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All Main River Cruises

The Main river flows through Germany from modern, densely populated Mainz to more traditional medieval Bavarian towns lined with lovely forests and small towns and dotted with hilltop castles and churches. Choose from 2,409 river cruises along the Main river traveling with the world's leading river cruise lines.
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125 River Cruises (2,409 River Cruise Departures)
6 Day Festive Season in the Heart of Germany with Avalon River Cruises
River Cruise
 (2)

6 Days Frankfurt to Nuremberg
Operated By: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Panorama
Departures: Dec 2025 to Dec 2026
Rivers: Main
Countries Visited: Germany
Avalon Exclusive
INSIDE
-
RIVER VIEW
$2,788
BALCONY
$4,025
SUITE
$4,979
Save (per person) 276
From (per person) 2,788
View Trip
8 Day Festive Season in the Heart of Germany with Prague with Avalon River Cruises
River Cruise

8 Days Prague to Frankfurt
Operated By: Avalon River Cruises
Ships: Avalon Illumination, Avalon Imagery II, Avalon Panorama
Departures: Dec 2025 to Dec 2026
Rivers: Main
Countries Visited: Czech Republic, Germany
Avalon Exclusive
INSIDE
-
RIVER VIEW
$3,430
BALCONY
$4,668
SUITE
$5,622
Save (per person) 283
From (per person) 3,430
View Trip
8 Day Classic Christmas Markets with Uniworld River Cruises
River Cruise

8 Days Nuremberg to Frankfurt
Ships: River Duchess, S.S. Elisabeth
Departures: Dec 2025 to Dec 2026
Rivers: Main
Countries Visited: Germany
Earlybird Saving
Save (per person) 500
From (per person) 4,289
View Trip
8 Day Festive Season in the Heart of Germany with Prague with Avalon River Cruises
River Cruise

8 Days Frankfurt to Prague
Operated By: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Panorama
Departures: Dec 2025 to Dec 2026
Rivers: Main
Countries Visited: Germany, Czech Republic
Avalon Exclusive
INSIDE
-
RIVER VIEW
$3,430
BALCONY
$4,668
SUITE
$5,622
Save (per person) 283
From (per person) 3,430
View Trip
8 Day Classic Christmas Markets with Uniworld River Cruises
River Cruise

8 Days Frankfurt to Nuremberg
Ships: River Duchess, S.S. Elisabeth
Departures: Nov 2025 to Dec 2026
Rivers: Main
Countries Visited: Germany
Earlybird Saving
Save (per person) 500
From (per person) 3,869
View Trip
6 Day Festive Season in the Heart of Germany with Avalon River Cruises
River Cruise

6 Days Nuremberg to Frankfurt
Operated By: Avalon River Cruises
Ships: Avalon Illumination, Avalon Imagery II, Avalon Panorama
Departures: Dec 2025 to Dec 2026
Rivers: Main
Countries Visited: Germany
Avalon Exclusive
INSIDE
-
RIVER VIEW
$2,788
BALCONY
$4,025
SUITE
$4,979
Save (per person) 276
From (per person) 2,788
View Trip
9 Day German Grandeur with Avalon River Cruises
River Cruise
 (1)

9 Days Basel to Nuremberg
Operated By: Avalon River Cruises
Ship: Avalon Tranquility II
Departures: May 2025 to May 2026
Rivers: Rhine, Main
Countries Visited: Switzerland, France, Germany
Avalon Exclusive
INSIDE
-
RIVER VIEW
$4,025
BALCONY
$6,004
SUITE
-
Save (per person) 1,038
From (per person) 4,025
View Trip
11 Day German Grandeur with Munich with Avalon River Cruises
River Cruise
 (1)

