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Mediterranean Luxury Cruises

Explore the best luxury cruises sailing in and around the Mediterranean. Choose from 780 unique cruise itineraries with 1760 past traveler reviews from 10 leading cruise lines. September is the most popular month to join a luxury cruise sailing in and around the Mediterranean with 900 departures starting between May 2026 and April 2029.
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780 Cruises (900 Cruise Departures)
10 Day A Journey of Iberian Scenery & Moorish Charm with Explora Journeys
Cruise

10 Days (9 Nights) Barcelona to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 03 April 2027
Visit: Spain, Morocco, Portugal
Inside
-
Oceanview
-
Balcony
-
Suite
$5,640
From
US$5,640
Per Person
View Trip
15 Day Dalmatian Coast, Montenegro, Malta & Sicily with Seabourn
Cruise

15 Days (14 Nights) Dubrovnik to Rome
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 16 September 2028
Visit: Croatia, Slovenia, Montenegro, Malta, Sicily, Italy
Inside
-
Oceanview
-
Balcony
$11,069
Suite
$17,279
From
US$11,069
Per Person
View Trip
21 Day Legacies & Empires with Regent Seven Seas
Cruise

21 Days (20 Nights) Rome to London
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 07 August 2027
Visit: Italy, Monaco, France, Spain, Morocco, Portugal, England
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$20,599
Suite
$22,949
From
US$20,599
Save 20,599
Per Person
View Trip
11 Day A Journey Of Mediterranean Spirit & Cultural Exploration with Explora Journeys
Cruise

11 Days (10 Nights) Barcelona to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 23 April 2027
Visit: Spain, Portugal, Morocco, Algeria
Inside
-
Oceanview
-
Balcony
-
Suite
$6,280
From
US$6,280
Per Person
View Trip
23 Day Ultimate Cultures & Wonders of Europe: Italy to Ireland with Scenic
New ReleaseCruise

23 Days (22 Nights) Rome to Dublin
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 May 2027
Visit: Italy, Sicily, Malta, Tunisia (+5 more), Algeria, Spain, Portugal, France, Ireland
Inside
-
Oceanview
-
Balcony
$33,920
Suite
$46,570
From
US$33,920
Per Person
View Trip
19 Day Timeless Shores with Regent Seven Seas
Cruise

19 Days (18 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 08 June 2027
Visit: Portugal, Spain, Morocco, Corsica, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$22,199
Suite
$22,399
From
US$22,199
Save 22,199
Per Person
View Trip
8 Day A Journey Of Balearic Allure, Classic Culture & Italian Artistry with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora VI
Departures: Sep 2028 to Oct 2028
Visit: Spain, Tunisia, Sicily, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$4,285
From
US$4,285
Per Person
View Trip
15 Day Exploring Pompeii, Sicily, Montenegro & Greece with Seabourn
Cruise

15 Days (14 Nights) Monte Carlo to Athens
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 14 October 2028
Visit: Monaco, Italy, Sicily, Malta, Montenegro, Croatia, Greece
Inside
-
Oceanview
-
Balcony
$9,449
Suite
$15,119
From
US$9,449
Per Person
View Trip
12 Day A Grand Journey Of Maritime Majesty & Middle Eastern Soul with Explora Journeys
Cruise

12 Days (11 Nights) Barcelona to Jeddah
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 08 November 2027
Visit: Spain, Malta, Greece, Cyprus, Egypt, Saudi Arabia
Inside
-
Oceanview
-
Balcony
-
Suite
$4,965
From
US$4,965
Per Person
View Trip
8 Day A Journey Through Sparkling Bays & Riviera Radiance with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departures: May 2027 to Sep 2027
Visit: Spain, Sardinia, France, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$4,290
From
US$4,290
Per Person
View Trip
8 Day Montenegro, Italy & Greece with Seabourn
Cruise

8 Days (7 Nights) Athens to Dubrovnik
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departures: Aug 2027 to Sep 2028
Visit: Greece, Italy, Montenegro, Croatia
Inside
-
Oceanview
-
Balcony
$5,099
Suite
$8,369
From
US$5,099
Per Person
View Trip
9 Day Spring Awakening on the Mediterranean with Ponant
Cruise

9 Days (8 Nights) Malaga to Barcelona
Cruise Line: Ponant
Ship: L'Austral
Departure: 16 April 2027
Visit: Spain, Algeria, Sardinia
Inside
-
Oceanview
$5,940
Balcony
$6,260
Suite
$12,880
From
US$5,940
Per Person
View Trip
12 Day Cultures of the Mediterranean Barcelona to Civitavecchia with Emerald Cruises
New ReleaseCruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departures: May 2027 to Sep 2027
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
$8,622
Balcony
-
Suite
$11,691
From
US$8,622
Save 1,928
Per Person
View Trip
9 Day Monte Carlo to Civitavecchia (Rome) with Silversea
Cruise

9 Days (8 Nights) Monte Carlo to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 11 September 2027
Visit: Monaco, France, Sardinia, Corsica, Italy
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,300
Suite
$11,400
From
US$7,300
Save 2,500
Per Person
View Trip
15 Day French Yacht Harbors, Southern France & Corsica with Seabourn
Cruise

15 Days (14 Nights) Rome to Monte Carlo
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 30 September 2028
Visit: Italy, France, Spain, Sardinia, Corsica, Monaco
Inside
-
Oceanview
-
Balcony
$9,449
Suite
$15,119
From
US$9,449
Per Person
View Trip
8 Day Pompeii, Sicily, Malta & Montenegro with Seabourn
Cruise

