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Sicily Cruises

Are you looking for a cruise to Sicily? Choose from 404 unique cruise itineraries to Sicily, departing from Amalfi, Antalya, Athens, Barcelona, Bari and more. October is the most popular month to cruise to Sicily and we have over 2,304 departures available from twenty-four of the world's leading cruise lines.
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404 Cruises (2,304 Cruise Departures)
8 Day Adriatic & Greece From Bologna To Rome with Norwegian Cruise Line
Cruise

8 Days (7 Nights) Bologna to Rome
Cruise Line: Norwegian Cruise Line
Ships: Norwegian Gem, Norwegian Sun
Departures: Jun 2026 to Aug 2027
Visit: Italy, Croatia, Montenegro, Greece, Sicily
Inside
$1,009
Oceanview
$1,069
Balcony
$1,759
Suite
$1,829
From
US$1,009
Per Person
View Trip
12 Day Mediterranean with Greek Isles & Italy with Princess
Cruise
 (1)

12 Days (11 Nights) Istanbul to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 26 October 2027
Visit: Turkey, Greece, Malta, Sicily, Italy
Princess Standard
Inside
$1,985
Oceanview
$2,394
Balcony
$2,255
Suite
$2,640
From
US$1,985
Per Person
View Trip
13 Day Sweet Mediterranean Escape with Ponant
Cruise
 (2)

13 Days (12 Nights) Athens to Nice
Cruise Line: Ponant
Ship: Le Boreal
Departure: 17 July 2026
Visit: Greece, Sicily, Italy, Corsica, France
Inside
-
Oceanview
$9,270
Balcony
$9,770
Suite
$18,170
From
US$9,270
Per Person
View Trip
9 Day Barcelona to Amalfi, Sicily & Greece with Virgin Voyages
Cruise
 (1)

9 Days (8 Nights) Barcelona to Athens
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 08 May 2027
Visit: Spain, Corsica, Italy, Sicily, Greece
Limited Time Offer
Inside
$1,837
Oceanview
$2,140
Balcony
$2,254
Suite
$5,275
From
US$1,837
Per Person
View Trip
15 Day Harbors Of Heritage with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to Athens
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 22 July 2027
Visit: Italy, Sicily, Montenegro, Croatia, Greece
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,349
Suite
$17,599
From
US$17,349
Save 17,349
Per Person
View Trip
8 Day Adriatic Reflections with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Trieste
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 10 April 2027
Visit: Italy, Sicily, Greece, Montenegro, Croatia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,849
Oceanview
$3,349
Balcony
$3,699
Suite
$5,049
From
US$2,849
Save 2,849
Per Person
View Trip
11 Day Best Of Greece with Regent Seven Seas
Cruise

11 Days (10 Nights) Athens to Athens
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 10 October 2027
Visit: Greece, Sicily, Tunisia, Malta, Turkey
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,899
Suite
$12,099
From
US$10,899
Save 10,899
Per Person
View Trip
8 Day Rome to Barcelona with Silversea
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Nova
Departure: 23 November 2026
Visit: Italy, Sicily, Tunisia, Sardinia, Spain
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,000
Suite
$8,000
From
US$5,000
Save 1,500
Per Person
View Trip
11 Day Fusina (Venice) to Nice with Silversea
Cruise

11 Days (10 Nights) Venice to Nice
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 07 May 2027
Visit: Italy, Croatia, Sicily, Malta, France
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$6,700
Balcony
$8,100
Suite
$13,100
From
US$6,700
Save 1,500
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

22 Days (21 Nights) Santos to Valencia
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visit: Brazil, Spain, France, Italy, Sicily
Inside
$1,503
Oceanview
$1,723
Balcony
$2,293
Suite
-
From
US$1,503
Per Person
View Trip
10 Day A Journey To Spain's Icons & North Africa's Sunlit Shores with Explora Journeys
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 02 February 2027
Visit: Italy, Sicily, Tunisia, Algeria, Spain
Inside
-
Oceanview
-
Balcony
-
Suite
$4,865
From
US$4,865
Per Person
View Trip
15 Day Western Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 10 August 2026
Visit: Italy, Spain, France, Sardinia, Sicily
Inside
$2,859
Oceanview
$3,159
Balcony
$3,669
Suite
$7,889
From
US$2,859
Per Person
View Trip
11 Day Adriatic Antiquities: Italy & Croatia with Holland America
Cruise
 (3)

11 Days (10 Nights) Rome to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 11 September 2027
Visit: Italy, Sicily, Greece, Montenegro, Croatia
Book Early & Have It All Fare Option
Inside
$2,094
Oceanview
$2,164
Balcony
$3,244
Suite
$4,264
From
US$2,094
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Genoa to Genoa
Cruise Line: MSC Cruises
Ships: MSC World Asia, MSC World Europa
Departures: Apr 2026 to Mar 2028
Visit: Italy, Sicily, Malta, Spain, France
Inside
$781
Oceanview
$981
Balcony
$1,101
Suite
$1,841
From
US$781
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Naples to Naples
Cruise Line: MSC Cruises
Ships: MSC World Asia, MSC World Europa
Departures: Apr 2026 to Oct 2027
Visit: Italy, Sicily, Malta, Spain, France
Inside
$964
Oceanview
$1,424
Balcony
$1,424
Suite
$2,300
From
US$964
Per Person
View Trip
8 Day Adriatic & Greece From Bologna To Rome with Norwegian Cruise Line
Cruise

