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Mediterranean Luxury Cruises

Explore the best luxury cruises sailing in and around the Mediterranean. Choose from 634 unique cruise itineraries with 1184 past traveler reviews from 10 leading cruise lines. September is the most popular month to join a luxury cruise sailing in and around the Mediterranean with 714 departures starting between March 2026 and October 2028.
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634 Cruises (714 Cruise Departures)
17 Day An Extended Journey of Colourful Cultures & Boundless Beauty with Explora Journeys
Cruise
 (1)

17 Days (16 Nights) Barcelona to Athens
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 25 April 2026
Visit: Spain, Monaco, Italy, Greece, Turkey
Inside
-
Oceanview
-
Balcony
-
Suite
$10,240
From
US$10,240
Per Person
View Trip
10 Day Trojan Trek Revisited with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 19 July 2027
Visit: Italy, Sicily, Greece, Turkey
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$2,837
Oceanview
$3,080
Balcony
$4,680
Suite
$6,523
From
US$2,837
Save 2,961
Per Person
View Trip
30 Day Mediterranean Medley: Italy, Greece & Ephesus with Seabourn
Cruise

30 Days (29 Nights) Genoa to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 30 April 2027
Visit: Italy, Corsica, Sardinia, Tunisia (+6 more), Sicily, Malta, Croatia, Montenegro, Greece, Turkey
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$27,694
Suite
-
From
US$27,694
Save 505
Per Person
View Trip
11 Day Rome to Athens with Silversea
Cruise

11 Days (10 Nights) Rome to Athens
Cruise Line: Silversea
Ship: Silver Muse
Departure: 15 March 2026
Visit: Italy, Sicily, Greece, Egypt
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,000
Suite
-
From
US$9,000
Save 1,000
Per Person
View Trip
11 Day Italian & Aegean Idyll with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Athens
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 01 May 2026
Visit: Italy, Sicily, Tunisia, Greece, Turkey
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$3,083
Oceanview
$3,389
Balcony
-
Suite
-
From
US$3,083
Save 3,915
Per Person
View Trip
10 Day Civitavecchia (Rome) to Athens (Piraeus) with Silversea
Cruise
 (1)

10 Days (9 Nights) Rome to Athens
Cruise Line: Silversea
Ship: Silver Nova
Departure: 16 April 2027
Visit: Italy, Sicily, Malta, Greece
All-Inclusive Fare
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,800
Suite
$9,400
From
US$6,800
Save 1,700
Per Person
View Trip
11 Day Coastal Charisma with Oceania Cruises
Cruise

11 Days (10 Nights) Barcelona to Athens
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 08 March 2028
Visit: Spain, Italy, Sicily, Malta, Greece
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,516
Suite
$6,038
From
US$3,516
Save 3,682
Per Person
View Trip
22 Day Discover the Wonders of the Mediterranean & Red Sea with Emerald Cruises
New ReleaseCruise

22 Days (21 Nights) Athens to Aqaba
Cruise Line: Emerald Cruises
Ship: Emerald Kaia
Departure: 21 October 2026
Visit: Greece, Turkey, Cyprus, Israel, Egypt, Jordan
Fly Free Economy
Fly Free Premium Economy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$23,186
From
US$23,186
Save 24,394
Per Person
View Trip
22 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise
 (1)

22 Days (21 Nights) Rome to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 14 September 2026
Visit: Italy, France, Sicily, Greece, Turkey
Bonus Onboard Credit
Inside
-
Oceanview
-
Balcony
$5,499
Suite
$9,354
From
US$5,499
Per Person
View Trip
19 Day Greece, Egypt & Italy Cruise: Alexandria, Athens & Amalfi Coast with Azamara Cruises
Cruise
 (3)

19 Days (18 Nights) Athens to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 15 February 2028
Visit: Greece, Egypt, Cyprus, Turkey, Sicily, Italy
Azamara Always Included
Exclusive Savings
Inside
$5,358
Oceanview
$6,386
Balcony
$7,812
Suite
$11,139
From
US$5,358
Save 121
Per Person
View Trip
8 Day Istanbul And Greek Islands with Cunard
Cruise
 (1)

8 Days (7 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 28 September 2026
Visit: Turkey, Greece, Sicily, Italy
Bonus Onboard Credit
Inside
$1,589
Oceanview
$1,669
Balcony
$2,149
Suite
-
From
US$1,589
Per Person
View Trip
11 Day Visions Of Byzantium with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 17 August 2026
Visit: Spain, Sicily, Greece, Turkey
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,581
Oceanview
$2,951
Balcony
$4,395
Suite
$5,590
From
US$2,581
Save 3,617
Per Person
View Trip
40 Day Athens To Lisbon Grand Voyage with Azamara Cruises
Cruise
 (3)

40 Days (39 Nights) Athens to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 15 February 2028
Visit: Greece, Egypt, Cyprus, Turkey (+6 more), Sicily, Italy, France, Spain, Gibraltar, Portugal
Azamara Always Included
Exclusive Savings
Inside
$9,800
Oceanview
$11,953
Balcony
$15,057
Suite
$22,041
From
US$9,800
Save 219
Per Person
View Trip
10 Day Italy & Greece Cruise: Amalfi, Crete & Santorini with Azamara Cruises
Cruise
 (8)

10 Days (9 Nights) Rome to Athens
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 06 August 2027
Visit: Italy, Sicily, Greece, Turkey
Azamara Always Included
Exclusive Savings
Inside
$4,048
Oceanview
$4,582
Balcony
$5,600
Suite
$8,171
From
US$4,048
Save 101
Per Person
View Trip
9 Day Peaceful Islands and Ancient Treasures of the Mediterranean with Ponant
Cruise

