Home > Cruises > South America Cruises > September 2025

South America Cruises Starting In September 2025

If you're looking at joining a cruise around South America in September 2025, we have 62 unique expeditions and cruises with 1,155 departures from the world's leading cruise lines departing in September.
Filter Results
Departures (September 2025)
< August 2025 October 2025 >
Duration
6 Days
30 Days
Regions
Start & End Cities
Ship Size
Cruise Lines
Price
$300pp
$169,995pp
Countries
Show More...
Filter Results
62 Cruises (1,155 Cruise Departures)
30 Day Ultimate South America with Brazil's Amazon & Galapagos Cruise with Cosmos
Tour + Cruise
 (3)

30 Days Manaus to Guayaquil
Operated By: Cosmos
Departures: Oct 2025 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador (+1 more), Galapagos
Exclusive Savings
Save (per person) 264
From (per person) 11,439
View Trip
10 Day Complete Galapagos (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departure: 30 September 2025
Countries Visited: Ecuador, Galapagos
Exclusive Deal
Save (per person) 906
From (per person) 6,958
View Trip
10 Day Ultimate Galapagos: Central Islands (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jun 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Exclusive Deal
Save (per person) 1,281
From (per person) 6,584
View Trip
26 Day Ultimate South America with Galapagos Cruise with Cosmos
Tour + Cruise
 (1)

26 Days Rio de Janeiro to Guayaquil
Operated By: Cosmos
Departures: Aug 2025 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador (+1 more), Galapagos
Exclusive Savings
Save (per person) 227
From (per person) 9,738
View Trip
9 Day Galapagos - Central & West Islands Aboard the Treasure with Explore!
Cruise

9 Days (8 Nights) Quito to Quito
Operated By: Explore!
Departures: May 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save (per person) 1,021
From (per person) 7,629
View Trip
8 Day Galápagos - West & Central Islands aboard the Eden with G Adventures
Cruise

8 Days (7 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jun 2025 to Dec 2027
Countries Visited: Ecuador, Galapagos
Exclusive Savings
Save (per person) 92
From (per person) 4,193
View Trip
7 Day Independent Galapagos Cruise Aboard the Galapagos Legend with Globus
New ReleaseTour + Cruise

7 Days Quito to Guayaquil
Operated By: Globus
Departures: Jul 2025 to Mar 2026
Trip Styles: Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Ecuador, Galapagos
Exclusive Savings
Save (per person) 154
From (per person) 4,864
View Trip
10 Day Galapagos - Central, West & East Islands aboard the Archipel I with Explore!
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: Explore!
Departures: Jun 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save (per person) 1,011
From (per person) 6,747
View Trip
8 Day Galápagos – Central and East Islands aboard the Reina Silvia Voyager (Cruise Only) with G Adventures
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Operated By: G Adventures
Departures: Jun 2025 to Dec 2026
Countries Visited: Galapagos
Last Minute OfferMay Sale
Save (per person) 1,908
From (per person) 5,108
View Trip
6 Day Galapagos Escape - Solaris (Itinerary C) with Exodus Adventure Travels
Cruise

6 Days (5 Nights) Quito to Guayaquil
Departures: Jun 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save (per person) 614
From (per person) 4,221
View Trip
6 Day Galapagos Escape (Itinerary B) with Exodus Adventure Travels
Cruise

6 Days (5 Nights) Quito to Guayaquil
Departures: May 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save (per person) 614
From (per person) 4,221
View Trip
10 Day Galápagos - North, West & Central Islands aboard the Yolita with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: May 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Last Minute OfferMay Sale
Save (per person) 2,135
From (per person) 4,664
View Trip
23 Day South American Discovery with Galápagos Cruise with Globus
Tour + Cruise

23 Days Rio de Janeiro to Guayaquil
Operated By: Globus
Departures: Jul 2025 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador (+1 more), Galapagos
Flash Sale
Save (per person) 311
From (per person) 11,916
View Trip
7 Day Galapagos Express - Central, South & East Islands aboard the Archipel I with Explore!
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: Explore!
Departures: May 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save (per person) 621
From (per person) 4,639
View Trip
17 Day Complete Galápagos - Eden with G Adventures
Cruise

17 Days (16 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jun 2025 to Dec 2027
Countries Visited: Ecuador, Galapagos
Exclusive Savings
Save (per person) 221
From (per person) 9,946
View Trip
14 Day Peru & Galapagos by Yacht with Collette
Tour + Cruise

14 Days Lima to Quito
Operated By: Collette
Departures: Sep 2025 to Mar 2026
Trip Styles: Coach, Small Group, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Peru, Ecuador, Galapagos
Exclusive Savings
Save (per person) 158
From (per person) 9,245
View Trip
7 Day Galápagos Land & Sea - Central & South Islands aboard the Yolita with G Adventures
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: G Adventures
Departures: May 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Last Minute OfferMay Sale
Save (per person) 1,506
From (per person) 2,643
View Trip
8 Day Galapagos Inner Loop Cruise with Celebrity Cruises
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Cruise Line: Celebrity Cruises
Ship: Celebrity Flora
Departures: Jul 2025 to Dec 2027
Countries Visited: Galapagos
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$7,204
Save (per person) 5,782
From (per person) 7,204
View Trip
9 Day Galapagos - Central & West Islands Aboard the Solaris with Explore!
Cruise

