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South America Cruises Starting In March 2027, 2028 and 2029

Are you planning a cruise around South America in March 2027, 2028 or 2029? Choose from 96 unique expeditions and cruises with 1,156 departures operated by South America's leading cruise lines. Easily compare prices, itineraries, inclusions and traveler reviews to find the South America cruise that best matches your travel style, budget and dates.
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96 Cruises (1,156 Cruise Departures)
10 Day Complete Galapagos (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jun 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$6,994
Save 1,256
Per Person
View Trip
7 Day Galapagos Explorer: Southern Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

7 Days (6 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jun 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$3,850
Save 1,274
Per Person
View Trip
13 Day Treasures of Galapagos: Western & Central Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

13 Days (12 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jul 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$9,491
Save 1,634
Per Person
View Trip
10 Day Ultimate Galapagos: Central Islands (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jun 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$5,847
Save 1,873
Per Person
View Trip
7 Day Ocean Voyage: Ushuaia - Buenos Aires with Ponant
Cruise
 (2)

7 Days (6 Nights) Ushuaia to Buenos Aires
Cruise Line: Ponant
Ship: Le Boreal
Departure: 12 March 2028
Visit: Argentina
Inside
-
Oceanview
$1,950
Balcony
$2,080
Suite
$3,250
From
US$1,950
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Musica
Departures: Nov 2026 to Mar 2027
Visit: Brazil
Inside
$403
Oceanview
$463
Balcony
$583
Suite
$948
From
US$403
Per Person
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (3)

16 Days (15 Nights) Buenos Aires to Santiago
Cruise Line: Holland America
Ships: Nieuw Amsterdam, Oosterdam
Departures: Mar 2027 to Mar 2028
Visit: Argentina, Uruguay, Falkland Islands, Chile
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,499
Oceanview
$2,699
Balcony
$3,999
Suite
$4,999
From
US$2,499
Per Person
View Trip
18 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (3)

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 21 March 2028
Visit: Chile, Peru, Ecuador, Panama, Cayman Islands, USA
Book Early & Have It All Fare Option
Inside
$2,794
Oceanview
$3,094
Balcony
$3,794
Suite
$5,694
From
US$2,794
Per Person
View Trip
14 Day Argentina & the Chilean Fjords with Viking Cruises
Cruise
 (1)

14 Days (13 Nights) Buenos Aires to Santiago
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2027 to Mar 2029
Visit: Argentina, Chile
Flights Included
Inside
-
Oceanview
-
Balcony
$9,999
Suite
$14,999
From
US$9,999
Per Person
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Santos to Salvador
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 14 March 2027
Visit: Brazil
Inside
-
Oceanview
-
Balcony
$622
Suite
$832
From
US$622
Per Person
View Trip
13 Day Bossa Nova Reverie with Oceania Cruises
Cruise
 (1)

13 Days (12 Nights) Buenos Aires to Rio de Janeiro
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 07 March 2027
Visit: Argentina, Uruguay, Brazil
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,899
Oceanview
$4,299
Balcony
$6,449
Suite
$8,349
From
US$3,899
Save 3,899
Per Person
View Trip
2 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

2 Days (1 Nights) Santos to Rio de Janeiro
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Virtuosa
Departures: Mar 2027 to Apr 2027
Visit: Brazil
Inside
$99
Oceanview
$139
Balcony
$189
Suite
$379
From
US$99
Per Person
View Trip
33 Day Panama Canal, Inca & South America: Chilean Fjords with Holland America
Cruise
 (3)

33 Days (32 Nights) Buenos Aires to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 06 March 2028
Visit: Argentina, Uruguay, Falkland Islands, Chile (+5 more), Peru, Ecuador, Panama, Cayman Islands, USA
Book Early & Have It All Fare Option
Inside
$5,129
Oceanview
$5,659
Balcony
$7,559
Suite
$10,689
From
US$5,129
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Mar 2027
Visit: Brazil
Inside
$525
Oceanview
$595
Balcony
$715
Suite
-
From
US$525
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 15 March 2027
Visit: Brazil
Inside
$525
Oceanview
$595
Balcony
$715
Suite
-
From
US$525
Per Person
View Trip
18 Day Fjords & Glaciers of Southern Chile & Patagonia with Scenic
New ReleaseCruise

