Inside
$10,820
Oceanview
$11,696
Balcony
$14,414
Suite
$20,354
From (Per Person)
A$10,820
Save 739
Per Person
View Trip
15 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Istanbul
Operator: Cunard
Ship: Queen Victoria
Departure: 14 September 2026
Visits: Italy, France, Greece, Turkey
Exclusive Savings
Inside
$2,835
Oceanview
$3,073
Balcony
$3,964
Suite
-
From (Per Person)
A$2,835
Per Person
View Trip
22 Day Around Italy's Boot: Greek Isles & Venice Overnight with Holland America
Cruise
 (3)

22 Days (21 Nights) Rome to Istanbul
Operator: Holland America
Ship: Rotterdam
Departure: 11 November 2028
Visits: Italy, Sicily, Montenegro, Croatia, Greece, Turkey
Fare Saver
Exclusive Savings
Inside
$4,384
Oceanview
$5,572
Balcony
$6,236
Suite
$7,948
From (Per Person)
A$4,384
Per Person
View Trip
11 Day Eastbound Adventure with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Istanbul
Operator: Oceania
Ship: Oceania Marina
Departure: 18 October 2027
Visits: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$4,393
Oceanview
$6,061
Balcony
$6,818
Suite
$9,311
From (Per Person)
A$4,393
Save 2,097
Per Person
View Trip
10 Day Trojan Trek Revisited with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Operator: Oceania
Ship: Oceania Sirena
Departure: 19 July 2027
Visits: Italy, Sicily, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$3,753
Oceanview
$4,034
Balcony
$5,965
Suite
$7,895
From (Per Person)
A$3,753
Save 2,077
Per Person
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Operator: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: Jul 2027 to Oct 2028
Visits: Italy, Sicily, Malta, Greece, Turkey
Just Cruise Fare
Exclusive Savings
Inside
$3,653
Oceanview
$4,397
Balcony
$5,216
Suite
$6,557
From (Per Person)
A$3,653
Per Person
View Trip
8 Day Istanbul, Greek Isles And Italy with Cunard
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Operator: Cunard
Ship: Queen Victoria
Departure: 21 September 2026
Visits: Italy, Greece, Turkey
Exclusive Savings
Inside
$1,486
Oceanview
$1,684
Balcony
-
Suite
-
From (Per Person)
A$1,486
Per Person
View Trip
8 Day Ancient Sites & Cities with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Operator: Oceania
Ship: Oceania Sirena
Departure: 05 November 2026
Visits: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$2,305
Balcony
-
Suite
$4,012
From (Per Person)
A$2,305
Save 3,955
Per Person
View Trip
9 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

9 Days (8 Nights) Rome to Istanbul
Operator: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 28 August 2027
Visits: Italy, Sicily, Greece, Turkey
Just Cruise Fare
Exclusive Savings
Inside
$3,329
Oceanview
$4,103
Balcony
$4,445
Suite
$5,740
From (Per Person)
A$3,329
Per Person
View Trip
8 Day A Journey Through Italy's Timeless Wonders to Istanbul's Vibrant Soul with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Istanbul
Operator: Explora Journeys
Ship: Explora V
Departure: 04 December 2027
Visits: Italy, Sicily, Greece, Turkey
Exclusive Savings
Suite
$6,385
From (Per Person)
A$6,385
Save 130
Per Person
View Trip
22 Day Exploring Italy, Malta, Greece & Evening At Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Operator: Seabourn
Ship: Seabourn Ovation
Departures: Apr 2028 to Aug 2028
Visits: Italy, Sicily, Malta, Montenegro, Croatia, Greece, Turkey
Exclusive Savings
Balcony
$22,877
Suite
$46,495
From (Per Person)
A$22,877
Save 509
Per Person
View Trip
11 Day Carthage To Constantinople with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Operator: Oceania
Ship: Oceania Allura
Departure: 15 November 2028
Visits: Italy, Sicily, Tunisia, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Balcony
$5,564
Suite
$9,221
From (Per Person)
A$5,564
Save 2,156
Per Person
View Trip
22 Day Mediterranean Mosaic: Croatia, Greece & Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Operator: Seabourn
Ship: Seabourn Ovation
Departure: 08 May 2027
Visits: Italy, Sicily, Malta, Croatia, Montenegro, Greece, Turkey
Exclusive Savings
Balcony
$37,267
Suite
-
From (Per Person)
A$37,267
Save 731
Per Person
View Trip
11 Day Hellenic Islands & Turkey with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Operator: Oceania
Ship: Oceania Allura
Departure: 15 October 2028
Visits: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Balcony
$5,835
Suite
$9,628
From (Per Person)
A$5,835
Save 2,165
Per Person
View Trip
22 Day Adriatic & Mediterranean Sojourn with Viking Cruises
Cruise

22 Days (21 Nights) Rome to Istanbul
Operator: Viking
Ships: Viking Jupiter, Viking Mars +3 more, Viking Neptune, Viking Sky, Viking Vesta
Departures: Mar 2027 to Jul 2028
Visits: Italy, Sicily, Croatia, Montenegro, Greece, Turkey
Exclusive Savings
Balcony
$19,595
Suite
$29,003
From (Per Person)
A$19,595
Save 512
Per Person
View Trip
11 Day Ancient Civilizations with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Operator: Oceania
Ship: Oceania Allura
Departure: 09 February 2028
Visits: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Balcony
$4,853
Suite
$8,616
From (Per Person)
A$4,853
Save 2,107
Per Person
View Trip
15 Day Ancient Mediterranean Antiquities with Viking Cruises
Cruise

15 Days (14 Nights) Rome to Istanbul
Operator: Viking
Ships: Viking Astrea, Viking Libra +4 more, Viking Mira, Viking Neptune, Viking Vela, Viking Vesta
Departures: Dec 2026 to Jan 2029
Visits: Italy, Sicily, Greece, Turkey
Exclusive Savings
Balcony
$9,550
Suite
$12,588
From (Per Person)
A$9,550
Save 1,447
Per Person
View Trip
22 Day Mediterranean Mosaic: Dalmatian Gems, Malta & Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Operator: Seabourn
Ship: Seabourn Ovation
Departure: 02 October 2027
Visits: Italy, Sicily, Malta, Montenegro +4 more, Croatia, Slovenia, Greece, Turkey
Exclusive Savings
Balcony
$34,366
Suite
-
From (Per Person)
A$34,366
Save 672
Per Person
View Trip
Results: 24 results

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