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All Main River Cruises

The Main river flows through Germany from modern, densely populated Mainz to more traditional medieval Bavarian towns lined with lovely forests and small towns and dotted with hilltop castles and churches. Choose from 1,572 river cruises along the Main traveling with the world's leading river cruise lines.
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134 River Cruises (1,572 River Cruise Departures)
6 Day Festive Season in the Heart of Germany with Avalon River Cruises
River Cruise
 (2)

6 Days Frankfurt to Nuremberg
Cruise Line: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Tranquility II
Departures: Dec 2026 to Dec 2026
Rivers: Main
Visit: Germany
Exclusive Savings
Inside
-
River View
$2,804
Balcony
$4,107
Suite
-
From
US$2,804
Save 360
Per Person
View Trip
6 Day Christmastime in the Heart of Germany with Avalon River Cruises
New ReleaseRiver Cruise

6 Days Frankfurt to Nuremberg
Cruise Line: Avalon River Cruises
Ships: Avalon Expression, Avalon Panorama (+2 more), Avalon Passion, Avalon Vista
Departures: Nov 2027 to Dec 2027
Rivers: Main
Visit: Germany
Exclusive Savings
Inside
-
River View
$2,987
Balcony
$4,358
Suite
$5,661
From
US$2,987
Save 492
Per Person
View Trip
8 Day Festive Season in the Heart of Germany with Prague with Avalon River Cruises
River Cruise

8 Days Frankfurt to Prague
Cruise Line: Avalon River Cruises
Ships: Avalon Expression, Avalon Imagery II (+4 more), Avalon Panorama, Avalon Passion, Avalon Tranquility II, Avalon Vista
Departures: Dec 2026 to Dec 2027
Rivers: Main
Visit: Germany, Czech Republic
Exclusive Savings
Inside
-
River View
$3,465
Balcony
$4,768
Suite
$6,380
From
US$3,465
Save 522
Per Person
View Trip
6 Day Christmastime in the Heart of Germany with Avalon River Cruises
New ReleaseRiver Cruise

6 Days Nuremberg to Frankfurt
Cruise Line: Avalon River Cruises
Ships: Avalon Passion, Avalon Vista
Departures: Dec 2027 to Dec 2027
Rivers: Main
Visit: Germany
Exclusive Savings
Inside
-
River View
$3,107
Balcony
$4,478
Suite
$5,781
From
US$3,107
Save 372
Per Person
View Trip
6 Day Festive Season in the Heart of Germany with Avalon River Cruises
River Cruise

6 Days Nuremberg to Frankfurt
Cruise Line: Avalon River Cruises
Ships: Avalon Illumination, Avalon Imagery II, Avalon Tranquility II
Departures: Dec 2026 to Dec 2026
Rivers: Main
Visit: Germany
Exclusive Savings
Inside
-
River View
$2,684
Balcony
$3,987
Suite
-
From
US$2,684
Save 480
Per Person
View Trip
8 Day Classic Christmas Markets with Uniworld River Cruises
River Cruise

8 Days Nuremberg to Frankfurt
Cruise Line: Uniworld River Cruises
Ships: S.S. Elisabeth, S.S. Emilie
Departures: Dec 2026 to Dec 2026
Rivers: Main
Visit: Germany
Exclusive Savings
Inside
-
River View
-
Balcony
$6,249
Suite
$7,305
From
US$6,249
Save 292
Per Person
View Trip
8 Day Classic Christmas Markets with Uniworld River Cruises
River Cruise

8 Days Frankfurt to Nuremberg
Cruise Line: Uniworld River Cruises
Ships: S.S. Elisabeth, S.S. Emilie
Departures: Nov 2026 to Dec 2026
Rivers: Main
Visit: Germany
Exclusive Savings
Inside
-
River View
-
Balcony
$5,193
Suite
$8,553
From
US$5,193
Save 298
Per Person
View Trip
8 Day Festive Season in the Heart of Germany with Prague with Avalon River Cruises
River Cruise

8 Days Prague to Frankfurt
Cruise Line: Avalon River Cruises
Ships: Avalon Illumination, Avalon Imagery II (+3 more), Avalon Tranquility II, Avalon Passion, Avalon Vista
Departures: Nov 2026 to Dec 2027
Rivers: Main
Visit: Czech Republic, Germany
Exclusive Savings
Inside
-
River View
$3,345
Balcony
$4,648
Suite
$6,500
From
US$3,345
Save 508
Per Person
View Trip
9 Day German Grandeur (Eastbound) with Avalon River Cruises
River Cruise
 (1)

9 Days Basel to Nuremberg
Cruise Line: Avalon River Cruises
Ships: Avalon Tranquility II, Avalon Imagery II
Departures: May 2026 to Oct 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany
Exclusive Savings
Inside
-
River View
$3,695
Balcony
$5,779
Suite
$7,863
From
US$3,695
Save 1,392
Per Person
View Trip
11 Day German Grandeur with Munich (Eastbound) with Avalon River Cruises
River Cruise
 (1)

