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South America Cruises Starting In March 2027 and 2028

Are you planning a cruise around South America in March 2027 or 2028? Choose from 95 unique expeditions and cruises with 1,338 departures operated by South America's leading cruise lines. Easily compare prices, itineraries, inclusions and traveler reviews to find the South America cruise that best matches your travel style, budget and dates.
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95 Cruises (1,338 Cruise Departures)
10 Day Complete Galapagos (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$6,784
Save 1,406
Per Person
View Trip
7 Day Galapagos Explorer: Southern Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

7 Days (6 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$4,167
Save 1,148
Per Person
View Trip
13 Day Treasures of Galapagos: Western & Central Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

13 Days (12 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jul 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$10,791
Save 350
Per Person
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10 Day Ultimate Galapagos: Central Islands (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jun 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$7,488
Save 258
Per Person
View Trip
23 Day South American Discovery with Galápagos Cruise with Globus
Tour + Cruise

23 Days Rio de Janeiro to Guayaquil
Operated By: Globus
Departures: Oct 2026 to Oct 2027
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
Exclusive Savings
From
US$12,099
Save 647
Per Person
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21 Day Mysteries of the Inca Empire with Peru's Amazon & Galapagos Cruise with Cosmos
Tour + Cruise

21 Days Lima to Quito
Operated By: Cosmos
Departures: Nov 2026 to Oct 2027
Visit: Peru, Ecuador, Galapagos
Exclusive Savings
From
US$8,310
Save 284
Per Person
View Trip
10 Day Classic Galapagos: Southern Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$6,955
Save 1,440
Per Person
View Trip
17 Day Peru Splendors with Peru's Amazon & Galapagos Cruise with Globus
Tour + Cruise

17 Days Lima to Guayaquil
Operated By: Globus
Departures: Nov 2026 to Nov 2027
Visit: Peru, Ecuador, Galapagos
Exclusive Savings
From
US$8,369
Save 298
Per Person
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8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Preziosa
Departures: Mar 2026 to Mar 2027
Visit: Brazil, Uruguay, Argentina
Drinks & WiFi Package
Exclusive Savings
Inside
$1,018
Oceanview
$1,098
Balcony
$1,248
Suite
$1,547
From
US$1,018
Save 111
Per Person
View Trip
8 Day Galápagos – Central and East Islands aboard the Reina Silvia Voyager (Cruise Only) with G Adventures
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Operated By: G Adventures
Departures: Apr 2026 to Dec 2027
Visit: Galapagos
Exclusive Savings
From
US$5,780
Save 1,669
Per Person
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17 Day Mysteries of the Inca Empire with Galapagos Cruise with Cosmos
Tour + Cruise

17 Days Lima to Quito
Operated By: Cosmos
Departures: Dec 2026 to Nov 2027
Visit: Peru, Ecuador, Galapagos
Exclusive Savings
From
US$6,957
Save 241
Per Person
View Trip
14 Day Patagonia: Edge of the World with Collette
Tour + Cruise

14 Days Buenos Aires to Buenos Aires
Operated By: Collette
Departures: Oct 2026 to Mar 2027
Visit: Argentina, Chile
Exclusive Savings
From
US$10,010
Save 209
Per Person
View Trip
14 Day Chilean Fjords & The Glaciers of The Beagle Channel with Scenic
Cruise

14 Days (13 Nights) Buenos Aires to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 08 March 2027
Visit: Chile, Argentina
Select Fare
Preferred Plus Fare + Air Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,613
Suite
$24,182
From
US$16,613
Save 2,817
Per Person
View Trip
6 Day Galapagos at a Glance: Southern Islands (Grand Daphne) with Intrepid Travel
Cruise

6 Days (5 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$3,544
Save 716
Per Person
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8 Day San Cristóbal to San Cristóbal with Silversea
Cruise

8 Days (7 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departures: Apr 2026 to Mar 2028
Visit: Ecuador, Galapagos
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,200
Suite
$17,930
From
US$11,200
Save 2,800
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise

9 Days (8 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departures: Dec 2026 to Mar 2027
Visit: Argentina, Brazil, Uruguay
Inside
$999
Oceanview
$1,307
Balcony
$1,439
Suite
$2,031
From
US$999
Per Person
View Trip
7 Day Galápagos - South & East Islands aboard the Yolita with G Adventures
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: G Adventures
Departures: Apr 2026 to Dec 2027
Visit: Ecuador
Exclusive Savings
From
US$3,569
Save 1,093
Per Person
View Trip
8 Day Galápagos - West & Central Islands aboard the Eden with G Adventures
Cruise

