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Cruises from Istanbul to Rome

Are you looking for a cruise from Istanbul to Rome? May and October are the most popular months to cruise between Istanbul and Rome and there are 52 departures available from seven of the world's leading cruise lines.
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21 Cruises (52 Cruise Departures)
12 Day Tales Of The Ancients with Oceania Cruises
Cruise
 (1)

12 Days (11 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 16 June 2027
Visit: Turkey, Greece, Malta, Sicily, Italy
Your World Inclusions
Exclusive Savings
Inside
$3,427
Oceanview
$3,718
Balcony
$5,707
Suite
$8,083
From
US$3,427
Save 3,571
Per Person
View Trip
21 Day Revered & Romantic Shores with Oceania Cruises
Cruise
 (3)

21 Days (20 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 12 November 2026
Visit: Turkey, Greece, Montenegro, Croatia (+4 more), Italy, Slovenia, Malta, Sicily
Your World Inclusions
Exclusive Savings
Inside
$5,585
Oceanview
$5,973
Balcony
$8,980
Suite
$12,666
From
US$5,585
Save 5,813
Per Person
View Trip
24 Day Mediterranean Mosaic: Turkey, Greece, Croatia & Italy with Seabourn
Cruise

24 Days (23 Nights) Istanbul to Rome
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 29 May 2027
Visit: Turkey, Greece, Montenegro, Croatia (+4 more), Slovenia, Italy, Malta, Sicily
More Moments On Us Offer
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,828
Suite
$27,686
From
US$15,828
Save 271
Per Person
View Trip
15 Day Ancient Mediterranean Antiquities with Viking Cruises
Cruise
 (6)

15 Days (14 Nights) Istanbul to Rome
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+7 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Nov 2026 to Apr 2028
Visit: Turkey, Greece, Sicily, Italy
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$5,798
Suite
$7,998
From
US$5,798
Save 1,000
Per Person
View Trip
8 Day Greece And Italy with Cunard
Cruise
 (13)

8 Days (7 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 21 May 2027
Visit: Turkey, Greece, Sicily, Italy
Inside
$1,449
Oceanview
$1,649
Balcony
$1,949
Suite
$4,399
From
US$1,449
Per Person
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Istanbul to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: May 2026 to Aug 2027
Visit: Turkey, Greece, Malta, Sicily, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$5,295
From
US$5,295
Save 165
Per Person
View Trip
12 Day Mediterranean with Greek Isles & Italy with Princess
Cruise
 (1)

12 Days (11 Nights) Istanbul to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 01 June 2027
Visit: Turkey, Greece, Malta, Sicily, Italy
Princess Standard
Inside
$1,870
Oceanview
$2,269
Balcony
$2,143
Suite
$3,463
From
US$1,870
Per Person
View Trip
10 Day Medieval Mediterranean with Oceania Cruises
Cruise

10 Days (9 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 19 February 2028
Visit: Turkey, Greece, Malta, Sicily, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,646
Suite
$5,168
From
US$2,646
Save 2,752
Per Person
View Trip
22 Day Adriatic & Mediterranean Sojourn with Viking Cruises
Cruise
 (8)

22 Days (21 Nights) Istanbul to Rome
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+6 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Vesta
Departures: Apr 2026 to Aug 2028
Visit: Turkey, Greece, Montenegro, Croatia, Sicily, Italy
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,497
Suite
$19,497
From
US$12,497
Save 200
Per Person
View Trip
15 Day Mediterranean Mosaic with Oceania Cruises
Cruise
 (3)

15 Days (14 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 27 August 2026
Visit: Turkey, Greece, Croatia, Montenegro, Albania, Sicily, Italy
Fall Upgrade Offer
Your World Inclusions
Exclusive Savings
Inside
$4,397
Oceanview
$4,591
Balcony
$5,222
Suite
$8,083
From
US$4,397
Save 102
Per Person
View Trip
10 Day Alluring Ancient Ruins with Oceania Cruises
Cruise
 (3)

10 Days (9 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 15 May 2027
Visit: Turkey, Greece, Sicily, Italy, Sardinia
Your World Inclusions
Exclusive Savings
Inside
$2,645
Oceanview
$2,887
Balcony
$4,391
Suite
$6,234
From
US$2,645
Save 2,753
Per Person
View Trip
11 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Istanbul to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 13 October 2027
Visit: Turkey, Greece, Sicily, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$5,819
From
US$5,819
Save 160
Per Person
View Trip
8 Day Greece And Turkey with Cunard
Cruise
 (13)

8 Days (7 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 08 October 2027
Visit: Turkey, Greece, Sicily, Italy
Inside
$1,579
Oceanview
$1,729
Balcony
$1,979
Suite
$4,229
From
US$1,579
Per Person
View Trip
22 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise

22 Days (21 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 11 May 2026
Visit: Turkey, Greece, Sicily, Spain, France, Italy, Corsica
Explore With More
Inside
$3,579
Oceanview
$3,189
Balcony
$3,999
Suite
$13,107
From
US$3,189
Per Person
View Trip
19 Day The Best of the Mediterranean with Princess
Cruise
 (6)

19 Days (18 Nights) Istanbul to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 04 August 2027
Visit: Turkey, Greece, Sicily, Italy, Spain, France, Corsica
Princess Premier
Princess Standard
Inside
$3,200
Oceanview
$3,819
Balcony
$4,632
Suite
$5,578
From
US$3,200
Per Person
View Trip
12 Day Mediterranean with Greek Isles & Italy with Princess
Cruise
 (1)

12 Days (11 Nights) Istanbul to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departures: Sep 2027 to Oct 2027
Visit: Turkey, Greece, Malta, Sicily, Italy
Princess Standard
Inside
$1,860
Oceanview
$2,059
Balcony
$1,939
Suite
$2,710
From
US$1,860
Per Person
View Trip
11 Day Iconic Greek Isles with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 09 July 2027
Visit: Turkey, Greece, Sicily, Italy
Your World Inclusions
Exclusive Savings
Inside
$3,230
Oceanview
$3,473
Balcony
$5,267
Suite
$7,304
From
US$3,230
Save 3,368
Per Person
View Trip
15 Day A Mythical Sojourn with Regent Seven Seas
Cruise

15 Days (14 Nights) Istanbul to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 02 October 2026
Visit: Turkey, Greece, Egypt, Malta, Sicily, Italy
Exclusive Savings
Inside
-
Oceanview
$10,815
Balcony
$12,873
Suite
$14,343
From
US$10,815
Save 18,183
Per Person
View Trip
8 Day Istanbul And Greek Islands with Cunard
Cruise

8 Days (7 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 28 September 2026
Visit: Turkey, Greece, Italy
Explore With More
Inside
$1,149
Oceanview
$1,239
Balcony
$1,469
Suite
$3,819
From
US$1,149
Per Person
View Trip
15 Day Turkey, Greece & Roman Gems with Seabourn
Cruise

15 Days (14 Nights) Istanbul to Rome
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 18 October 2026
Visit: Turkey, Greece, Albania, Italy
More Moments On Us Offer
Exclusive Savings
Inside
-
Oceanview
$9,732
Balcony
$12,966
Suite
$25,559
From
US$9,732
Save 167
Per Person
View Trip
13 Day Knights & Emperors with Regent Seven Seas
Cruise

13 Days (12 Nights) Istanbul to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 28 June 2026
Visit: Turkey, Greece, Croatia, Montenegro, Malta, Sicily, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,508
Suite
$12,125
From
US$10,508
Save 16,290
Per Person
View Trip
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