11 Days Basel to Munich
Operated By: Avalon River Cruises
Ship: Avalon Tranquility II
Departures: May 2025 to May 2026
Rivers: Rhine, Main
Countries Visited: Switzerland, France, Germany
Avalon Exclusive
INSIDE
-
RIVER VIEW
$4,866
BALCONY
$6,845
SUITE
-
Save (per person) 1,046
From (per person) 4,866
View Trip
10 Day Christmastime from Nuremberg to Basel with Avalon River Cruises
River Cruise

10 Days Nuremberg to Basel
Operated By: Avalon River Cruises
Ships: Avalon Illumination, Avalon Imagery II, Avalon Panorama
Departures: Dec 2025 to Dec 2026
Rivers: Main, Rhine
Countries Visited: Germany, France, Switzerland
Avalon Exclusive
INSIDE
-
RIVER VIEW
$5,245
BALCONY
$7,472
SUITE
$9,190
Save (per person) 550
From (per person) 5,245
View Trip
10 Day Christmastime from Basel to Nuremberg with Avalon River Cruises
River Cruise

10 Days Basel to Nuremberg
Operated By: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Panorama
Departures: Nov 2025 to Dec 2026
Rivers: Rhine, Main
Countries Visited: Switzerland, France, Germany
Avalon Exclusive
INSIDE
-
RIVER VIEW
$5,369
BALCONY
$7,595
SUITE
$9,314
Save (per person) 426
From (per person) 5,369
View Trip
11 Day Christmas on the Rhine & Main with Viking River Cruises
New ReleaseRiver Cruise

11 Days Nuremberg to Basel
Operated By: Viking River Cruises
Ships: Viking Modi, Viking Skirnir
Departures: Nov 2025 to Dec 2027
Rivers: Main, Rhine
Countries Visited: Germany, France, Switzerland
Viking $799 Air DealViking $999 Air Deal
INSIDE
-
RIVER VIEW
$3,999
BALCONY
$6,299
SUITE
$9,499
Save (per person) 500
From (per person) 3,999
View Trip
8 Day Three-Rivers Cruise with Amadeus River Cruises
New ReleaseRiver Cruise

8 Days Amsterdam to Nuremberg
Operated By: Amadeus River Cruises
Ship: Amadeus Riva
Departure: 06 May 2025
Rivers: Rhine, Main
Countries Visited: Holland, Germany
INSIDE
-
RIVER VIEW
$3,141
BALCONY
$3,876
SUITE
$4,927
From (per person) 3,141
View Trip
11 Day Christmas on the Rhine & Main with Viking River Cruises
New ReleaseRiver Cruise

11 Days Basel to Nuremberg
Operated By: Viking River Cruises
Ships: Viking Modi, Viking Skirnir
Departures: Nov 2025 to Dec 2027
Rivers: Rhine, Main
Countries Visited: Switzerland, France, Germany
Viking $799 Air DealViking $999 Air Deal
INSIDE
-
RIVER VIEW
$3,999
BALCONY
$6,299
SUITE
$9,499
Save (per person) 500
From (per person) 3,999
View Trip
12 Day Christmastime from Nuremberg to Basel with Prague with Avalon River Cruises
River Cruise

12 Days Prague to Basel
Operated By: Avalon River Cruises
Ship: Avalon Panorama
Departure: 06 December 2025
Rivers: Main, Rhine
Countries Visited: Czech Republic, Germany, France, Switzerland
Exclusive Savings
INSIDE
$6,420
RIVER VIEW
$6,078
BALCONY
-
SUITE
-
Save (per person) 119
From (per person) 6,078
View Trip
11 Day Rhine & Main Explorer with Viking River Cruises
New ReleaseRiver Cruise

11 Days Nuremberg to Basel
Operated By: Viking River Cruises
Ships: Viking Modi, Viking Skirnir
Departures: May 2025 to Nov 2027
Rivers: Main, Rhine
Countries Visited: Germany, France, Switzerland
Mutiple Deals Available
INSIDE
-
RIVER VIEW
$2,099
BALCONY
$2,399
SUITE
$5,999
Save (per person) 1,500
From (per person) 2,099
View Trip
12 Day Christmastime from Basel to Nuremberg with Prague with Avalon River Cruises
River Cruise

