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Cruises from Rome to Istanbul

Are you looking for a cruise from Rome to Istanbul? September and October are the most popular months to cruise between Rome and Istanbul and there are 42 departures available from eight of the world's leading cruise lines.
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24 Cruises (42 Cruise Departures)
8 Day Istanbul, Greek Isles And Italy with Cunard
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 21 September 2026
Visit: Italy, Greece, Turkey
Bonus Onboard Credit
Value Fare
Cunard Fare
Inside
$1,539
Oceanview
$1,709
Balcony
$2,109
Suite
$7,889
From
US$1,539
Per Person
View Trip
15 Day Ancient Mediterranean Antiquities with Viking Cruises
Cruise
 (6)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Viking Cruises
Ships: Viking Mira, Viking Neptune (+4 more), Viking Saturn, Viking Star, Viking Vela, Viking Vesta
Departures: Oct 2026 to Feb 2028
Visit: Italy, Sicily, Greece, Turkey
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$5,298
Suite
$6,698
From
US$5,298
Save 2,500
Per Person
View Trip
10 Day Trojan Trek Revisited with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 19 July 2027
Visit: Italy, Sicily, Greece, Turkey
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,899
Oceanview
$3,149
Balcony
$4,799
Suite
$6,699
From
US$2,899
Save 2,899
Per Person
View Trip
11 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 16 September 2026
Visit: Italy, Sicily, Greece, Turkey
Inside
$2,829
Oceanview
$3,029
Balcony
$3,179
Suite
$4,829
From
US$2,829
Per Person
View Trip
32 Day The Best of the Mediterranean with Princess
Cruise
 (1)

32 Days (31 Nights) Rome to Istanbul
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 01 May 2027
Visit: Italy, Corsica, Sardinia, Malta (+6 more), Montenegro, Croatia, Greece, Cyprus, Turkey, Sicily
Princess Standard
Inside
$6,349
Oceanview
$8,566
Balcony
$8,074
Suite
$9,199
From
US$6,349
Per Person
View Trip
22 Day Adriatic & Mediterranean Sojourn with Viking Cruises
Cruise
 (1)

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+3 more), Viking Neptune, Viking Sky, Viking Vesta
Departures: Mar 2027 to Jul 2028
Visit: Italy, Sicily, Croatia, Montenegro, Greece, Turkey
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,597
Suite
$16,997
From
US$12,597
Save 1,300
Per Person
View Trip
8 Day Ancient Sites & Cities with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 November 2026
Visit: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$1,960
Balcony
$2,880
Suite
$3,760
From
US$1,960
Save 2,938
Per Person
View Trip
10 Day Exploring Ancient Empires with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 29 March 2027
Visit: Italy, Sicily, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$2,160
Oceanview
$2,385
Balcony
$3,780
Suite
$5,490
From
US$2,160
Save 2,638
Per Person
View Trip
11 Day Eastbound Adventure with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 18 October 2027
Visit: Italy, Sicily, Malta, Greece, Turkey
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,149
Oceanview
$3,949
Balcony
$4,699
Suite
$6,699
From
US$3,149
Save 3,149
Per Person
View Trip
15 Day Mediterranean And Greece with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2027
Visit: Italy, France, Corsica, Spain, Sicily, Greece, Turkey
Bonus Onboard Credit
Value Fare
Inside
$2,229
Oceanview
$2,439
Balcony
$2,659
Suite
$5,749
From
US$2,229
Per Person
View Trip
10 Day Mysteries Of History with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 24 May 2027
Visit: Italy, Sicily, Greece, Turkey
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,699
Oceanview
$2,949
Balcony
$4,499
Suite
$6,399
From
US$2,699
Save 2,699
Per Person
View Trip
32 Day The Best of the Mediterranean with Princess
Cruise
 (1)

32 Days (31 Nights) Rome to Istanbul
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 14 August 2027
Visit: Italy, Corsica, Malta, Sicily (+5 more), Montenegro, Croatia, Greece, Cyprus, Turkey
Princess Standard
Inside
$4,849
Oceanview
$7,106
Balcony
$6,659
Suite
$8,409
From
US$4,849
Per Person
View Trip
32 Day The Best of the Mediterranean with Princess
Cruise
 (1)

32 Days (31 Nights) Rome to Istanbul
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 25 September 2027
Visit: Italy, Corsica, Sardinia, Malta (+6 more), Montenegro, Croatia, Greece, Cyprus, Turkey, Sicily
Princess Standard
Inside
$6,429
Oceanview
$10,166
Balcony
$9,624
Suite
$12,829
From
US$6,429
Per Person
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: Jul 2027 to Aug 2027
Visit: Italy, Sicily, Malta, Greece, Turkey
Inside
$2,249
Oceanview
$2,709
Balcony
$3,169
Suite
$4,179
From
US$2,249
Per Person
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 22 July 2026
Visit: Italy, Sicily, Malta, Greece, Turkey
Inside
$1,709
Oceanview
$1,809
Balcony
$2,309
Suite
$3,359
From
US$1,709
Per Person
View Trip
15 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 14 September 2026
Visit: Italy, France, Greece, Turkey
Bonus Onboard Credit
Value Fare
Cunard Fare
Inside
$2,539
Oceanview
$2,679
Balcony
$3,189
Suite
$5,519
From
US$2,539
Per Person
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 27 May 2026
Visit: Italy, Sicily, Malta, Greece, Turkey
Inside
$1,359
Oceanview
$1,359
Balcony
$1,429
Suite
$2,209
From
US$1,359
Per Person
View Trip
22 Day Mediterranean Mosaic: Croatia, Greece & Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 08 May 2027
Visit: Italy, Sicily, Malta, Croatia, Montenegro, Greece, Turkey
Inside
-
Oceanview
-
Balcony
$20,059
Suite
-
From
US$20,059
Per Person
View Trip
8 Day A Journey Through Italy's Timeless Wonders to Istanbul's Vibrant Soul with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Explora Journeys
Ship: Explora V
Departure: 04 December 2027
Visit: Italy, Sicily, Greece, Turkey
Inside
-
Oceanview
-
Balcony
-
Suite
$4,420
From
US$4,420
Per Person
View Trip
11 Day Ancient Civilizations with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 09 February 2028
Visit: Italy, Sicily, Malta, Greece, Turkey
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,199
Suite
$5,699
From
US$3,199
Save 3,199
Per Person
View Trip
13 Day Artifacts & Antiquities with Oceania Cruises
Cruise

13 Days (12 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 14 September 2026
Visit: Italy, Sardinia, Sicily, Malta, Greece, Turkey
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,649
Suite
$10,649
From
US$6,649
Save 6,649
Per Person
View Trip
22 Day Exploring Italy, Malta, Greece & Evening At Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departures: Apr 2028 to Aug 2028
Visit: Italy, Sicily, Malta, Montenegro, Croatia, Greece, Turkey
Inside
-
Oceanview
-
Balcony
$13,409
Suite
$21,869
From
US$13,409
Per Person
View Trip
10 Day Spellbinding Mediterranean with Regent Seven Seas
Cruise

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 31 October 2027
Visit: Italy, Croatia, Greece, Turkey
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,499
Suite
$10,099
From
US$9,499
Save 9,499
Per Person
View Trip
22 Day Mediterranean Mosaic: Dalmatian Gems, Malta & Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 02 October 2027
Visit: Italy, Sicily, Malta, Montenegro (+4 more), Croatia, Slovenia, Greece, Turkey
Inside
-
Oceanview
-
Balcony
$19,124
Suite
$25,754
From
US$19,124
Per Person
View Trip
Results: 24 results

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