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All Main River Cruises

The Main river flows through Germany from modern, densely populated Mainz to more traditional medieval Bavarian towns lined with lovely forests and small towns and dotted with hilltop castles and churches. Choose from 1,274 river cruises along the Main river traveling with the world's leading river cruise lines.
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137 River Cruises (1,274 River Cruise Departures)
6 Day Festive Season in the Heart of Germany with Avalon River Cruises
River Cruise
 (2)

6 Days Frankfurt to Nuremberg
Cruise Line: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Panorama, Avalon Tranquility II
Departures: Dec 2025 to Dec 2026
Rivers: Main
Visit: Germany
Exclusive Savings
Inside
-
River View
$3,044
Balcony
$4,037
Suite
$5,718
From
US$2,837
Save 120
Per Person
View Trip
8 Day Festive Season in the Heart of Germany with Prague with Avalon River Cruises
River Cruise

8 Days Prague to Frankfurt
Cruise Line: Avalon River Cruises
Ships: Avalon Illumination, Avalon Imagery II (+4 more), Avalon Panorama, Avalon Tranquility II, Avalon Passion, Avalon Vista
Departures: Dec 2025 to Dec 2027
Rivers: Main
Visit: Czech Republic, Germany
Exclusive Savings
Inside
-
River View
$3,705
Balcony
$4,641
Suite
$6,379
From
US$3,441
Save 152
Per Person
View Trip
6 Day Christmastime in the Heart of Germany with Avalon River Cruises
New ReleaseRiver Cruise

6 Days Frankfurt to Nuremberg
Cruise Line: Avalon River Cruises
Ships: Avalon Panorama, Avalon Passion, Avalon Vista
Departures: Dec 2027 to Dec 2027
Rivers: Main
Visit: Germany
Exclusive Savings
Inside
-
River View
$3,155
Balcony
$4,458
Suite
$5,829
From
US$3,155
Save 400
Per Person
View Trip
6 Day Festive Season in the Heart of Germany with Avalon River Cruises
River Cruise

6 Days Nuremberg to Frankfurt
Cruise Line: Avalon River Cruises
Ships: Avalon Panorama, Avalon Illumination (+2 more), Avalon Imagery II, Avalon Tranquility II
Departures: Dec 2025 to Dec 2026
Rivers: Main
Visit: Germany
Exclusive Savings
Inside
-
River View
$3,044
Balcony
$4,037
Suite
$5,718
From
US$2,837
Save 120
Per Person
View Trip
8 Day Classic Christmas Markets with Uniworld River Cruises
River Cruise

8 Days Nuremberg to Frankfurt
Cruise Line: Uniworld River Cruises
Ships: River Duchess, S.S. Elisabeth, S.S. Emilie
Departures: Dec 2025 to Dec 2026
Rivers: Main
Visit: Germany
Exclusive Savings
Inside
-
River View
$2,888
Balcony
$4,588
Suite
$6,575
From
US$2,888
Save 2,111
Per Person
View Trip
8 Day Classic Christmas Markets with Uniworld River Cruises
River Cruise

8 Days Frankfurt to Nuremberg
Cruise Line: Uniworld River Cruises
Ships: River Duchess, S.S. Elisabeth, S.S. Emilie
Departures: Nov 2025 to Dec 2026
Rivers: Main
Visit: Germany
Exclusive Savings
Inside
-
River View
$2,888
Balcony
$4,424
Suite
$7,213
From
US$2,888
Save 2,111
Per Person
View Trip
8 Day Festive Season in the Heart of Germany with Prague with Avalon River Cruises
River Cruise

8 Days Frankfurt to Prague
Cruise Line: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Panorama (+3 more), Avalon Passion, Avalon Tranquility II, Avalon Vista
Departures: Dec 2025 to Dec 2027
Rivers: Main
Visit: Germany, Czech Republic
Exclusive Savings
Inside
-
River View
$3,705
Balcony
$4,641
Suite
$6,379
From
US$3,441
Save 428
Per Person
View Trip
6 Day Christmastime in the Heart of Germany with Avalon River Cruises
New ReleaseRiver Cruise

