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Cruises from Rome to Istanbul

Are you looking for a cruise from Rome to Istanbul? October is the most popular month to cruise between Rome and Istanbul and there are 39 departures available from seven of the world's leading cruise lines.
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19 Cruises (39 Cruise Departures)
8 Day Ancient Sites & Cities with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 November 2026
Visit: Italy, Sicily, Malta, Greece, Turkey
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$1,827
Oceanview
$1,955
Balcony
$2,822
Suite
$3,894
From
US$1,827
Save 2,471
Per Person
View Trip
11 Day Eastbound Adventure with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 18 October 2027
Visit: Italy, Sicily, Malta, Greece, Turkey
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$3,031
Oceanview
$3,855
Balcony
$4,583
Suite
$6,523
From
US$3,031
Save 3,167
Per Person
View Trip
32 Day The Best of the Mediterranean with Princess
Cruise
 (1)

32 Days (31 Nights) Rome to Istanbul
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 25 September 2027
Visit: Italy, Corsica, Sardinia, Malta (+6 more), Montenegro, Croatia, Greece, Cyprus, Turkey, Sicily
Princess Standard
Exclusive Savings
Inside
$6,056
Oceanview
$8,944
Balcony
$8,374
Suite
$10,838
From
US$6,056
Save 93
Per Person
View Trip
15 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 14 September 2026
Visit: Italy, France, Greece, Turkey
Inside
$2,959
Oceanview
$3,189
Balcony
$3,629
Suite
$6,292
From
US$2,959
Per Person
View Trip
22 Day Mediterranean Mosaic: Dalmatian Gems, Malta & Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 02 October 2027
Visit: Italy, Sicily, Malta, Montenegro (+4 more), Croatia, Slovenia, Greece, Turkey
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,032
Suite
$22,695
From
US$14,032
Save 247
Per Person
View Trip
10 Day Exploring Ancient Empires with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 29 March 2027
Visit: Italy, Sicily, Greece, Turkey
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$2,399
Oceanview
$2,594
Balcony
$4,098
Suite
$5,941
From
US$2,399
Save 2,399
Per Person
View Trip
22 Day Mediterranean Mosaic: Croatia, Greece & Ephesus with Seabourn
Cruise

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 08 May 2027
Visit: Italy, Sicily, Malta, Croatia, Montenegro, Greece, Turkey
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,198
Suite
-
From
US$16,198
Save 291
Per Person
View Trip
10 Day Spellbinding Mediterranean with Regent Seven Seas
Cruise

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 31 October 2027
Visit: Italy, Croatia, Greece, Turkey
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,877
Suite
$7,759
From
US$6,877
Save 12,121
Per Person
View Trip
15 Day Ancient Mediterranean Antiquities with Viking Cruises
Cruise
 (6)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mira (+5 more), Viking Neptune, Viking Saturn, Viking Star, Viking Vela, Viking Vesta
Departures: Apr 2026 to Feb 2028
Visit: Italy, Sicily, Greece, Turkey
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$5,198
Suite
$7,198
From
US$5,198
Save 1,900
Per Person
View Trip
15 Day Mediterranean And Greece with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2027
Visit: Italy, France, Corsica, Spain, Sicily, Greece, Turkey
Inside
$1,979
Oceanview
$2,219
Balcony
$2,459
Suite
$5,797
From
US$1,979
Per Person
View Trip
11 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 16 September 2026
Visit: Italy, Sicily, Greece, Turkey
Exclusive Savings
Inside
$3,073
Oceanview
$3,732
Balcony
$4,169
Suite
$5,430
From
US$3,073
Save 86
Per Person
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: Jul 2027 to Aug 2027
Visit: Italy, Sicily, Malta, Greece, Turkey
Exclusive Savings
Inside
$2,296
Oceanview
$2,820
Balcony
$3,421
Suite
$4,061
From
US$2,296
Save 64
Per Person
View Trip
32 Day The Best of the Mediterranean with Princess
Cruise
 (1)

32 Days (31 Nights) Rome to Istanbul
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 01 May 2027
Visit: Italy, Corsica, Sardinia, Malta (+6 more), Montenegro, Croatia, Greece, Cyprus, Turkey, Sicily
Princess Standard
Exclusive Savings
Inside
$5,811
Oceanview
$7,249
Balcony
$6,751
Suite
$7,977
From
US$5,811
Save 88
Per Person
View Trip
8 Day Istanbul, Greek Isles And Italy with Cunard
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 21 September 2026
Visit: Italy, Greece, Turkey
Inside
$1,539
Oceanview
$1,649
Balcony
$2,009
Suite
$4,289
From
US$1,539
Per Person
View Trip
32 Day The Best of the Mediterranean with Princess
Cruise
 (1)

32 Days (31 Nights) Rome to Istanbul
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 14 August 2027
Visit: Italy, Corsica, Malta, Sicily (+5 more), Montenegro, Croatia, Greece, Cyprus, Turkey
Princess Standard
Exclusive Savings
Inside
$5,513
Oceanview
$6,702
Balcony
$6,243
Suite
$8,257
From
US$5,513
Per Person
View Trip
22 Day Adriatic & Mediterranean Sojourn with Viking Cruises
Cruise
 (5)

22 Days (21 Nights) Rome to Istanbul
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+4 more), Viking Neptune, Viking Sea, Viking Sky, Viking Vesta
Departures: Jul 2026 to Jul 2028
Visit: Italy, Sicily, Croatia, Montenegro, Greece, Turkey
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,297
Suite
$17,297
From
US$12,297
Save 1,300
Per Person
View Trip
10 Day Trojan Trek Revisited with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 19 July 2027
Visit: Italy, Sicily, Greece, Turkey
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$2,837
Oceanview
$3,080
Balcony
$4,680
Suite
$6,523
From
US$2,837
Save 2,961
Per Person
View Trip
10 Day Mysteries Of History with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 24 May 2027
Visit: Italy, Sicily, Greece, Turkey
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$2,643
Oceanview
$2,885
Balcony
$4,389
Suite
$6,232
From
US$2,643
Save 2,755
Per Person
View Trip
11 Day Ancient Civilizations with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 09 February 2028
Visit: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,129
Suite
$5,554
From
US$3,129
Save 3,269
Per Person
View Trip
Results: 19 results

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