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South America Cruises Starting In March 2027, 2028 and 2029

Are you planning a cruise around South America in March 2027, 2028 or 2029? Choose from 102 unique expeditions and cruises with 1,107 departures operated by South America's leading cruise lines. Easily compare prices, itineraries, inclusions and traveller reviews to find the South America cruise that best matches your travel style, budget and dates.
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102 Cruises (1,107 Departures)
102 Cruises (1,107 Departures)
Departures
Duration
2 Days
63 Days
Sub Regions
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Price
$200pp
$133,895pp
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10 Day Galápagos – West & Central Islands aboard the Reina Silvia Voyager with G Adventures
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operator: G Adventures
Departures: Oct 2026 to Dec 2028
Visits: Ecuador, Galapagos
Exclusive Savings
From (Per Person)
A$11,563
Save 266
Per Person
View Trip
33 Day Panama Canal, Inca & South America: Chilean Fjords with Holland America
Cruise
 (3)

33 Days (32 Nights) Buenos Aires to Fort Lauderdale
Operator: Holland America
Ship: Nieuw Amsterdam
Departure: 06 March 2028
Visits: Argentina, Uruguay, Falkland Islands, Chile +5 more, Peru, Ecuador, Panama, Cayman Islands, USA
Book Early & Have It All Fare Option
Exclusive Savings
Inside
$7,476
Oceanview
$8,218
Balcony
$10,842
Suite
$15,049
From (Per Person)
A$7,476
Per Person
View Trip
9 Day Chile & Peru Cruise: Arica, Pisco & Lima with Azamara Cruises
Cruise
 (6)

9 Days (8 Nights) Santiago to Lima
Operator: Azamara
Ship: Azamara Journey
Departure: 10 March 2027
Visits: Chile, Peru
Azamara Always Included
Exclusive Savings
Inside
$3,354
Oceanview
$3,364
Balcony
$4,070
Suite
-
From (Per Person)
A$3,354
Save 55
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Operator: MSC Cruises
Ships: MSC Divina, MSC Musica
Departures: Feb 2027 to Mar 2027
Visits: Brazil
Exclusive Savings
Inside
$852
Oceanview
$951
Balcony
$1,168
Suite
$1,653
From (Per Person)
A$852
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Operator: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Mar 2027
Visits: Brazil
Exclusive Savings
Inside
$1,280
Oceanview
$1,449
Balcony
$1,815
Suite
$2,560
From (Per Person)
A$1,280
Per Person
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Santos to Salvador
Operator: MSC Cruises
Ship: MSC Divina
Departure: 14 March 2027
Visits: Brazil
Exclusive Savings
Inside
-
Oceanview
$1,033
Balcony
$1,182
Suite
$1,489
From (Per Person)
A$1,033
Per Person
View Trip
6 Day South America with MSC Cruises
Cruise
 (1)

6 Days (5 Nights) Rio de Janeiro to Itajai
Operator: MSC Cruises
Ship: MSC Musica
Departure: 09 March 2027
Visits: Brazil
Exclusive Savings
Inside
-
Oceanview
$839
Balcony
$1,176
Suite
$2,919
From (Per Person)
A$839
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Paranagua to Paranagua
Operator: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Mar 2027
Visits: Brazil
Exclusive Savings
Inside
$1,280
Oceanview
$1,449
Balcony
$1,815
Suite
$2,164
From (Per Person)
A$1,280
Per Person
View Trip
18 Day South Georgia & Falklands - From Punta Arenas to Montevideo  with HX Expeditions
Cruise
 (1)

18 Days (17 Nights) Santiago to Montevideo
Operator: HX Expeditions
Ship: MS Fram
Departure: 12 March 2027
Visits: Chile, Argentina, Falkland Islands, South Georgia Island, Uruguay
Exclusive Savings
Inside
-
Oceanview
$16,051
Suite
$20,290
From (Per Person)
A$16,051
Save 325
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Sao Paulo to Sao Paulo
Operator: MSC Cruises
Ships: MSC Divina, MSC Musica +2 more, MSC Seaview, MSC Virtuosa
Departures: Nov 2026 to Mar 2027
Visits: Brazil
Exclusive Savings
Inside
$716
Oceanview
$735
Balcony
$854
Suite
$1,211
From (Per Person)
A$716
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Operator: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Mar 2027
Visits: Brazil
Exclusive Savings
Inside
$852
Oceanview
$951
Balcony
$1,119
Suite
$1,836
From (Per Person)
A$852
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Itajai to Santos
Operator: MSC Cruises
Ship: MSC Musica
Departure: 07 March 2027
Visits: Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,100
Suite
-
From (Per Person)
A$2,100
Per Person
View Trip
7 Day Ocean Voyage: Ushuaia - Buenos Aires with Ponant
Cruise
 (2)

7 Days (6 Nights) Ushuaia to Buenos Aires
Operator: Ponant
Ships: Le Boreal, Le Lyrial
Departures: Mar 2028 to Mar 2029
Visits: Argentina
Exclusive Savings
Oceanview
$2,731
Balcony
$2,906
Suite
$4,322
From (Per Person)
A$2,731
Save 62
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Rio de Janeiro to Paranagua
Operator: MSC Cruises
Ship: MSC Musica
Departure: 09 March 2027
Visits: Brazil
Exclusive Savings
Inside
-
Oceanview
$693
Balcony
$901
Suite
$2,044
From (Per Person)
A$693
Per Person
View Trip
2 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

