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Spain Cruises Starting In September 2025

If you're looking at joining a cruise to Spain in September 2025, we have 37 unique cruise itineraries and 500 departures available, operated by eleven of the world's leading cruise lines departing in September.
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Departures (September 2025)
< August 2025 October 2025 >
Duration
2 Days
18 Days
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$84,798pp
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37 Cruises (500 Cruise Departures)
9 Day Cruising Southern Spain and Portugal - with Smithsonian Journeys with Ponant
Cruise
 (2)

9 Days (8 Nights) Barcelona to Lisbon
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 16 September 2025
Countries Visited: Spain, Portugal
Exclusive Solo Offer
Inside
-
Oceanview
-
Balcony
$10,100
Suite
$22,850
From
10,100
per person
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: Royal Caribbean
Ship: Allure of the Seas
Departures: Sep 2025 to Aug 2026
Countries Visited: Italy, Spain
Latest Offer
Inside
$1,391
Oceanview
$1,851
Balcony
$1,700
Suite
$3,805
Save
912
From
1,391
per person
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Barcelona
Cruise Line: Royal Caribbean
Ships: Allure of the Seas, Harmony of the Seas
Departures: Aug 2025 to Aug 2026
Countries Visited: Spain, Italy
Latest Offer
Inside
$1,421
Oceanview
$1,556
Balcony
$1,548
Suite
$2,808
Save
2,358
From
1,421
per person
View Trip
9 Day Rome to Barcelona with Silversea
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 23 September 2025
Countries Visited: Italy, Spain
Port-to-PortDoor-to-Door Upgrade Option
Inside
-
Oceanview
-
Balcony
-
Suite
$8,250
Save
1,250
From
8,250
per person
View Trip
2 Day Mediterranean with MSC Cruises
Cruise

2 Days (1 Nights) Valencia to Marseille
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 25 September 2025
Countries Visited: Spain, France
One Way Cruise Offer
Inside
$89
Oceanview
-
Balcony
$179
Suite
$349
From
89
per person
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+10 more), Viking Libra, Viking Mars, Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Sep 2025 to Sep 2028
Countries Visited: Italy, Monaco, France, Spain
Mutiple Deals Available
Inside
-
Oceanview
-
Balcony
$2,599
Suite
$3,799
Save
1,750
From
2,599
per person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seaview
Departures: Aug 2025 to Oct 2026
Countries Visited: Italy, Spain, France
Escape To Sea
Inside
$981
Oceanview
$1,121
Balcony
$1,261
Suite
$1,970
From
981
per person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Barcelona to Barcelona
Cruise Line: MSC Cruises
Ships: MSC Orchestra, MSC Splendida
Departures: Aug 2025 to Oct 2026
Countries Visited: Spain, Italy, France
Escape To Sea
Inside
$804
Oceanview
$989
Balcony
$1,041
Suite
$1,531
From
804
per person
View Trip
8 Day Rome To Barcelona with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 01 September 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
Inside
$939
Oceanview
$1,099
Balcony
-
Suite
-
From
939
per person
View Trip
12 Day Lisbon to Monte Carlo with Silversea
Cruise

12 Days (11 Nights) Lisbon to Monte Carlo
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 24 September 2025
Countries Visited: Portugal, Gibraltar, Spain, Monaco
Port-to-PortDoor-to-Door Upgrade Option
Inside
-
Oceanview
$7,450
Balcony
$9,050
Suite
$7,850
Save
1,250
From
7,450
per person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Genoa to Genoa
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seaview
Departures: Aug 2025 to Oct 2026
Countries Visited: Italy, Spain, France
Escape To Sea
Inside
$998
Oceanview
$1,138
Balcony
$1,278
Suite
$1,973
From
998
per person
View Trip
8 Day A Journey to White Isle Bohemia & Italian Riviera Romance with Explora Journeys
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 22 September 2025
Countries Visited: Spain, France, Italy
Inside
-
Oceanview
-
Balcony
$5,850
Suite
$8,450
From
5,850
per person
View Trip
17 Day Escapades In Iberia with Regent Seven Seas
Cruise

17 Days (16 Nights) Paris to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 September 2025
Countries Visited: France, Spain, Portugal
Early Booking Saving
Inside
-
Oceanview
-
Balcony
-
Suite
$36,599
Save
48,199
From
36,599
per person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Cannes to Cannes
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seaview
Departures: Aug 2025 to Oct 2026
Countries Visited: France, Italy, Spain
Escape To Sea
Inside
$1,018
Oceanview
$1,158
Balcony
$1,298
Suite
$2,143
From
1,018
per person
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: Royal Caribbean
Ship: Allure of the Seas
Departures: Aug 2025 to Oct 2026
Countries Visited: Italy, Spain, France
Latest Offer
Inside
$1,654
Oceanview
-
Balcony
$2,371
Suite
$5,442
Save
1,143
From
1,654
per person
View Trip
15 Day Northern Europe with MSC Cruises
Cruise

