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Central America Cruises Starting In April 2026, 2027 and 2028

Are you planning a cruise to Central America in April 2026, 2027 or 2028? Choose from 49 unique cruises and 225 departures operated by Central America's leading cruise lines. Easily compare prices, itineraries, inclusions and traveler reviews to find the Central America cruise that best matches your travel style, budget and dates.
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49 Cruises (225 Cruise Departures)
20 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

20 Days (19 Nights) New York to San Francisco
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Bliss
Departure: 14 April 2028
Visit: USA, Dominican Republic, Colombia, Panama, Costa Rica, Guatemala, Mexico
Exclusive Savings
Inside
$2,375
Oceanview
$3,151
Balcony
$4,024
Suite
$4,606
From
US$2,375
Save 54
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (6)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Island Princess
Departures: Oct 2027 to Apr 2028
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,399
Oceanview
$1,599
Balcony
$2,199
Suite
$3,636
From
US$1,399
Per Person
View Trip
8 Day Western Caribbean From New Orleans To New Orleans with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) New Orleans to New Orleans
Cruise Line: Norwegian Cruise Line
Ships: Norwegian Breakaway, Norwegian Escape, Norwegian Getaway
Departures: Mar 2026 to Apr 2028
Visit: USA, Mexico, Honduras, Belize
Inside
$619
Oceanview
$669
Balcony
$769
Suite
$899
From
US$619
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2028
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$2,971
Oceanview
$3,388
Balcony
$4,349
Suite
$15,872
From
US$2,971
Save 76
Per Person
View Trip
8 Day Western Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Tampa to Tampa
Cruise Line: Royal Caribbean
Ships: Enchantment of the Seas, Grandeur of the Seas
Departures: Mar 2026 to Oct 2026
Visit: USA, Mexico, Belize, Honduras
Exclusive Savings
Inside
$562
Oceanview
$672
Balcony
$1,134
Suite
$1,201
From
US$562
Save 553
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ships: Coral Princess, Island Princess
Departures: Sep 2026 to Apr 2027
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,497
Oceanview
$1,563
Balcony
$1,657
Suite
$2,247
From
US$1,497
Per Person
View Trip
16 Day Panama Canal Westward Cruise with Celebrity Cruises
Cruise

16 Days (15 Nights) Tampa to Los Angeles
Cruise Line: Celebrity Cruises
Ship: Celebrity Summit
Departure: 18 April 2027
Visit: USA, Cayman Islands, Colombia, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$3,070
Oceanview
$3,387
Balcony
$5,789
Suite
-
From
US$3,070
Save 1,640
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 08 April 2027
Visit: USA, Colombia, Panama, Mexico
Inside
$1,817
Oceanview
$2,418
Balcony
$3,311
Suite
$9,878
From
US$1,817
Per Person
View Trip
15 Day Los Angeles To Miami with Cunard
Cruise
 (13)

15 Days (14 Nights) Los Angeles to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 13 April 2028
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Inside
$3,119
Oceanview
$3,619
Balcony
$4,309
Suite
-
From
US$3,119
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 23 April 2026
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Grand Voyages Sale
Inside
$1,511
Oceanview
$1,731
Balcony
$1,998
Suite
$8,721
From
US$1,511
Per Person
View Trip
23 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

23 Days (22 Nights) New York to Seattle
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Bliss
Departure: 14 April 2028
Visit: USA, Dominican Republic, Colombia, Panama (+4 more), Costa Rica, Guatemala, Mexico, Canada
Exclusive Savings
Inside
$2,485
Oceanview
$3,261
Balcony
$4,134
Suite
$4,716
From
US$2,485
Save 54
Per Person
View Trip
8 Day Western Caribbean Holiday Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Tampa to Tampa
Cruise Line: Royal Caribbean
Ships: Enchantment of the Seas, Grandeur of the Seas (+2 more), Radiance of the Seas, Rhapsody of the Seas
Departures: Mar 2026 to Apr 2027
Visit: USA, Mexico, Honduras, Belize
Bonus Onboard Credit
Exclusive Savings
Inside
$516
Oceanview
$573
Balcony
$784
Suite
$1,205
From
US$516
Save 586
Per Person
View Trip
21 Day Panama Canal - Ocean to Ocean with Princess
Cruise

