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All Main River Cruises

The Main river flows through Germany from modern, densely populated Mainz to more traditional medieval Bavarian towns lined with lovely forests and small towns and dotted with hilltop castles and churches. Choose from 1,766 river cruises along the Main river travelling with the world's leading river cruise lines.
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152 River Cruises (1,766 River Cruise Departures)
Featured10 Day Three Rivers: Danube, Main & Rhine with Tauck
River Cruise

10 Days Amsterdam to Regensburg
Operated By: Tauck
Departures: Apr 2024 to Oct 2024
Rivers: Danube, Main, Rhine
Countries Visited: Holland, Germany
Exclusive Solo Offer
From 8,680
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8 Day Classic Christmas Markets with Uniworld River Cruises
River Cruise

8 Days Nuremberg to Frankfurt
Ships: River Duchess, River Princess (+1 more), River Queen
Departures: Dec 2024 to Dec 2025
Rivers: Main
Countries Visited: Germany
Earlybird Saving
Save 2,036
From 3,863
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6 Day Festive Season in the Heart of Germany with Avalon River Cruises
River Cruise

6 Days Nuremberg to Frankfurt
Operated By: Avalon River Cruises
Ships: Avalon Illumination, Avalon Panorama
Departure: 08 December 2025
Rivers: Main
Countries Visited: Germany
Earlybird Offer
Save 611
From 3,969
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8 Day Classic Christmas Markets with Uniworld River Cruises
River Cruise

8 Days Frankfurt to Nuremberg
Ships: River Duchess, River Princess (+1 more), River Queen
Departures: Dec 2024 to Dec 2025
Rivers: Main
Countries Visited: Germany
Earlybird Saving
Save 2,036
From 3,863
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8 Day Festive Season in the Heart of Germany with Prague with Avalon River Cruises
River Cruise

8 Days Prague to Frankfurt
Operated By: Avalon River Cruises
Ships: Avalon Illumination, Avalon Panorama
Departure: 06 December 2025
Rivers: Main
Countries Visited: Czech Republic, Germany
Earlybird Offer
Save 621
From 4,917
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8 Day Reflections of the Rhine and Main with Travelmarvel
River Cruise
 (2)

8 Days Amsterdam to Munich
Operated By: Travelmarvel
Ships: Capella, Polaris (+1 more), Vega
Departures: May 2024 to Dec 2024
Rivers: Rhine, Main
Countries Visited: Holland, Germany
Exclusive Deal
Save 529
From 2,577
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9 Day German Grandeur with Avalon River Cruises
River Cruise
 (1)

9 Days Basel to Nuremberg
Operated By: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Impression (+2 more), Avalon Tranquility II, Avalon View
Departures: Oct 2024 to May 2025
Rivers: Rhine, Main
Countries Visited: Switzerland, France, Germany
Exclusive DealEarlybird Offer
Save 2,137
From 4,239
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11 Day German Grandeur with Munich with Avalon River Cruises
River Cruise
 (1)

11 Days Basel to Munich
Operated By: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Impression (+2 more), Avalon Tranquility II, Avalon View
Departures: Oct 2024 to May 2025
Rivers: Rhine, Main
Countries Visited: Switzerland, France, Germany
Exclusive DealEarlybird Offer
Save 2,149
From 5,418
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8 Day Christmas Markets on the Rhine and Main with Emerald Cruises
River Cruise
 (2)

8 Days Amsterdam to Nuremberg
Operated By: Emerald Cruises
Ship: Emerald Dawn
Departure: 26 November 2024
Rivers: Rhine, Main
Countries Visited: Holland, Germany
Exclusive Savings
INSIDE
-
RIVER VIEW
$3,993
BALCONY
$5,160
SUITE
-
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From 3,993
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7 Day Magic of Advent on the Rhine & Main with Amadeus River Cruises
New ReleaseRiver Cruise

7 Days Strasbourg to Nuremberg
Operated By: Amadeus River Cruises
Ship: Amadeus Nova
Departure: 06 December 2025
Rivers: Rhine, Main
Countries Visited: France, Germany
Exclusive Deal
INSIDE
-
RIVER VIEW
-
BALCONY
-
SUITE
$4,450
Save 195
From 4,450
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11 Day Rhine & Main Explorer with Viking River Cruises
New ReleaseRiver Cruise

