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Cruises from Rome to Istanbul

Are you looking for a cruise from Rome to Istanbul? September is the most popular month to cruise between Rome and Istanbul and there are 37 departures available from seven of the world's leading cruise lines.
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20 Cruises (37 Cruise Departures)
10 Day Exploring Ancient Empires with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 29 March 2027
Visit: Italy, Sicily, Greece, Turkey
Your World Inclusions
Exclusive Savings
Inside
$2,250
Oceanview
$2,520
Balcony
$3,960
Suite
$5,760
From
US$2,250
Save 2,748
Per Person
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 22 July 2026
Visit: Italy, Sicily, Malta, Greece, Turkey
Inside
$1,759
Oceanview
$1,909
Balcony
$2,439
Suite
$3,359
From
US$1,759
Per Person
View Trip
15 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 14 September 2026
Visit: Italy, France, Greece, Turkey
Inside
$2,539
Oceanview
$2,679
Balcony
$3,079
Suite
$4,599
From
US$2,539
Per Person
View Trip
8 Day Ancient Sites & Cities with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 November 2026
Visit: Italy, Sicily, Malta, Greece, Turkey
Memorial Day Sale
Your World Inclusions
Exclusive Savings
Inside
$2,000
Oceanview
$2,040
Balcony
$3,000
Suite
$3,920
From
US$2,000
Save 2,998
Per Person
View Trip
22 Day Italy, Croatia & Greece Combination Cruise: Florence, Dubrovnik & Crete with Azamara Cruises
Cruise
 (8)

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 06 August 2028
Visit: Italy, Sicily, Montenegro, Slovenia, Croatia, Greece, Turkey
Azamara Always Included
Inside
$6,749
Oceanview
$7,289
Balcony
$8,969
Suite
$12,629
From
US$6,749
Per Person
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: Jul 2027 to Aug 2027
Visit: Italy, Sicily, Malta, Greece, Turkey
Inside
$2,249
Oceanview
$2,709
Balcony
$3,169
Suite
$4,179
From
US$2,249
Per Person
View Trip
10 Day Trojan Trek Revisited with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 19 July 2027
Visit: Italy, Sicily, Greece, Turkey
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,899
Oceanview
$3,149
Balcony
$4,799
Suite
$6,699
From
US$2,899
Save 2,899
Per Person
View Trip
15 Day Ancient Mediterranean Antiquities with Viking Cruises
Cruise
 (6)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Viking Cruises
Ships: Viking Mira, Viking Neptune (+3 more), Viking Star, Viking Vela, Viking Vesta
Departures: Oct 2026 to Feb 2028
Visit: Italy, Sicily, Greece, Turkey
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$5,098
Suite
$6,698
From
US$5,098
Save 1,700
Per Person
View Trip
8 Day Greece And Turkiye with Cunard
Cruise
 (13)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 26 May 2028
Visit: Italy, Sicily, Greece, Turkey
Cunard Fare
Value Fare
Inside
$1,819
Oceanview
$1,909
Balcony
$2,359
Suite
$4,564
From
US$1,819
Per Person
View Trip
15 Day Mediterranean And Greece with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2027
Visit: Italy, France, Corsica, Spain, Sicily, Greece, Turkey
Bonus Onboard Credit
Value Fare
Inside
$2,229
Oceanview
$2,439
Balcony
$2,659
Suite
$5,749
From
US$2,229
Per Person
View Trip
22 Day Adriatic & Mediterranean Sojourn with Viking Cruises
Cruise
 (1)

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+3 more), Viking Neptune, Viking Sky, Viking Vesta
Departures: Mar 2027 to Jul 2028
Visit: Italy, Sicily, Croatia, Montenegro, Greece, Turkey
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,597
Suite
$16,997
From
US$12,597
Save 1,500
Per Person
View Trip
8 Day Istanbul, Greek Isles And Italy with Cunard
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 21 September 2026
Visit: Italy, Greece, Turkey
Inside
$1,429
Oceanview
$1,429
Balcony
$1,629
Suite
$6,229
From
US$1,429
Per Person
View Trip
11 Day Eastbound Adventure with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 18 October 2027
Visit: Italy, Sicily, Malta, Greece, Turkey
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,149
Oceanview
$4,099
Balcony
$4,699
Suite
$6,699
From
US$3,149
Save 3,149
Per Person
View Trip
10 Day Mysteries Of History with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 24 May 2027
Visit: Italy, Sicily, Greece, Turkey
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,799
Oceanview
$2,949
Balcony
$4,499
Suite
$6,399
From
US$2,799
Save 2,799
Per Person
View Trip
11 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 16 September 2026
Visit: Italy, Sicily, Greece, Turkey
Inside
$2,759
Oceanview
$2,829
Balcony
$3,029
Suite
$4,489
From
US$2,759
Per Person
View Trip
8 Day A Journey Through Italy's Timeless Wonders to Istanbul's Vibrant Soul with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Explora Journeys
Ship: Explora V
Departure: 04 December 2027
Visit: Italy, Sicily, Greece, Turkey
Inside
-
Oceanview
-
Balcony
-
Suite
$4,875
From
US$4,875
Per Person
View Trip
22 Day Mediterranean Mosaic: Dalmatian Gems, Malta & Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 02 October 2027
Visit: Italy, Sicily, Malta, Montenegro (+4 more), Croatia, Slovenia, Greece, Turkey
Inside
-
Oceanview
-
Balcony
$19,124
Suite
$26,179
From
US$19,124
Per Person
View Trip
13 Day Artifacts & Antiquities with Oceania Cruises
Cruise

13 Days (12 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 14 September 2026
Visit: Italy, Sardinia, Sicily, Malta, Greece, Turkey
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,849
Suite
$10,649
From
US$6,849
Save 6,849
Per Person
View Trip
22 Day Exploring Italy, Malta, Greece & Evening At Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departures: Apr 2028 to Aug 2028
Visit: Italy, Sicily, Malta, Montenegro, Croatia, Greece, Turkey
Inside
-
Oceanview
-
Balcony
$13,409
Suite
$22,679
From
US$13,409
Per Person
View Trip
11 Day Ancient Civilizations with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 09 February 2028
Visit: Italy, Sicily, Malta, Greece, Turkey
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,199
Suite
$5,699
From
US$3,199
Save 3,199
Per Person
View Trip
Results: 20 results

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