8 Days (7 Nights) Bologna to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Gem
Departure: 21 June 2026
Visit: Italy, Croatia, Montenegro, Greece, Sicily
Inside
$959
Oceanview
$1,129
Balcony
$1,779
Suite
$2,029
From
US$959
Per Person
View Trip
18 Day Adriatic Splendor: Amalfi Coast With History Channel with Holland America
Cruise
 (3)

18 Days (17 Nights) Athens to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 04 September 2027
Visit: Greece, Montenegro, Sicily, Italy, Croatia
Book Early & Have It All Fare Option
Inside
$3,264
Oceanview
$3,504
Balcony
$4,834
Suite
$6,784
From
US$3,264
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Visit: Spain, Corsica, Sicily, Italy, France
Bonus Onboard Credit
Inside
$3,049
Oceanview
$2,869
Balcony
$3,639
Suite
-
From
US$2,869
Per Person
View Trip
15 Day Mediterranean Cruise: Spain, France & Italy with Azamara Cruises
Cruise
 (8)

15 Days (14 Nights) Barcelona to Athens
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 28 November 2026
Visit: Spain, France, Italy, Sicily, Greece
Azamara Always Included
Inside
$3,969
Oceanview
$4,529
Balcony
$5,239
Suite
$8,349
From
US$3,969
Per Person
View Trip
22 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise
 (1)

22 Days (21 Nights) Rome to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 14 September 2026
Visit: Italy, France, Sicily, Greece, Turkey
Bonus Onboard Credit
Inside
-
Oceanview
-
Balcony
$5,499
Suite
$9,439
From
US$5,499
Per Person
View Trip
7 Day Valletta to Nice with Silversea
Cruise

7 Days (6 Nights) Valletta to Nice
Cruise Line: Silversea
Ship: Silver Shadow
Departures: May 2026 to Jun 2026
Visit: Malta, Sicily, Italy, Corsica, France
All-Inclusive Plus Fare
Last Minute Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$4,350
Balcony
$4,550
Suite
-
From
US$4,350
Save 1,500
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Valletta to Valletta
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Apr 2027 to Oct 2027
Visit: Malta, Spain, France, Italy, Sicily
Inside
$1,046
Oceanview
$1,186
Balcony
$1,326
Suite
$2,286
From
US$1,046
Per Person
View Trip
8 Day Mediterranean with Greece & Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Athens to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Oct 2026 to Oct 2026
Visit: Greece, Montenegro, Sicily, Italy, Spain
Princess Standard
Sanctuary Collection
Inside
$1,029
Oceanview
$1,359
Balcony
$1,524
Suite
$1,829
From
US$1,029
Per Person
View Trip
11 Day Italian & Aegean Idyll with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Athens
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 01 May 2026
Visit: Italy, Sicily, Tunisia, Greece, Turkey
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,499
Oceanview
$3,749
Balcony
-
Suite
-
From
US$3,499
Save 3,499
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Genoa to Genoa
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Apr 2027 to Jan 2028
Visit: Italy, Sicily, Malta, Spain, France
Inside
$839
Oceanview
$999
Balcony
$1,129
Suite
$1,649
From
US$839
Per Person
View Trip
12 Day Mediterranean with Greek Isles & Italy with Princess
Cruise
 (6)

12 Days (11 Nights) Istanbul to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Jul 2027 to Aug 2027
Visit: Turkey, Greece, Sicily, Italy, Spain
Princess Standard
Sanctuary Collection
Inside
$1,484
Oceanview
$1,795
Balcony
$2,020
Suite
$2,570
From
US$1,484
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Naples
Cruise Line: MSC Cruises
Ships: MSC World Asia, MSC World Europa
Departures: Apr 2026 to Apr 2027
Visit: Italy, Sicily, Malta, Spain, France
Inside
$1,104
Oceanview
$1,264
Balcony
$1,364
Suite
$2,094
From
US$1,104
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Messina to Messina
Cruise Line: MSC Cruises
Ships: MSC World Asia, MSC World Europa
Departures: Apr 2026 to Oct 2027
Visit: Sicily, Malta, Spain, France, Italy
Inside
$791
Oceanview
$1,226
Balcony
$1,111
Suite
$2,386
From
US$791
Per Person
View Trip
15 Day Mediterranean, Greece And Turkey with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 01 October 2027
Visit: Spain, Sicily, Greece, Turkey, Italy
Bonus Onboard Credit
Inside
$2,399
Oceanview
$2,699
Balcony
$2,859
Suite
$5,539
From
US$2,399
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Marseille to Marseille
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 08 November 2027
Visit: France, Italy, Sicily, Malta, Spain
Inside
$1,021
Oceanview
$1,181
Balcony
$1,311
Suite
$1,831
From
US$1,021
Per Person
View Trip
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