9 Days (8 Nights) Valletta to Athens
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departure: 14 June 2027
Visit: Malta, Sicily, Italy, Greece
Inside
-
Oceanview
-
Balcony
$6,910
Suite
$12,870
From
US$6,910
Per Person
View Trip
40 Day Venice To Lisbon Grand Voyage with Azamara Cruises
Cruise
 (3)

40 Days (39 Nights) Venice to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 November 2027
Visit: Italy, Greece, Cyprus, Turkey (+6 more), Egypt, Sicily, France, Spain, Gibraltar, Portugal
Azamara Always Included
Exclusive Savings
Inside
$9,991
Oceanview
$12,339
Balcony
$15,249
Suite
$22,233
From
US$9,991
Save 208
Per Person
View Trip
8 Day Under Sail from Sicily to the Greek Islands with Ponant
Cruise

8 Days (7 Nights) Palermo to Athens
Cruise Line: Ponant
Ship: Le Ponant
Departure: 08 June 2027
Visit: Sicily, Italy, Greece
Inside
-
Oceanview
$12,790
Balcony
$19,470
Suite
$21,690
From
US$12,790
Per Person
View Trip
30 Day Mediterranean Medley: Croatia, Greece & Italy with Seabourn
Cruise

30 Days (29 Nights) Dubrovnik to Dubrovnik
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 06 August 2027
Visit: Croatia, Montenegro, Italy, Greece, Turkey
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$24,071
Suite
$38,967
From
US$24,071
Save 428
Per Person
View Trip
11 Day Ancient Civilizations with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 09 February 2028
Visit: Italy, Sicily, Malta, Greece, Turkey
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,129
Suite
$5,554
From
US$3,129
Save 3,269
Per Person
View Trip
11 Day 10th Annual Piano Festival at Sea with Ponant
Cruise

11 Days (10 Nights) Valletta to Antalya
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Mar 2026 to Apr 2027
Visit: Malta, Sicily, Italy, Greece, Turkey
Inside
-
Oceanview
-
Balcony
$8,140
Suite
$15,130
From
US$8,140
Per Person
View Trip
23 Day Mediterranean Mosaic: Croatia, Greece & Ephesus with Seabourn
Cruise

23 Days (22 Nights) Dubrovnik to Athens
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 06 August 2027
Visit: Croatia, Montenegro, Italy, Greece, Turkey
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$18,568
Suite
$29,936
From
US$18,568
Save 331
Per Person
View Trip
16 Day Croatia, Montenegro & Ephesus with Seabourn
Cruise

16 Days (15 Nights) Dubrovnik to Istanbul
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 06 August 2027
Visit: Croatia, Montenegro, Italy, Greece, Turkey
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,457
Suite
$20,807
From
US$13,457
Save 242
Per Person
View Trip
22 Day Canals, Canaries & Colosseum with Oceania Cruises
Cruise
 (1)

22 Days (21 Nights) Venice to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 05 August 2027
Visit: Italy, Croatia, Greece, Sicily (+5 more), France, Spain, Gibraltar, Morocco, Portugal
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$6,414
Oceanview
$6,754
Balcony
$10,634
Suite
$14,805
From
US$6,414
Save 6,684
Per Person
View Trip
23 Day Ultimate Cultures & Wonders of Europe: Italy to Ireland with Scenic
New ReleaseCruise

23 Days (22 Nights) Rome to Dublin
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 May 2027
Visit: Italy, Sicily, Malta, Tunisia (+5 more), Algeria, Spain, Portugal, France, Ireland
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$31,087
Suite
$41,321
From
US$31,087
Save 32,993
Per Person
View Trip
11 Day Barcelona to Lisbon with Silversea
Cruise

11 Days (10 Nights) Barcelona to Lisbon
Cruise Line: Silversea
Ship: Silver Ray
Departure: 18 November 2026
Visit: Spain, Morocco, Portugal
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,480
Suite
$6,260
From
US$6,260
Save 3,640
Per Person
View Trip
11 Day New Year's Mediterranean & Morocco Cruise: Malaga, Seville & Lisbon with Azamara Cruises
Cruise
 (8)

11 Days (10 Nights) Barcelona to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 29 December 2026
Visit: Spain, Morocco, Portugal
Azamara Always Included
Exclusive Savings
Inside
$3,481
Oceanview
$3,743
Balcony
$4,412
Suite
$7,225
From
US$3,481
Save 78
Per Person
View Trip
9 Day Western Mediterranean with Cunard
Cruise

9 Days (8 Nights) Rome to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 12 September 2026
Visit: Italy, France, Spain, Gibraltar, England
Bonus Onboard Credit
Inside
$1,799
Oceanview
-
Balcony
$3,379
Suite
$8,121
From
US$1,799
Per Person
View Trip
12 Day A Journey Of Beguiling Landscapes & Enchanting Mediterranean Delights with Explora Journeys
Cruise

12 Days (11 Nights) Barcelona to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 21 October 2026
Visit: Spain, Portugal, Morocco
Sky & Sea
Inside
-
Oceanview
-
Balcony
-
Suite
$8,370
From
US$8,370
Per Person
View Trip
8 Day Stars Of Spain & Portugal with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 16 June 2026
Visit: Spain, Gibraltar, Portugal
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,299
Oceanview
$2,444
Balcony
$3,705
Suite
$5,063
From
US$2,299
Save 2,299
Per Person
View Trip
12 Day Moroccan Interlude with Oceania Cruises
Cruise
 (1)

12 Days (11 Nights) Barcelona to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 15 August 2027
Visit: Spain, Gibraltar, Morocco, Portugal
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$3,375
Oceanview
$3,618
Balcony
$5,849
Suite
$8,177
From
US$3,375
Save 3,523
Per Person
View Trip
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