21 Days (20 Nights) Fort Lauderdale to Seattle
Cruise Line: Princess
Ship: Star Princess
Departure: 13 April 2026
Visit: USA, Aruba, Panama, Mexico
Princess Standard
Princess Premier
Inside
$1,799
Oceanview
$2,259
Balcony
$2,299
Suite
$2,399
From
US$1,799
Per Person
View Trip
23 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

23 Days (22 Nights) Miami to Seattle
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Encore
Departure: 11 April 2026
Visit: USA, Colombia, Panama, Costa Rica, Guatemala, Mexico, Canada
Inside
$1,879
Oceanview
$1,899
Balcony
$2,149
Suite
$9,003
From
US$1,879
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Star Princess
Departure: 03 April 2027
Visit: USA, Aruba, Panama, Mexico
Princess Standard
Inside
$1,499
Oceanview
$2,199
Balcony
$3,229
Suite
$5,487
From
US$1,499
Per Person
View Trip
17 Day Panama Canal with Holland America
Cruise

17 Days (16 Nights) Fort Lauderdale to San Diego
Cruise Line: Holland America
Ship: Eurodam
Departure: 01 April 2028
Visit: USA, Colombia, Panama, Costa Rica, El Salvador, Guatemala, Mexico
Book Early & Have It All Fare Option
Inside
$2,864
Oceanview
$3,264
Balcony
$4,494
Suite
$7,042
From
US$2,864
Per Person
View Trip
8 Day Perfect Day Cococay & West Carib with Royal Caribbean
Cruise

8 Days (7 Nights) Miami to Miami
Cruise Line: Royal Caribbean
Ship: Icon Of The Seas
Departures: Mar 2026 to Jul 2027
Visit: USA, Mexico, Honduras, Bahamas
Bonus Onboard Credit
Exclusive Savings
Inside
$1,260
Oceanview
$1,360
Balcony
$1,423
Suite
$2,622
From
US$1,317
Save 1,277
Per Person
View Trip
11 Day Panama Canal Westward Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Colon to Los Angeles
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 25 April 2026
Visit: Panama, Costa Rica, Mexico, USA
Exclusive Savings
Inside
$757
Oceanview
$902
Balcony
$1,537
Suite
-
From
US$757
Save 311
Per Person
View Trip
23 Day Panama Canal with Holland America
Cruise

23 Days (22 Nights) Fort Lauderdale to Vancouver
Cruise Line: Holland America
Ship: Eurodam
Departure: 01 April 2028
Visit: USA, Colombia, Panama, Costa Rica (+4 more), El Salvador, Guatemala, Mexico, Canada
Book Early & Have It All Fare Option
Inside
$3,409
Oceanview
$3,759
Balcony
$5,132
Suite
$7,680
From
US$3,409
Per Person
View Trip
19 Day An Extended Journey of Ancient Mysteries & Pacific Coastal Wonders with Explora Journeys
Cruise

19 Days (18 Nights) Panama City to Vancouver
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visit: Panama, El Salvador, Guatemala, Mexico, USA, Canada
Inside
-
Oceanview
-
Balcony
-
Suite
$11,760
From
US$11,760
Per Person
View Trip
22 Day Panama Canal with Holland America
Cruise
 (3)

22 Days (21 Nights) Fort Lauderdale to Vancouver
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 11 April 2027
Visit: USA, Aruba, Panama, Costa Rica (+4 more), El Salvador, Guatemala, Mexico, Canada
Fare Saver
Inside
$2,534
Oceanview
$2,734
Balcony
$4,076
Suite
$6,820
From
US$2,534
Per Person
View Trip
19 Day Panama Canal Cruise From Miami To San Francisco with Norwegian Cruise Line
Cruise

