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South America Cruises Starting In March 2026, 2027 and 2028

Are you planning a cruise around South America in March 2026, 2027 or 2028? Choose from 127 unique expeditions and cruises with 1,730 departures operated by South America's leading cruise lines. Easily compare prices, itineraries, inclusions and traveler reviews to find the South America cruise that best matches your travel style, budget and dates.
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127 Cruises (1,730 Cruise Departures)
10 Day Complete Galapagos (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jan 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$7,173
Save 258
Per Person
View Trip
7 Day Galapagos Explorer: Southern Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

7 Days (6 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jan 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$4,661
Save 167
Per Person
View Trip
13 Day Treasures of Galapagos: Western & Central Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

13 Days (12 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$9,734
Save 350
Per Person
View Trip
10 Day Ultimate Galapagos: Central Islands (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Feb 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$7,183
Save 258
Per Person
View Trip
8 Day Galápagos - South & East Islands aboard the Eden with G Adventures
Cruise

8 Days (7 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jan 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$4,267
Save 139
Per Person
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8 Day Galapagos Inner Loop Cruise with Celebrity Cruises
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Cruise Line: Celebrity Cruises
Ship: Celebrity Flora
Departures: Jan 2026 to Dec 2027
Visit: Galapagos
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$8,045
From
US$8,045
Save 4,721
Per Person
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (2)

16 Days (15 Nights) Buenos Aires to Santiago
Cruise Line: Holland America
Ship: Oosterdam
Departures: Mar 2027 to Mar 2028
Visit: Argentina, Uruguay, Falkland Islands, Chile
Book Early & Have It All Fare Option
Inside
$2,429
Oceanview
$2,679
Balcony
$3,672
Suite
$4,848
From
US$2,429
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departures: Jan 2026 to Mar 2026
Visit: Brazil
Inside
$942
Oceanview
$1,072
Balcony
$1,626
Suite
$1,914
From
US$942
Per Person
View Trip
9 Day In Darwin’s Footsteps (Eastern Route) with HX Expeditions
Cruise

9 Days (8 Nights) Quito to Quito
Cruise Line: HX Expeditions
Ship: MS Santa Cruz II
Departures: Mar 2026 to Dec 2026
Visit: Ecuador, Galapagos
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
$6,652
Balcony
-
Suite
$8,748
From
US$6,652
Save 2,857
Per Person
View Trip
10 Day Galápagos - East, Central, & West Islands aboard the Eden with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jan 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$5,606
Save 187
Per Person
View Trip
8 Day Pure Galapagos (Grand Daphne) with Intrepid Travel
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Operated By: Intrepid Travel
Departures: Jan 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$6,290
Save 226
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (2)

10 Days (9 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ships: MSC Fantasia, MSC Splendida
Departures: Jan 2026 to Jan 2027
Visit: Uruguay, Argentina, Brazil
Exclusive Savings
Inside
$1,177
Oceanview
$1,497
Balcony
$1,657
Suite
$2,382
From
US$1,177
Save 66
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (2)

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ships: MSC Fantasia, MSC Splendida
Departures: Jan 2026 to Feb 2027
Visit: Argentina, Brazil, Uruguay
Exclusive Savings
Inside
$1,250
Oceanview
$1,500
Balcony
$1,630
Suite
$2,240
From
US$1,250
Save 57
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ships: MSC Fantasia, MSC Splendida
Departures: Dec 2025 to Mar 2027
Visit: Argentina, Brazil, Uruguay
Exclusive Savings
Inside
$884
Oceanview
$1,094
Balcony
$1,214
Suite
$1,804
From
US$884
Save 183
Per Person
View Trip
7 Day Galápagos Land & Sea - Central & South Islands aboard the Yolita with G Adventures
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jan 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$3,976
Save 130
Per Person
View Trip
14 Day Argentina & the Chilean Fjords with Viking Cruises
Cruise
 (1)

14 Days (13 Nights) Buenos Aires to Santiago
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2026 to Mar 2028
Visit: Argentina, Chile
Flights Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,995
Suite
$14,995
From
US$9,995
Save 500
Per Person
View Trip
10 Day Galápagos – Central and East Islands aboard the Reina Silvia Voyager with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jan 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$7,662
Save 258
Per Person
View Trip
8 Day Galápagos – Central and East Islands aboard the Reina Silvia Voyager (Cruise Only) with G Adventures
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Operated By: G Adventures
Departures: Jan 2026 to Dec 2026
Visit: Galapagos
Exclusive Savings
From
US$6,983
Save 229
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ships: MSC Seaview, MSC Virtuosa
Departures: Jan 2026 to Mar 2027
Visit: Brazil
Inside
$844
Oceanview
$894
Balcony
$1,014
Suite
$1,374
From
US$844
Per Person
View Trip
10 Day Galápagos - Central, South & East Islands aboard the Yolita with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jan 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$6,498
Save 210
Per Person
View Trip
15 Day South America Passage with Holland America
Cruise
 (2)