18 Days (17 Nights) Buenos Aires to Buenos Aires
Cruise Line: Scenic
Ships: Scenic Eclipse I, Scenic Ikon
Departures: Feb 2027 to Feb 2029
Visit: Argentina, Chile, Uruguay
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,780
Suite
$28,669
From
US$22,562
Save 2,845
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departures: Dec 2026 to Mar 2027
Visit: Brazil
Inside
$981
Oceanview
$1,027
Balcony
$1,165
Suite
$1,579
From
US$981
Per Person
View Trip
10 Day Classic Galapagos: Central Eastern Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jul 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$6,036
Save 2,041
Per Person
View Trip
8 Day Galápagos - West & Central Islands aboard the Eden with G Adventures
Cruise

8 Days (7 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jul 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$3,519
Save 880
Per Person
View Trip
17 Day Complete Galápagos - Eden with G Adventures
Cruise

17 Days (16 Nights) Quito to Quito
Operated By: G Adventures
Departures: Sep 2026 to Dec 2027
Visit: Ecuador, Galapagos
From
US$10,449
Per Person
View Trip
13 Day Peru Splendors with Galapagos Cruise with Globus
Tour + Cruise

13 Days Lima to Guayaquil
Operated By: Globus
Departures: Aug 2026 to Nov 2026
Visit: Peru, Ecuador, Galapagos
From
US$7,376
Per Person
View Trip
10 Day Galápagos - East, Central, & West Islands aboard the Eden with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jul 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$4,623
Save 1,156
Per Person
View Trip
15 Day Peru & the Galapagos Islands with Tauck
Tour + Cruise

15 Days Lima to Guayaquil
Operated By: Tauck
Departures: Mar 2027 to Oct 2027
Visit: Peru, Ecuador, Galapagos
From
US$14,790
Per Person
View Trip
8 Day Galápagos – Central and East Islands aboard the Reina Silvia Voyager (Cruise Only) with G Adventures
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Operated By: G Adventures
Departures: Jun 2026 to Dec 2027
Visit: Galapagos
Exclusive Savings
From
US$5,759
Save 1,490
Per Person
View Trip
29 Day Best of South America with Amazon & Galápagos Cruises with APT
Tour + Cruise

29 Days Rio de Janeiro to Guayaquil
Operated By: APT
Ship: Delfin III
Departures: Feb 2028 to Sep 2028
Visit: Brazil, Argentina, Chile, Peru, Ecuador, Galapagos
Inside
-
Oceanview
-
Balcony
-
Suite
$32,195
From
US$32,195
Per Person
View Trip
12 Day Rhythms of the Brazilian Coastline with Scenic
New ReleaseCruise

12 Days (11 Nights) Buenos Aires to Rio de Janeiro
Cruise Line: Scenic
Ships: Scenic Eclipse I
Departures: Mar 2027 to Mar 2028
Visit: Argentina, Uruguay, Brazil
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,520
Suite
$11,624
From
US$9,520
Save 3,160
Per Person
View Trip
7 Day Galápagos - North & Central Islands aboard the Eden with G Adventures
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jul 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$3,239
Save 810
Per Person
View Trip
8 Day San Cristóbal to San Cristóbal with Silversea
Cruise

8 Days (7 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departures: May 2026 to Mar 2028
Visit: Ecuador, Galapagos
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,600
Suite
$17,400
From
US$11,600
Save 2,500
Per Person
View Trip
8 Day Pure Galapagos (Grand Daphne) with Intrepid Travel
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Operated By: Intrepid Travel
Departures: Jun 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$5,131
Save 1,738
Per Person
View Trip
17 Day Peru Splendors with Peru's Amazon & Galapagos Cruise with Globus
Tour + Cruise

17 Days Lima to Guayaquil
Operated By: Globus
Departures: Aug 2026 to Nov 2026
Visit: Peru, Ecuador, Galapagos
From
US$8,635
Per Person
View Trip
Results: 1-30 of 96

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Cruise Lines Exploring South & Central America

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