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Cruises from Istanbul to Rome

Are you looking for a cruise from Istanbul to Rome? May and October are the most popular months to cruise between Istanbul and Rome and there are 51 departures available from eight of the world's leading cruise lines.
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21 Cruises (51 Cruise Departures)
15 Day Ancient Mediterranean Antiquities with Viking Cruises
Cruise
 (6)

15 Days (14 Nights) Istanbul to Rome
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+7 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Nov 2026 to Apr 2028
Visit: Turkey, Greece, Sicily, Italy
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$5,198
Suite
$6,998
From
US$5,198
Save 1,950
Per Person
View Trip
11 Day Iconic Greek Isles with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 09 July 2027
Visit: Turkey, Greece, Sicily, Italy
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$3,230
Oceanview
$3,473
Balcony
$5,267
Suite
$7,304
From
US$3,230
Save 3,368
Per Person
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Istanbul to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: May 2026 to Aug 2027
Visit: Turkey, Greece, Malta, Sicily, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$4,763
From
US$4,763
Save 185
Per Person
View Trip
15 Day Turkey, Greece & Roman Gems with Seabourn
Cruise
 (1)

15 Days (14 Nights) Istanbul to Rome
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 18 October 2026
Visit: Turkey, Greece, Albania, Italy
Explore More
Exclusive Savings
Inside
-
Oceanview
$8,860
Balcony
$11,692
Suite
$22,271
From
US$8,860
Save 149
Per Person
View Trip
8 Day Greece And Turkey with Cunard
Cruise
 (13)

8 Days (7 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 08 October 2027
Visit: Turkey, Greece, Sicily, Italy
Inside
$1,319
Oceanview
$1,429
Balcony
$1,579
Suite
$3,279
From
US$1,319
Per Person
View Trip
10 Day Alluring Ancient Ruins with Oceania Cruises
Cruise
 (3)

10 Days (9 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 15 May 2027
Visit: Turkey, Greece, Sicily, Italy, Sardinia
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$2,645
Oceanview
$2,887
Balcony
$4,391
Suite
$6,234
From
US$2,645
Save 2,753
Per Person
View Trip
22 Day Adriatic & Mediterranean Sojourn with Viking Cruises
Cruise
 (8)

22 Days (21 Nights) Istanbul to Rome
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+5 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Vesta
Departures: Apr 2026 to Aug 2028
Visit: Turkey, Greece, Montenegro, Croatia, Sicily, Italy
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,697
Suite
$18,497
From
US$12,697
Save 1,400
Per Person
View Trip
24 Day Mediterranean Mosaic: Turkey, Greece, Croatia & Italy with Seabourn
Cruise

24 Days (23 Nights) Istanbul to Rome
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 29 May 2027
Visit: Turkey, Greece, Montenegro, Croatia (+4 more), Slovenia, Italy, Malta, Sicily
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,461
Suite
$24,457
From
US$15,461
Save 263
Per Person
View Trip
8 Day Greece And Italy with Cunard
Cruise
 (13)

8 Days (7 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 21 May 2027
Visit: Turkey, Greece, Sicily, Italy
Inside
$1,319
Oceanview
$1,429
Balcony
$1,629
Suite
$3,279
From
US$1,319
Per Person
View Trip
12 Day Mediterranean with Greek Isles & Italy with Princess
Cruise
 (1)

12 Days (11 Nights) Istanbul to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 26 October 2027
Visit: Turkey, Greece, Malta, Sicily, Italy
Princess Standard
Inside
$2,110
Oceanview
$2,309
Balcony
$1,998
Suite
$2,450
From
US$1,998
Per Person
View Trip
11 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Istanbul to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 13 October 2027
Visit: Turkey, Greece, Sicily, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$5,810
From
US$5,810
Save 169
Per Person
View Trip
12 Day Mediterranean with Greek Isles & Italy with Princess
Cruise
 (1)

12 Days (11 Nights) Istanbul to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departures: Jun 2027 to Sep 2027
Visit: Turkey, Greece, Malta, Sicily, Italy
Princess Standard
Inside
$1,420
Oceanview
$1,819
Balcony
$1,539
Suite
$2,220
From
US$1,420
Per Person
View Trip
12 Day Tales Of The Ancients with Oceania Cruises
Cruise
 (1)

12 Days (11 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 16 June 2027
Visit: Turkey, Greece, Malta, Sicily, Italy
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$3,427
Oceanview
$3,718
Balcony
$5,707
Suite
$8,083
From
US$3,427
Save 3,571
Per Person
View Trip
13 Day Knights & Emperors with Regent Seven Seas
Cruise

13 Days (12 Nights) Istanbul to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 28 June 2026
Visit: Turkey, Greece, Croatia, Montenegro, Malta, Sicily, Italy
Upgrade Your Horizon
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$26,873
Suite
$18,152
From
US$18,152
Save 24,246
Per Person
View Trip
33 Day Ultimate Voyage: Ancient Empires, Adriatic & Amalfi Coast with Scenic
New ReleaseCruise

33 Days (32 Nights) Istanbul to Rome
Cruise Line: Scenic
Ship: Scenic Ikon
Departure: 12 August 2028
Visit: Turkey, Greece, Montenegro, Croatia, Slovenia, Italy, Sicily
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$99,894
Suite
$107,363
From
US$99,894
Save 2,956
Per Person
View Trip
15 Day Mediterranean Mosaic with Oceania Cruises
Cruise
 (3)

15 Days (14 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 27 August 2026
Visit: Turkey, Greece, Croatia, Montenegro, Albania, Sicily, Italy
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$3,962
Oceanview
$4,311
Balcony
$6,493
Suite
$8,938
From
US$3,962
Save 5,036
Per Person
View Trip
8 Day Istanbul And Greek Islands with Cunard
Cruise
 (1)

8 Days (7 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 28 September 2026
Visit: Turkey, Greece, Sicily, Italy
Inside
$1,529
Oceanview
$1,659
Balcony
$1,919
Suite
$3,489
From
US$1,529
Per Person
View Trip
19 Day The Best of the Mediterranean with Princess
Cruise
 (6)

19 Days (18 Nights) Istanbul to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 04 August 2027
Visit: Turkey, Greece, Sicily, Italy, Spain, France, Corsica
Princess Standard
Sanctuary Collection
Inside
$2,603
Oceanview
$3,278
Balcony
$3,643
Suite
$4,064
From
US$2,603
Per Person
View Trip
10 Day Medieval Mediterranean with Oceania Cruises
Cruise

10 Days (9 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 19 February 2028
Visit: Turkey, Greece, Malta, Sicily, Italy
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,646
Suite
$5,168
From
US$2,646
Save 2,752
Per Person
View Trip
21 Day Revered & Romantic Shores with Oceania Cruises
Cruise
 (3)

21 Days (20 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 12 November 2026
Visit: Turkey, Greece, Montenegro, Croatia (+4 more), Italy, Slovenia, Malta, Sicily
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$5,585
Oceanview
$5,973
Balcony
$8,980
Suite
$12,957
From
US$5,585
Save 5,813
Per Person
View Trip
15 Day A Mythical Sojourn with Regent Seven Seas
Cruise

15 Days (14 Nights) Istanbul to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 02 October 2026
Visit: Turkey, Greece, Egypt, Malta, Sicily, Italy
Upgrade Your Horizon
Exclusive Savings
Inside
-
Oceanview
$11,354
Balcony
$29,532
Suite
$25,809
From
US$11,354
Save 18,744
Per Person
View Trip
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