15 Days (14 Nights) London to London
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 13 September 2025
Countries Visited: England, Spain, Portugal
Escape To Sea
Inside
$1,438
Oceanview
$1,898
Balcony
$2,128
Suite
$4,568
From
1,438
per person
View Trip
8 Day Spain & France Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) London to London
Cruise Line: Royal Caribbean
Ship: Independence of the Seas
Departure: 22 September 2025
Countries Visited: England, France, Spain
Latest Offer
Inside
$1,166
Oceanview
$1,892
Balcony
$1,676
Suite
-
Save
569
From
1,166
per person
View Trip
15 Day Istanbul And Greek Islands with Cunard
Cruise

15 Days (14 Nights) Barcelona to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 29 September 2025
Countries Visited: Spain, Greece, Turkey
Exclusive Deal
Inside
$1,609
Oceanview
-
Balcony
$2,459
Suite
-
From
1,609
per person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Palma de Mallorca to Palma de Mallorca
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seaview
Departures: Aug 2025 to Oct 2026
Countries Visited: Spain, France, Italy
Escape To Sea
Inside
$989
Oceanview
$1,129
Balcony
$1,269
Suite
$1,989
From
989
per person
View Trip
9 Day Monte Carlo to Rome with Silversea
Cruise

9 Days (8 Nights) Monte Carlo to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 07 September 2025
Countries Visited: Monaco, France, Spain, Italy
Port-to-PortDoor-to-Door Upgrade Option
Inside
-
Oceanview
-
Balcony
-
Suite
$12,450
Save
1,250
From
12,450
per person
View Trip
12 Day Canaries & Portugal Cruise with Celebrity Cruises
Cruise
 (1)

12 Days (11 Nights) London to London
Cruise Line: Celebrity Cruises
Ship: Celebrity Apex
Departures: Sep 2025 to Oct 2026
Countries Visited: England, Portugal, Spain
Exclusive Deal
Inside
$2,086
Oceanview
$2,815
Balcony
$3,230
Suite
$5,673
Save
12,088
From
2,086
per person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ships: MSC Orchestra, MSC Splendida
Departures: Aug 2025 to Oct 2026
Countries Visited: Italy, France, Spain
Escape To Sea
Inside
$794
Oceanview
$914
Balcony
$1,024
Suite
$1,517
From
794
per person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Valencia to Valencia
Cruise Line: MSC Cruises
Ships: MSC Orchestra, MSC Splendida
Departures: Aug 2025 to Oct 2026
Countries Visited: Spain, Italy, France
Escape To SeaDrinks and Wi-Fi Included
Inside
$784
Oceanview
$904
Balcony
$1,014
Suite
$1,668
From
784
per person
View Trip
10 Day Italian Riviera & France Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 30 September 2025
Countries Visited: Italy, France, Spain
Bonus Onboard Credit + SaveExclusive Deal
Inside
-
Oceanview
-
Balcony
-
Suite
$9,331
From
15,150
per person
View Trip
10 Day Spain, Portugal & Morocco with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Sep 2025 to Sep 2026
Countries Visited: Spain, Portugal, Morocco
Exclusive Deal
Inside
$1,942
Oceanview
$2,519
Balcony
$2,492
Suite
$6,017
Save
5,448
From
1,942
per person
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Barcelona
Cruise Line: Royal Caribbean
Ships: Allure of the Seas, Harmony of the Seas
Departures: Aug 2025 to Oct 2026
Countries Visited: Spain, France, Italy
Latest Offer
Inside
$1,284
Oceanview
$1,435
Balcony
$1,647
Suite
$2,982
Save
4,825
From
1,284
per person
View Trip
8 Day Northern Europe with MSC Cruises
Cruise

8 Days (7 Nights) London to London
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 06 September 2025
Countries Visited: England, Spain, France
Escape To Sea
Inside
$791
Oceanview
-
Balcony
$1,141
Suite
-
From
791
per person
View Trip
10 Day Western Mediterranean From Barcelona To Barcelona with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Barcelona to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Breakaway
Departure: 19 September 2025
Countries Visited: Spain, Italy, France
Inside
$1,230
Oceanview
$1,720
Balcony
$2,240
Suite
$2,500
From
1,230
per person
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Sep 2025 to Sep 2026
Countries Visited: Italy, France, Spain
Exclusive Deal
Inside
$1,814
Oceanview
$2,315
Balcony
$1,503
Suite
$3,954
Save
1,957
From
1,503
per person
View Trip
18 Day Crossing the Equator: Portugal to Brazil with Scenic
Cruise

18 Days (17 Nights) Lisbon to Rio de Janeiro
Cruise Line: Scenic
Ships: Scenic Eclipse I
Departure: 24 September 2025
Countries Visited: Portugal, Spain, Brazil
Fly Free Premium EconomyFly Free Business Class
Inside
-
Oceanview
-
Balcony
$15,115
Suite
$22,715
Save
15,175
From
15,115
per person
View Trip
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