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Tours from Rome to Palermo

Are you looking for a tour from Rome to Palermo? September is the most popular month to tour between Rome and Palermo and there are 200 departures available from five of the world's leading tour operators.
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10 Tours (200 Tour Departures)
17 Day Grand Italy & Sicily with Insight Vacations
Tour
 (13)

17 Days Rome to Palermo
Operated By: Insight Vacations
Departures: Apr 2026 to Oct 2027
Trip Styles: Coach, Scenic
Visit: Italy, Sicily
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US$6,534
Save 845
Per Person
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14 Day Country Roads of Southern Italy & Sicily with Insight Vacations
Tour
 (8)

14 Days Rome to Palermo
Operated By: Insight Vacations
Departures: Apr 2026 to Oct 2027
Trip Styles: Coach, Scenic
Visit: Italy, Sicily
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Exclusive Savings
From
US$5,175
Save 600
Per Person
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14 Day Highlights of Sicily & Southern Italy with Globus
Tour
 (5)

14 Days Rome to Palermo
Operated By: Globus
Departures: Apr 2026 to Nov 2027
Trip Styles: Coach, Scenic
Visit: Italy, Sicily
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From
US$4,149
Save 150
Per Person
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10 Day Southern Italy and Sicily with Trafalgar
Tour
 (2)

10 Days Rome to Palermo
Operated By: Trafalgar
Departures: Apr 2026 to Oct 2027
Trip Styles: Coach, Scenic
Visit: Italy, Sicily
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Exclusive Savings
From
US$3,425
Save 150
Per Person
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17 Day Grand Italy & Sicily (Small Group) with Insight Vacations
Tour

17 Days Rome to Palermo
Operated By: Insight Vacations
Departure: 15 May 2026
Trip Styles: Coach, Small Group, Scenic
Visit: Italy, Sicily
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From
US$9,945
Save 150
Per Person
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22 Day Ultimate Italy with Contiki
Tour

22 Days Rome to Palermo
Operated By: Contiki
Departures: Apr 2026 to Sep 2026
Trip Styles: Coach, 18-30's, Scenic
Visit: Italy, Sicily
Exclusive Savings
From
US$4,578
Save 543
Per Person
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13 Day Italian Escape & Sicily (Ages 27 to 35) with Contiki
Tour

13 Days Rome to Palermo
Operated By: Contiki
Departures: Jun 2026 to Sep 2027
Trip Styles: Coach, 18-30's, Scenic
Visit: Italy, Sicily
Exclusive Savings
From
US$2,710
Save 322
Per Person
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13 Day Italian Escape & Sicily with Contiki
Tour

13 Days Rome to Palermo
Operated By: Contiki
Departures: May 2026 to Sep 2027
Trip Styles: Coach, 18-30's, Scenic
Visit: Italy, Sicily
Exclusive Savings
From
US$2,848
Save 345
Per Person
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23 Day Rome to Sicily with Intrepid Travel
Tour

23 Days Rome to Palermo
Operated By: Intrepid Travel
Departures: Jul 2026 to Oct 2027
Trip Styles: Adventure, Small Group, Rail
Visit: Italy, Sicily
From
US$8,265
Per Person
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22 Day Ultimate Italy (Ages 27 to 35) with Contiki
Tour

22 Days Rome to Palermo
Operated By: Contiki
Departures: Jun 2026 to Sep 2026
Trip Styles: Coach, 18-30's, Scenic
Visit: Italy, Sicily
Exclusive Savings
From
US$4,658
Save 502
Per Person
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Results: 10 results

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Italy & Sicily

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Trip Lengths

10 Day 2 Week 7 Day

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April May June July August September October November March

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Routes

Tours from Rome to Palermo

Popular Italy Operators

APT Italy Tours CIE Italy Tours Collette Italy Tours Cosmos Italy Tours Costsaver Italy Tours Exodus Italy Tours Explore's Italy Tours G Adventures Italy Tours Globus Italy Tours Insight Vacations Italy Tours Intrepid Italy Tours Trafalgar Italy Tours

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