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Panama Tours & Cruises Starting In October 2025

If you're looking at joining a tour to Panama in October 2025, we have 29 unique cruises, small group tours and adventures with 293 departures from the world's leading tour operators departing in October.
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Departures (October 2025)
< September 2025 November 2025 >
Duration
6 Days
58 Days
Types
Budget
Start & End Cities
Operators
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Price
$100pp
$169,995pp
Countries
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29 Trips (293 Trip Departures)
6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operated By: Globus
Departures: Jun 2025 to Mar 2026
Trip Styles: Short Break, Scenic
Countries Visited: Panama
Flash Sale
Save (per person) 56
From (per person) 1,709
View Trip
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: Jun 2025 to Dec 2026
Trip Styles: Adventure, Small Group
Countries Visited: Costa Rica, Panama
Exclusive Deal
Save (per person) 508
From (per person) 1,522
View Trip
14 Day Cycle Nicaragua to the Panama Canal with Explore!
Tour

14 Days Granada to Panama City
Operated By: Explore!
Departures: Nov 2025 to Nov 2026
Trip Styles: Adventure, Small Group, Cycling
Countries Visited: Costa Rica, Panama, Nicaragua
Sign Up Savings
Save (per person) 571
From (per person) 4,181
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Jewel of the Seas, Serenade of the Seas
Departures: Oct 2025 to Jan 2027
Countries Visited: Panama, Colombia, Curacao, Aruba
Latest Offer
INSIDE
$909
OCEANVIEW
$949
BALCONY
$1,072
SUITE
$1,406
Save (per person) 757
From (per person) 909
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ships: Jewel of the Seas, Serenade of the Seas
Departures: Oct 2025 to Apr 2027
Countries Visited: Colombia, Aruba, Curacao, Panama
Latest OfferExclusive Solo Offer
INSIDE
$887
OCEANVIEW
$927
BALCONY
$1,049
SUITE
$1,364
Save (per person) 907
From (per person) 887
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ships: Jewel of the Seas, Serenade of the Seas
Departures: Oct 2025 to Jan 2027
Countries Visited: Colombia, Curacao, Aruba, Panama
Latest OfferExclusive Solo Offer
INSIDE
$977
OCEANVIEW
$1,028
BALCONY
$1,150
SUITE
$1,515
Save (per person) 907
From (per person) 977
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Jewel of the Seas, Serenade of the Seas
Departures: Oct 2025 to Apr 2027
Countries Visited: Panama, Colombia, Aruba, Curacao
Latest Offer
INSIDE
$829
OCEANVIEW
$859
BALCONY
$981
SUITE
$1,276
Save (per person) 693
From (per person) 829
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (2)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ships: Coral Princess, Island Princess
Departures: Oct 2025 to Apr 2027
Countries Visited: USA, Mexico, Costa Rica, Panama (+1 more), Aruba
Summer Swing Sale
INSIDE
$1,299
OCEANVIEW
$1,429
BALCONY
$1,909
SUITE
$2,735
From (per person) 1,299
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Island Princess
Departure: 22 October 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+1 more), Curacao
Summer Swing Sale
INSIDE
$1,549
OCEANVIEW
$1,599
BALCONY
$2,179
SUITE
$2,349
From (per person) 1,549
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Fort Lauderdale to Panama City
Operated By: Viking Cruises
Ship: Viking Mars
Departures: Oct 2025 to Dec 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Viking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$3,499
SUITE
$5,499
Save (per person) 500
From (per person) 3,499
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Fort Lauderdale to Santiago
Operated By: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2025 to Nov 2026
Countries Visited: USA, Mexico, Panama, Ecuador (+2 more), Peru, Chile
FLY FREE With VikingViking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,995
SUITE
$14,995
Save (per person) 1,500
From (per person) 7,995
View Trip
24 Day Panama Canal & Pacific Coast with Princess
Cruise
 (2)

