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Central America Cruises Starting In April 2027, 2028 and 2029

Are you planning a cruise to Central America in April 2027, 2028 or 2029? Choose from 37 unique cruises and 175 departures operated by Central America's leading cruise lines. Easily compare prices, itineraries, inclusions and traveler reviews to find the Central America cruise that best matches your travel style, budget and dates.
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37 Cruises (175 Cruise Departures)
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Bellot, Le Bougainville, Le Laperouse
Departures: Dec 2026 to Apr 2028
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$6,040
Suite
$10,060
From
US$6,040
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ships: Coral Princess, Island Princess
Departures: Sep 2026 to Apr 2027
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,429
Oceanview
$1,769
Balcony
$1,859
Suite
$2,379
From
US$1,429
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 08 April 2027
Visit: USA, Colombia, Panama, Mexico
Inside
$1,514
Oceanview
$1,931
Balcony
$2,491
Suite
$10,167
From
US$1,514
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2028
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Inside
$1,757
Oceanview
$2,127
Balcony
$3,297
Suite
$15,177
From
US$1,757
Per Person
View Trip
8 Day Western Caribbean From New Orleans To New Orleans with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) New Orleans to New Orleans
Cruise Line: Norwegian Cruise Line
Ships: Norwegian Breakaway, Norwegian Getaway
Departures: Nov 2026 to Apr 2028
Visit: USA, Mexico, Honduras, Belize
Inside
$659
Oceanview
$729
Balcony
$979
Suite
$1,029
From
US$659
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (6)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Island Princess
Departures: Oct 2027 to Apr 2028
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,399
Oceanview
$1,679
Balcony
$2,259
Suite
$3,709
From
US$1,399
Per Person
View Trip
15 Day Los Angeles To Miami with Cunard
Cruise
 (13)

15 Days (14 Nights) Los Angeles to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 13 April 2028
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Value Fare
Inside
$3,119
Oceanview
$3,619
Balcony
$4,309
Suite
-
From
US$3,119
Per Person
View Trip
17 Day Panama Canal with Holland America
Cruise

17 Days (16 Nights) Fort Lauderdale to San Diego
Cruise Line: Holland America
Ship: Eurodam
Departure: 01 April 2028
Visit: USA, Colombia, Panama, Costa Rica, El Salvador, Guatemala, Mexico
Book Early & Have It All Fare Option
Inside
$2,864
Oceanview
$3,264
Balcony
$4,564
Suite
$7,164
From
US$2,864
Per Person
View Trip
20 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

20 Days (19 Nights) New York to San Francisco
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Bliss
Departure: 14 April 2028
Visit: USA, Dominican Republic, Colombia, Panama, Costa Rica, Guatemala, Mexico
Inside
$2,429
Oceanview
$3,229
Balcony
$4,129
Suite
$4,729
From
US$2,429
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Star Princess
Departure: 03 April 2027
Visit: USA, Aruba, Panama, Mexico
Princess Standard
Sanctuary Collection
Inside
$1,509
Oceanview
$2,159
Balcony
$2,909
Suite
$5,679
From
US$1,509
Per Person
View Trip
8 Day Perfect Day Cococay & West Caribbean with Royal Caribbean
Cruise

8 Days (7 Nights) Miami to Miami
Cruise Line: Royal Caribbean
Ship: Icon Of The Seas
Departures: Jun 2026 to Jul 2027
Visit: USA, Mexico, Honduras, Bahamas
Bonus Onboard Credit
Exclusive Savings
Inside
$1,222
Oceanview
$1,502
Balcony
$1,569
Suite
$2,586
From
US$1,222
Save 1,123
Per Person
View Trip
16 Day Panama Canal Westward Cruise with Celebrity Cruises
Cruise

16 Days (15 Nights) Tampa to Los Angeles
Cruise Line: Celebrity Cruises
Ship: Celebrity Summit
Departure: 18 April 2027
Visit: USA, Cayman Islands, Colombia, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$4,170
Oceanview
$4,687
Balcony
$8,488
Suite
-
From
US$4,170
Save 2,300
Per Person
View Trip
8 Day Western Caribbean Holiday Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Tampa to Tampa
Cruise Line: Royal Caribbean
Ships: Enchantment of the Seas, Radiance of the Seas
Departures: Nov 2026 to Apr 2027
Visit: USA, Mexico, Honduras, Belize
Bonus Onboard Credit
Exclusive Savings
Inside
$459
Oceanview
$597
Balcony
$735
Suite
$1,245
From
US$459
Save 489
Per Person
View Trip
23 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

23 Days (22 Nights) New York to Seattle
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Bliss
Departure: 14 April 2028
Visit: USA, Dominican Republic, Colombia, Panama (+4 more), Costa Rica, Guatemala, Mexico, Canada
Inside
$2,539
Oceanview
$3,339
Balcony
$4,239
Suite
$4,839
From
US$2,539
Per Person
View Trip
19 Day An Extended Journey of Ancient Mysteries & Pacific Coastal Wonders with Explora Journeys
Cruise

19 Days (18 Nights) Panama City to Vancouver
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visit: Panama, El Salvador, Guatemala, Mexico, USA, Canada
Inside
-
Oceanview
-
Balcony
-
Suite
$13,160
From
US$13,160
Per Person
View Trip
23 Day Panama Canal with Holland America
Cruise