6 Days Nuremberg to Frankfurt
Cruise Line: Avalon River Cruises
Ships: Avalon Passion, Avalon Vista
Departures: Dec 2027 to Dec 2027
Rivers: Main
Visit: Germany
Exclusive Savings
Inside
-
River View
$3,155
Balcony
$4,458
Suite
$5,829
From
US$3,155
Save 124
Per Person
View Trip
9 Day German Grandeur (Eastbound) with Avalon River Cruises
River Cruise
 (1)

9 Days Basel to Nuremberg
Cruise Line: Avalon River Cruises
Ships: Avalon Tranquility II, Avalon Imagery II
Departures: May 2026 to Oct 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany
Exclusive Savings
Inside
-
River View
$4,703
Balcony
$6,677
Suite
$8,762
From
US$4,703
Save 196
Per Person
View Trip
11 Day German Grandeur with Munich (Eastbound) with Avalon River Cruises
River Cruise
 (1)

11 Days Basel to Munich
Cruise Line: Avalon River Cruises
Ships: Avalon Tranquility II, Avalon Imagery II
Departures: May 2026 to Oct 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany
Exclusive Savings
Inside
-
River View
$5,547
Balcony
$7,521
Suite
$9,606
From
US$5,547
Save 231
Per Person
View Trip
11 Day Rhine & Main Explorer with Viking River Cruises
New ReleaseRiver Cruise

11 Days Nuremberg to Basel
Cruise Line: Viking River Cruises
Ships: Viking Modi, Viking Skirnir
Departures: Apr 2026 to Nov 2027
Rivers: Main, Rhine
Visit: Germany, France, Switzerland
Multiple Deals Available
Inside
-
River View
$2,999
Balcony
$3,599
Suite
$4,999
From
US$2,999
Save 1,000
Per Person
View Trip
10 Day Christmastime from Basel to Nuremberg with Avalon River Cruises
River Cruise

10 Days Basel to Nuremberg
Cruise Line: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Panorama (+2 more), Avalon Tranquility II, Avalon Vista
Departures: Nov 2025 to Nov 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany
Exclusive Savings
Inside
-
River View
$5,719
Balcony
$8,064
Suite
$10,532
From
US$5,356
Save 234
Per Person
View Trip
12 Day Christmastime from Nuremberg to Basel with Prague with Avalon River Cruises
River Cruise

12 Days Prague to Basel
Cruise Line: Avalon River Cruises
Ships: Avalon Illumination, Avalon Imagery II (+3 more), Avalon Panorama, Avalon Tranquility II, Avalon Vista
Departures: Dec 2025 to Dec 2027
Rivers: Main, Rhine
Visit: Czech Republic, Germany, France, Switzerland
Exclusive Savings
Inside
-
River View
$6,381
Balcony
$8,726
Suite
$11,193
From
US$5,960
Save 261
Per Person
View Trip
7 Day Magic of Advent on the Rhine & Main with Amadeus River Cruises
New ReleaseRiver Cruise

7 Days Nuremberg to Strasbourg
Cruise Line: Amadeus River Cruises
Ship: Amadeus Aurea
Departure: 04 December 2026
Rivers: Main, Rhine
Visit: Germany, France
Exclusive Savings
Inside
-
River View
$1,759
Balcony
-
Suite
-
From
US$1,759
Save 150
Per Person
View Trip
11 Day Christmas on the Rhine & Main with Viking River Cruises
New ReleaseRiver Cruise