19 Days (18 Nights) Miami to San Francisco
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Encore
Departure: 11 April 2026
Visit: USA, Colombia, Panama, Costa Rica, Guatemala, Mexico
Inside
$1,599
Oceanview
$1,849
Balcony
$2,179
Suite
$9,051
From
US$1,599
Per Person
View Trip
12 Day A Journey Of Mayan Discovery & Mexican Exploration with Explora Journeys
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visit: Panama, El Salvador, Guatemala, Mexico, USA
Inside
-
Oceanview
-
Balcony
-
Suite
$6,535
From
US$6,535
Per Person
View Trip
19 Day Panama Canal Cruise From Miami To Seattle with Norwegian Cruise Line
Cruise
 (1)

19 Days (18 Nights) Miami to Seattle
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Joy
Departure: 25 April 2026
Visit: USA, Colombia, Panama, Costa Rica, Guatemala, Mexico
Inside
$1,499
Oceanview
-
Balcony
$1,969
Suite
$2,348
From
US$1,499
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (7)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ships: Crown Princess, Emerald Princess (+3 more), Grand Princess, Island Princess, Sapphire Princess
Departures: Apr 2026 to Apr 2028
Visit: USA, Aruba, Panama, Costa Rica, Mexico
Princess Standard
Inside
$1,299
Oceanview
$1,599
Balcony
$2,199
Suite
$3,397
From
US$1,299
Per Person
View Trip
18 Day Panama Canal with Holland America
Cruise
 (3)

18 Days (17 Nights) Fort Lauderdale to San Diego
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 11 April 2027
Visit: USA, Aruba, Panama, Costa Rica, El Salvador, Guatemala, Mexico
Fare Saver
Inside
$2,194
Oceanview
$2,394
Balcony
$3,583
Suite
$6,307
From
US$2,194
Per Person
View Trip
16 Day Panama Canal Repositioning Cruise From Miami To Los Angeles with Norwegian Cruise Line
Cruise
 (1)

16 Days (15 Nights) Miami to Los Angeles
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Joy
Departures: Apr 2026 to Apr 2028
Visit: USA, Colombia, Panama, Costa Rica, Guatemala, Mexico
Inside
$1,349
Oceanview
$2,258
Balcony
$2,510
Suite
$2,762
From
US$1,349
Per Person
View Trip
18 Day Panama Canal Westward Cruise with Celebrity Cruises
Cruise

18 Days (17 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Celebrity Cruises
Ship: Celebrity Summit
Departure: 13 April 2026
Visit: USA, Cayman Islands, Colombia, Panama, Costa Rica, Guatemala, Mexico
Exclusive Savings
Inside
-
Oceanview
$2,728
Balcony
$5,383
Suite
-
From
US$2,775
Save 1,451
Per Person
View Trip
23 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

23 Days (22 Nights) New York to Seattle
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Bliss
Departure: 09 April 2027
Visit: USA, Dominican Republic, Colombia, Panama (+4 more), Costa Rica, Guatemala, Mexico, Canada
Exclusive Savings
Inside
$2,599
Oceanview
$3,036
Balcony
$3,860
Suite
$4,539
From
US$2,599
Save 60
Per Person
View Trip
15 Day Panama Canal with Holland America
Cruise

15 Days (14 Nights) Fort Lauderdale to San Diego
Cruise Line: Holland America
Ship: Eurodam
Departure: 03 April 2027
Visit: USA, Colombia, Costa Rica, Guatemala, Mexico
Fare Saver
Inside
$1,804
Oceanview
$2,004
Balcony
$3,144
Suite
$5,697
From
US$1,804
Per Person
View Trip
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