15 Days (14 Nights) Buenos Aires to San Antonio
Cruise Line: Holland America
Ship: Oosterdam
Departure: 08 March 2026
Visit: Argentina, Uruguay, Falkland Islands, Chile
Have It All Fare Option
Fare Saver
Inside
$2,359
Oceanview
$2,409
Balcony
$3,479
Suite
$4,488
From
US$2,359
Per Person
View Trip
15 Day Highlights of Ecuador & the Galapagos with Exodus Adventure Travels
New ReleaseTour + Cruise

15 Days Quito to Quito
Departures: Feb 2026 to Dec 2027
Visit: Ecuador, Galapagos
Sign Up Savings
Exclusive Savings
From
US$6,022
Save 914
Per Person
View Trip
14 Day Patagonia: Edge of the World with Collette
Tour + Cruise

14 Days Buenos Aires to Buenos Aires
Operated By: Collette
Departures: Dec 2025 to Mar 2027
Visit: Argentina, Chile
Exclusive Savings
From
US$9,814
Save 885
Per Person
View Trip
14 Day Chile, Peru & Panama Voyage with Azamara Cruises
Cruise
 (4)

14 Days (13 Nights) San Antonio to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 March 2026
Visit: Chile, Peru, Panama
Azamara Always Included
Inside
$2,758
Oceanview
$2,519
Balcony
$2,971
Suite
$4,640
From
US$2,519
Per Person
View Trip
17 Day Absolute Galapagos (Grand Daphne) with Intrepid Travel
Cruise

17 Days (16 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jan 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$14,477
Save 470
Per Person
View Trip
8 Day Galápagos - West & Central Islands aboard the Reina Silvia Voyager (Cruise Only) with G Adventures
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Operated By: G Adventures
Departures: Jan 2026 to Dec 2026
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$6,983
Save 229
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Salvador to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 30 March 2027
Visit: Brazil
Inside
$469
Oceanview
$549
Balcony
$649
Suite
$1,079
From
US$469
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Preziosa, MSC Sinfonia
Departures: Jan 2026 to Mar 2027
Visit: Brazil
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$855
From
US$475
Per Person
View Trip
7 Day Galápagos Islands – Iconic Wildlife & Sublime Scenery (Western Route) with HX Expeditions
Cruise

7 Days (6 Nights) Quito to Quito
Cruise Line: HX Expeditions
Ship: MS Santa Cruz II
Departures: Mar 2026 to Dec 2026
Visit: Ecuador, Galapagos
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
$6,370
Balcony
-
Suite
$8,341
From
US$6,370
Save 1,226
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Maceio to Maceio
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departures: Jan 2026 to Mar 2026
Visit: Brazil
Inside
$843
Oceanview
$1,013
Balcony
$1,453
Suite
$1,723
From
US$843
Per Person
View Trip
Results: 1-30 of 127

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South & Central America Cruises

Central America Cruises South America Cruises Mexico Cruises Galapagos Cruises Bermunda Cruises Bahamas Cruises Caribbean Cruises Amazon Cruises Patagonia Cruises Cape Horn Cruises Falkland Island Cruises Panama Cruises

Travel Styles

Active Adventures Coach Cruises Luxury Cruises Short Cruise Breaks Wellness Cruises Wildlife Cruises

Countries

Antarctica Argentina Barbados Brazil Chile Ecuador Falkland Islands French Polynesia Galapagos Morocco Panama Peru Portugal Spain Uruguay

Cities

Cruises from Baltra Island Cruises from Buenos Aires Cruises from Lima Cruises from Maceio Cruises from Manaus Cruises from Montevideo Cruises from Panama City Cruises from Quito Cruises from Rio de Janeiro Cruises from Salvador Cruises from San Antonio Cruises from San Cristobal Island Cruises from Santiago Cruises from Santiago Cruises from Santos Cruises from Sao Paulo Cruises from Valparaiso

Routes

Cruises from Baltra Island to Baltra Island Cruises from Buenos Aires to Rio de Janeiro Cruises from Buenos Aires to Buenos Aires Cruises from Buenos Aires to Santiago Cruises from Lima to Buenos Aires Cruises from Lima to Quito Cruises from Panama City to Miami Cruises from Quito to Guayaquil Cruises from Quito to Quito Cruises from Rio de Janeiro to Buenos Aires Cruises from Rio de Janeiro to Rio de Janeiro Cruises from Rio de Janeiro to Barcelona Cruises from San Antonio to Buenos Aires Cruises from San Cristobal Island to San Cristobal Island Cruises from Santiago to Buenos Aires Cruises from Santos to Santos Cruises from Sao Paulo to Sao Paulo Cruises from Ushuaia to Ushuaia

Country Routes

Cruises from Peru to Argentina Cruises from Chile to USA Cruises from Brazil to Spain Cruises from Argentina to Brazil Cruises from USA to Brazil Cruises from Argentina to Chile Cruises from Brazil to Italy Cruises from Argentina to USA Cruises from Peru to USA Cruises from Brazil to Argentina Cruises from Chile to Argentina Cruises from Panama to USA Cruises from Peru to Ecuador Cruises from USA to Barbados Cruises from USA to Chile Cruises from USA to Italy Cruises from USA to Panama Cruises from USA to Peru Cruises from USA to Spain

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking Central America Cruises Viking South America Cruises

South America Tours

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