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Cruises from Istanbul to Rome

Are you looking for a cruise from Istanbul to Rome? May and October are the most popular months to cruise between Istanbul and Rome and there are 45 departures available from eight of the world's leading cruise lines.
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21 Cruises (45 Cruise Departures)
15 Day Ancient Mediterranean Antiquities with Viking Cruises
Cruise
 (6)

15 Days (14 Nights) Istanbul to Rome
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+7 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Nov 2026 to Apr 2028
Visit: Turkey, Greece, Sicily, Italy
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$5,098
Suite
$6,998
From
US$5,098
Save 2,100
Per Person
View Trip
12 Day Mediterranean with Greek Isles & Italy with Princess
Cruise
 (1)

12 Days (11 Nights) Istanbul to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 26 October 2027
Visit: Turkey, Greece, Malta, Sicily, Italy
Princess Standard
Inside
$2,010
Oceanview
$2,419
Balcony
$2,205
Suite
$2,540
From
US$2,010
Per Person
View Trip
8 Day Greece And Turkey with Cunard
Cruise
 (13)

8 Days (7 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 08 October 2027
Visit: Turkey, Greece, Sicily, Italy
Bonus Onboard Credit
Inside
$1,319
Oceanview
$1,429
Balcony
$1,549
Suite
$3,229
From
US$1,319
Per Person
View Trip
15 Day Mediterranean Mosaic with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 27 August 2026
Visit: Turkey, Greece, Croatia, Montenegro, Albania, Sicily, Italy
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$4,136
Oceanview
$4,311
Balcony
$6,843
Suite
$8,938
From
US$4,136
Save 5,262
Per Person
View Trip
11 Day Iconic Greek Isles with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 09 July 2027
Visit: Turkey, Greece, Sicily, Italy
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$3,230
Oceanview
$3,667
Balcony
$5,267
Suite
$7,304
From
US$3,230
Save 3,368
Per Person
View Trip
10 Day Alluring Ancient Ruins with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 15 May 2027
Visit: Turkey, Greece, Sicily, Italy, Sardinia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,645
Oceanview
$2,887
Balcony
$4,391
Suite
$6,234
From
US$2,645
Save 2,753
Per Person
View Trip
12 Day Mediterranean with Greek Isles & Italy with Princess
Cruise
 (1)

12 Days (11 Nights) Istanbul to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departures: Jun 2027 to Sep 2027
Visit: Turkey, Greece, Malta, Sicily, Italy
Princess Standard
Inside
$1,410
Oceanview
$2,089
Balcony
$1,885
Suite
$2,140
From
US$1,410
Per Person
View Trip
8 Day Istanbul And Greek Islands with Cunard
Cruise
 (1)

8 Days (7 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 28 September 2026
Visit: Turkey, Greece, Sicily, Italy
Bonus Onboard Credit
Inside
$1,589
Oceanview
$1,669
Balcony
$2,149
Suite
-
From
US$1,589
Per Person
View Trip
11 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Istanbul to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 13 October 2027
Visit: Turkey, Greece, Sicily, Italy
Exclusive Savings
Inside
$2,435
Oceanview
$2,968
Balcony
$3,773
Suite
$4,579
From
US$2,435
Save 64
Per Person
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Istanbul to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: Sep 2026 to Aug 2027
Visit: Turkey, Greece, Malta, Sicily, Italy
Exclusive Savings
Inside
$2,299
Oceanview
$2,736
Balcony
$3,318
Suite
$4,181
From
US$2,299
Save 88
Per Person
View Trip
19 Day The Best of the Mediterranean with Princess
Cruise
 (6)

19 Days (18 Nights) Istanbul to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 04 August 2027
Visit: Turkey, Greece, Sicily, Italy, Spain, France, Corsica
Princess Standard
Sanctuary Collection
Inside
$2,405
Oceanview
$3,098
Balcony
$3,198
Suite
$3,842
From
US$2,405
Per Person
View Trip
22 Day Adriatic & Mediterranean Sojourn with Viking Cruises
Cruise
 (1)