11 Days Basel to Nuremberg
Cruise Line: Viking River Cruises
Ships: Viking Modi, Viking Skirnir
Departures: Nov 2026 to Dec 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany
Viking $999 Air Deal
Inside
-
River View
$4,799
Balcony
$6,299
Suite
-
From
US$4,799
Per Person
View Trip
10 Day Christmastime from Nuremberg to Basel with Avalon River Cruises
River Cruise

10 Days Nuremberg to Basel
Cruise Line: Avalon River Cruises
Ships: Avalon Illumination, Avalon Imagery II (+3 more), Avalon Panorama, Avalon Tranquility II, Avalon Vista
Departures: Dec 2025 to Dec 2027
Rivers: Main, Rhine
Visit: Germany, France, Switzerland
Exclusive Savings
Inside
-
River View
$5,719
Balcony
$8,064
Suite
$10,532
From
US$5,356
Save 234
Per Person
View Trip
8 Day Medieval Treasures with AmaWaterways
New ReleaseRiver Cruise

8 Days Basel to Nuremberg
Cruise Line: AmaWaterways
Ships: AmaCerto, AmaPrima
Departures: Mar 2027 to Oct 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany
Exclusive Savings
Inside
-
River View
$3,159
Balcony
$4,694
Suite
$7,190
From
US$3,159
Save 1,400
Per Person
View Trip
8 Day Three-Rivers Cruise with Amadeus River Cruises
New ReleaseRiver Cruise

8 Days Nuremberg to Amsterdam
Cruise Line: Amadeus River Cruises
Ship: Amadeus Aurea
Departure: 21 July 2026
Rivers: Main, Rhine
Visit: Germany, Holland
Exclusive Savings
Inside
-
River View
$3,086
Balcony
$3,843
Suite
$4,928
From
US$3,086
Save 150
Per Person
View Trip
7 Day Magic of Advent on the Rhine & Main with Amadeus River Cruises
New ReleaseRiver Cruise

7 Days Strasbourg to Nuremberg
Cruise Line: Amadeus River Cruises
Ship: Amadeus Nova
Departure: 06 December 2025
Rivers: Rhine, Main
Visit: France, Germany
Inside
-
River View
$1,805
Balcony
$2,166
Suite
-
From
US$1,805
Per Person
View Trip
8 Day Medieval Treasures (Wine Cruise) with AmaWaterways
New ReleaseRiver Cruise

8 Days Basel to Nuremberg
Cruise Line: AmaWaterways
Ships: AmaCerto, AmaPrima
Departures: Mar 2027 to Aug 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany
Exclusive Savings
Inside
-
River View
$3,543
Balcony
$5,078
Suite
$7,574
From
US$3,543
Save 1,388
Per Person
View Trip
8 Day Three-Rivers Cruise with Amadeus River Cruises
New ReleaseRiver Cruise

8 Days Amsterdam to Nuremberg
Cruise Line: Amadeus River Cruises
Ships: Amadeus Cara, Amadeus Queen
Departures: May 2026 to May 2026
Rivers: Rhine, Main
Visit: Holland, Germany
Exclusive Savings
Inside
-
River View
$2,680
Balcony
$3,561
Suite
$4,928
From
US$2,680
Save 150
Per Person
View Trip
12 Day Christmastime from Basel to Nuremberg with Prague with Avalon River Cruises
River Cruise

12 Days Basel to Prague
Cruise Line: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Panorama (+2 more), Avalon Tranquility II, Avalon Vista
Departures: Nov 2025 to Nov 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany, Czech Republic
Exclusive Savings
Inside
-
River View
$6,381
Balcony
$8,726
Suite
$11,193
From
US$5,960
Save 261
Per Person
View Trip
11 Day Rhine & Main Explorer with Viking River Cruises
New ReleaseRiver Cruise

11 Days Basel to Nuremberg
Cruise Line: Viking River Cruises
Ships: Viking Modi, Viking Skirnir
Departures: Apr 2026 to Nov 2027
Rivers: Rhine, Main
Visit: Switzerland, France, Germany
Multiple Deals Available
Inside
-
River View
$2,999
Balcony
$3,599
Suite
$4,999
From
US$2,999
Save 1,000
Per Person
View Trip
11 Day Christmas on the Rhine & Main with Viking River Cruises
New ReleaseRiver Cruise

