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Cruises from San Diego

Choose from 75 unique cruises starting in San Diego, and traveling to Buenos Aires, Fort Lauderdale, London, Miami, Santiago and more. December and January are the most popular months to join a cruise from San Diego and you can select from 135 departures available from five leading cruise lines.
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37 Days
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75 Cruises (135 Cruise Departures)
5 Day Catalina & Ensenada Cruise with Royal Caribbean
Cruise

5 Days (4 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2026 to Apr 2027
Visit: USA, Mexico
Bonus Onboard Credit
Exclusive Savings
Inside
$376
Oceanview
$455
Balcony
$515
Suite
$688
From
US$376
Save 209
Per Person
View Trip
7 Day Pacific Coastal Cruise with Holland America
Cruise

7 Days (6 Nights) San Diego to Vancouver
Cruise Line: Holland America
Ship: Eurodam
Departure: 17 April 2027
Visit: USA, Canada
Fare Saver
Inside
$799
Oceanview
$849
Balcony
$1,099
Suite
$1,699
From
US$799
Per Person
View Trip
8 Day Cabo Overnight, Catalina & Ensenada with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 13 December 2026
Visit: USA, Mexico
Exclusive Savings
Inside
$517
Oceanview
$637
Balcony
$787
Suite
$1,286
From
US$517
Save 334
Per Person
View Trip
16 Day Panama Canal Eastward Cruise with Royal Caribbean
Cruise

16 Days (15 Nights) San Diego to Tampa
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 07 October 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia, Cayman Islands
Bonus Onboard Credit
Exclusive Savings
Inside
$1,777
Oceanview
$2,216
Balcony
$3,019
Suite
$5,539
From
US$1,777
Save 716
Per Person
View Trip
8 Day Cabo, Mazatlan & La Paz Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2026 to Dec 2026
Visit: USA, Mexico
Exclusive Savings
Inside
$866
Oceanview
$977
Balcony
$1,263
Suite
$1,887
From
US$866
Save 559
Per Person
View Trip
8 Day Ensenada, Cabo & Mazatlan with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2026 to Feb 2027
Visit: USA, Mexico
Bonus Onboard Credit
Exclusive Savings
Inside
$437
Oceanview
$636
Balcony
$780
Suite
$1,220
From
US$437
Save 344
Per Person
View Trip
5 Day Catalina & Ensenada Cruise with Royal Caribbean
Cruise

5 Days (4 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 07 March 2027
Visit: USA, Mexico
Bonus Onboard Credit
Exclusive Savings
Inside
$414
Oceanview
$495
Balcony
$605
Suite
$764
From
US$414
Save 192
Per Person
View Trip
8 Day Mexican Riviera From San Diego To San Diego with Norwegian Cruise Line
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Star
Departures: Dec 2026 to Feb 2027
Visit: USA, Mexico
Inside
$659
Oceanview
$709
Balcony
$1,079
Suite
$1,179
From
US$659
Per Person
View Trip
7 Day Pacific Coastal Cruise with Holland America
Cruise

7 Days (6 Nights) San Diego to Vancouver
Cruise Line: Holland America
Ship: Eurodam
Departure: 17 April 2028
Visit: USA, Canada
Book Early & Have It All Fare Option
Inside
$829
Oceanview
$929
Balcony
$1,229
Suite
$1,679
From
US$829
Per Person
View Trip
8 Day Cabo, Mazatlan & La Paz Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 27 December 2026
Visit: USA, Mexico
Exclusive Savings
Inside
$1,055
Oceanview
$1,153
Balcony
$1,712
Suite
$2,413
From
US$1,055
Save 566
Per Person
View Trip
17 Day Panama Canal with Holland America
Cruise

