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Panama Tours & Cruises Starting In October 2025

If you're looking at joining a tour to Panama in October 2025, we have 16 unique cruises, small group tours and adventures with 229 departures from the world's leading tour operators departing in October.
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Departures (October 2025)
< September 2025 November 2025 >
Duration
11 Days
47 Days
Types
Start & End Cities
Operators
Price
$1,300pp
$132,495pp
Countries
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16 Trips (229 Trip Departures)
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: May 2024 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Costa Rica, Panama
Limited Time Sale
Save 302
From 1,608
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14 Day Cycle Nicaragua to the Panama Canal with Explore!
Tour

14 Days Granada to Panama City
Operated By: Explore!
Departures: Oct 2024 to Nov 2025
Trip Styles: Adventure, Small Group, Cycling
Countries Visited: Costa Rica, Panama, Nicaragua
Exclusive Savings
Save 147
From 7,203
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17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (1)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ships: Coral Princess, Island Princess
Departures: Feb 2025 to Feb 2026
Countries Visited: USA, Mexico, Nicaragua, Costa Rica (+2 more), Panama, Aruba
INSIDE
$2,603
OCEANVIEW
$2,848
BALCONY
$3,699
SUITE
$4,708
From 2,603
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (1)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ships: Coral Princess, Island Princess
Departures: Dec 2024 to Oct 2025
Countries Visited: USA, Mexico, Nicaragua, Costa Rica (+2 more), Panama, Curacao
INSIDE
$2,775
OCEANVIEW
$3,038
BALCONY
$4,088
SUITE
$4,631
From 2,775
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (4)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Oct 2024 to Dec 2025
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$5,440
SUITE
$8,410
Save 1,073
From 5,440
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18 Day Panama & Scenic South America with Viking Cruises
Cruise

18 Days (17 Nights) Fort Lauderdale to Santiago
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2024 to Oct 2025
Countries Visited: USA, Mexico, Panama, Ecuador (+2 more), Peru, Chile
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$14,845
SUITE
$20,785
Save 1,150
From 14,845
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19 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

19 Days (18 Nights) San Francisco to Miami
Ship: Norwegian Joy
Departure: 02 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
Free At Sea Offer
INSIDE
$5,092
OCEANVIEW
$6,079
BALCONY
$6,686
SUITE
$7,672
From 5,092
View Trip
16 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Los Angeles to Miami
Ships: Norwegian Bliss, Norwegian Encore (+1 more), Norwegian Joy
Departures: Oct 2025 to Feb 2026
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
Free At Sea OfferExclusive Solo Offer
INSIDE
$4,177
OCEANVIEW
$5,164
BALCONY
$5,737
SUITE
$6,496
From 4,177
View Trip
28 Day Amazing Central America with Intrepid Travel
Tour

28 Days Antigua to Panama City
Operated By: Intrepid Travel
Departures: May 2024 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Guatemala, Honduras, El Salvador, Nicaragua (+2 more), Costa Rica, Panama
Limited Time Sale
Save 655
From 3,480
View Trip
15 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

15 Days (14 Nights) San Diego to Miami
Ship: Norwegian Jade
Departure: 18 October 2025
Countries Visited: USA, Mexico, Guatemala, Panama (+2 more), Colombia, Cayman Islands
Free At Sea Offer
INSIDE
$4,186
OCEANVIEW
$4,870
BALCONY
$6,615
SUITE
$7,375
From 4,186
View Trip
24 Day Panama Canal & Pacific Coast with Princess
Cruise
 (1)

24 Days (23 Nights) Vancouver to Fort Lauderdale
Cruise Line: Princess
Ship: Coral Princess
Departure: 21 October 2025
Countries Visited: Canada, USA, Mexico, Nicaragua (+3 more), Costa Rica, Panama, Aruba
INSIDE
$4,203
OCEANVIEW
$4,607
BALCONY
$5,965
SUITE
$6,892
From 4,203
View Trip
13 Day Panama Canal with Costa Rica & Caribbean with Princess
Cruise

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Princess
Ships: Caribbean Princess, Emerald Princess
Departures: Oct 2024 to Mar 2026
Countries Visited: USA, Aruba, Curacao, Colombia (+3 more), Panama, Costa Rica, Cayman Islands
INSIDE
$1,747
OCEANVIEW
$1,885
BALCONY
$2,975
SUITE
$3,599
From 1,747
View Trip
44 Day Best of Central America with Intrepid Travel
Tour
 (1)

44 Days Playa del Carmen to Panama City
Operated By: Intrepid Travel
Departures: May 2024 to Nov 2025
Trip Styles: Adventure, Small Group
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Limited Time Sale
Save 758
From 6,192
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18 Day West Indies & Panama Canal Passage with Viking Cruises
New ReleaseCruise
 (4)

18 Days (17 Nights) Los Angeles to San Juan
Cruise Line: Viking Cruises
Ship: Viking Sea
Departure: 02 October 2025
Countries Visited: USA, Mexico, Nicaragua, Costa Rica (+4 more), Panama, Colombia, Curacao, Puerto Rico
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$9,895
SUITE
$19,795
Save 1,100
From 9,895
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41 Day The Americas & Antarctic Explorer with Viking Cruises
Cruise

41 Days (40 Nights) Fort Lauderdale to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departures: Oct 2024 to Oct 2025
Countries Visited: USA, Mexico, Panama, Ecuador (+4 more), Peru, Chile, Argentina, Antarctica
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$44,545
SUITE
$64,345
Save 2,470
From 44,545
View Trip
47 Day The Americas, Chile & Antarctica with Viking Cruises
Cruise

47 Days (46 Nights) Fort Lauderdale to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Octantis
Departure: 13 October 2025
Countries Visited: USA, Mexico, Panama, Ecuador (+6 more), Peru, Chile, Argentina, Antarctica, South Georgia Island, Falkland Islands
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$52,465
SUITE
$79,195
Save 2,530
From 52,465
View Trip
Results: 16 results

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Central America Tours

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