22 Days (21 Nights) Istanbul to Rome
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+4 more), Viking Mira, Viking Neptune, Viking Sea, Viking Vesta
Departures: Jun 2026 to Aug 2028
Visit: Turkey, Greece, Montenegro, Croatia, Sicily, Italy
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,297
Suite
$17,497
From
US$12,297
Save 3,850
Per Person
View Trip
21 Day Revered & Romantic Shores with Oceania Cruises
Cruise
 (1)

21 Days (20 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 12 November 2026
Visit: Turkey, Greece, Montenegro, Croatia (+4 more), Italy, Slovenia, Malta, Sicily
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$5,585
Oceanview
$5,973
Balcony
$9,271
Suite
$12,957
From
US$5,585
Save 5,813
Per Person
View Trip
12 Day Tales Of The Ancients with Oceania Cruises
Cruise
 (1)

12 Days (11 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 16 June 2027
Visit: Turkey, Greece, Malta, Sicily, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,573
Oceanview
$3,718
Balcony
$5,707
Suite
$8,083
From
US$3,573
Save 3,725
Per Person
View Trip
15 Day Turkey, Greece & Roman Gems with Seabourn
Cruise
 (1)

15 Days (14 Nights) Istanbul to Rome
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 18 October 2026
Visit: Turkey, Greece, Albania, Italy
Explore More
Exclusive Savings
Inside
-
Oceanview
$9,110
Balcony
$12,775
Suite
$22,271
From
US$9,110
Save 154
Per Person
View Trip
8 Day Greece And Italy with Cunard
Cruise
 (13)

8 Days (7 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 21 May 2027
Visit: Turkey, Greece, Sicily, Italy
Bonus Onboard Credit
Inside
$1,389
Oceanview
$1,429
Balcony
$2,029
Suite
$3,499
From
US$1,389
Per Person
View Trip
24 Day Mediterranean Mosaic: Turkey, Greece, Croatia & Italy with Seabourn
Cruise

24 Days (23 Nights) Istanbul to Rome
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 29 May 2027
Visit: Turkey, Greece, Montenegro, Croatia (+4 more), Slovenia, Italy, Malta, Sicily
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,960
Suite
$26,540
From
US$17,960
Save 314
Per Person
View Trip
13 Day Knights & Emperors with Regent Seven Seas
Cruise

13 Days (12 Nights) Istanbul to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 28 June 2026
Visit: Turkey, Greece, Croatia, Montenegro, Malta, Sicily, Italy
Upgrade Your Horizon
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,370
Suite
$13,105
From
US$12,370
Save 18,228
Per Person
View Trip
15 Day A Mythical Sojourn with Regent Seven Seas
Cruise

15 Days (14 Nights) Istanbul to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 02 October 2026
Visit: Turkey, Greece, Egypt, Malta, Sicily, Italy
Upgrade Your Horizon
Exclusive Savings
Inside
-
Oceanview
$11,942
Balcony
$14,049
Suite
$15,078
From
US$11,942
Save 19,356
Per Person
View Trip
10 Day Medieval Mediterranean with Oceania Cruises
Cruise

10 Days (9 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 19 February 2028
Visit: Turkey, Greece, Malta, Sicily, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,374
Suite
$5,168
From
US$3,374
Save 3,524
Per Person
View Trip
33 Day Ultimate Voyage: Ancient Empires, Adriatic & Amalfi Coast with Scenic
New ReleaseCruise

33 Days (32 Nights) Istanbul to Rome
Cruise Line: Scenic
Ship: Scenic Ikon
Departure: 12 August 2028
Visit: Turkey, Greece, Montenegro, Croatia, Slovenia, Italy, Sicily
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$92,134
Suite
$107,363
From
US$92,134
Save 2,716
Per Person
View Trip
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