17 Days (16 Nights) San Diego to Fort Lauderdale
Cruise Line: Holland America
Ship: Eurodam
Departures: Oct 2026 to Oct 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Aruba
Fare Saver
Book Early & Have It All Fare Option
Inside
$1,899
Oceanview
$1,969
Balcony
$3,069
Suite
$5,239
From
US$1,899
Per Person
View Trip
8 Day Mexican Riviera with Holland America
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Holland America
Ship: Zuiderdam
Departure: 16 January 2027
Visit: USA, Mexico
Fare Saver
Inside
$849
Oceanview
$949
Balcony
$1,249
Suite
$2,299
From
US$849
Per Person
View Trip
8 Day Ensenada, Cabo & La Paz Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2026 to Apr 2027
Visit: USA, Mexico
Bonus Onboard Credit
Exclusive Savings
Inside
$537
Oceanview
$637
Balcony
$786
Suite
$1,302
From
US$537
Save 432
Per Person
View Trip
8 Day Ensenada, Cabo & La Paz Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2026 to Nov 2026
Visit: USA, Mexico
Exclusive Savings
Inside
$437
Oceanview
$637
Balcony
$786
Suite
$1,307
From
US$437
Save 292
Per Person
View Trip
3 Day Ensenada Cruise with Royal Caribbean
Cruise

3 Days (2 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 02 October 2026
Visit: USA, Mexico
Exclusive Savings
Inside
$336
Oceanview
$356
Balcony
$456
Suite
$696
From
US$336
Save 186
Per Person
View Trip
Results: 61-75 of 75

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Trip Lengths

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Departure Months

April May October November December January February March

Cities

Amsterdam Anchorage Baltimore Boston Cape Liberty Fort Lauderdale Galveston Honolulu Jacksonville Los Angeles Miami New Orleans New York Orlando Philadelphia San Diego San Francisco San Juan Seattle Seward Tampa Vancouver

Routes

Anchorage to Vancouver Baltimore to Baltimore Barcelona to Fort Lauderdale Barcelona to Miami Boston to Montreal Boston to Quebec City Boston to Boston Bridgetown to Miami Cape Liberty to Cape Liberty Fort Lauderdale to London Fort Lauderdale to Barcelona Fort Lauderdale to Fort Lauderdale Fort Lauderdale to San Diego Fort Lauderdale to Vancouver Galveston to Galveston Honolulu to Tahiti Honolulu to Vancouver Jacksonville to Jacksonville London to Fort Lauderdale London to New York Los Angeles to Miami Los Angeles to Vancouver Los Angeles to Los Angeles Miami to San Juan Miami to Lisbon Miami to Los Angeles Miami to Rome Miami to Bridgetown Miami to Panama City Miami to Barcelona Miami to Miami Miami to London Montreal to Boston Montreal to Miami Montreal to New York New Orleans to New Orleans New York to Montreal New York to New York New York to London Orlando to Orlando Panama City to Miami Philadelphia to Philadelphia Quebec City to Boston Rome to Fort Lauderdale Rotterdam to Fort Lauderdale San Diego to Fort Lauderdale San Diego to Vancouver San Diego to San Diego San Francisco to San Francisco San Juan to Miami Seattle to Vancouver Seattle to Seattle Seward to Vancouver Sydney to Honolulu Tahiti to Honolulu Tampa to Tampa Toronto to Boston Vancouver to Los Angeles Vancouver to Honolulu Vancouver to Seward Vancouver to Seattle Vancouver to Anchorage Vancouver to San Diego

Country Routes

Argentina to USA Australia to USA Barbados to USA Canada to USA Chile to USA Dominican Republic to USA England to USA France to USA French Polynesia to USA Greece to USA Holland to USA Iceland to USA Italy to USA Japan to USA New Zealand to USA Panama to USA Peru to USA Portugal to USA Puerto Rico to USA Spain to USA USA to Portugal USA to Germany USA to Iceland USA to Puerto Rico USA to Brazil USA to Dominican Republic USA to Argentina USA to Australia USA to Barbados USA to Canada USA to Chile USA to England USA to French Polynesia USA to Holland USA to Italy USA to Japan USA to Panama USA to Peru USA to Spain

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