8 Days (7 Nights) Monte Carlo to Dubrovnik
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 17 June 2028
Visit: Monaco, Italy, Sicily, Malta, Montenegro, Croatia
Inside
-
Oceanview
-
Balcony
$5,219
Suite
$8,369
From
US$5,219
Per Person
View Trip
8 Day Monte Carlo to Civitavecchia (Rome) with Silversea
Cruise

8 Days (7 Nights) Monte Carlo to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 10 July 2027
Visit: Monaco, Italy, Corsica, France
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,100
Suite
$8,000
From
US$5,100
Save 3,000
Per Person
View Trip
12 Day Idyllic Islands of the Mediterranean with Scenic
New ReleaseCruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Scenic
Ship: Scenic Ikon
Departure: 13 September 2028
Visit: Italy, Sardinia, Corsica, Spain
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,424
Suite
$17,985
From
US$15,424
Save 2,321
Per Person
View Trip
18 Day Muse & Marble with Regent Seven Seas
Cruise

18 Days (17 Nights) Bologna to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 05 July 2027
Visit: Italy, Greece, Sicily, Spain, Corsica, France, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$18,399
Suite
$18,849
From
US$18,399
Save 18,399
Per Person
View Trip
15 Day Hidden Gems Of Montenegro, Greece, Croatia & Slovenia with Seabourn
Cruise

15 Days (14 Nights) Dubrovnik to Venice
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 21 October 2028
Visit: Croatia, Montenegro, Italy, Greece, Slovenia
Inside
-
Oceanview
-
Balcony
$9,449
Suite
$15,119
From
US$9,449
Per Person
View Trip
33 Day Ultimate Voyage: Ancient Empires, Adriatic & Amalfi Coast with Scenic
New ReleaseCruise

33 Days (32 Nights) Istanbul to Rome
Cruise Line: Scenic
Ship: Scenic Ikon
Departure: 12 August 2028
Visit: Turkey, Greece, Montenegro, Croatia, Slovenia, Italy, Sicily
Inside
-
Oceanview
-
Balcony
$55,435
Suite
$59,275
From
US$55,435
Per Person
View Trip
13 Day Nice to Nice with Silversea
Cruise

13 Days (12 Nights) Nice to Nice
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 06 August 2026
Visit: France, Corsica, Sardinia, Spain
All-Inclusive Fare
Inside
-
Oceanview
$11,700
Balcony
-
Suite
$23,700
From
US$11,700
Per Person
View Trip
12 Day Stars Of Iberia with Regent Seven Seas
Cruise

12 Days (11 Nights) Lisbon to Valletta
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 October 2026
Visit: Portugal, Spain, Sardinia, Tunisia, Sicily, Malta
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,299
Suite
$16,899
From
US$15,299
Save 15,299
Per Person
View Trip
8 Day A Journey Of Shoreline Splendour & Spectacular Architecture with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Venice
Cruise Line: Explora Journeys
Ship: Explora VI
Departure: 30 October 2028
Visit: Italy, Sicily, Albania, Croatia
Inside
-
Oceanview
-
Balcony
-
Suite
$4,150
From
US$4,150
Per Person
View Trip
8 Day Under Sail from Sicily to the Greek Islands with Ponant
Cruise

8 Days (7 Nights) Palermo to Athens
Cruise Line: Ponant
Ship: Le Ponant
Departure: 08 June 2027
Visit: Sicily, Italy, Greece
Inside
-
Oceanview
$12,050
Balcony
$19,470
Suite
$21,690
From
US$12,050
Per Person
View Trip
15 Day An Extended Journey Of Scenic Cities, Renowned Monuments & Spectacular Shorelines with Explora Journeys
Cruise

15 Days (14 Nights) Rome to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 27 September 2027
Visit: Italy, Corsica, Monaco, France (+4 more), Spain, Tunisia, Malta, Sicily
Inside
-
Oceanview
-
Balcony
-
Suite
$9,675
From
US$9,675
Per Person
View Trip
10 Day Nice to Nice with Silversea
Cruise

10 Days (9 Nights) Nice to Nice
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 06 July 2027
Visit: France, Italy, Sicily, Malta
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$5,700
Balcony
$6,400
Suite
$9,300
From
US$5,700
Save 3,000
Per Person
View Trip
11 Day Rome to Barcelona with Silversea
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Muse
Departure: 31 July 2026
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
Last Minute Fare
All-Inclusive Plus Fare
Inside
-
Oceanview
$5,650
Balcony
$5,950
Suite
$13,700
From
US$5,650
Per Person
View Trip
9 Day Greece, Italy, Montenegro, Croatia & Slovenia with Seabourn
Cruise

9 Days (8 Nights) Athens to Venice
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 05 June 2027
Visit: Greece, Montenegro, Croatia, Slovenia, Italy
Inside
-
Oceanview
-
Balcony
$7,649
Suite
$11,899
From
US$7,649
Per Person
View Trip
9 Day Dalmatian Rhapsody with Regent Seven Seas
Cruise

9 Days (8 Nights) Rome to Venice
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 25 May 2027
Visit: Italy, Sicily, Montenegro, Croatia, Slovenia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,499
Suite
$11,099
From
US$10,499
Save 10,499
Per Person
View Trip
Results: 571-600 of 780

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