11 Days Basel to Munich
Cruise Line: Avalon River Cruises
Ships: Avalon Tranquility II, Avalon Imagery II
Departures: May 2026 to Oct 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany
Exclusive Savings
Inside
-
River View
$4,606
Balcony
$6,690
Suite
$8,774
From
US$4,606
Save 1,430
Per Person
View Trip
8 Day Three-Rivers Cruise with Amadeus River Cruises
New ReleaseRiver Cruise

8 Days Amsterdam to Nuremberg
Cruise Line: Amadeus River Cruises
Ship: Amadeus Queen
Departure: 10 May 2026
Rivers: Rhine, Main
Visit: Holland, Germany
Inside
-
River View
-
Balcony
$4,400
Suite
$5,078
From
US$4,400
Per Person
View Trip
11 Day Christmas on the Rhine & Main with Viking River Cruises
New ReleaseRiver Cruise

11 Days Nuremberg to Basel
Cruise Line: Viking River Cruises
Ships: Viking Modi, Viking Skirnir
Departures: Nov 2026 to Dec 2027
Rivers: Main, Rhine
Visit: Germany, France, Switzerland
Viking $999 Air Deal
Exclusive Savings
Inside
-
River View
$4,699
Balcony
$6,399
Suite
-
From
US$4,699
Save 100
Per Person
View Trip
11 Day Christmas on the Rhine & Main with Viking River Cruises
New ReleaseRiver Cruise

11 Days Basel to Nuremberg
Cruise Line: Viking River Cruises
Ships: Viking Modi, Viking Skirnir
Departures: Nov 2026 to Dec 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany
Viking $999 Air Deal
Exclusive Savings
Inside
-
River View
$4,699
Balcony
$6,699
Suite
-
From
US$4,699
Save 100
Per Person
View Trip
11 Day Rhine & Main Explorer with Viking River Cruises
New ReleaseRiver Cruise

11 Days Basel to Nuremberg
Cruise Line: Viking River Cruises
Ships: Viking Modi, Viking Skirnir
Departures: Apr 2026 to Nov 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany
Multiple Deals Available
Inside
-
River View
$3,099
Balcony
$3,499
Suite
$4,999
From
US$3,099
Save 500
Per Person
View Trip
10 Day Christmastime from Nuremberg to Basel with Avalon River Cruises
River Cruise

10 Days Nuremberg to Basel
Cruise Line: Avalon River Cruises
Ships: Avalon Illumination, Avalon Tranquility II, Avalon Vista
Departures: Dec 2026 to Dec 2027
Rivers: Main, Rhine
Visit: Germany, France, Switzerland
Exclusive Savings
Inside
-
River View
$6,274
Balcony
$7,344
Suite
$11,087
From
US$4,999
Save 946
Per Person
View Trip
10 Day Christmastime from Basel to Nuremberg with Avalon River Cruises
River Cruise

10 Days Basel to Nuremberg
Cruise Line: Avalon River Cruises
Ships: Avalon Tranquility II, Avalon Expression (+2 more), Avalon Panorama, Avalon Vista
Departures: Dec 2026 to Nov 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany
Exclusive Savings
Inside
-
River View
$6,034
Balcony
$7,920
Suite
$10,847
From
US$5,575
Save 488
Per Person
View Trip
12 Day Christmastime from Nuremberg to Basel with Prague with Avalon River Cruises
River Cruise

12 Days Prague to Basel
Cruise Line: Avalon River Cruises
Ships: Avalon Illumination, Avalon Tranquility II, Avalon Vista
Departures: Dec 2026 to Dec 2027
Rivers: Main, Rhine
Visit: Czech Republic, Germany, France, Switzerland
Exclusive Savings
Inside
-
River View
$6,993
Balcony
$8,006
Suite
$11,806
From
US$5,661
Save 973
Per Person
View Trip
8 Day Castles, Vineyards & Villages with Viking River Cruises
New ReleaseRiver Cruise

8 Days Nuremberg to Amsterdam
Cruise Line: Viking River Cruises
Ships: Viking Alsvin, Viking Idi
Departures: Jun 2026 to Jun 2026
Rivers: Main, Rhine
Visit: Germany, Holland
Viking $799 Air Deal
Exclusive Savings
Inside
-
River View
$2,999
Balcony
$4,299
Suite
$7,999
From
US$2,999
Save 500
Per Person
View Trip
12 Day Christmastime from Basel to Nuremberg with Prague with Avalon River Cruises
River Cruise

12 Days Basel to Prague
Cruise Line: Avalon River Cruises
Ships: Avalon Tranquility II, Avalon Expression (+2 more), Avalon Panorama, Avalon Vista
Departures: Dec 2026 to Nov 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany, Czech Republic
Exclusive Savings
Inside
-
River View
$6,888
Balcony
$8,582
Suite
$11,700
From
US$6,237
Save 523
Per Person
View Trip
8 Day Castles, Vineyards & Villages with Viking River Cruises
New ReleaseRiver Cruise