11 Days Basel to Nuremberg
Operated By: Viking River Cruises
Ships: Viking Modi, Viking Skirnir
Departures: Apr 2025 to Nov 2025
Rivers: Rhine, Main
Countries Visited: Switzerland, France, Germany
Discover More Sale
INSIDE
-
RIVER VIEW
$4,648
BALCONY
$5,638
SUITE
$10,687
Save 2,372
From 4,648
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10 Day Zurich & the Rhine River Valley with Uniworld River Cruises
New ReleaseRiver Cruise

10 Days Nuremberg to Zurich
Ship: River Princess
Departures: Jul 2024 to Oct 2024
Rivers: Rhine, Main
Countries Visited: Germany, France, Switzerland
Exclusive Deal
Save 2,543
From 4,556
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8 Day Rhine River Valley with Uniworld River Cruises
New ReleaseRiver Cruise

8 Days Basel to Nuremberg
Ship: River Princess
Departures: Jun 2024 to Oct 2024
Rivers: Rhine, Main
Countries Visited: Switzerland, France, Germany
Exclusive DealExclusive Solo Offer
Save 2,526
From 2,873
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8 Day Highlights of the Rhine and Main with APT
River Cruise

8 Days Amsterdam to Munich
Operated By: APT
Ships: MS AmaStella, MS AmaVenita (+2 more), APT Ostara, APT Solara
Departures: Jun 2024 to Nov 2025
Rivers: Rhine, Main
Countries Visited: Holland, Germany
Exclusive Deal
Save 1,349
From 4,161
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8 Day Rhine River Valley with Uniworld River Cruises
New ReleaseRiver Cruise

8 Days Nuremberg to Basel
Ship: River Princess
Departures: Jun 2024 to Oct 2024
Rivers: Rhine, Main
Countries Visited: Germany, France, Switzerland
Exclusive Deal
Save 2,526
From 2,873
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10 Day Zurich & the Rhine River Valley with Uniworld River Cruises
New ReleaseRiver Cruise

10 Days Zurich to Nuremberg
Ship: River Princess
Departures: Jul 2024 to Oct 2024
Rivers: Rhine, Main
Countries Visited: Switzerland, France, Germany
Exclusive DealExclusive Solo Offer
Save 2,543
From 4,556
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8 Day Three-Rivers Cruise with Amadeus River Cruises
New ReleaseRiver Cruise

8 Days Amsterdam to Nuremberg
Operated By: Amadeus River Cruises
Ship: Amadeus Riva
Departure: 06 May 2025
Rivers: Rhine, Main
Countries Visited: Holland, Germany
Exclusive Deal
INSIDE
-
RIVER VIEW
$3,861
BALCONY
-
SUITE
-
Save 189
From 3,861
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11 Day Rhine & Main Explorer with Viking River Cruises
New ReleaseRiver Cruise

11 Days Nuremberg to Basel
Operated By: Viking River Cruises
Ships: Viking Modi, Viking Skirnir
Departures: Apr 2025 to Nov 2025
Rivers: Main, Rhine
Countries Visited: Germany, France, Switzerland
Discover More Sale
INSIDE
-
RIVER VIEW
$4,648
BALCONY
$5,638
SUITE
$10,687
Save 2,372
From 4,648
View Trip
10 Day Authentic Danube & Prague with Uniworld River Cruises
River Cruise

10 Days Vienna to Prague
Ship: River Princess
Departures: Jun 2024 to Oct 2024
Rivers: Danube, Main
Countries Visited: Austria, Germany, Czech Republic
Exclusive Deal2-for-1 Fare
Save 5,047
From 4,457
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10 Day Authentic Danube & Prague with Uniworld River Cruises
River Cruise

10 Days Prague to Vienna
Ship: River Princess
Departures: May 2024 to Sep 2024
Rivers: Main, Danube
Countries Visited: Czech Republic, Germany, Austria
Mutiple Deals Available
Save 4,743
From 4,457
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9 Day Christmastime on the Danube with Prague with Avalon River Cruises
River Cruise

9 Days Prague to Vienna
Operated By: Avalon River Cruises
Ships: Avalon Envision, Avalon Expression (+2 more), Avalon Impression, Avalon Tranquility II
Departures: Dec 2025 to Dec 2025
Rivers: Main, Danube
Countries Visited: Czech Republic, Germany, Austria
Earlybird Offer
Save 852
From 5,659
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12 Day Christmas on the Main & Moselle with Viking River Cruises
River Cruise