24 Days (23 Nights) Vancouver to Fort Lauderdale
Cruise Line: Princess
Ship: Coral Princess
Departure: 21 October 2025
Countries Visited: Canada, USA, Mexico, Costa Rica (+2 more), Panama, Aruba
Summer Swing Sale
INSIDE
-
OCEANVIEW
$2,309
BALCONY
$2,919
SUITE
$4,069
From (per person) 2,309
View Trip
28 or 27 Day Amazing Central America with Intrepid Travel
Tour

28 or 27 Days Antigua to Panama City
Operated By: Intrepid Travel
Departures: Jun 2025 to Dec 2026
Trip Styles: Adventure, Small Group
Countries Visited: Guatemala, Honduras, El Salvador, Nicaragua (+2 more), Costa Rica, Panama
Exclusive Deal
Save (per person) 914
From (per person) 3,316
View Trip
19 Day Panama Canal Repositioning Cruise From San Francisco To Miami with Norwegian Cruise Line
Cruise

19 Days (18 Nights) San Francisco to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Joy
Departure: 02 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
INSIDE
$1,789
OCEANVIEW
$2,099
BALCONY
$2,659
SUITE
$2,969
From (per person) 1,789
View Trip
17 Day Panama Canal Repositioning Cruise From Los Angeles To Miami with Norwegian Cruise Line
Cruise

17 Days (16 Nights) Los Angeles to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Encore
Departure: 23 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
INSIDE
$2,149
OCEANVIEW
$2,519
BALCONY
$2,899
SUITE
$3,179
From (per person) 2,149
View Trip
21 Day Panama Canal Repositioning Cruise From Seattle To Miami with Norwegian Cruise Line
Cruise

21 Days (20 Nights) Seattle to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Encore
Departure: 19 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
INSIDE
$2,298
OCEANVIEW
$2,668
BALCONY
$3,228
SUITE
$3,578
From (per person) 2,298
View Trip
19 Day Panama Canal Repositioning Cruise From San Francisco To Miami with Norwegian Cruise Line
Cruise

19 Days (18 Nights) San Francisco to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Encore
Departure: 21 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
INSIDE
$2,181
OCEANVIEW
$2,551
BALCONY
$2,932
SUITE
$3,211
From (per person) 2,181
View Trip
16 Day Panama Canal Repositioning Cruise From Los Angeles To Miami with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Los Angeles to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Joy
Departure: 05 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
INSIDE
$1,722
OCEANVIEW
$2,031
BALCONY
$2,591
SUITE
$2,901
From (per person) 1,722
View Trip
13 Day Panama Canal Sunfarer with Holland America
Cruise
 (2)

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Rotterdam
Departures: Oct 2025 to Mar 2026
Countries Visited: USA, Bahamas, Curacao, Colombia (+3 more), Panama, Costa Rica, Cayman Islands
Exclusive Deal
INSIDE
$1,149
OCEANVIEW
$1,599
BALCONY
$1,899
SUITE
$2,899
From (per person) 1,149
View Trip
13 Day Panama Canal with Costa Rica & Caribbean From Fort Lauderdale with Princess
Cruise

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Princess
Ship: Caribbean Princess
Departures: Oct 2025 to Jan 2026
Countries Visited: USA, Aruba, Curacao, Colombia (+3 more), Panama, Costa Rica, Cayman Islands
Summer Swing Sale
INSIDE
$1,099
OCEANVIEW
$1,279
BALCONY
$2,199
SUITE
$2,639
From (per person) 1,099
View Trip
17 Day Panama Canal Cruise with Royal Caribbean
Cruise

17 Days (16 Nights) San Diego to Fort Lauderdale
Cruise Line: Royal Caribbean
Ship: Radiance of the Seas
Departure: 04 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+3 more), Panama, Colombia, Cayman Islands
Latest Offer
INSIDE
$3,445
OCEANVIEW
-
BALCONY
-
SUITE
-
Save (per person) 1,359
From (per person) 3,445
View Trip
44 or 45 Day Best of Central America with Intrepid Travel
Tour
 (1)