11 Days Nuremberg to Basel
Cruise Line: Viking River Cruises
Ships: Viking Modi, Viking Skirnir
Departures: Nov 2026 to Dec 2027
Rivers: Main, Rhine
Visit: Germany, France, Switzerland
Viking $999 Air Deal
Inside
-
River View
$4,799
Balcony
$6,299
Suite
-
From
US$4,799
Per Person
View Trip
12 Day Christmastime from Frankfurt to Vienna with Avalon River Cruises
River Cruise

12 Days Frankfurt to Vienna
Cruise Line: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Tranquility II (+2 more), Avalon Impression, Avalon Vista
Departures: Dec 2025 to Dec 2027
Rivers: Main, Danube
Visit: Germany, Austria
Exclusive Savings
Inside
-
River View
$6,601
Balcony
$9,467
Suite
$12,483
From
US$6,280
Save 272
Per Person
View Trip
13 Day Festive Season from Frankfurt to Budapest with Avalon River Cruises
River Cruise

13 Days Frankfurt to Budapest
Cruise Line: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Panorama, Avalon Passion
Departures: Dec 2025 to Dec 2027
Rivers: Main, Danube
Visit: Germany, Austria, Hungary
Exclusive Savings
Inside
-
River View
$6,790
Balcony
$10,660
Suite
$13,951
From
US$6,790
Save 296
Per Person
View Trip
12 Day Christmastime from Vienna to Frankfurt with Avalon River Cruises
River Cruise

12 Days Vienna to Frankfurt
Cruise Line: Avalon River Cruises
Ships: Avalon Imagery II, Avalon Vista
Departure: 03 December 2027
Rivers: Danube, Main
Visit: Austria, Germany
Exclusive Savings
Inside
-
River View
$6,922
Balcony
$9,788
Suite
$12,804
From
US$6,922
Save 272
Per Person
View Trip
15 Day Christmastime from Budapest to Frankfurt with Budapest with Avalon River Cruises
New ReleaseRiver Cruise

15 Days Budapest to Frankfurt
Cruise Line: Avalon River Cruises
Ships: Avalon Illumination, Avalon Passion, Avalon Panorama
Departures: Nov 2025 to Nov 2027
Rivers: Danube, Main
Visit: Hungary, Austria, Germany
Exclusive Savings
Inside
-
River View
$7,888
Balcony
$11,014
Suite
$14,305
From
US$7,269
Save 311
Per Person
View Trip
9 Day Christmastime on the Danube with Prague with Avalon River Cruises
River Cruise

9 Days Prague to Vienna
Cruise Line: Avalon River Cruises
Ships: Avalon Envision, Avalon Expression (+6 more), Avalon Tranquility II, Avalon Imagery II, Avalon Impression, Avalon Passion, Avalon Visionary, Avalon Vista
Departures: Dec 2025 to Dec 2027
Rivers: Main, Danube
Visit: Czech Republic, Germany, Austria
Exclusive Savings
Inside
-
River View
$4,218
Balcony
$5,404
Suite
$7,427
From
US$4,047
Save 176
Per Person
View Trip
13 Day Christmastime from Budapest to Frankfurt with Avalon River Cruises
River Cruise

13 Days Budapest to Frankfurt
Cruise Line: Avalon River Cruises
Ships: Avalon Illumination, Avalon Passion, Avalon Panorama
Departures: Dec 2025 to Nov 2027
Rivers: Danube, Main
Visit: Hungary, Austria, Germany
Exclusive Savings
Inside
-
River View
$7,342
Balcony
$10,468
Suite
$13,759
From
US$6,790
Save 288
Per Person
View Trip
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