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Cruises from Istanbul to Rome

Are you looking for a cruise from Istanbul to Rome? May and October are the most popular months to cruise between Istanbul and Rome and there are 49 departures available from nine of the world's leading cruise lines.
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26 Cruises (49 Cruise Departures)
22 Day Adriatic & Mediterranean Sojourn with Viking Cruises
Cruise
 (5)

22 Days (21 Nights) Istanbul to Rome
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+4 more), Viking Mira, Viking Neptune, Viking Sky, Viking Vesta
Departures: Oct 2026 to Aug 2028
Visit: Turkey, Greece, Montenegro, Croatia, Sicily, Italy
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,297
Suite
$17,497
From
US$12,297
Save 1,550
Per Person
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Istanbul to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: Sep 2026 to Aug 2027
Visit: Turkey, Greece, Malta, Sicily, Italy
Inside
$2,589
Oceanview
$2,769
Balcony
$3,089
Suite
$4,119
From
US$2,589
Per Person
View Trip
8 Day Istanbul And Greek Islands with Cunard
Cruise
 (1)

8 Days (7 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 28 September 2026
Visit: Turkey, Greece, Sicily, Italy
Bonus Onboard Credit
Inside
$1,539
Oceanview
$1,669
Balcony
$1,879
Suite
$5,649
From
US$1,539
Per Person
View Trip
11 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Istanbul to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 13 October 2027
Visit: Turkey, Greece, Sicily, Italy
Inside
$2,559
Oceanview
$3,159
Balcony
$3,479
Suite
$4,289
From
US$2,559
Per Person
View Trip
10 Day Alluring Ancient Ruins with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 15 May 2027
Visit: Turkey, Greece, Sicily, Italy, Sardinia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,799
Oceanview
$2,949
Balcony
$4,499
Suite
$6,399
From
US$2,799
Save 2,799
Per Person
View Trip
12 Day Mediterranean with Greek Isles & Italy with Princess
Cruise
 (1)

12 Days (11 Nights) Istanbul to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 26 October 2027
Visit: Turkey, Greece, Malta, Sicily, Italy
Princess Standard
Inside
$1,885
Oceanview
$2,334
Balcony
$2,197
Suite
$2,580
From
US$1,885
Per Person
View Trip
11 Day Iconic Greek Isles with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 09 July 2027
Visit: Turkey, Greece, Sicily, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,299
Oceanview
$3,749
Balcony
$5,399
Suite
$7,499
From
US$3,299
Save 3,299
Per Person
View Trip
12 Day Mediterranean with Greek Isles & Italy with Princess
Cruise
 (1)

12 Days (11 Nights) Istanbul to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departures: Jun 2027 to Sep 2027
Visit: Turkey, Greece, Malta, Sicily, Italy
Princess Standard
Inside
$1,535
Oceanview
$2,094
Balcony
$1,965
Suite
$2,720
From
US$1,535
Per Person
View Trip
8 Day Greece And Italy with Cunard
Cruise
 (13)

8 Days (7 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 21 May 2027
Visit: Turkey, Greece, Sicily, Italy
Bonus Onboard Credit
Inside
$1,389
Oceanview
$1,429
Balcony
$2,029
Suite
-
From
US$1,389
Per Person
View Trip
19 Day The Best of the Mediterranean with Princess
Cruise
 (7)

19 Days (18 Nights) Istanbul to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 04 August 2027
Visit: Turkey, Greece, Sicily, Italy, Spain, France, Corsica
Princess Standard
Sanctuary Collection
Inside
$2,306
Oceanview
$2,936
Balcony
$3,258
Suite
$3,963
From
US$2,306
Per Person
View Trip
15 Day Ancient Mediterranean Antiquities with Viking Cruises
Cruise
 (6)

15 Days (14 Nights) Istanbul to Rome
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+7 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Nov 2026 to Apr 2028
Visit: Turkey, Greece, Sicily, Italy
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$4,998
Suite
$6,998
From
US$4,998
Save 1,900
Per Person
View Trip
12 Day Tales Of The Ancients with Oceania Cruises
Cruise
 (1)

12 Days (11 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 16 June 2027
Visit: Turkey, Greece, Malta, Sicily, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,549
Oceanview
$3,799
Balcony
$5,899
Suite
$8,299
From
US$3,549
Save 3,549
Per Person
View Trip
15 Day Mediterranean Mosaic with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 27 August 2026
Visit: Turkey, Greece, Croatia, Montenegro, Albania, Sicily, Italy
Your World Inclusions
Exclusive Savings
Inside
$3,525
Oceanview
$3,675
Balcony
$5,850
Suite
$7,650
From
US$3,525
Save 5,873
Per Person
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Istanbul to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 18 May 2026
Visit: Turkey, Greece, Malta, Sicily, Italy
Inside
$959
Oceanview
$1,157
Balcony
$1,349
Suite
$2,199
From
US$959
Per Person
View Trip
8 Day Greece And Turkey with Cunard
Cruise
 (13)