8 Days (7 Nights) Quito to Quito
Operated By: G Adventures
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$3,491
Save 1,008
Per Person
View Trip
34 Day Highlights of South America and Chilean Fjords Cruise with Travelmarvel
Tour + Cruise

34 Days Rio de Janeiro to Lima
Operated By: Travelmarvel
Departure: 02 March 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Brazil, Argentina, Uruguay, Falkland Islands, Chile, Peru
Exclusive Savings
Inside
-
Oceanview
$14,059
Balcony
$15,324
Suite
-
From
US$14,059
Save 236
Per Person
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (3)

16 Days (15 Nights) Buenos Aires to Santiago
Cruise Line: Holland America
Ship: Oosterdam
Departure: 09 March 2027
Visit: Argentina, Uruguay, Falkland Islands, Chile
Fare Saver
Inside
$2,429
Oceanview
$2,629
Balcony
$3,674
Suite
$4,752
From
US$2,429
Per Person
View Trip
20 Day Falklands, South Georgia & Valdes Peninsula: In the Heart of the Wilderness with Ponant
Cruise

20 Days (19 Nights) Buenos Aires to Buenos Aires
Cruise Line: Ponant
Ship: Le Lyrial
Departure: 02 March 2028
Visit: Argentina, South Georgia Island, Falkland Islands
Inside
-
Oceanview
$19,070
Balcony
$20,400
Suite
$31,910
From
US$19,070
Per Person
View Trip
10 Day Galápagos - North, Central, & South Islands aboard the Eden with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$4,485
Save 1,366
Per Person
View Trip
7 Day Galápagos - North & Central Islands aboard the Eden with G Adventures
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: G Adventures
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$3,142
Save 936
Per Person
View Trip
6 Day Galapagos Escape (Itinerary B) with Exodus Tours
Cruise

6 Days (5 Nights) Quito to Guayaquil
Operated By: Exodus Tours
Departures: Mar 2026 to Dec 2027
Visit: Ecuador, Galapagos
Sign Up Savings
Exclusive Savings
From
US$5,500
Save 838
Per Person
View Trip
16 Day Chilean Fjords – Discovering The Heart Of Patagonia (Northbound) with HX Expeditions
Cruise
 (2)

16 Days (15 Nights) Buenos Aires to Valparaiso
Cruise Line: HX Expeditions
Ship: MS Roald Amundsen
Departure: 26 March 2026
Visit: Argentina, Chile
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
$6,961
Balcony
$7,384
Suite
$8,862
From
US$6,961
Save 2,513
Per Person
View Trip
18 Day Fjords & Glaciers of Southern Chile & Patagonia with Scenic
New ReleaseCruise

18 Days (17 Nights) Buenos Aires to Buenos Aires
Cruise Line: Scenic
Ships: Scenic Eclipse I, Scenic Ikon
Departures: Feb 2027 to Feb 2029
Visit: Argentina, Chile, Uruguay
Preferred Plus Fare + Air Credit
Select Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,253
Suite
$29,364
From
US$23,439
Save 2,372
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 29 March 2026
Visit: Brazil
Inside
-
Oceanview
-
Balcony
$1,240
Suite
$1,637
From
US$1,240
Per Person
View Trip
14 Day Argentina & the Chilean Fjords with Viking Cruises
Cruise
 (1)

14 Days (13 Nights) Buenos Aires to Santiago
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2027 to Mar 2028
Visit: Argentina, Chile
Flights Included
Inside
-
Oceanview
-
Balcony
$10,995
Suite
$15,995
From
US$10,995
Per Person
View Trip
7 Day Ocean Voyage: Ushuaia - Buenos Aires with Ponant
Cruise
 (2)

7 Days (6 Nights) Ushuaia to Buenos Aires
Cruise Line: Ponant
Ship: Le Boreal
Departure: 12 March 2028
Visit: Argentina
Inside
-
Oceanview
$1,950
Balcony
$2,080
Suite
$3,040
From
US$1,950
Per Person
View Trip
7 Day Independent Galapagos Cruise Aboard the Galapagos Legend with Globus
New ReleaseTour + Cruise

7 Days Quito to Guayaquil
Operated By: Globus
Departures: Apr 2026 to Mar 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$5,000
Save 219
Per Person
View Trip
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Country Routes

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Cruise Lines Exploring South & Central America

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