12 Days Prague to Paris
Operated By: Viking River Cruises
Ships: Viking Alsvin, Viking Idi
Departures: Nov 2025 to Dec 2026
Rivers: Main, Moselle
Countries Visited: Czech Republic, Germany, France
Discover More Sale
INSIDE
-
RIVER VIEW
$5,143
BALCONY
$6,133
SUITE
$9,103
Save 2,362
From 5,143
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12 Day Christmas on the Main & Moselle with Viking River Cruises
River Cruise

12 Days Paris to Prague
Operated By: Viking River Cruises
Ships: Viking Alsvin, Viking Idi
Departures: Dec 2024 to Dec 2026
Rivers: Main, Moselle
Countries Visited: France, Germany, Czech Republic
Discover More Sale
INSIDE
-
RIVER VIEW
$5,143
BALCONY
$6,133
SUITE
$9,103
Save 2,362
From 5,143
View Trip
14 Day Romantic Capitals: Prague to Paris with Tauck
New ReleaseRiver Cruise

14 Days Prague to Paris
Operated By: Tauck
Departures: Apr 2025 to Oct 2025
Rivers: Main, Moselle
Countries Visited: Czech Republic, Germany, Luxembourg, France
Exclusive Solo Offer
From 14,840
View Trip
14 Day Romantic Capitals: Paris to Prague with Tauck
New ReleaseRiver Cruise

14 Days Paris to Prague
Operated By: Tauck
Departures: May 2025 to Oct 2025
Rivers: Moselle, Main
Countries Visited: France, Luxembourg, Germany, Czech Republic
Exclusive Solo Offer
From 14,840
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15 Day European Gems with Travelmarvel
River Cruise
 (31)

15 Days Amsterdam to Budapest
Operated By: Travelmarvel
Ships: Capella, Polaris (+4 more), Vega, Capella, Polaris, Vega
Departures: May 2024 to Dec 2025
Rivers: Rhine, Main, Danube
Countries Visited: Holland, Germany, Austria, Hungary
Exclusive DealFlights Included and Save
Save 3,045
From 4,465
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15 Day Magnificent Europe with APT
River Cruise
 (59)

15 Days Amsterdam to Budapest
Operated By: APT
Ships: MS AmaReina, MS AmaStella (+3 more), MS AmaVenita, APT Ostara, APT Solara
Departures: May 2024 to Dec 2025
Rivers: Rhine, Main, Danube
Countries Visited: Holland, Germany, Austria, Slovakia (+1 more), Hungary
Last Minute DealsFlights Included
Save 1,785
From 7,930
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15 Day European Gems - Budapest to Amsterdam with Travelmarvel
River Cruise
 (32)

15 Days Budapest to Amsterdam
Operated By: Travelmarvel
Ships: Capella, Polaris (+4 more), Vega, Capella, Polaris, Vega
Departures: May 2024 to Dec 2025
Rivers: Danube, Main, Rhine
Countries Visited: Hungary, Austria, Germany, Holland
Mutiple Deals Available
Save 3,545
From 4,465
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15 Day Magnificent Europe - Budapest to Amsterdam with APT
River Cruise
 (30)

15 Days Budapest to Amsterdam
Operated By: APT
Ships: MS AmaReina, MS AmaStella (+3 more), MS AmaVenita, APT Ostara, APT Solara
Departures: May 2024 to Dec 2025
Rivers: Danube, Main, Rhine
Countries Visited: Hungary, Slovakia, Austria, Germany (+1 more), Holland
Last Minute DealsFlights Included
Save 1,785
From 7,865
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15 Day Magnificent Europe with Avalon River Cruises
River Cruise
 (78)

15 Days Amsterdam to Budapest
Operated By: Avalon River Cruises
Ships: Avalon Artistry II, Avalon Envision (+5 more), Avalon Expression, Avalon Illumination, Avalon Imagery II, Avalon Impression, Avalon Passion
Departures: Jul 2024 to Oct 2025
Rivers: Rhine, Main, Danube
Countries Visited: Holland, Germany, Austria, Hungary
Exclusive DealEarlybird Offer
Save 4,068
From 7,243
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15 Day Splendours of Europe with Emerald Cruises
River Cruise

15 Days Amsterdam to Budapest
Operated By: Emerald Cruises
Ships: Emerald Dawn, Emerald Destiny (+4 more), Emerald Luna, Emerald Sky, Emerald Star, Emerald Sun
Departures: May 2024 to Oct 2025
Rivers: Rhine, Main, Danube
Countries Visited: Holland, Germany, Austria, Slovakia (+1 more), Hungary
Exclusive Savings
INSIDE
-
RIVER VIEW
$7,149
BALCONY
$9,550
SUITE
$12,402
Save 265
From 7,149
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