8 Days (7 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 08 October 2027
Visit: Turkey, Greece, Sicily, Italy
Bonus Onboard Credit
Inside
$1,319
Oceanview
$1,429
Balcony
$1,549
Suite
$3,229
From
US$1,319
Per Person
View Trip
15 Day Turkey, Greece & Roman Gems with Seabourn
Cruise
 (1)

15 Days (14 Nights) Istanbul to Rome
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 18 October 2026
Visit: Turkey, Greece, Albania, Italy
Yours to Explore
Inside
-
Oceanview
$10,649
Balcony
$15,999
Suite
$27,599
From
US$10,649
Per Person
View Trip
21 Day Revered & Romantic Shores with Oceania Cruises
Cruise
 (1)

21 Days (20 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 12 November 2026
Visit: Turkey, Greece, Montenegro, Croatia (+4 more), Italy, Slovenia, Malta, Sicily
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$5,699
Oceanview
$6,099
Balcony
$9,199
Suite
$12,999
From
US$5,699
Save 5,699
Per Person
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Istanbul to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 13 July 2026
Visit: Turkey, Greece, Malta, Sicily, Italy
Inside
$1,899
Oceanview
$1,969
Balcony
$2,509
Suite
$3,419
From
US$1,899
Per Person
View Trip
15 Day President's Cruise with Regent Seven Seas
Cruise

15 Days (14 Nights) Istanbul to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 02 October 2026
Visit: Turkey, Greece, Egypt, Malta, Sicily, Italy
Exclusive Savings
Inside
-
Oceanview
$15,899
Balcony
$18,499
Suite
$19,599
From
US$15,899
Save 15,899
Per Person
View Trip
29 Day Yacht Harbor Exploration: From The Aegean To Italy with Seabourn
Cruise

29 Days (28 Nights) Istanbul to Rome
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 02 September 2028
Visit: Turkey, Greece, Italy, Montenegro (+4 more), Croatia, Slovenia, Malta, Sicily
Inside
-
Oceanview
-
Balcony
$20,899
Suite
$33,499
From
US$20,899
Per Person
View Trip
22 Day Yacht Harbors Of Greece & Dalmatian Gems with Seabourn
Cruise

22 Days (21 Nights) Istanbul to Rome
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departures: May 2028 to Jul 2028
Visit: Turkey, Greece, Montenegro, Croatia, Slovenia, Italy, Malta
Inside
-
Oceanview
-
Balcony
$15,199
Suite
$25,199
From
US$15,199
Per Person
View Trip
8 Day A Journey Through Istanbul's Cosmopolitan Vibrancy to Rome's Timeless Wonders with Explora Journeys
Cruise

8 Days (7 Nights) Istanbul to Rome
Cruise Line: Explora Journeys
Ship: Explora V
Departure: 12 December 2027
Visit: Turkey, Greece, Sicily, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$4,420
From
US$4,420
Per Person
View Trip
33 Day Ultimate Voyage: Ancient Empires, Adriatic & Amalfi Coast with Scenic
New ReleaseCruise

33 Days (32 Nights) Istanbul to Rome
Cruise Line: Scenic
Ship: Scenic Ikon
Departure: 12 August 2028
Visit: Turkey, Greece, Montenegro, Croatia, Slovenia, Italy, Sicily
Inside
-
Oceanview
-
Balcony
$102,850
Suite
$110,550
From
US$102,850
Per Person
View Trip
24 Day Mediterranean Mosaic: Turkey, Greece, Croatia & Italy with Seabourn
Cruise

24 Days (23 Nights) Istanbul to Rome
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 29 May 2027
Visit: Turkey, Greece, Montenegro, Croatia (+4 more), Slovenia, Italy, Malta, Sicily
Yours to Explore
Inside
-
Oceanview
-
Balcony
$23,599
Suite
-
From
US$23,599
Per Person
View Trip
10 Day Medieval Mediterranean with Oceania Cruises
Cruise

10 Days (9 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 19 February 2028
Visit: Turkey, Greece, Malta, Sicily, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,449
Suite
$5,299
From
US$3,449
Save 3,449
Per Person
View Trip
13 Day Knights & Emperors with Regent Seven Seas
Cruise

13 Days (12 Nights) Istanbul to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 28 June 2026
Visit: Turkey, Greece, Croatia, Montenegro, Malta, Sicily, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,499
Suite
$15,899
From
US$15,499
Save 15,499
Per Person
View Trip
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