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Mediterranean Luxury Cruises

Explore the best luxury cruises sailing in and around the Mediterranean. Choose from 604 unique cruise itineraries with 2 past traveler reviews from 10 leading cruise lines. September is the most popular month to join a luxury cruise sailing in and around the Mediterranean with 654 departures starting between February 2026 and October 2028.
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604 Cruises (654 Cruise Departures)
23 Day Mediterranean Mosaic: Croatia, Greece & Ephesus with Seabourn
Cruise

23 Days (22 Nights) Dubrovnik to Athens
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 06 August 2027
Visit: Croatia, Montenegro, Italy, Greece, Turkey
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,456
Suite
$25,452
From
US$15,456
Save 268
Per Person
View Trip
11 Day Ancient Civilizations with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 09 February 2028
Visit: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,129
Suite
$5,554
From
US$3,129
Save 3,269
Per Person
View Trip
11 Day Coastal Charisma with Oceania Cruises
Cruise

11 Days (10 Nights) Barcelona to Athens
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 08 March 2028
Visit: Spain, Italy, Sicily, Malta, Greece
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,516
Suite
$6,038
From
US$3,516
Save 3,682
Per Person
View Trip
19 Day Greece, Egypt & Italy Cruise: Alexandria, Athens & Amalfi Coast with Azamara Cruises
Cruise
 (3)

19 Days (18 Nights) Athens to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 15 February 2028
Visit: Greece, Egypt, Cyprus, Turkey, Sicily, Italy
Azamara Always Included
Exclusive Savings
Inside
$5,358
Oceanview
$6,386
Balcony
$7,812
Suite
$11,139
From
US$5,358
Save 121
Per Person
View Trip
10 Day Exploring Ancient Empires with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 29 March 2027
Visit: Italy, Sicily, Greece, Turkey
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$2,399
Oceanview
$2,594
Balcony
$4,098
Suite
$5,941
From
US$2,399
Save 2,399
Per Person
View Trip
15 Day Journey To The Golden Horn with Regent Seven Seas
Cruise

15 Days (14 Nights) Barcelona to Istanbul
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 21 April 2026
Visit: Spain, Sicily, Egypt, Greece, Turkey
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$13,746
From
US$13,746
Save 20,452
Per Person
View Trip
8 Day Barcelona To Istanbul with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 04 May 2026
Visit: Spain, Greece, Turkey
Inside
$1,249
Oceanview
$1,519
Balcony
$1,819
Suite
-
From
US$1,249
Per Person
View Trip
10 Day Civitavecchia (Rome) to Athens (Piraeus) with Silversea
Cruise
 (1)

10 Days (9 Nights) Rome to Athens
Cruise Line: Silversea
Ship: Silver Nova
Departure: 16 April 2027
Visit: Italy, Sicily, Malta, Greece
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,400
Suite
$9,180
From
US$6,400
Save 1,600
Per Person
View Trip
15 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 14 September 2026
Visit: Italy, France, Greece, Turkey
Inside
$2,959
Oceanview
$3,189
Balcony
$3,629
Suite
$6,292
From
US$2,959
Per Person
View Trip
15 Day Istanbul And Greek Islands with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 21 September 2026
Visit: Italy, Sicily, Greece, Turkey
Inside
$2,969
Oceanview
$3,249
Balcony
$3,839
Suite
$6,965
From
US$2,969
Per Person
View Trip
40 Day Athens To Lisbon Grand Voyage with Azamara Cruises
Cruise
 (3)

40 Days (39 Nights) Athens to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 15 February 2028
Visit: Greece, Egypt, Cyprus, Turkey (+6 more), Sicily, Italy, France, Spain, Gibraltar, Portugal
Azamara Always Included
Exclusive Savings
Inside
$9,800
Oceanview
$11,953
Balcony
$15,057
Suite
$22,041
From
US$9,800
Save 219
Per Person
View Trip
14 Day Turkey, Egypt & Italy Cruise: Ephesus, Alexandria & Amalfi Coast with Azamara Cruises
Cruise
 (3)

14 Days (13 Nights) Athens to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 21 November 2027
Visit: Greece, Turkey, Egypt, Sicily, Italy
Azamara Always Included
Exclusive Savings
Inside
$3,368
Oceanview
$4,153
Balcony
$5,181
Suite
$7,509
From
US$3,368
Save 71
Per Person
View Trip
11 Day Heavenly Mediterranean Islands with Regent Seven Seas
Cruise

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 25 October 2027
Visit: Italy, Greece, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,333
Suite
$9,921
From
US$9,333
Save 15,665
Per Person
View Trip
22 Day Mediterranean, Greece And Turkey with Cunard
Cruise
 (13)

22 Days (21 Nights) Rome to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2027
Visit: Italy, France, Corsica, Spain, Sicily, Greece, Turkey
Inside
$2,969
Oceanview
$3,339
Balcony
$4,089
Suite
$9,097
From
US$2,969
Per Person
View Trip
11 Day Rome to Athens with Silversea
Cruise

11 Days (10 Nights) Rome to Athens
Cruise Line: Silversea
Ship: Silver Muse
Departure: 15 March 2026
Visit: Italy, Sicily, Greece, Egypt
All-Inclusive Fare
Inside
-
Oceanview
$8,400
Balcony
-
Suite
$14,880
From
US$8,400
Per Person
View Trip
11 Day Antiquities & Ancients with Regent Seven Seas
Cruise