23 Days (22 Nights) Fort Lauderdale to Vancouver
Cruise Line: Holland America
Ship: Eurodam
Departure: 01 April 2028
Visit: USA, Colombia, Panama, Costa Rica (+4 more), El Salvador, Guatemala, Mexico, Canada
Book Early & Have It All Fare Option
Inside
$3,409
Oceanview
$3,759
Balcony
$5,209
Suite
$7,809
From
US$3,409
Per Person
View Trip
26 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

26 Days (25 Nights) Miami to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 08 April 2027
Visit: USA, Colombia, Panama, Mexico, Canada
Inside
-
Oceanview
$2,936
Balcony
$3,986
Suite
-
From
US$2,936
Per Person
View Trip
18 Day Panama Canal with Holland America
Cruise
 (3)

18 Days (17 Nights) Fort Lauderdale to San Diego
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 11 April 2027
Visit: USA, Aruba, Panama, Costa Rica, El Salvador, Guatemala, Mexico
Fare Saver
Inside
$1,724
Oceanview
$1,984
Balcony
$3,264
Suite
$6,204
From
US$1,724
Per Person
View Trip
22 Day Panama Canal with Holland America
Cruise
 (3)

22 Days (21 Nights) Fort Lauderdale to Vancouver
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 11 April 2027
Visit: USA, Aruba, Panama, Costa Rica (+4 more), El Salvador, Guatemala, Mexico, Canada
Fare Saver
Inside
$2,049
Oceanview
$2,349
Balcony
$3,749
Suite
$6,699
From
US$2,049
Per Person
View Trip
16 Day Panama Canal Repositioning Cruise From Miami To Los Angeles with Norwegian Cruise Line
Cruise
 (1)

16 Days (15 Nights) Miami to Los Angeles
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Joy
Departures: Apr 2027 to Apr 2028
Visit: USA, Colombia, Panama, Costa Rica, Guatemala, Mexico
Inside
$1,929
Oceanview
$2,379
Balcony
$2,699
Suite
$2,949
From
US$1,929
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (1)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ships: Emerald Princess, Island Princess, Sapphire Princess
Departures: Nov 2026 to Apr 2028
Visit: USA, Aruba, Panama, Costa Rica, Mexico
Princess Standard
Inside
$1,399
Oceanview
$1,599
Balcony
$2,049
Suite
$2,839
From
US$1,399
Per Person
View Trip
12 Day A Journey Of Mayan Discovery & Mexican Exploration with Explora Journeys
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visit: Panama, El Salvador, Guatemala, Mexico, USA
Inside
-
Oceanview
-
Balcony
-
Suite
$7,280
From
US$7,280
Per Person
View Trip
23 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

23 Days (22 Nights) New York to Seattle
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Bliss
Departure: 09 April 2027
Visit: USA, Dominican Republic, Colombia, Panama (+4 more), Costa Rica, Guatemala, Mexico, Canada
Inside
$2,559
Oceanview
$2,959
Balcony
$3,859
Suite
$4,459
From
US$2,559
Per Person
View Trip
15 Day Panama Canal with Holland America
Cruise

15 Days (14 Nights) Fort Lauderdale to San Diego
Cruise Line: Holland America
Ship: Eurodam
Departure: 03 April 2027
Visit: USA, Colombia, Costa Rica, Guatemala, Mexico
Fare Saver
Inside
$1,624
Oceanview
$1,774
Balcony
$2,964
Suite
$5,644
From
US$1,624
Per Person
View Trip
27 Day Los Angeles To Southampton with Cunard
Cruise
 (13)

27 Days (26 Nights) Los Angeles to London
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 13 April 2028
Visit: USA, Mexico, Costa Rica, Panama, Aruba, Portugal, England
Value Fare
Inside
$4,879
Oceanview
$5,679
Balcony
$7,179
Suite
$16,879
From
US$4,879
Per Person
View Trip
12 Day Panama Canal From Miami To Miami with Norwegian Cruise Line
Cruise
 (1)

12 Days (11 Nights) Miami to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sun
Departure: 05 April 2027
Visit: USA, Jamaica, Colombia, Panama, Costa Rica, Belize, Mexico
Inside
$1,929
Oceanview
$2,159
Balcony
$3,459
Suite
$4,639
From
US$1,929
Per Person
View Trip
11 Day A Journey Through Enchanting Nature & The Marvels Of The Panama Canal with Explora Journeys
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 12 April 2027
Visit: USA, Jamaica, Curacao, Aruba, Colombia, Panama
Inside
-
Oceanview
-
Balcony
-
Suite
$9,135
From
US$9,135
Per Person
View Trip
12 Day Pristine islands of the Caribbean & the Panama Canal with Scenic
New ReleaseCruise

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 03 April 2027
Visit: Panama, Colombia, Curacao, Saint Vincent, Saint Lucia, Barbados
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,891
Suite
$12,118
From
US$9,891
Save 2,539
Per Person
View Trip
20 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

20 Days (19 Nights) New York to San Francisco
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Bliss
Departure: 09 April 2027
Visit: USA, Dominican Republic, Colombia, Panama, Costa Rica, Guatemala, Mexico
Inside
$2,439
Oceanview
$2,839
Balcony
$3,739
Suite
$4,339
From
US$2,439
Per Person
View Trip
22 Day An Extended Journey from Majestic Horizons to Mayan Gems with Explora Journeys
Cruise

22 Days (21 Nights) Miami to Los Angeles
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 12 April 2027
Visit: USA, Jamaica, Curacao, Aruba (+5 more), Colombia, Panama, El Salvador, Guatemala, Mexico
Inside
-
Oceanview
-
Balcony
-
Suite
$16,560
From
US$16,560
Per Person
View Trip
Results: 1-30 of 37

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