44 or 45 Days Playa del Carmen to Panama City
Operated By: Intrepid Travel
Departures: May 2025 to Nov 2026
Trip Styles: Adventure, Small Group
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Deal
Save (per person) 1,470
From (per person) 5,033
View Trip
58 or 59 Day Ultimate Central America with Intrepid Travel
Tour

58 or 59 Days Mexico City to Panama City
Operated By: Intrepid Travel
Departures: Jun 2025 to Nov 2026
Trip Styles: Adventure, Small Group
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Deal
Save (per person) 2,067
From (per person) 7,154
View Trip
45 Day Epic Central America with Intrepid Travel
Tour

45 Days Mexico City to San Jose
Operated By: Intrepid Travel
Departures: Jun 2025 to Dec 2025
Trip Styles: Adventure, Small Group, 18-30's
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Deal
Save (per person) 648
From (per person) 4,212
View Trip
22 Day Panama Canal & Southern Caribbean: ABC Islands with Holland America
Cruise
 (2)

22 Days (21 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Rotterdam
Departures: Oct 2025 to Mar 2026
Countries Visited: USA, Bahamas, Curacao, Colombia (+5 more), Panama, Costa Rica, Cayman Islands, Bonaire, Aruba
Exclusive Deal
INSIDE
$1,969
OCEANVIEW
$2,449
BALCONY
$3,169
SUITE
$4,559
From (per person) 1,969
View Trip
47 Day The Americas, Chile & Antarctica with Viking Cruises
Cruise

47 Days (46 Nights) Fort Lauderdale to Buenos Aires
Operated By: Viking Cruises
Ship: Viking Octantis
Departure: 13 October 2025
Countries Visited: USA, Mexico, Panama, Ecuador (+6 more), Peru, Chile, Argentina, Antarctica, South Georgia Island, Falkland Islands
Viking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$37,485
SUITE
$116,885
Save (per person) 1,500
From (per person) 37,485
View Trip
25 Day Panama Canal & Eastern Caribbean with Holland America
Cruise

25 Days (24 Nights) San Diego to Fort Lauderdale
Cruise Line: Holland America
Ship: Eurodam
Departure: 09 October 2025
Countries Visited: USA, Mexico, Guatemala, El Salvador (+7 more), Costa Rica, Panama, Aruba, Turks and Caicos Islands, Puerto Rico, Virgin Islands, Bahamas
Exclusive Deal
INSIDE
$2,599
OCEANVIEW
$2,689
BALCONY
$4,049
SUITE
$8,019
From (per person) 2,599
View Trip
30 Day Panama Canal & Eastern Caribbean with Holland America
Cruise

30 Days (29 Nights) Seattle to Fort Lauderdale
Cruise Line: Holland America
Ship: Eurodam
Departure: 04 October 2025
Countries Visited: USA, Canada, Mexico, Guatemala (+8 more), El Salvador, Costa Rica, Panama, Aruba, Turks and Caicos Islands, Puerto Rico, Virgin Islands, Bahamas
Exclusive Deal
INSIDE
$3,099
OCEANVIEW
$3,239
BALCONY
$4,569
SUITE
$8,839
From (per person) 3,099
View Trip
29 Day Panama Canal & Eastern Caribbean with Holland America
Cruise

29 Days (28 Nights) Vancouver to Fort Lauderdale
Cruise Line: Holland America
Ship: Eurodam
Departure: 05 October 2025
Countries Visited: Canada, USA, Mexico, Guatemala (+8 more), El Salvador, Costa Rica, Panama, Aruba, Turks and Caicos Islands, Puerto Rico, Virgin Islands, Bahamas
Exclusive Deal
INSIDE
$2,914
OCEANVIEW
$3,044
BALCONY
$4,374
SUITE
$8,564
From (per person) 2,914
View Trip
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