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 21 August 2027
Visit: Italy, Greece, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,236
Suite
$9,726
From
US$9,236
Save 15,562
Per Person
View Trip
13 Day Eastern Mediterranean Gems with Regent Seven Seas
Cruise

13 Days (12 Nights) Barcelona to Athens
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 21 May 2026
Visit: Spain, Sicily, Croatia, Montenegro, Greece
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,566
Suite
$12,860
From
US$12,566
Save 18,232
Per Person
View Trip
13 Day Historic Harbors with Oceania Cruises
Cruise

13 Days (12 Nights) Rome to Athens
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 26 November 2027
Visit: Italy, Sicily, Greece, Cyprus, Egypt, Turkey
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,394
Suite
$7,304
From
US$4,394
Save 4,604
Per Person
View Trip
16 Day Croatia, Montenegro & Ephesus with Seabourn
Cruise

16 Days (15 Nights) Dubrovnik to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 06 August 2027
Visit: Croatia, Montenegro, Italy, Greece, Turkey
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,110
Suite
$17,691
From
US$11,110
Save 194
Per Person
View Trip
15 Day Spice Trail Sail with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to Athens
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 21 December 2026
Visit: Italy, Sicily, Malta, Egypt, Cyprus, Greece, Turkey
Exclusive Savings
Inside
-
Oceanview
$6,693
Balcony
$8,555
Suite
$9,829
From
US$6,693
Save 13,905
Per Person
View Trip
30 Day Mediterranean Medley: Croatia, Greece & Italy with Seabourn
Cruise

30 Days (29 Nights) Dubrovnik to Dubrovnik
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 06 August 2027
Visit: Croatia, Montenegro, Italy, Greece, Turkey
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$19,970
Suite
$33,131
From
US$19,970
Save 344
Per Person
View Trip
17 Day Rome to Lisbon with Silversea
Cruise
 (1)

17 Days (16 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Nova
Departure: 23 November 2026
Visit: Italy, Sicily, Tunisia, Sardinia (+4 more), Spain, Gibraltar, Morocco, Portugal
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$8,400
Suite
$14,300
From
US$8,400
Per Person
View Trip
22 Day Canals, Canaries & Colosseum with Oceania Cruises
Cruise
 (1)

22 Days (21 Nights) Venice to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 05 August 2027
Visit: Italy, Croatia, Greece, Sicily (+5 more), France, Spain, Gibraltar, Morocco, Portugal
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$6,317
Oceanview
$6,657
Balcony
$10,537
Suite
$14,805
From
US$6,317
Save 6,581
Per Person
View Trip
11 Day New Year's Mediterranean & Morocco Cruise: Malaga, Seville & Lisbon with Azamara Cruises
Cruise
 (8)

11 Days (10 Nights) Barcelona to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 29 December 2026
Visit: Spain, Morocco, Portugal
Azamara Always Included
Exclusive Savings
Inside
$2,773
Oceanview
$3,258
Balcony
$3,840
Suite
$6,255
From
US$2,773
Save 56
Per Person
View Trip
27 Day Ramblas To Renaissance with Oceania Cruises
Cruise
 (1)

27 Days (26 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 09 December 2026
Visit: Spain, Gibraltar, Morocco, Portugal, France, Italy, Corsica
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$7,285
Oceanview
$7,673
Balcony
$11,699
Suite
$16,694
From
US$7,285
Save 7,613
Per Person
View Trip
23 Day Ultimate Cultures & Wonders of Europe: Italy to Ireland with Scenic
New ReleaseCruise

23 Days (22 Nights) Rome to Dublin
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 May 2027
Visit: Italy, Sicily, Malta, Tunisia (+5 more), Algeria, Spain, Portugal, France, Ireland
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$55,943
Suite
$88,535
From
US$55,943
Save 1,637
Per Person
View Trip
12 Day Moroccan Interlude with Oceania Cruises
Cruise
 (1)

12 Days (11 Nights) Barcelona to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 15 August 2027
Visit: Spain, Gibraltar, Morocco, Portugal
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$3,375
Oceanview
$3,618
Balcony
$5,752
Suite
$8,177
From
US$3,375
Save 3,523
Per Person
View Trip
13 Day Springtime Splendor with Oceania Cruises
Cruise
 (3)

13 Days (12 Nights) Barcelona to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 28 April 2027
Visit: Spain, Morocco, Portugal
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$3,862
Oceanview
$4,832
Balcony
$5,899
Suite
$8,033
From
US$3,862
Save 4,036
Per Person
View Trip
27 Day Heavenly Holidays with Oceania Cruises
Cruise

27 Days (26 Nights) Athens to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 08 December 2027
Visit: Greece, Cyprus, Turkey, Malta (+6 more), Sicily, Sardinia, Spain, Morocco, Tunisia, Italy
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,445
Suite
$14,471
From
US$10,445
Save 10,953
Per Person
View Trip
20 Day Mediterranean Isles Legacy with Oceania Cruises
Cruise
 (1)

20 Days (19 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 December 2026
Visit: Italy, Corsica, France, Spain, Gibraltar, Morocco, Portugal
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$4,848
Oceanview
$5,381
Balcony
$8,000
Suite
$11,153
From
US$4,848
Save 5,050
Per Person
View Trip
Results: 541-570 of 604

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