12 Days Basel to Prague
Operated By: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Panorama
Departures: Nov 2025 to Dec 2025
Rivers: Rhine, Main
Countries Visited: Switzerland, France, Germany, Czech Republic
Exclusive Savings
INSIDE
$6,420
RIVER VIEW
$6,078
BALCONY
-
SUITE
-
Save (per person) 119
From (per person) 6,078
View Trip
11 Day Rhine & Main Explorer with Viking River Cruises
New ReleaseRiver Cruise

11 Days Basel to Nuremberg
Operated By: Viking River Cruises
Ships: Viking Modi, Viking Skirnir
Departures: Jun 2025 to Nov 2027
Rivers: Rhine, Main
Countries Visited: Switzerland, France, Germany
Mutiple Deals Available
INSIDE
-
RIVER VIEW
$2,099
BALCONY
$2,399
SUITE
$5,999
Save (per person) 1,300
From (per person) 2,099
View Trip
12 Day Christmastime from Frankfurt to Vienna with Avalon River Cruises
River Cruise

12 Days Frankfurt to Vienna
Operated By: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Impression
Departure: 05 December 2025
Rivers: Main, Danube
Countries Visited: Germany, Austria
Exclusive Savings
INSIDE
-
RIVER VIEW
$6,404
BALCONY
-
SUITE
-
Save (per person) 124
From (per person) 6,404
View Trip
13 Day Christmastime from Budapest to Frankfurt with Avalon River Cruises
River Cruise

13 Days Budapest to Frankfurt
Operated By: Avalon River Cruises
Ships: Avalon Illumination, Avalon Passion, Avalon Panorama
Departures: Dec 2025 to Dec 2026
Rivers: Danube, Main
Countries Visited: Hungary, Austria, Germany
Avalon Exclusive
INSIDE
-
RIVER VIEW
$6,978
BALCONY
$9,947
SUITE
-
Save (per person) 316
From (per person) 6,924
View Trip
9 Day Christmastime on the Danube with Prague with Avalon River Cruises
River Cruise

9 Days Prague to Vienna
Operated By: Avalon River Cruises
Ships: Avalon Envision, Avalon Expression (+2 more), Avalon Impression, Avalon Tranquility II
Departures: Dec 2025 to Dec 2025
Rivers: Main, Danube
Countries Visited: Czech Republic, Germany, Austria
Avalon Exclusive
INSIDE
-
RIVER VIEW
$3,673
BALCONY
$5,073
SUITE
$6,218
Save (per person) 535
From (per person) 3,673
View Trip
13 Day Festive Season from Frankfurt to Budapest with Avalon River Cruises
River Cruise

13 Days Frankfurt to Budapest
Operated By: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Panorama, Avalon Passion
Departures: Dec 2025 to Dec 2025
Rivers: Main, Danube
Countries Visited: Germany, Austria, Hungary
Exclusive Savings
INSIDE
-
RIVER VIEW
$6,924
BALCONY
-
SUITE
-
Save (per person) 134
From (per person) 6,924
View Trip
8 Day Europe's Rivers & Castles (Wine Cruise) with AmaWaterways
New ReleaseRiver Cruise

8 Days Nuremberg to Luxembourg
Operated By: AmaWaterways
Ships: AmaPrima
Departures: Aug 2025 to Aug 2026
Rivers: Main, Moselle
Countries Visited: Germany, Luxembourg
INSIDE
-
RIVER VIEW
$4,239
BALCONY
$5,638
SUITE
$8,138
From (per person) 4,239
View Trip
14 Day Europe's Rivers & Castles with Prague, Reims and Paris (Wine Cruise) with AmaWaterways
New ReleaseRiver Cruise