8 Days Amsterdam to Nuremberg
Cruise Line: Viking River Cruises
Ships: Viking Alsvin, Viking Idi
Departures: Jun 2026 to Jun 2026
Rivers: Rhine, Main
Visit: Holland, Germany
Viking $799 Air Deal
Exclusive Savings
Inside
-
River View
$2,999
Balcony
$4,299
Suite
$7,499
From
US$2,999
Save 500
Per Person
View Trip
8 Day Medieval Treasures (Wine Cruise) with AmaWaterways
New ReleaseRiver Cruise

8 Days Basel to Nuremberg
Cruise Line: AmaWaterways
Ships: AmaCerto, AmaPrima
Departures: Mar 2027 to Aug 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany
Exclusive Savings
Inside
-
River View
$3,543
Balcony
$5,078
Suite
$7,574
From
US$3,543
Save 1,388
Per Person
View Trip
8 Day Three-Rivers Cruise with Amadeus River Cruises
New ReleaseRiver Cruise

8 Days Nuremberg to Amsterdam
Cruise Line: Amadeus River Cruises
Ship: Amadeus Aurea
Departure: 21 July 2026
Rivers: Main, Rhine
Visit: Germany, Holland
Inside
-
River View
$3,236
Balcony
-
Suite
-
From
US$3,236
Per Person
View Trip
11 Day Rhine & Main Explorer with Viking River Cruises
New ReleaseRiver Cruise

11 Days Nuremberg to Basel
Cruise Line: Viking River Cruises
Ships: Viking Modi, Viking Skirnir
Departures: Apr 2026 to Nov 2027
Rivers: Main, Rhine
Visit: Germany, France, Switzerland
Multiple Deals Available
Inside
-
River View
$3,099
Balcony
$3,499
Suite
$4,999
From
US$3,099
Save 1,700
Per Person
View Trip
8 Day Medieval Treasures with AmaWaterways
New ReleaseRiver Cruise

8 Days Basel to Nuremberg
Cruise Line: AmaWaterways
Ships: AmaCerto, AmaPrima
Departures: Mar 2027 to Oct 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany
Exclusive Savings
Inside
-
River View
$3,159
Balcony
$4,694
Suite
$7,190
From
US$3,159
Save 1,400
Per Person
View Trip
15 Day Christmastime from Budapest to Frankfurt with Budapest with Avalon River Cruises
New ReleaseRiver Cruise

15 Days Budapest to Frankfurt
Cruise Line: Avalon River Cruises
Ship: Avalon Passion
Departure: 27 November 2027
Rivers: Danube, Main
Visit: Hungary, Austria, Germany
Exclusive Savings
Inside
-
River View
$8,493
Balcony
$11,783
Suite
$14,910
From
US$8,493
Save 336
Per Person
View Trip
9 Day Christmastime on the Danube with Prague (Eastbound) with Avalon River Cruises
River Cruise

9 Days Prague to Vienna
Cruise Line: Avalon River Cruises
Ships: Avalon Expression, Avalon Imagery II (+5 more), Avalon Impression, Avalon Passion, Avalon Tranquility II, Avalon Visionary, Avalon Vista
Departures: Dec 2026 to Dec 2027
Rivers: Main, Danube
Visit: Czech Republic, Germany, Austria
Exclusive Savings
Inside
-
River View
$3,498
Balcony
$5,061
Suite
$7,166
From
US$3,498
Save 906
Per Person
View Trip
12 Day Christmastime from Vienna to Frankfurt with Avalon River Cruises
River Cruise

12 Days Vienna to Frankfurt
Cruise Line: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Vista
Departure: 03 December 2027
Rivers: Danube, Main
Visit: Austria, Germany
Exclusive Savings
Inside
-
River View
$7,066
Balcony
$10,082
Suite
$12,948
From
US$7,066
Save 528
Per Person
View Trip
13 Day Christmastime from Budapest to Frankfurt with Avalon River Cruises
River Cruise

13 Days Budapest to Frankfurt
Cruise Line: Avalon River Cruises
Ship: Avalon Passion
Departure: 29 November 2027
Rivers: Danube, Main
Visit: Hungary, Austria, Germany
Exclusive Savings
Inside
-
River View
$7,918
Balcony
$11,208
Suite
$14,335
From
US$7,918
Save 312
Per Person
View Trip
13 Day Christmastime from Frankfurt to Budapest with Avalon River Cruises
River Cruise

13 Days Frankfurt to Budapest
Cruise Line: Avalon River Cruises
Ship: Avalon Panorama
Departure: 01 December 2027
Rivers: Main, Danube
Visit: Germany, Austria, Hungary
Exclusive Savings
Inside
-
River View
$7,918
Balcony
$11,208
Suite
$14,335
From
US$7,918
Save 312
Per Person
View Trip
12 Day Christmastime from Frankfurt to Vienna with Avalon River Cruises
River Cruise

12 Days Frankfurt to Vienna
Cruise Line: Avalon River Cruises
Ships: Avalon Tranquility II, Avalon Vista (+2 more), Avalon Expression, Avalon Imagery II
Departures: Dec 2026 to Dec 2027
Rivers: Main, Danube
Visit: Germany, Austria
Exclusive Savings
Inside
-
River View
$7,066
Balcony
$8,897
Suite
$12,948
From
US$5,881
Save 980
Per Person
View Trip
Results: 1-30 of 134

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