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Cruises from Istanbul to Rome

Are you looking for a cruise from Istanbul to Rome? October is the most popular month to cruise between Istanbul and Rome and there are 43 departures available from eight of the world's leading cruise lines.
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8 Days
22 Days
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$1,100pp
$27,598pp
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17 Cruises (43 Cruise Departures)
12 Day Mediterranean with Greek Isles & Italy with Princess
Cruise
 (1)

12 Days (11 Nights) Istanbul to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departures: Sep 2027 to Oct 2027
Countries Visited: Turkey, Greece, Malta, Sicily (+1 more), Italy
Bonus Instant Savings
INSIDE
$1,700
OCEANVIEW
$1,899
BALCONY
$1,759
SUITE
$2,450
From (per person) 1,700
View Trip
22 Day Adriatic & Mediterranean Sojourn with Viking Cruises
Cruise

22 Days (21 Nights) Istanbul to Rome
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+6 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Vesta
Departures: Nov 2025 to Jul 2027
Countries Visited: Turkey, Greece, Montenegro, Croatia (+2 more), Sicily, Italy
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$11,497
SUITE
$14,697
Save (per person) 2,000
From (per person) 11,497
View Trip
19 Day The Best of the Mediterranean with Princess
Cruise
 (3)

19 Days (18 Nights) Istanbul to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 04 August 2027
Countries Visited: Turkey, Greece, Sicily, Italy (+3 more), Spain, Gibraltar, France
Exclusive DealBonus Instant Savings
INSIDE
$3,430
OCEANVIEW
$4,180
BALCONY
$5,080
SUITE
$6,130
From (per person) 3,430
View Trip
21 Day Revered & Romantic Shores with Oceania Cruises
Cruise
 (3)

21 Days (20 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 12 November 2026
Countries Visited: Turkey, Greece, Montenegro, Croatia (+4 more), Italy, Slovenia, Malta, Sicily
Exclusive Deal
INSIDE
$5,699
OCEANVIEW
$6,099
BALCONY
$9,199
SUITE
$12,999
Save (per person) 5,699
From (per person) 5,699
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Istanbul to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: May 2026 to Sep 2026
Countries Visited: Turkey, Greece, Malta, Sicily (+1 more), Italy
INSIDE
$2,299
OCEANVIEW
$2,769
BALCONY
$3,519
SUITE
$4,099
From (per person) 2,299
View Trip
13 Day Greek Isles & Eastern Med with Norwegian Cruise Line
Cruise

13 Days (12 Nights) Istanbul to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sky
Departure: 02 October 2025
Countries Visited: Turkey, Greece, Malta, Sicily (+2 more), Italy, France
INSIDE
$1,696
OCEANVIEW
$1,755
BALCONY
$3,356
SUITE
$4,835
From (per person) 1,696
View Trip
8 Day Greece And Turkey with Cunard
Cruise
 (13)

8 Days (7 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 08 October 2027
Countries Visited: Turkey, Greece, Sicily, Italy
Exclusive Deal
INSIDE
$1,579
OCEANVIEW
$1,729
BALCONY
$1,979
SUITE
$4,229
From (per person) 1,579
View Trip
9 Day A Journey Through Aegean Artefacts & Mediterranean Spectacle with Explora Journeys
Cruise

9 Days (8 Nights) Istanbul to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 26 July 2025
Countries Visited: Turkey, Greece, Sicily, Italy
Best Available FareUnique Summer Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,735
SUITE
$5,990
From (per person) 5,735
View Trip
15 Day Mediterranean Mosaic with Oceania Cruises
Cruise
 (3)

15 Days (14 Nights) Istanbul to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 27 August 2026
Countries Visited: Turkey, Greece, Croatia, Montenegro (+3 more), Albania, Sicily, Italy
Exclusive Deal
INSIDE
$4,275
OCEANVIEW
$4,465
BALCONY
$5,082
SUITE
$7,885
From (per person) 4,275
View Trip
12 Day Mediterranean with Greek Isles & Italy with Princess
Cruise
 (1)

12 Days (11 Nights) Istanbul to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 01 June 2027
Countries Visited: Turkey, Greece, Malta, Sicily (+1 more), Italy
Bonus Instant Savings
INSIDE
$1,800
OCEANVIEW
$2,199
BALCONY
$2,049
SUITE
$3,200
From (per person) 1,800
View Trip
13 Day Knights & Emperors with Regent Seven Seas
Cruise

13 Days (12 Nights) Istanbul to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 28 June 2026
Countries Visited: Turkey, Greece, Croatia, Montenegro (+2 more), Italy, Malta
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$11,099
SUITE
$12,749
Save (per person) 16,499
From (per person) 11,099
View Trip
8 Day Greece And Italy with Cunard
Cruise
 (13)

8 Days (7 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 21 May 2027
Countries Visited: Turkey, Greece, Sicily, Italy
Exclusive Deal
INSIDE
$1,449
OCEANVIEW
$1,649
BALCONY
$1,899
SUITE
$4,399
From (per person) 1,449
View Trip
15 Day Ancient Mediterranean Antiquities with Viking Cruises
Cruise
 (6)

15 Days (14 Nights) Istanbul to Rome
Operated By: Viking Cruises
Ships: Viking Mira, Viking Neptune (+5 more), Viking Saturn, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Oct 2025 to Jan 2027
Countries Visited: Turkey, Greece, Sicily, Italy
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$5,148
SUITE
$7,298
Save (per person) 2,400
From (per person) 5,148
View Trip
8 Day Istanbul And Greek Islands with Cunard
Cruise

8 Days (7 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 28 September 2026
Countries Visited: Turkey, Greece, Italy
Exclusive Deal
INSIDE
$1,129
OCEANVIEW
$1,219
BALCONY
$1,449
SUITE
$4,059
From (per person) 1,129
View Trip
15 Day Turkey, Greece & Roman Gems with Seabourn
Cruise

15 Days (14 Nights) Istanbul to Rome
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 18 October 2026
Countries Visited: Turkey, Greece, Albania, Italy
A Sail To Remember
INSIDE
-
OCEANVIEW
$8,414
BALCONY
$11,049
SUITE
$21,678
From (per person) 8,414
View Trip
17 Day Jewels Of The Adriatic & Aegean with Seabourn
Cruise

17 Days (16 Nights) Istanbul to Rome
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 26 October 2025
Countries Visited: Turkey, Greece, Montenegro, Italy
A Sail To Remember
INSIDE
-
OCEANVIEW
-
BALCONY
$6,884
SUITE
$11,023
From (per person) 6,884
View Trip
22 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise

22 Days (21 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 11 May 2026
Countries Visited: Turkey, Greece, Sicily, Spain (+3 more), France, Italy, Corsica
Exclusive Deal
INSIDE
$2,889
OCEANVIEW
$3,169
BALCONY
$3,929
SUITE
$13,999
From (per person) 2,889
View Trip
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