14 Days Prague to Paris
Operated By: AmaWaterways
Ship: AmaPrima
Departure: 03 August 2025
Rivers: Main, Moselle
Countries Visited: Czech Republic, Germany, Luxembourg, France
INSIDE
-
RIVER VIEW
$6,699
BALCONY
$8,098
SUITE
$10,598
From (per person) 6,699
View Trip
12 Day Christmas on the Main & Moselle with Viking River Cruises
River Cruise

12 Days Paris to Prague
Operated By: Viking River Cruises
Ships: Viking Alsvin, Viking Idi
Departures: Nov 2025 to Dec 2027
Rivers: Main, Moselle
Countries Visited: France, Germany, Czech Republic
Viking $799 Air DealViking $999 Air Deal
INSIDE
-
RIVER VIEW
$3,999
BALCONY
$4,999
SUITE
$7,999
From (per person) 3,999
View Trip
14 Day Europe's Rivers & Castles with Prague, Reims and Paris with AmaWaterways
New ReleaseRiver Cruise

14 Days Prague to Paris
Operated By: AmaWaterways
Ships: AmaCerto, AmaPrima
Departures: Apr 2025 to Oct 2025
Rivers: Main, Moselle
Countries Visited: Czech Republic, Germany, Luxembourg, France
INSIDE
-
RIVER VIEW
$6,299
BALCONY
$7,698
SUITE
$10,198
From (per person) 6,299
View Trip
14 Day Europe's Rivers & Castles with Paris and Prague with AmaWaterways
New ReleaseRiver Cruise

14 Days Paris to Prague
Operated By: AmaWaterways
Ships: AmaCerto, AmaPrima
Departures: Apr 2025 to Oct 2026
Rivers: Moselle, Main
Countries Visited: France, Luxembourg, Germany, Czech Republic
Summer Triple Savings
INSIDE
-
RIVER VIEW
$5,699
BALCONY
$7,098
SUITE
$9,598
Save (per person) 1,000
From (per person) 5,699
View Trip
14 Day Europe's Rivers & Castles with Paris, Reims and Prague with AmaWaterways
New ReleaseRiver Cruise

14 Days Paris to Prague
Operated By: AmaWaterways
Ships: AmaCerto, AmaPrima
Departures: Apr 2025 to Oct 2025
Rivers: Moselle, Main
Countries Visited: France, Luxembourg, Germany, Czech Republic
Summer Triple Savings
INSIDE
-
RIVER VIEW
$5,699
BALCONY
$7,098
SUITE
$9,598
Save (per person) 1,000
From (per person) 5,699
View Trip
14 Day Europe's Rivers & Castles with Prague and Paris with AmaWaterways
New ReleaseRiver Cruise

14 Days Prague to Paris
Operated By: AmaWaterways
Ships: AmaCerto, AmaPrima
Departures: Apr 2025 to Aug 2026
Rivers: Main, Moselle
Countries Visited: Czech Republic, Germany, Luxembourg, France
Summer Triple Savings
INSIDE
-
RIVER VIEW
$6,014
BALCONY
$7,513
SUITE
$10,013
Save (per person) 1,000
From (per person) 6,014
View Trip
14 Day Europe's Rivers & Castles with Prague and Paris (Wine Cruise) with AmaWaterways
New ReleaseRiver Cruise

14 Days Prague to Paris
Operated By: AmaWaterways
Ships: AmaPrima
Departures: Aug 2025 to Aug 2026
Rivers: Main, Moselle
Countries Visited: Czech Republic, Germany, Luxembourg, France
INSIDE
-
RIVER VIEW
$6,699
BALCONY
$8,098
SUITE
$10,598
From (per person) 6,699
View Trip
14 Day Romantic Capitals: Paris to Prague with Tauck
New ReleaseRiver Cruise

14 Days Paris to Prague
Operated By: Tauck
Departures: May 2025 to Oct 2026
Rivers: Moselle, Main
Countries Visited: France, Luxembourg, Germany, Czech Republic
Complimentary Hotel NightExclusive Solo Offer
From (per person) 9,790
View Trip
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