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Panama Tours & Cruises Starting In May 2025

If you're looking at joining a tour to Panama in May 2025, we have 8 unique cruises, small group tours and adventures with 196 departures from the world's leading tour operators departing in May.
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Departures (May 2025)
< April 2025 June 2025 >
Duration
8 Days
44 Days
Types
Budget
Start & End Cities
Operators
Price
$1,600pp
$161,495pp
Countries
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8 Trips (196 Trip Departures)
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: May 2024 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Costa Rica, Panama
Limited Time Sale
Save 302
From 1,608
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8 Day Panama City to Fort Lauderdale with Silversea
Cruise

8 Days (7 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 20 May 2025
Countries Visited: Panama, Colombia, USA
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$4,158
BALCONY
$5,049
SUITE
-
From 4,158
View Trip
12 Day Los Angeles to Panama City with Silversea
Cruise

12 Days (11 Nights) Los Angeles to Panama City
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 09 May 2025
Countries Visited: USA, Mexico, Costa Rica, Panama
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$6,138
BALCONY
$7,326
SUITE
-
From 6,138
View Trip
19 Day Los Angeles to Fort Lauderdale with Silversea
Cruise

19 Days (18 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 09 May 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+1 more), Colombia
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$14,058
BALCONY
$15,345
SUITE
$24,948
From 14,058
View Trip
19 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (2)

19 Days (18 Nights) Los Angeles to New York
Cruise Line: Princess
Ship: Island Princess
Departures: May 2025 to May 2026
Countries Visited: USA, Mexico, Nicaragua, Costa Rica (+2 more), Panama, Aruba
INSIDE
$3,093
OCEANVIEW
$3,213
BALCONY
$4,330
SUITE
$5,403
From 3,093
View Trip
28 Day Amazing Central America with Intrepid Travel
Tour

28 Days Antigua to Panama City
Operated By: Intrepid Travel
Departures: May 2024 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Guatemala, Honduras, El Salvador, Nicaragua (+2 more), Costa Rica, Panama
Exclusive Savings
Save 96
From 4,052
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44 Day Best of Central America with Intrepid Travel
Tour
 (1)

44 Days Playa del Carmen to Panama City
Operated By: Intrepid Travel
Departures: May 2024 to Nov 2025
Trip Styles: Adventure, Small Group
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Limited Time Sale
Save 758
From 6,192
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34 Day Los Angeles to New York with Silversea
Cruise

34 Days (33 Nights) Los Angeles to New York
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 09 May 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+5 more), Colombia, Aruba, Jamaica, Virgin Islands, Bermuda
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$13,959
BALCONY
$17,622
SUITE
$40,194
From 13,959
View Trip
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