2 Days (1 Nights) Santos to Rio de Janeiro
Operator: MSC Cruises
Ships: MSC Divina, MSC Musica, MSC Virtuosa
Departures: Mar 2027 to Apr 2027
Visits: Brazil
Exclusive Savings
Inside
$253
Oceanview
$302
Balcony
$401
Suite
$669
From (Per Person)
A$253
Per Person
View Trip
2 Day South America with MSC Cruises
Cruise
 (1)

2 Days (1 Nights) Itajai to Santos
Operator: MSC Cruises
Ship: MSC Musica
Departure: 14 March 2027
Visits: Brazil
Exclusive Savings
Inside
$305
Oceanview
$335
Balcony
$414
Suite
$489
From (Per Person)
A$305
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Sao Paulo to Sao Paulo
Operator: MSC Cruises
Ships: MSC Divina, MSC Musica
Departures: Nov 2026 to Mar 2027
Visits: Brazil
Exclusive Savings
Inside
$666
Oceanview
$735
Balcony
$924
Suite
$1,248
From (Per Person)
A$666
Per Person
View Trip
3 Day South America with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Paranagua to Santos
Operator: MSC Cruises
Ship: MSC Musica
Departure: 13 March 2027
Visits: Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$738
Suite
$730
From (Per Person)
A$730
Per Person
View Trip
2 Day South America with MSC Cruises
Cruise
 (1)

2 Days (1 Nights) Paranagua to Itajai
Operator: MSC Cruises
Ship: MSC Musica
Departure: 13 March 2027
Visits: Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$483
Suite
$727
From (Per Person)
A$483
Per Person
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (3)

16 Days (15 Nights) Buenos Aires to Santiago
Operator: Holland America
Ship: Nieuw Amsterdam
Departure: 06 March 2028
Visits: Argentina, Uruguay, Falkland Islands, Chile
Book Early & Have It All Fare Option
Exclusive Savings
Inside
$3,792
Oceanview
$4,188
Balcony
$5,920
Suite
$7,900
From (Per Person)
A$3,792
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Operator: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Mar 2027
Visits: Brazil
Exclusive Savings
Inside
$1,300
Oceanview
$1,449
Balcony
$1,686
Suite
$2,995
From (Per Person)
A$1,300
Per Person
View Trip
18 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (3)

18 Days (17 Nights) Santiago to Fort Lauderdale
Operator: Holland America
Ship: Nieuw Amsterdam
Departure: 21 March 2028
Visits: Chile, Peru, Ecuador, Panama, Cayman Islands, USA
Book Early & Have It All Fare Option
Exclusive Savings
Inside
$4,327
Oceanview
$4,624
Balcony
$5,614
Suite
$8,039
From (Per Person)
A$4,327
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Sao Paulo to São Paulo
Operator: MSC Cruises
Ship: MSC Divina
Departures: Nov 2026 to Mar 2027
Visits: Brazil
Exclusive Savings
Inside
$911
Oceanview
$1,069
Balcony
$1,198
Suite
$1,644
From (Per Person)
A$911
Per Person
View Trip
7 Day South America with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Rio de Janeiro to Santos
Operator: MSC Cruises
Ship: MSC Musica
Departure: 09 March 2027
Visits: Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$1,570
Suite
$3,061
From (Per Person)
A$1,570
Per Person
View Trip
7 Day Galápagos - South & East Islands aboard the Yolita with G Adventures
Cruise

7 Days (6 Nights) Quito to Quito
Operator: G Adventures
Departures: Oct 2026 to Dec 2027
Visits: Ecuador
Exclusive Savings
From (Per Person)
A$7,153
Save 155
Per Person
View Trip
11 Day Galápagos Islands - Nine of the Best Isles (Western & Northern Route) with HX Expeditions
Cruise

11 Days (10 Nights) Quito to Quito
Operator: HX Expeditions
Ship: MS Santa Cruz II
Departures: Jun 2027 to Mar 2028
Visits: Ecuador, Galapagos
Exclusive Savings
Oceanview
$14,377
Suite
$18,526
From (Per Person)
A$14,377
Save 335
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise

9 Days (8 Nights) Rio de Janeiro to Rio de Janeiro
Operator: MSC Cruises
Ship: MSC Splendida
Departures: Dec 2026 to Mar 2027
Visits: Brazil, Uruguay, Argentina
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,238
Suite
$3,327
From (Per Person)
A$2,238
Per Person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Chile to Panama with Scenic
New ReleaseCruise

14 Days (13 Nights) Santiago to Panama City
Operator: Scenic
Ship: Scenic Eclipse II
Departure: 21 March 2027
Visits: Chile, Peru, Ecuador, Colombia, Panama
Exclusive Savings
Balcony
$12,533
Suite
$17,712
From (Per Person)
A$12,533
Save 4,212
Per Person
View Trip
11 Day Independent Galapagos Cruise Aboard the Galápagos Legend with Ecuador's Amazon with Globus
New ReleaseTour + Cruise

11 Days Quito to Guayaquil
Operator: Globus
Departures: Sep 2026 to Mar 2028
Trip Styles: Cruise, Island Hopping, Wildlife, Scenic
Visits: Ecuador, Galapagos
Exclusive Savings
From (Per Person)
A$12,010
Save 397
Per Person
View Trip
6 Day Galapagos Escape - Solaris (Itinerary C) with Exodus Tours
Cruise

6 Days (5 Nights) Quito to Guayaquil
Operator: Exodus
Departures: Sep 2026 to Dec 2027
Visits: Ecuador, Galapagos
Exclusive Savings
From (Per Person)
A$8,352
Save 271
Per Person
View Trip
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