9 Days (8 Nights) Quito to Quito
Operated By: Explore!
Departures: Jun 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save (per person) 1,024
From (per person) 7,656
View Trip
10 Day Galápagos – Central and East Islands aboard the Reina Silvia Voyager with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jun 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Last Minute OfferMay Sale
Save (per person) 2,080
From (per person) 5,585
View Trip
17 Day Galapagos Wildlife Cruise (Archipel I) with Exodus Adventure Travels
Cruise

17 Days (16 Nights) Quito to Guayaquil
Departures: Jul 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save (per person) 2,000
From (per person) 13,748
View Trip
10 Day Galapagos - Central, South & East Islands aboard the Archipel I with Explore!
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: Explore!
Departures: May 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save (per person) 903
From (per person) 6,747
View Trip
10 Day Galápagos - East, Central, & West Islands aboard the Eden with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jun 2025 to Dec 2027
Countries Visited: Ecuador, Galapagos
Last Minute Offer
Save (per person) 664
From (per person) 4,965
View Trip
17 Day Mysteries of the Inca Empire with Galapagos Cruise with Cosmos
Tour + Cruise

17 Days Lima to Quito
Operated By: Cosmos
Departures: Aug 2025 to Dec 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Peru, Ecuador, Galapagos
Exclusive Savings
Save (per person) 170
From (per person) 6,817
View Trip
14 Day Patagonia: Edge of the World with Collette
Tour + Cruise

14 Days Buenos Aires to Buenos Aires
Operated By: Collette
Departures: Oct 2025 to Mar 2026
Trip Styles: Adventure, Coach, Small Group, Cruise, Scenic
Countries Visited: Argentina, Chile
50% Off Air
Save (per person) 199
From (per person) 9,324
View Trip
10 Day Galapagos Encounter (Itinerary B) with Exodus Adventure Travels
Cruise

10 Days (9 Nights) Quito to Guayaquil
Departures: May 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save (per person) 1,067
From (per person) 7,331
View Trip
13 Day Highlights of Peru with Galápagos Legend North and Central Cruise with Trafalgar
Tour + Cruise

13 Days Lima to Quito
Operated By: Trafalgar
Departures: Oct 2025 to Dec 2025
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Peru, Ecuador, Galapagos
Sign Up Savings
Save (per person) 198
From (per person) 6,427
View Trip
6 Day Galapagos at a Glance: Southern Islands (Grand Daphne) with Intrepid Travel
Cruise

6 Days (5 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jun 2025 to Nov 2025
Countries Visited: Ecuador, Galapagos
Exclusive Deal
Save (per person) 849
From (per person) 3,281
View Trip
7 Day Nature And Wildlife Expedition Cruise (Northern Route) with HX Hurtigruten Expeditions
Cruise

7 Days (6 Nights) Quito to Quito
Ship: MS Santa Cruz II
Departures: Jun 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Anniversary Offers
INSIDE
-
OCEANVIEW
$5,558
BALCONY
-
SUITE
$7,255
Save (per person) 3,490
From (per person) 5,558
View Trip
7 Day Galápagos - South & East Islands aboard the Yolita with G Adventures
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jun 2025 to Dec 2026
Countries Visited: Ecuador
Last Minute OfferMay Sale
Save (per person) 1,428
From (per person) 3,121
View Trip
Results: 1-30 of 62

No Results found. Try changing your search filters.




Cruises found! Scroll up to view

South & Central America Cruises

Central America Cruises South America Cruises Mexico Cruises Galapagos Cruises Bermunda Cruises Bahamas Cruises Caribbean Cruises Amazon Cruises Patagonia Cruises Cape Horn Cruises Falkland Island Cruises Panama Cruises

Travel Styles

Active Adventures Coach Cruises Locally Guided Tours Luxury Cruises Short Cruise Breaks Wildlife Cruises

Countries

Antarctica Argentina Barbados Brazil Chile Ecuador Falkland Islands French Polynesia Galapagos Panama Peru Portugal Spain Uruguay

Cities

Baltra Island Buenos Aires Lima Lisbon Manaus Quito Rio de Janeiro Santiago Santiago Santiago

Routes

Cruises from Baltra Island to Baltra Island Cruises from Buenos Aires to Rio de Janeiro Cruises from Buenos Aires to Buenos Aires Cruises from Lima to Buenos Aires Cruises from Lima to Quito Cruises from Quito to Guayaquil Cruises from Quito to Quito Cruises from Rio de Janeiro to Buenos Aires Cruises from Rio de Janeiro to Rio de Janeiro Cruises from San Antonio to Buenos Aires Cruises from Santiago to Buenos Aires Cruises from Santos to Santos Cruises from Sao Paulo to Sao Paulo Cruises from Ushuaia to Ushuaia

Country Routes

Cruises from Peru to Argentina Cruises from Argentina to Brazil Cruises from Brazil to Argentina Cruises from Chile to Argentina Cruises from Peru to Ecuador

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant South America Cruises Ponant Central America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking Central America Cruises Viking South America Cruises

South America Tours

All South America Tours Amazon Tours Argentina Tours Brazil Tours Chile Tours Colombia Tours Ecuador Tours Galapagos Tours Patagonia Tours Peru Tours

© 2010-2025. Global Journeys. You're viewing our site in US dollars.

    

About Us | View Your Booking | Terms & Conditions | Site Map

Global Journeys Travel Inc. is a Member of the American Society of Travel Advisors (ASTA No: 900374670), CLIA (No. 00046729) & is TICO Accredited (No. 50027921).

Travel Industry Associations