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Panama Tours & Cruises Starting In April 2025

If you're looking at joining a tour to Panama in April 2025, we have 17 unique cruises, small group tours and adventures with 215 departures from the world's leading tour operators departing in April.
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Departures (April 2025)
< March 2025 May 2025 >
Duration
11 Days
44 Days
Types
Budget
Start & End Cities
Operators
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Price
$1,500pp
$261,495pp
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17 Trips (215 Trip Departures)
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: May 2024 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Costa Rica, Panama
Limited Time Sale
Save 302
From 1,608
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18 Day Panama Canal & the Pacific Coast with Viking Cruises
Cruise

18 Days (17 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Neptune
Departure: 05 April 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+1 more), Colombia
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$10,885
SUITE
$20,785
Save 1,110
From 10,885
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18 Day Pacific Latin America — Ancient Wonders And National Parks with Hurtigruten
Cruise

18 Days (17 Nights) Valparaiso to Puntarenas
Cruise Line: Hurtigruten
Ship: MS Roald Amundsen
Departure: 04 April 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+1 more), Costa Rica
Exclusive Deal
INSIDE
-
OCEANVIEW
$13,547
BALCONY
$16,121
SUITE
$19,238
Save 6,877
From 13,547
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17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (1)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ships: Coral Princess, Island Princess
Departures: Mar 2025 to Feb 2026
Countries Visited: USA, Aruba, Panama, Costa Rica (+2 more), Nicaragua, Mexico
INSIDE
$2,546
OCEANVIEW
$2,791
BALCONY
$3,651
SUITE
$4,877
From 2,546
View Trip
17 Day Panama Canal Westward Cruise with Royal Caribbean
Cruise

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 13 April 2025
Countries Visited: USA, Cayman Islands, Colombia, Panama (+2 more), Guatemala, Mexico
Exclusive Deal
INSIDE
$3,624
OCEANVIEW
$3,843
BALCONY
$5,569
SUITE
-
Save 1,208
From 3,157
View Trip
19 Day Fort Lauderdale to Los Angeles with Silversea
Cruise

19 Days (18 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Silversea
Ship: Silver Moon
Departure: 01 April 2025
Countries Visited: Colombia, Costa Rica, Guatemala, Mexico (+2 more), Panama, USA
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$13,662
BALCONY
$15,147
SUITE
$26,334
From 13,662
View Trip
12 Day Panama Canal & Southern Caribbean with Celebrity Cruises
Cruise

12 Days (11 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ships: Celebrity Ascent, Celebrity Beyond
Departures: Jan 2025 to Mar 2026
Countries Visited: USA, Colombia, Panama, Aruba (+2 more), Curacao, Bonaire
Exclusive DealExclusive Offer
INSIDE
$2,795
OCEANVIEW
$2,982
BALCONY
$3,777
SUITE
$10,020
Save 3,623
From 2,795
View Trip
25 Day Central American Explorer with Explore!
Tour

25 Days Panama City to Antigua
Operated By: Explore!
Departures: Jan 2025 to Nov 2025
Trip Styles: Adventure, Small Group
Countries Visited: Panama, Costa Rica, Nicaragua, El Salvador (+2 more), Honduras, Guatemala
Exclusive Savings
Save 176
From 8,399
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17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Orlando to Los Angeles
Cruise Line: Princess
Ship: Caribbean Princess
Departure: 14 April 2025
Countries Visited: USA, Bahamas, Colombia, Panama (+2 more), Costa Rica, Mexico
INSIDE
$2,424
OCEANVIEW
$2,650
BALCONY
$3,651
SUITE
$5,413
From 2,424
View Trip
16 Day Panama Canal Cruise with Royal Caribbean
Cruise

16 Days (15 Nights) Tampa to Los Angeles
Cruise Line: Royal Caribbean
Ship: Radiance of the Seas
Departure: 19 April 2025
Countries Visited: USA, Cayman Islands, Colombia, Panama (+2 more), Guatemala, Mexico
Exclusive Deal
INSIDE
$2,837
OCEANVIEW
$3,090
BALCONY
$4,885
SUITE
-
Save 935
From 2,492
View Trip
28 Day Amazing Central America with Intrepid Travel
Tour

28 Days Antigua to Panama City
Operated By: Intrepid Travel
Departures: May 2024 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Guatemala, Honduras, El Salvador, Nicaragua (+2 more), Costa Rica, Panama
Exclusive Savings
Save 96
From 4,052
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11 Day Captivating Panama Canal with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 April 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+3 more), Bonaire, Jamaica, USA
Exclusive Deal
INSIDE
$5,147
OCEANVIEW
$5,533
BALCONY
$7,751
SUITE
$10,285
Save 2,033
From 5,147
View Trip
24 Day Panama Canal & Pacific Coast with Princess
Cruise
 (1)

24 Days (23 Nights) Fort Lauderdale to Vancouver
Cruise Line: Princess
Ship: Coral Princess
Departure: 10 April 2025
Countries Visited: USA, Aruba, Panama, Costa Rica (+3 more), Nicaragua, Mexico, Canada
INSIDE
$3,722
OCEANVIEW
$4,443
BALCONY
$6,242
SUITE
$6,646
From 3,722
View Trip
26 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

26 Days (25 Nights) Tampa to Whittier
Ship: Norwegian Jade
Departure: 03 April 2025
Countries Visited: USA, Colombia, Panama, Costa Rica (+3 more), Nicaragua, Guatemala, Mexico
Free At Sea Offer
INSIDE
$6,265
OCEANVIEW
$6,949
BALCONY
$9,682
SUITE
$11,427
From 6,265
View Trip
17 Day Panama Canal Westward Cruise with Celebrity Cruises
Cruise

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Celebrity Cruises
Ship: Celebrity Summit
Departure: 17 April 2025
Countries Visited: USA, Cayman Islands, Colombia, Panama (+3 more), Costa Rica, Guatemala, Mexico
Exclusive Deal
INSIDE
$3,215
OCEANVIEW
$3,983
BALCONY
$6,076
SUITE
$26,800
Save 4,698
From 3,215
View Trip
22 Day Panama Canal & Pacific Coast with Princess
Cruise

22 Days (21 Nights) Orlando to Vancouver
Cruise Line: Princess
Ship: Caribbean Princess
Departure: 14 April 2025
Countries Visited: USA, Bahamas, Colombia, Panama (+3 more), Costa Rica, Mexico, Canada
INSIDE
$3,104
OCEANVIEW
$3,374
BALCONY
$4,619
SUITE
$6,737
From 3,104
View Trip
44 Day Best of Central America with Intrepid Travel
Tour
 (1)

44 Days Playa del Carmen to Panama City
Operated By: Intrepid Travel
Departures: May 2024 to Nov 2025
Trip Styles: Adventure, Small Group
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Limited Time Sale
Save 418
From 6,365
View Trip
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